Brian W McCrindle

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Dis Child 92:509-14. 2007
  2. ncbi Familial hypercholesterolemia in children and adolescents
    Brian W McCrindle
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 23:525-31. 2012
  3. ncbi Factors associated with thrombotic complications after the Fontan procedure: a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure
    Brian W McCrindle
    Labatt Family Heart Centre, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 61:346-53. 2013
  4. ncbi Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and design
    Beverly Walpole
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    BMC Public Health 11:459. 2011
  5. ncbi Population trends toward increasing cardiovascular risk factors in Canadian adolescents
    Brian W McCrindle
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 157:837-43. 2010
  6. ncbi Postoperative chylothorax after cardiothoracic surgery in children
    Emily H Chan
    Division of Pediatric Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1864-70. 2005
  7. ncbi Is balloon aortic valvuloplasty a feasible treatment for neonates and young infants with aortic valve stenosis?
    Brian W McCrindle
    The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:340-1. 2005
  8. ncbi Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    University of Toronto, Hospital for Sick Children, Toronto, Canada
    Circulation 113:1123-9. 2006
  9. ncbi Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 116:174-9. 2007
  10. ncbi Hyperlipidemia in children
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Thromb Res 118:49-58. 2006

Detail Information

Publications123 found, 100 shown here

  1. ncbi Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Dis Child 92:509-14. 2007
    ..To determine physical activity levels in paediatric patients who underwent the Fontan procedure, and their relationship to functional status and exercise capacity...
  2. ncbi Familial hypercholesterolemia in children and adolescents
    Brian W McCrindle
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Lipidol 23:525-31. 2012
    ..This review provides an update and highlights the controversies regarding recent advances and recommendations regarding screening, diagnosis and treatment of children and adolescents with familial hypercholesterolemia...
  3. ncbi Factors associated with thrombotic complications after the Fontan procedure: a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure
    Brian W McCrindle
    Labatt Family Heart Centre, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 61:346-53. 2013
    ..The study sought to identify factors associated with increased risk of thrombosis after Fontan...
  4. ncbi Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and design
    Beverly Walpole
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    BMC Public Health 11:459. 2011
    ....
  5. ncbi Population trends toward increasing cardiovascular risk factors in Canadian adolescents
    Brian W McCrindle
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 157:837-43. 2010
    ..To determine prevalence and cross-sectional trends over time for cardiovascular risk factors in Canadian adolescents...
  6. ncbi Postoperative chylothorax after cardiothoracic surgery in children
    Emily H Chan
    Division of Pediatric Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1864-70. 2005
    ..The purpose of this study is to determine the incidence, risk factors, and outcomes for chylothorax in children undergoing cardiothoracic surgery...
  7. ncbi Is balloon aortic valvuloplasty a feasible treatment for neonates and young infants with aortic valve stenosis?
    Brian W McCrindle
    The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:340-1. 2005
  8. ncbi Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    University of Toronto, Hospital for Sick Children, Toronto, Canada
    Circulation 113:1123-9. 2006
    ..After the Fontan procedure, patients are at risk for suboptimal health status related to their complex healthcare experience, physiological limitations, medical complications, and guarded long-term prognosis...
  9. ncbi Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 116:174-9. 2007
    ..Analysis of serial normalized artery measurements may reveal a broader continuous spectrum of involvement and different risk factors...
  10. ncbi Hyperlipidemia in children
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Thromb Res 118:49-58. 2006
    ....
  11. ncbi A randomized crossover trial of combination pharmacologic therapy in children with familial hyperlipidemia
    Brian W McCrindle
    Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Pediatr Res 51:715-21. 2002
    ..Compliance with medication regimens using the bile acid-binding resins is suboptimal, although combination with a low dose of a statin may result in better lipid lowering...
  12. ncbi Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure
    Brian W McCrindle
    Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 121:34-42. 2010
    ..Patients after the Fontan procedure are at risk for suboptimal functional health status, and associations with laboratory measures are important for planning interventions and outcome measures for clinical trials...
  13. ncbi Are patients after Kawasaki disease at increased risk for accelerated atherosclerosis?
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 151:244-8, 248.e1. 2007
    ..To assess whether patients after Kawasaki disease (KD) have increased risk factors and abnormalities suggestive of early atherosclerosis in systemic arteries...
