Brian W McCrindle

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Dis Child 92:509-14. 2007
  2. doi request reprint The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Cardiol 35:632-40. 2014
  3. doi request reprint Familial hypercholesterolemia in children and adolescents
    Brian W McCrindle
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 23:525-31. 2012
  4. doi request reprint Factors associated with thrombotic complications after the Fontan procedure: a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure
    Brian W McCrindle
    Labatt Family Heart Centre, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 61:346-53. 2013
  5. pmc Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and design
    Beverly Walpole
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    BMC Public Health 11:459. 2011
  6. ncbi request reprint Are patients after Kawasaki disease at increased risk for accelerated atherosclerosis?
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 151:244-8, 248.e1. 2007
  7. pmc Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure
    Brian W McCrindle
    Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 121:34-42. 2010
  8. ncbi request reprint Hyperlipidemia in children
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Thromb Res 118:49-58. 2006
  9. ncbi request reprint A randomized crossover trial of combination pharmacologic therapy in children with familial hyperlipidemia
    Brian W McCrindle
    Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Pediatr Res 51:715-21. 2002
  10. pmc Presentation, management and outcomes of thrombosis for children with cardiomyopathy
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Can J Cardiol 22:685-90. 2006

Detail Information

Publications128 found, 100 shown here

  1. pmc Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Dis Child 92:509-14. 2007
    ..To determine physical activity levels in paediatric patients who underwent the Fontan procedure, and their relationship to functional status and exercise capacity...
  2. doi request reprint The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Cardiol 35:632-40. 2014
    ..Further longitudinal study is necessary to better understand the relationship between clinical morbidities and functional health status as these patients transition into adulthood...
  3. doi request reprint Familial hypercholesterolemia in children and adolescents
    Brian W McCrindle
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 23:525-31. 2012
    ..This review provides an update and highlights the controversies regarding recent advances and recommendations regarding screening, diagnosis and treatment of children and adolescents with familial hypercholesterolemia...
  4. doi request reprint Factors associated with thrombotic complications after the Fontan procedure: a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure
    Brian W McCrindle
    Labatt Family Heart Centre, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 61:346-53. 2013
    ..The study sought to identify factors associated with increased risk of thrombosis after Fontan...
  5. pmc Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and design
    Beverly Walpole
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    BMC Public Health 11:459. 2011
    ....
  6. ncbi request reprint Are patients after Kawasaki disease at increased risk for accelerated atherosclerosis?
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 151:244-8, 248.e1. 2007
    ..To assess whether patients after Kawasaki disease (KD) have increased risk factors and abnormalities suggestive of early atherosclerosis in systemic arteries...
  7. pmc Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure
    Brian W McCrindle
    Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 121:34-42. 2010
    ..Patients after the Fontan procedure are at risk for suboptimal functional health status, and associations with laboratory measures are important for planning interventions and outcome measures for clinical trials...
  8. ncbi request reprint Hyperlipidemia in children
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Thromb Res 118:49-58. 2006
    ....
  9. ncbi request reprint A randomized crossover trial of combination pharmacologic therapy in children with familial hyperlipidemia
    Brian W McCrindle
    Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Pediatr Res 51:715-21. 2002
    ..Compliance with medication regimens using the bile acid-binding resins is suboptimal, although combination with a low dose of a statin may result in better lipid lowering...
  10. pmc Presentation, management and outcomes of thrombosis for children with cardiomyopathy
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Can J Cardiol 22:685-90. 2006
    ..Thrombosis in children with dilated and inflammatory cardiomyopathy is an unpredictable complication with potentially important morbidity...
  11. ncbi request reprint Postoperative chylothorax after cardiothoracic surgery in children
    Emily H Chan
    Division of Pediatric Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1864-70. 2005
    ..The purpose of this study is to determine the incidence, risk factors, and outcomes for chylothorax in children undergoing cardiothoracic surgery...
  12. doi request reprint Assessment and management of hypertension in children and adolescents
    Brian W McCrindle
    The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Cardiol 7:155-63. 2010
    ..Pharmacological management is reserved for patients with hypertension who do not respond to behavioral changes, have additional cardiovascular risk factors or diabetes, are symptomatic, or have developed target-organ damage...