  14. ncbi Presentation, management and outcomes of thrombosis for children with cardiomyopathy
    Brian W McCrindle
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Can J Cardiol 22:685-90. 2006
    ..Thrombosis in children with dilated and inflammatory cardiomyopathy is an unpredictable complication with potentially important morbidity...
  15. ncbi Assessment and management of hypertension in children and adolescents
    Brian W McCrindle
    The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Cardiol 7:155-63. 2010
    ..Pharmacological management is reserved for patients with hypertension who do not respond to behavioral changes, have additional cardiovascular risk factors or diabetes, are symptomatic, or have developed target-organ damage...
  16. ncbi Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial
    Brian W McCrindle
    Division of Pediatric Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 143:74-80. 2003
    ..To determine the safety and efficacy of atorvastatin (10 to 20 mg) in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia...
  17. ncbi Truncus arteriosus associated with interrupted aortic arch in 50 neonates: a Congenital Heart Surgeons Society study
    Igor E Konstantinov
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 81:214-22. 2006
    ..CONCLUSIONS: The combination of IAA and TA carries high early mortality, with high risk of reinterventions in survivors. One stage repair of both TA and IAA is the optimal management...
  18. ncbi Impaired left ventricular myocardial mechanics and their relation to pulmonary regurgitation, right ventricular enlargement and exercise capacity in asymptomatic children after repair of tetralogy of Fallot
    Fernanda P Fernandes
    Labatt Family Heart Centre, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 25:494-503. 2012
    ..The hypothesis was that impaired LV myocardial mechanics are related to pulmonary regurgitation, right ventricular (RV) enlargement, and exercise capacity...
  19. ncbi Outcome and growth potential of left heart structures after neonatal intervention for aortic valve stenosis
    Ra K Han
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 50:2406-14. 2007
    ..The purpose of this study was to determine trends of growth of left heart structures after intervention for neonatal aortic valve stenosis...
  20. ncbi Late status of Fontan patients with persistent surgical fenestration
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Am Coll Cardiol 57:2437-43. 2011
    ..This study was undertaken to determine the effects of creating a systemic-to-pulmonary venous atrial-level communication (fenestration) at the time of the Fontan procedure on late outcomes...
  21. ncbi Impaired right and left ventricular diastolic myocardial mechanics and filling in asymptomatic children and adolescents after repair of tetralogy of Fallot
    Mark K Friedberg
    Division of Paediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Eur Heart J Cardiovasc Imaging 13:905-13. 2012
    ..We hypothesized that children after TOF repair have diastolic dysfunction and dyssynchrony by this measure, and sought to determine their relationship with pulmonary regurgitation (PR), RV enlargement, and aerobic exercise capacity...
  22. ncbi Neurodevelopmental outcomes after open heart operations before 3 months of age
    Renee Sananes
    Labatt Family Heart Centre and Division of Neurology, Department of Paediatrics, Surgery and Critical Care Medicine, The University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 93:1577-83. 2012
    ....
  23. ncbi Factors associated with mortality and reoperation in 377 children with total anomalous pulmonary venous connection
    Tara Karamlou
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Circulation 115:1591-8. 2007
    ..We sought to determine era-specific changes in the incidence of mortality and reoperation in children with total anomalous pulmonary venous connection...
  24. ncbi Longer blood storage is associated with suboptimal outcomes in high-risk pediatric cardiac surgery
    Cedric Manlhiot
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 93:1563-9. 2012
    ..The negative effects of long-term storage of allogeneic red blood cells (RBCs) on outcomes in adult cardiac surgery have been established, but evidence of a similar effect in pediatric cardiac surgery is limited...
  25. ncbi Congenital supravalvular aortic stenosis: defining surgical and nonsurgical outcomes
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Ann Thorac Surg 86:1919-27; discussion 1927. 2008
    ..Supravalvular aortic stenosis is a rare stenotic lesion of the left ventricular outflow tract (LVOT). We characterized the natural history of the disease and the effect of surgical intervention...
  26. ncbi Hyperglycemia after pediatric cardiac surgery: impact of age and residual lesions
    Michael Alice Moga
    Division of Cardiac Critical Care Medicine, Department of Pediatrics, The Labatt Family Heart Center, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Crit Care Med 39:266-72. 2011
    ..The incidence, severity, and duration of hyperglycemia in this patient population and perioperative factors predisposing to hyperglycemia were also delineated...