  13. doi request reprint Population trends toward increasing cardiovascular risk factors in Canadian adolescents
    Brian W McCrindle
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 157:837-43. 2010
    ..To determine prevalence and cross-sectional trends over time for cardiovascular risk factors in Canadian adolescents...
  14. ncbi request reprint Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    University of Toronto, Hospital for Sick Children, Toronto, Canada
    Circulation 113:1123-9. 2006
    ..After the Fontan procedure, patients are at risk for suboptimal health status related to their complex healthcare experience, physiological limitations, medical complications, and guarded long-term prognosis...
  15. ncbi request reprint Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial
    Brian W McCrindle
    Division of Pediatric Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 143:74-80. 2003
    ..To determine the safety and efficacy of atorvastatin (10 to 20 mg) in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia...
  16. ncbi request reprint Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 116:174-9. 2007
    ..Analysis of serial normalized artery measurements may reveal a broader continuous spectrum of involvement and different risk factors...
  17. ncbi request reprint Is balloon aortic valvuloplasty a feasible treatment for neonates and young infants with aortic valve stenosis?
    Brian W McCrindle
    The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:340-1. 2005
  18. ncbi request reprint Truncus arteriosus associated with interrupted aortic arch in 50 neonates: a Congenital Heart Surgeons Society study
    Igor E Konstantinov
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 81:214-22. 2006
    ..Patients with both interrupted aortic arch (IAA) and truncus arteriosus (TA) have worse outcomes than those with either lesion in isolation. We determined outcomes and associated factors in this rare group...
  19. doi request reprint Impaired left ventricular myocardial mechanics and their relation to pulmonary regurgitation, right ventricular enlargement and exercise capacity in asymptomatic children after repair of tetralogy of Fallot
    Fernanda P Fernandes
    Labatt Family Heart Centre, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 25:494-503. 2012
    ..The hypothesis was that impaired LV myocardial mechanics are related to pulmonary regurgitation, right ventricular (RV) enlargement, and exercise capacity...
  20. ncbi request reprint Outcome and growth potential of left heart structures after neonatal intervention for aortic valve stenosis
    Ra K Han
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 50:2406-14. 2007
    ..The purpose of this study was to determine trends of growth of left heart structures after intervention for neonatal aortic valve stenosis...
  21. pmc Late status of Fontan patients with persistent surgical fenestration
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Am Coll Cardiol 57:2437-43. 2011
    ..This study was undertaken to determine the effects of creating a systemic-to-pulmonary venous atrial-level communication (fenestration) at the time of the Fontan procedure on late outcomes...
  22. doi request reprint Longer blood storage is associated with suboptimal outcomes in high-risk pediatric cardiac surgery
    Cedric Manlhiot
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 93:1563-9. 2012
    ..The negative effects of long-term storage of allogeneic red blood cells (RBCs) on outcomes in adult cardiac surgery have been established, but evidence of a similar effect in pediatric cardiac surgery is limited...
  23. doi request reprint Impaired right and left ventricular diastolic myocardial mechanics and filling in asymptomatic children and adolescents after repair of tetralogy of Fallot
    Mark K Friedberg
    Division of Paediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Eur Heart J Cardiovasc Imaging 13:905-13. 2012
    ..We hypothesized that children after TOF repair have diastolic dysfunction and dyssynchrony by this measure, and sought to determine their relationship with pulmonary regurgitation (PR), RV enlargement, and aerobic exercise capacity...
  24. doi request reprint Neurodevelopmental outcomes after open heart operations before 3 months of age
    Renee Sananes
    Labatt Family Heart Centre and Division of Neurology, Department of Paediatrics, Surgery and Critical Care Medicine, The University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 93:1577-83. 2012
    ....
  25. ncbi request reprint Factors associated with mortality and reoperation in 377 children with total anomalous pulmonary venous connection
    Tara Karamlou
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Circulation 115:1591-8. 2007
    ..We sought to determine era-specific changes in the incidence of mortality and reoperation in children with total anomalous pulmonary venous connection...
  26. doi request reprint Congenital supravalvular aortic stenosis: defining surgical and nonsurgical outcomes
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Ann Thorac Surg 86:1919-27; discussion 1927. 2008
    ..Supravalvular aortic stenosis is a rare stenotic lesion of the left ventricular outflow tract (LVOT). We characterized the natural history of the disease and the effect of surgical intervention...
  27. doi request reprint Hyperglycemia after pediatric cardiac surgery: impact of age and residual lesions
    Michael Alice Moga
    Division of Cardiac Critical Care Medicine, Department of Pediatrics, The Labatt Family Heart Center, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Crit Care Med 39:266-72. 2011
    ..The incidence, severity, and duration of hyperglycemia in this patient population and perioperative factors predisposing to hyperglycemia were also delineated...
  28. doi request reprint Thrombotic complications and thromboprophylaxis across all three stages of single ventricle heart palliation
    Cedric Manlhiot
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 161:513-519.e3. 2012
    ..To describe the incidence of thrombotic complications across all 3 stages of single ventricle palliation and the association between thromboprophylaxis use and thrombotic risk...
  29. ncbi request reprint Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:441-8. 2007
    ..We used measured oxygen consumption to characterize hemodynamics and oxygen transport after the classic Norwood procedure...
  30. doi request reprint Infective endocarditis in children: native valve preservation is frequently possible despite advanced clinical disease
    Edward J Hickey
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Canada
    Eur J Cardiothorac Surg 35:130-5. 2009
    ..We therefore reviewed all cases of culture-proven IE referred for surgical intervention at our institution over the last three decades...
  31. pmc Surgical management of complete atrioventricular septal defect: associations with surgical technique, age, and trisomy 21
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Thorac Cardiovasc Surg 141:1371-9. 2011
    ..We sought to evaluate the contemporary results after repair of a complete atrioventricular septal defect and to determine the factors associated with suboptimal outcomes...
  32. doi request reprint Jugular venous valved conduit (Contegra) matches allograft performance in infant truncus arteriosus repair
    Edward J Hickey
    The Congenital Heart Surgeons Society Data Center, Toronto, Canada
    Eur J Cardiothorac Surg 33:890-8. 2008
    ..Limited availability and durability of allograft conduits require that alternatives be considered. We compared bovine jugular venous valved (JVV) and allograft conduit performance in 107 infants who survived truncus arteriosus repair...
  33. doi request reprint Percutaneous pulmonary valve implantation in the young 2-year follow-up
    Marko Vezmar
    Department of Pediatrics, The Hospital for Sick Children, The Labatt Family Heart Centre, University of Toronto School of Medicine, Toronto, Canada
    JACC Cardiovasc Interv 3:439-48. 2010
    ..The aim of this study was to investigate physiological and clinical consequences of percutaneous pulmonary valve implantation (PPVI) in patients with chronic right ventricular outflow tract (RVOT) obstruction and volume overload...
  34. doi request reprint Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair
    Mark K Friedberg
    Division of Paediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, Canada
    Am Heart J 165:551-7. 2013
    ..We investigated RV myocardial deformation and dyssynchrony in children after TOF repair and their association with exercise capacity...
  35. doi request reprint Biventricular strategies for neonatal critical aortic stenosis: high mortality associated with early reintervention
    Edward J Hickey
    Congenital Heart Surgeons Society Data Center, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:409-17, 417.e1. 2012
    ..To characterize the risk of reintervention after biventricular strategies to treat neonatal critical aortic stenosis, and the effect of reintervention on survival...
  36. ncbi request reprint Role of waist measures in characterizing the lipid and blood pressure assessment of adolescents classified by body mass index
    Michael Khoury
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 166:719-24. 2012
    ....
  37. doi request reprint Persistent risk of subsequent procedures and mortality in patients after interrupted aortic arch repair: a Congenital Heart Surgeons' Society study
    Anusha Jegatheeswaran
    Division of Cardiovascular Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 140:1059-75.e2. 2010
    ..We the investigated patterns and factors associated with these subsequent procedures and mortality...
  38. ncbi request reprint Functional state of patients with heterotaxy syndrome following the Fontan operation
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Children s Hospital, Charleston, South Carolina 29425, United States of America
    Cardiol Young 17:44-53. 2007
    ..Little is known, however, about the functional state of surviving patients with heterotaxy following a Fontan operation...
  39. doi request reprint Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Eur J Cardiothorac Surg 35:156-64; discussion 164. 2009
    ..We investigated an inception cohort who underwent surgical repair. We aimed to characterize late hazard or risk for death, and determine the time-related risk of late re-operation and pulmonary valve replacement (PVR)...