  27. ncbi Thrombotic complications and thromboprophylaxis across all three stages of single ventricle heart palliation
    Cedric Manlhiot
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 161:513-519.e3. 2012
    ..To describe the incidence of thrombotic complications across all 3 stages of single ventricle palliation and the association between thromboprophylaxis use and thrombotic risk...
  28. ncbi Surgical management of complete atrioventricular septal defect: associations with surgical technique, age, and trisomy 21
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Thorac Cardiovasc Surg 141:1371-9. 2011
    ..We sought to evaluate the contemporary results after repair of a complete atrioventricular septal defect and to determine the factors associated with suboptimal outcomes...
  29. ncbi Infective endocarditis in children: native valve preservation is frequently possible despite advanced clinical disease
    Edward J Hickey
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Canada
    Eur J Cardiothorac Surg 35:130-5. 2009
    ..We therefore reviewed all cases of culture-proven IE referred for surgical intervention at our institution over the last three decades...
  30. ncbi Jugular venous valved conduit (Contegra) matches allograft performance in infant truncus arteriosus repair
    Edward J Hickey
    The Congenital Heart Surgeons Society Data Center, Toronto, Canada
    Eur J Cardiothorac Surg 33:890-8. 2008
    ..Limited availability and durability of allograft conduits require that alternatives be considered. We compared bovine jugular venous valved (JVV) and allograft conduit performance in 107 infants who survived truncus arteriosus repair...
  31. ncbi Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:441-8. 2007
    ..We used measured oxygen consumption to characterize hemodynamics and oxygen transport after the classic Norwood procedure...
  32. ncbi Biventricular strategies for neonatal critical aortic stenosis: high mortality associated with early reintervention
    Edward J Hickey
    Congenital Heart Surgeons Society Data Center, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:409-17, 417.e1. 2012
    ..To characterize the risk of reintervention after biventricular strategies to treat neonatal critical aortic stenosis, and the effect of reintervention on survival...
  33. ncbi Role of waist measures in characterizing the lipid and blood pressure assessment of adolescents classified by body mass index
    Michael Khoury
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 166:719-24. 2012
    ....
  34. ncbi Arterial complications associated with cardiac catheterization in pediatric patients with a previous history of Kawasaki disease
    Rebecca C Gurofsky
    Department of Pediatrics, Division of Cardiology, Labatt Family Heart Centre, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Catheter Cardiovasc Interv 73:809-13. 2009
    ....
  35. ncbi Frequency, predictors, and neurologic outcomes of vaso-occlusive strokes associated with cardiac surgery in children
    Trish Domi
    Department of Child Health and Evaluative Sciences, Hospital for Sick Children, and Institute of Medical Sciences, University of Toronto, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 122:1292-8. 2008
    ..Our aim was to define the frequency, predictors, and outcomes of stroke associated with cardiac surgery in children with congenital heart disease...
  36. ncbi Ross and Yasui operations for complex biventricular repair in infants with critical left ventricular outflow tract obstruction
    Edward J Hickey
    John Kirklin Fellow, The Congenital Heart Surgeons Society Data, Hospital for Sick Children, Toronto, ON, Canada
    Eur J Cardiothorac Surg 37:279-88. 2010
    ..To define the outcomes following Ross and Yasui procedures for complex biventricular repair of critical left ventricular outflow tract obstruction (LVOTO)...
  37. ncbi Outcome after prenatal diagnosis of tricuspid atresia: a multicenter experience
    Rachel M Wald
    The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 153:772-8. 2007
    ..The outcome of prenatally diagnosed tricuspid atresia (TA) is undefined. We sought to characterize clinical and echocardiographic features of fetal TA and to determine factors associated with mortality...
  38. ncbi Functional state of patients with heterotaxy syndrome following the Fontan operation
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Children s Hospital, Charleston, South Carolina 29425, United States of America
    Cardiol Young 17:44-53. 2007
    ..Little is known, however, about the functional state of surviving patients with heterotaxy following a Fontan operation...
  39. ncbi Risk factors associated with mortality and interventions in 472 neonates with interrupted aortic arch: a Congenital Heart Surgeons Society study
    Brian W McCrindle
    Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:343-50. 2005
    ..CONCLUSION: Anatomic features affect mortality and initial left ventricular outflow tract procedures, whereas characteristics of the arch repair affect arch reintervention...
  40. ncbi Persistent risk of subsequent procedures and mortality in patients after interrupted aortic arch repair: a Congenital Heart Surgeons' Society study
    Anusha Jegatheeswaran
    Division of Cardiovascular Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 140:1059-75.e2. 2010
    ..We the investigated patterns and factors associated with these subsequent procedures and mortality...
  41. ncbi Determinants of mortality and type of repair in neonates with pulmonary atresia and intact ventricular septum
    David A Ashburn
    Division of Cardiothoracic Surgery, Hospital for Sick Children, Toronto, Onario, Canada
    J Thorac Cardiovasc Surg 127:1000-7; discussion 1007-8. 2004
    ..In the current era, 85% of neonates are likely to reach a definitive surgical end point, with 2-ventricle repair achieved in an estimated 50%...
  42. ncbi Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Eur J Cardiothorac Surg 35:156-64; discussion 164. 2009
    ..We investigated an inception cohort who underwent surgical repair. We aimed to characterize late hazard or risk for death, and determine the time-related risk of late re-operation and pulmonary valve replacement (PVR)...
  43. ncbi Heparin brand is associated with postsurgical outcomes in children undergoing cardiac surgery
    Colleen E Gruenwald
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 93:878-82. 2012
    ....
  44. ncbi Percutaneous pulmonary valve implantation in the young 2-year follow-up
    Marko Vezmar
    Department of Pediatrics, The Hospital for Sick Children, The Labatt Family Heart Centre, University of Toronto School of Medicine, Toronto, Canada
    JACC Cardiovasc Interv 3:439-48. 2010
    ..The aim of this study was to investigate physiological and clinical consequences of percutaneous pulmonary valve implantation (PPVI) in patients with chronic right ventricular outflow tract (RVOT) obstruction and volume overload...
  45. ncbi Anatomic repair of anomalous left coronary artery from the pulmonary artery by aortic reimplantation: early survival, patterns of ventricular recovery and late outcome
    Anthony Azakie
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 75:1535-41. 2003
    ..To determine the early and late outcomes of patients presenting with anomalous left coronary artery from the pulmonary artery who had repair by aortic reimplantation...
  46. ncbi The impact of pulmonary valve replacement after tetralogy of Fallot repair: a matched comparison
    Aungkana Gengsakul
    The Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Eur J Cardiothorac Surg 32:462-8. 2007
    ..We sought to determine the impact of PVR on clinical outcomes...
  47. ncbi Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation
    Derek Wong
    Hospital for Sick Children, Labatt Heart Centre, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:466-72. 2008
    ..This study was designed to determine whether coronary artery pulse Doppler flow patterns obtained by transesophageal echocardiography during the arterial switch operation are correlated with acute postoperative outcomes...
  48. ncbi Office-based randomized controlled trial to reduce screen time in preschool children
    Catherine S Birken
    Division of Paediatric Medicine, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 130:1110-5. 2012
    ..To determine if an intervention for preschool-aged children in primary care is effective in reducing screen time, meals in front of the television, and BMI...
  49. ncbi Factors associated with low physical activity levels following pediatric cardiac transplantation
    Laura Banks
    Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Transplant 16:716-21. 2012
    ..We sought to determine factors associated with MVPA in a pediatric cohort who had undergone cardiac transplantation...
  50. ncbi Functional health status in adult survivors of operative repair of tetralogy of fallot
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Cardiol 109:873-80. 2012
    ..Efforts to limit ventricular and outflow tract dysfunction may translate into improved late functional status...
  51. ncbi Feasibility of very-high resolution ultrasound to assess elastic and muscular arterial wall morphology in adolescents attending an outpatient clinic for obesity and lipid abnormalities
    Taisto Sarkola
    Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Atherosclerosis 219:610-5. 2011
    ..We hypothesized that very-high resolution ultrasound (VHRU, 25-55 MHz) could feasibly detect early arterial changes in adolescents with risk factors...
  52. ncbi Exercise capacity improves with time in pediatric heart transplant recipients
    Anne I Dipchand
    Labatt Family Heart Centre, Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    J Heart Lung Transplant 28:585-90. 2009
    ..The purpose of this study was to profile the exercise capacity of pediatric heart transplant recipients over time and to identify factors associated with lower exercise capacity...
  53. ncbi Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension
    Jaime Alkon
    Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Cardiol 106:430-6. 2010
    ..40 was associated with a high risk of a negative outcome. In conclusion, in children with PAH, an increased S:D ratio is temporally associated with worse RV function, hemodynamics, exercise capability, clinical status, and survival...