  40. ncbi request reprint Outcome after prenatal diagnosis of tricuspid atresia: a multicenter experience
    Rachel M Wald
    The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 153:772-8. 2007
    ..The outcome of prenatally diagnosed tricuspid atresia (TA) is undefined. We sought to characterize clinical and echocardiographic features of fetal TA and to determine factors associated with mortality...
  41. ncbi request reprint Determinants of mortality and type of repair in neonates with pulmonary atresia and intact ventricular septum
    David A Ashburn
    Division of Cardiothoracic Surgery, Hospital for Sick Children, Toronto, Onario, Canada
    J Thorac Cardiovasc Surg 127:1000-7; discussion 1007-8. 2004
    ..We sought to define the prevalence of definitive end states and their determinants in children given a diagnosis of pulmonary atresia and intact ventricular septum during the neonatal period...
  42. ncbi request reprint Risk factors associated with mortality and interventions in 472 neonates with interrupted aortic arch: a Congenital Heart Surgeons Society study
    Brian W McCrindle
    Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:343-50. 2005
    ..We sought to determine the prevalence of outcomes and associated patient and management factors for neonates with interrupted aortic arch...
  43. ncbi request reprint Frequency, predictors, and neurologic outcomes of vaso-occlusive strokes associated with cardiac surgery in children
    Trish Domi
    Department of Child Health and Evaluative Sciences, Hospital for Sick Children, and Institute of Medical Sciences, University of Toronto, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 122:1292-8. 2008
    ..Our aim was to define the frequency, predictors, and outcomes of stroke associated with cardiac surgery in children with congenital heart disease...
  44. doi request reprint Arterial complications associated with cardiac catheterization in pediatric patients with a previous history of Kawasaki disease
    Rebecca C Gurofsky
    Department of Pediatrics, Division of Cardiology, Labatt Family Heart Centre, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Catheter Cardiovasc Interv 73:809-13. 2009
    ....
  45. doi request reprint Ross and Yasui operations for complex biventricular repair in infants with critical left ventricular outflow tract obstruction
    Edward J Hickey
    John Kirklin Fellow, The Congenital Heart Surgeons Society Data, Hospital for Sick Children, Toronto, ON, Canada
    Eur J Cardiothorac Surg 37:279-88. 2010
    ..To define the outcomes following Ross and Yasui procedures for complex biventricular repair of critical left ventricular outflow tract obstruction (LVOTO)...
  46. doi request reprint Foetal echocardiographic assessment of borderline small left ventricles can predict the need for postnatal intervention
    Roland W Weber
    The Hospital for Sick Children, Labatt Family Heart Centre, Toronto, Ontario, Canada
    Cardiol Young 23:99-107. 2013
    ..We sought to prospectively determine foetal echocardiographic factors associated with neonatal interventions in borderline hypoplastic left ventricles...
  47. doi request reprint Heparin brand is associated with postsurgical outcomes in children undergoing cardiac surgery
    Colleen E Gruenwald
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 93:878-82. 2012
    ....
  48. doi request reprint Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation
    Derek Wong
    Hospital for Sick Children, Labatt Heart Centre, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:466-72. 2008
    ..This study was designed to determine whether coronary artery pulse Doppler flow patterns obtained by transesophageal echocardiography during the arterial switch operation are correlated with acute postoperative outcomes...
  49. ncbi request reprint Anatomic repair of anomalous left coronary artery from the pulmonary artery by aortic reimplantation: early survival, patterns of ventricular recovery and late outcome
    Anthony Azakie
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 75:1535-41. 2003
    ..To determine the early and late outcomes of patients presenting with anomalous left coronary artery from the pulmonary artery who had repair by aortic reimplantation...
  50. ncbi request reprint The impact of pulmonary valve replacement after tetralogy of Fallot repair: a matched comparison
    Aungkana Gengsakul
    The Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Eur J Cardiothorac Surg 32:462-8. 2007
    ..We sought to determine the impact of PVR on clinical outcomes...
  51. doi request reprint Risk factors for mortality or delisting of patients from the pediatric heart transplant waiting list
    Aamir Jeewa
    Labatt Family Heart Centre, Hospital for Sick Children, Toronto, Ontario, Canada Electronic address
    J Thorac Cardiovasc Surg 147:462-8. 2014
    ..Our aim was to determine risk factors associated with the outcomes of delisting, transplant, or death while waiting...