  54. ncbi Pulmonary atresia with intact ventricular septum: management of, and outcomes for, a cohort of 210 consecutive patients
    Umesh Dyamenahalli
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Cardiol Young 14:299-308. 2004
    ..We sought to determine trends, and outcomes, for a cohort of patients with pulmonary atresia with intact ventricular septum born between 1965 and 1998...
  55. ncbi Competing outcomes after neonatal and infant wait-listing for heart transplantation
    Stacey M Pollock-Barziv
    Heart Transplant Program, Labatt Family Heart Centre, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 26:980-5. 2007
    ..We sought to ascertain outcomes after listing for heart transplantation using a competing outcomes methodology, and to identify factors predicting each outcome...
  56. ncbi Prevalence and associated risk factors for intervention in 313 children with subaortic stenosis
    Tara Karamlou
    Division of Cardiovascular Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 84:900-6; discussion 906. 2007
    ....
  57. ncbi Echocardiographic definition and surgical decision-making in unbalanced atrioventricular septal defect: a Congenital Heart Surgeons' Society multiinstitutional study
    Anusha Jegatheeswaran
    Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Circulation 122:S209-15. 2010
    ....
  58. ncbi Randomized, controlled trial of individualized heparin and protamine management in infants undergoing cardiac surgery with cardiopulmonary bypass
    Colleen E Gruenwald
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 56:1794-802. 2010
    ..We sought to determine whether infants (younger than 1 year old) had similar clinical benefits with individualized anticoagulation management as older children and adult undergoing cardiopulmonary bypass (CPB)...
  59. ncbi Management options in neonates and infants with critical left ventricular outflow tract obstruction
    Bahaaldin Alsoufi
    The Cardiac Center, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    Eur J Cardiothorac Surg 31:1013-21. 2007
    ..Therefore, the aim of this review is to describe the different therapeutic strategies that can be applied to neonates presenting with critical LVOTO taking into consideration each patient's unique physiologic and anatomic findings...
  60. ncbi Post-transplant lymphoproliferative disorder in pediatric heart transplant recipients
    Cedric Manlhiot
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 29:648-57. 2010
    ..Post-transplantation lymphoproliferative disorder (PTLD) is a major cause of morbidity and mortality after pediatric heart transplantation...
  61. ncbi Can pulmonary conduit dysfunction and failure be reduced in infants and children less than age 2 years at initial implantation?
    Tara Karamlou
    Division of Cardiovascular Surgery and Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 132:829-38. 2006
    ..We sought to examine risk factors for pulmonary conduit failure or dysfunction in infants less than age 2 years at initial implantation...
  62. ncbi Interaction between myocardial and vascular changes in obese children: a pilot study
    Laurens P Koopman
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 25:401-410.e1. 2012
    ..The aims of this study were to investigate vascular and myocardial changes in obese children with lipid abnormalities and to study the interactions between vascular and myocardial parameters...
  63. ncbi Anthropometric growth and utilization of enteral feeding support in pediatric heart transplant recipients
    Louise Bannister
    Labatt Family Heart Centre, SickKids Transplant Centre, The Hospital for Sick Children, The University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 14:879-86. 2010
    ..This study suggests that further investigation into the role of EFS is warranted to identify strategies to improve growth in pediatric heart transplant recipients...
  64. ncbi Macrophage activation syndrome in the acute phase of Kawasaki disease
    Giuseppe A Latino
    Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 32:527-31. 2010
    ..All patients eventually recovered with no long-term sequelae. A high index of suspicion for clinical features associated with MAS is warranted for KD patients to provide appropriate and timely treatment...
  65. ncbi Long-term anticoagulation in Kawasaki disease: Initial use of low molecular weight heparin is a viable option for patients with severe coronary artery abnormalities
    Cedric Manlhiot
    Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Pediatr Cardiol 31:834-42. 2010
    ..03) but not for those on warfarin (P = 0.55). This study suggests that LMWH is a potentially viable alternative for patients, especially young ones, with severe coronary artery involvement after KD...
  66. ncbi Risk, clinical features, and outcomes of thrombosis associated with pediatric cardiac surgery
    Cedric Manlhiot
    The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Circulation 124:1511-9. 2011
    ..Thrombosis, usually considered a serious but rare complication of pediatric cardiac surgery, has not been a major clinical and/or research focus in the past...
  67. ncbi Functional health status of adolescents after the Fontan procedure -- comparison with their siblings
    Cedric Manlhiot
    Division of Cardiology, Labatt Family Heart Centre, Toronto, Canada
    Can J Cardiol 25:e294-300. 2009
    ..Studies have suggested that patients who have undergone the Fontan procedure experience lower functional health status and diminished exercise capacity compared with other children...
  68. ncbi Quality of life of children after repair of transposition of the great arteries
    Erin L Culbert
    Congenital Heart Surgeons Society Data Center, Hospital for Sick Children, Toronto, Ontario M5G 1X8
    Circulation 108:857-62. 2003
    ..CONCLUSIONS: Quality of life and health status as perceived by children 11 to 15 years after TGA repair is excellent when compared with published normative data and is better after arterial switch operation than after atrial repair...
  69. ncbi Somatic growth in children with single ventricle physiology impact of physiologic state
    Kelly N Vogt
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 50:1876-83. 2007
    ..We sought to define somatic growth patterns for patients with single ventricle (SV) physiology and associated factors...
  70. ncbi Impact of selective laser ablation of placental anastomoses on the cardiovascular pathology of the recipient twin in severe twin-twin transfusion syndrome
    Catherine Barrea
    Department of Pediatrics, Division of Cardiology, Fetal Cardiac Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Obstet Gynecol 195:1388-95. 2006
    ..CONCLUSIONS: Selective laser ablation in severe twin-twin transfusion syndrome acutely improves biventricular systolic function and tends to improve diastolic function in the recipient twin...
  71. ncbi Left ventricular hypoplasia: a spectrum of disease involving the left ventricular outflow tract, aortic valve, and aorta
    Edward J Hickey
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 59:S43-54. 2012
    ..quot;..
  72. ncbi Outcomes in 45 children with ductal origin of the distal pulmonary artery
    Kalyani R Trivedi
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 81:950-7. 2006
    ..Early diagnosis and repair of the ductal PA, especially in children presenting with pulmonary overcirculation, may improve outcomes...
  73. ncbi Outcomes of mitral valve replacement in children: a competing-risks analysis
    Fatemeh Kojori
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Thorac Cardiovasc Surg 128:703-9. 2004
    ..However, with the appropriate selection of the prosthetic valve and reduction of cardiopulmonary bypass time, surgeons might decrease mortality and increase prosthesis longevity...
  74. ncbi Long-term tricuspid valve function after Norwood operation
    Maryam Elmi
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1341-7.e4. 2011
    ..Long-term functional outcomes after Norwood palliation are likely to depend on tricuspid valve performance in the systemic role. We therefore aimed to characterize features associated with tricuspid valve intervention...
  75. ncbi Effectiveness of serial increases in amino-terminal pro-B-type natriuretic peptide levels to indicate the need for mechanical circulatory support in children with acute decompensated heart failure
    Derek T H Wong
    Department of Pediatrics, Division of Pediatric Cardiology, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Am J Cardiol 107:573-8. 2011
    ....
  76. ncbi Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children
    Stacey M Pollock-Barziv
    SickKids Transplant Centre, Department of Pediatrics, The Hospital for Sick Children and University of Toronto Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 14:968-75. 2010
    ..003). In conclusion, high s.d. in serial tacrolimus concentrations associated with increased risk of late rejection and graft loss in pediatric organ transplant recipients, providing opportunities for screening and interventions...
  77. ncbi Feasibility and clinical impact of transcatheter closure of interatrial communications after a fenestrated Fontan procedure: medium-term outcomes
    Jaana Pihkala
    Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, The University of Toronto School of Medicine, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 69:1007-14. 2007
    ..This study was to review an institutional experience with transcatheter closure of Fontan fenestrations and its impact on clinical care...
  78. ncbi Surgical management of aortopulmonary window associated with interrupted aortic arch: a Congenital Heart Surgeons Society study
    Igor E Konstantinov
    Hospital for Sick Children, Toronto, Canada
    J Thorac Cardiovasc Surg 131:1136-1141.e2. 2006
    ..Reinterventions for aortic arch obstruction are the most frequent complication after repair, but pulmonary artery stenosis also occurs. Use of patch augmentation may reduce the need for subsequent arch reintervention...
  79. ncbi Associated factors and trends in outcomes of interrupted aortic arch
    Thomas Oosterhof
    Department of Pediatrics, Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 78:1696-702. 2004
    ..Freedom from reintervention for arch obstruction was 60% at 5 years. CONCLUSIONS: While improving, outcomes of IAA remain of concern, especially in patients with associated lesions...