  52. doi request reprint Late outcomes of mitral valve repair for mitral regurgitation due to degenerative disease
    Tirone E David
    Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Circulation 127:1485-92. 2013
    ..This study examines this issue...
  53. doi request reprint Office-based randomized controlled trial to reduce screen time in preschool children
    Catherine S Birken
    Division of Paediatric Medicine, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 130:1110-5. 2012
    ..To determine if an intervention for preschool-aged children in primary care is effective in reducing screen time, meals in front of the television, and BMI...
  54. doi request reprint Factors associated with low physical activity levels following pediatric cardiac transplantation
    Laura Banks
    Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Transplant 16:716-21. 2012
    ..We sought to determine factors associated with MVPA in a pediatric cohort who had undergone cardiac transplantation...
  55. doi request reprint Functional health status in adult survivors of operative repair of tetralogy of fallot
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Cardiol 109:873-80. 2012
    ..Efforts to limit ventricular and outflow tract dysfunction may translate into improved late functional status...
  56. doi request reprint Feasibility of very-high resolution ultrasound to assess elastic and muscular arterial wall morphology in adolescents attending an outpatient clinic for obesity and lipid abnormalities
    Taisto Sarkola
    Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Atherosclerosis 219:610-5. 2011
    ..We hypothesized that very-high resolution ultrasound (VHRU, 25-55 MHz) could feasibly detect early arterial changes in adolescents with risk factors...
  57. ncbi request reprint Competing outcomes after neonatal and infant wait-listing for heart transplantation
    Stacey M Pollock-Barziv
    Heart Transplant Program, Labatt Family Heart Centre, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 26:980-5. 2007
    ..We sought to ascertain outcomes after listing for heart transplantation using a competing outcomes methodology, and to identify factors predicting each outcome...
  58. ncbi request reprint Post-transplant lymphoproliferative disorder in pediatric heart transplant recipients
    Cedric Manlhiot
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 29:648-57. 2010
    ..Post-transplantation lymphoproliferative disorder (PTLD) is a major cause of morbidity and mortality after pediatric heart transplantation...
  59. doi request reprint Exercise capacity improves with time in pediatric heart transplant recipients
    Anne I Dipchand
    Labatt Family Heart Centre, Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    J Heart Lung Transplant 28:585-90. 2009
    ..The purpose of this study was to profile the exercise capacity of pediatric heart transplant recipients over time and to identify factors associated with lower exercise capacity...
  60. doi request reprint Randomized, controlled trial of individualized heparin and protamine management in infants undergoing cardiac surgery with cardiopulmonary bypass
    Colleen E Gruenwald
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 56:1794-802. 2010
    ..We sought to determine whether infants (younger than 1 year old) had similar clinical benefits with individualized anticoagulation management as older children and adult undergoing cardiopulmonary bypass (CPB)...
  61. ncbi request reprint Pulmonary atresia with intact ventricular septum: management of, and outcomes for, a cohort of 210 consecutive patients
    Umesh Dyamenahalli
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Cardiol Young 14:299-308. 2004
    ..We sought to determine trends, and outcomes, for a cohort of patients with pulmonary atresia with intact ventricular septum born between 1965 and 1998...
  62. doi request reprint Echocardiographic definition and surgical decision-making in unbalanced atrioventricular septal defect: a Congenital Heart Surgeons' Society multiinstitutional study
    Anusha Jegatheeswaran
    Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Circulation 122:S209-15. 2010
    ....
  63. ncbi request reprint Can pulmonary conduit dysfunction and failure be reduced in infants and children less than age 2 years at initial implantation?
    Tara Karamlou
    Division of Cardiovascular Surgery and Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 132:829-38. 2006
    ..We sought to examine risk factors for pulmonary conduit failure or dysfunction in infants less than age 2 years at initial implantation...
  64. ncbi request reprint Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension
    Jaime Alkon
    Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Cardiol 106:430-6. 2010
    ..40 was associated with a high risk of a negative outcome. In conclusion, in children with PAH, an increased S:D ratio is temporally associated with worse RV function, hemodynamics, exercise capability, clinical status, and survival...
  65. ncbi request reprint Management options in neonates and infants with critical left ventricular outflow tract obstruction
    Bahaaldin Alsoufi
    The Cardiac Center, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    Eur J Cardiothorac Surg 31:1013-21. 2007
    ..Therefore, the aim of this review is to describe the different therapeutic strategies that can be applied to neonates presenting with critical LVOTO taking into consideration each patient's unique physiologic and anatomic findings...
  66. ncbi request reprint Prevalence and associated risk factors for intervention in 313 children with subaortic stenosis
    Tara Karamlou
    Division of Cardiovascular Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 84:900-6; discussion 906. 2007
    ....
  67. doi request reprint Interaction between myocardial and vascular changes in obese children: a pilot study
    Laurens P Koopman
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 25:401-410.e1. 2012
    ..The aims of this study were to investigate vascular and myocardial changes in obese children with lipid abnormalities and to study the interactions between vascular and myocardial parameters...
  68. doi request reprint Anthropometric growth and utilization of enteral feeding support in pediatric heart transplant recipients
    Louise Bannister
    Labatt Family Heart Centre, SickKids Transplant Centre, The Hospital for Sick Children, The University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 14:879-86. 2010
    ..This study suggests that further investigation into the role of EFS is warranted to identify strategies to improve growth in pediatric heart transplant recipients...
  69. ncbi request reprint Impact of selective laser ablation of placental anastomoses on the cardiovascular pathology of the recipient twin in severe twin-twin transfusion syndrome
    Catherine Barrea
    Department of Pediatrics, Division of Cardiology, Fetal Cardiac Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Obstet Gynecol 195:1388-95. 2006
    ..We investigated the impact of selective laser ablation on the cardiovascular pathology of the recipient twin in twin-twin transfusion syndrome...
  70. ncbi request reprint Long-term anticoagulation in Kawasaki disease: Initial use of low molecular weight heparin is a viable option for patients with severe coronary artery abnormalities
    Cedric Manlhiot
    Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Pediatr Cardiol 31:834-42. 2010
    ..03) but not for those on warfarin (P = 0.55). This study suggests that LMWH is a potentially viable alternative for patients, especially young ones, with severe coronary artery involvement after KD...
  71. doi request reprint Macrophage activation syndrome in the acute phase of Kawasaki disease
    Giuseppe A Latino
    Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 32:527-31. 2010
    ..All patients eventually recovered with no long-term sequelae. A high index of suspicion for clinical features associated with MAS is warranted for KD patients to provide appropriate and timely treatment...
  72. doi request reprint Risk, clinical features, and outcomes of thrombosis associated with pediatric cardiac surgery
    Cedric Manlhiot
    The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Circulation 124:1511-9. 2011
    ..Thrombosis, usually considered a serious but rare complication of pediatric cardiac surgery, has not been a major clinical and/or research focus in the past...
  73. pmc Functional health status of adolescents after the Fontan procedure -- comparison with their siblings
    Cedric Manlhiot
    Division of Cardiology, Labatt Family Heart Centre, Toronto, Canada
    Can J Cardiol 25:e294-300. 2009
    ..Studies have suggested that patients who have undergone the Fontan procedure experience lower functional health status and diminished exercise capacity compared with other children...
  74. ncbi request reprint Quality of life of children after repair of transposition of the great arteries
    Erin L Culbert
    Congenital Heart Surgeons Society Data Center, Hospital for Sick Children, Toronto, Ontario M5G 1X8
    Circulation 108:857-62. 2003
    ..We sought to assess quality of life of children with transposition of the great arteries (TGA) enrolled during transition in management strategy from atrial to arterial switch operation...
  75. ncbi request reprint Somatic growth in children with single ventricle physiology impact of physiologic state
    Kelly N Vogt
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 50:1876-83. 2007
    ..We sought to define somatic growth patterns for patients with single ventricle (SV) physiology and associated factors...
  76. doi request reprint Left ventricular hypoplasia: a spectrum of disease involving the left ventricular outflow tract, aortic valve, and aorta
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 59:S43-54. 2012
    ....
  77. doi request reprint Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children
    Stacey M Pollock-Barziv
    SickKids Transplant Centre, Department of Pediatrics, The Hospital for Sick Children and University of Toronto Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 14:968-75. 2010
    ..003). In conclusion, high s.d. in serial tacrolimus concentrations associated with increased risk of late rejection and graft loss in pediatric organ transplant recipients, providing opportunities for screening and interventions...
  78. ncbi request reprint Associated factors and trends in outcomes of interrupted aortic arch
    Thomas Oosterhof
    Department of Pediatrics, Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 78:1696-702. 2004
    ..We sought to determine trends in presentation, management, outcomes and associated factors...
  79. ncbi request reprint Outcomes in 45 children with ductal origin of the distal pulmonary artery
    Kalyani R Trivedi
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 81:950-7. 2006
    ..There are no large series describing the morphologic spectrum and the clinical outcomes of children with ductal origin of the distal pulmonary artery (PA)...
  80. ncbi request reprint Surgical management of aortopulmonary window associated with interrupted aortic arch: a Congenital Heart Surgeons Society study
    Igor E Konstantinov
    Hospital for Sick Children, Toronto, Canada
    J Thorac Cardiovasc Surg 131:1136-1141.e2. 2006
    ..The objective was to determine outcomes and risk factors of surgical management of patients with aortopulmonary window associated with interrupted aortic arch...
  81. doi request reprint Effectiveness of serial increases in amino-terminal pro-B-type natriuretic peptide levels to indicate the need for mechanical circulatory support in children with acute decompensated heart failure
    Derek T H Wong
    Department of Pediatrics, Division of Pediatric Cardiology, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Am J Cardiol 107:573-8. 2011
    ....
  82. ncbi request reprint Feasibility and clinical impact of transcatheter closure of interatrial communications after a fenestrated Fontan procedure: medium-term outcomes
    Jaana Pihkala
    Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, The University of Toronto School of Medicine, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 69:1007-14. 2007
    ..This study was to review an institutional experience with transcatheter closure of Fontan fenestrations and its impact on clinical care...
  83. ncbi request reprint Outcomes of mitral valve replacement in children: a competing-risks analysis
    Fatemeh Kojori
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Thorac Cardiovasc Surg 128:703-9. 2004
    ..We sought to define patient characteristics, outcomes, and associated factors after mitral valve replacement in children...
  84. doi request reprint Long-term tricuspid valve function after Norwood operation
    Maryam Elmi
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1341-7.e4. 2011
    ..Long-term functional outcomes after Norwood palliation are likely to depend on tricuspid valve performance in the systemic role. We therefore aimed to characterize features associated with tricuspid valve intervention...
  85. doi request reprint Lesion-specific outcomes in neonates undergoing congenital heart surgery are related predominantly to patient and management factors rather than institution or surgeon experience: A Congenital Heart Surgeons Society Study
    Tara Karamlou
    Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario M5 G 1X8, Canada
    J Thorac Cardiovasc Surg 139:569-577.e1. 2010
    ..To identify the role of institution and surgeon factors, including case volume and experience, on survival of neonates with complex congenital heart disease...
  86. ncbi request reprint Case complexity scores in congenital heart surgery: a comparative study of the Aristotle Basic Complexity score and the Risk Adjustment in Congenital Heart Surgery (RACHS-1) system
    Osman O Al-Radi
    Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 133:865-75. 2007
    ..The Aristotle Basic Complexity score and the Risk Adjustment in Congenital Heart Surgery system were developed by consensus to compare outcomes of congenital cardiac surgery. We compared the predictive value of the 2 systems...
  87. ncbi request reprint Pressure half-time predicts hemodynamically significant pulmonary regurgitation in adult patients with repaired tetralogy of fallot
    Candice K Silversides
    Department of Diagnostic Imaging, University Health Network, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 16:1057-62. 2003
    ..Pulmonary pressure half-time < 100 milliseconds was found to be a good indicator of hemodynamically significant regurgitation. This measure is highly reproducible and easily accessible...
  88. ncbi request reprint Percutaneous balloon valvotomy in pulmonary atresia with intact ventricular septum: impact on patient care
    Tilman Humpl
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, The University of Toronto School of Medicine, Toronto, ON M5G 1X8, Canada
    Circulation 108:826-32. 2003
    ..This study analyzes the outcomes and morphological changes to right heart structures after percutaneous perforation and balloon dilation of the atretic valve...
  89. ncbi request reprint Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation interpretation after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 131:1099-107. 2006
    ..We sought to examine the correlation of the indirect indicators to VO2-derived measures of oxygen transport...
  90. ncbi request reprint Intravenous immunoglobulin preparation type: association with outcomes for patients with acute Kawasaki disease
    Cedric Manlhiot
    University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Allergy Immunol 21:515-21. 2010
    ..0001) and 6-8 weeks after the acute phase (+0.7 vs. +0.4, p < 0.0001). IVIG preparations with lower IgA content and stabilized with glucose appear to be associated with improved coronary artery outcomes for patients with KD...
  91. doi request reprint Parental anxiety associated with Kawasaki disease in previously healthy children
    Nita Chahal
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    J Pediatr Health Care 24:250-7. 2010
    ..The objective of this study was to explore the lived experience of parents of children diagnosed with Kawasaki disease (KD) and to identify factors associated with increased levels of parental anxiety...
  92. ncbi request reprint Outcomes and associated risk factors for aortic valve replacement in 160 children: a competing-risks analysis
    Tara Karamlou
    Division of Cardiovascular Surgery, Department of Pediatrics, University of Toronto, The Hospital of Sick Children, Toronto, Canada
    Circulation 112:3462-9. 2005
    ..We sought to define patient characteristics, outcomes, and associated risk factors after aortic valve replacement (AVR) in children...
  93. ncbi request reprint Outcomes for patients with an aortopulmonary window, and the impact of associated cardiovascular lesions
    Rajesh Bagtharia
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cardiol Young 14:473-80. 2004
    ..87 (p = 0.009). The outcome for an isolated lesion is excellent. Mortality occurs mainly before repair, mostly with complex associated lesions, particularly interruption of the aortic arch...
  94. ncbi request reprint Impact of the characteristics of patients and their clinical management on outcomes in children with homozygous familial hypercholesterolemia
    Adnan M Al-Shaikh
    Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Ontario, Canada
    Cardiol Young 12:105-12. 2002
    ..To relate clinical factors to the development of cardiovascular atherosclerosis for patients with homozygous familial hypercholesterolemia...
  95. doi request reprint Physical activity restrictions for children after the Fontan operation: disagreement between parent, cardiologist, and medical record reports
    Patricia E Longmuir
    Hospital for Sick Children and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 157:853-9. 2009
    ..Parents uncertain about physical activity have children who are more sedentary. To understand parent uncertainty, we examined agreement regarding activity restrictions from parents, cardiologists, and medical charts...
  96. pmc Echocardiographic and electrocardiographic trends in children with acute Kawasaki disease
    Matthew A Crystal
    Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada
    Can J Cardiol 24:776-80. 2008
    ..Many patients are noted to have ventricular dilation on initial echocardiography; however, functional and structural measurements may remain within the normal range...
  97. ncbi request reprint Noninvasive analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 18:461-7. 2005
  98. ncbi request reprint Usability assessment of pacemaker programmers
    Christine C Chiu
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pacing Clin Electrophysiol 27:1388-98. 2004
    ..This impacts on the safe and effective use of programmers. Guidelines in programmer design should be established, particularly with respect to labeling, location, and operation of critical controls...
  99. ncbi request reprint Randomized clinical trial of tacrolimus- vs cyclosporine-based immunosuppression in pediatric heart transplantation: preliminary results at 15-month follow-up
    Stacey M Pollock-Barziv
    Division of Cardiology, Department of Pediatrics and Immunology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:190-4. 2005
    ..While Tacrolimus (Tac) and Cyclosporine (Cya) immunosuppression are used after cardiac transplantation (tx), few studies have evaluated their use in pediatric patients...
  100. ncbi request reprint Outcomes of 829 neonates with complete transposition of the great arteries 12-17 years after repair
    William G Williams
    Congenital Heart Surgeons Society Data Center, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Eur J Cardiothorac Surg 24:1-9; discussion 9-10. 2003
    ..We sought to examine the intermediate outcomes and their associated risk factors in neonates repaired during the era of transition...
  101. doi request reprint Reconstituted fresh whole blood improves clinical outcomes compared with stored component blood therapy for neonates undergoing cardiopulmonary bypass for cardiac surgery: a randomized controlled trial
    Colleen E Gruenwald
    Labatt Family Heart Centre, Department of Perfusion, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 136:1442-9. 2008
    ..This study compared the effects of reconstituted fresh whole blood against standard blood component therapy in neonates undergoing cardiac surgery...