  80. ncbi Case complexity scores in congenital heart surgery: a comparative study of the Aristotle Basic Complexity score and the Risk Adjustment in Congenital Heart Surgery (RACHS-1) system
    Osman O Al Radi
    Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 133:865-75. 2007
    ..The Aristotle Basic Complexity score and the Risk Adjustment in Congenital Heart Surgery system were developed by consensus to compare outcomes of congenital cardiac surgery. We compared the predictive value of the 2 systems...
  81. ncbi Lesion-specific outcomes in neonates undergoing congenital heart surgery are related predominantly to patient and management factors rather than institution or surgeon experience: A Congenital Heart Surgeons Society Study
    Tara Karamlou
    Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario M5 G 1X8, Canada
    J Thorac Cardiovasc Surg 139:569-577.e1. 2010
    ..To identify the role of institution and surgeon factors, including case volume and experience, on survival of neonates with complex congenital heart disease...
  82. ncbi Pressure half-time predicts hemodynamically significant pulmonary regurgitation in adult patients with repaired tetralogy of fallot
    Candice K Silversides
    Department of Diagnostic Imaging, University Health Network, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 16:1057-62. 2003
    ..Pulmonary pressure half-time < 100 milliseconds was found to be a good indicator of hemodynamically significant regurgitation. This measure is highly reproducible and easily accessible...
  83. ncbi Percutaneous balloon valvotomy in pulmonary atresia with intact ventricular septum: impact on patient care
    Tilman Humpl
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, The University of Toronto School of Medicine, Toronto, ON M5G 1X8, Canada
    Circulation 108:826-32. 2003
    ..Despite the observation that right heart growth does not increase with body growth in early follow-up, it appears adequate to maintain a biventricular circulation in many patients...
  84. ncbi Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation interpretation after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 131:1099-107. 2006
    ..Measured VO2 and hemodynamics may improve the optimization of postoperative management strategy in the individual neonate...
  85. ncbi Outcomes for patients with an aortopulmonary window, and the impact of associated cardiovascular lesions
    Rajesh Bagtharia
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cardiol Young 14:473-80. 2004
    ..87 (p = 0.009). The outcome for an isolated lesion is excellent. Mortality occurs mainly before repair, mostly with complex associated lesions, particularly interruption of the aortic arch...
  86. ncbi Parental anxiety associated with Kawasaki disease in previously healthy children
    Nita Chahal
    Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    J Pediatr Health Care 24:250-7. 2010
    ..The objective of this study was to explore the lived experience of parents of children diagnosed with Kawasaki disease (KD) and to identify factors associated with increased levels of parental anxiety...
  87. ncbi Outcomes and associated risk factors for aortic valve replacement in 160 children: a competing-risks analysis
    Tara Karamlou
    Division of Cardiovascular Surgery, Department of Pediatrics, University of Toronto, The Hospital of Sick Children, Toronto, Canada
    Circulation 112:3462-9. 2005
    ..Pulmonary autograft use is associated with decreased mortality, slower gradient progression, and smaller left ventricular dimension...
  88. ncbi Intravenous immunoglobulin preparation type: association with outcomes for patients with acute Kawasaki disease
    Cedric Manlhiot
    University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Allergy Immunol 21:515-21. 2010
    ..0001) and 6-8 weeks after the acute phase (+0.7 vs. +0.4, p < 0.0001). IVIG preparations with lower IgA content and stabilized with glucose appear to be associated with improved coronary artery outcomes for patients with KD...
  89. ncbi Impact of the characteristics of patients and their clinical management on outcomes in children with homozygous familial hypercholesterolemia
    Adnan M Al-Shaikh
    Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Ontario, Canada
    Cardiol Young 12:105-12. 2002
    ..6 years. CONCLUSION: Complete cardiac assessment is recommended at presentation. The frequency of plasmapheresis should be adjusted according to the activity of low density lipoprotein receptors and the individual response of the patient...
  90. ncbi Physical activity restrictions for children after the Fontan operation: disagreement between parent, cardiologist, and medical record reports
    Patricia E Longmuir
    Hospital for Sick Children and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 157:853-9. 2009
    ..Parents uncertain about physical activity have children who are more sedentary. To understand parent uncertainty, we examined agreement regarding activity restrictions from parents, cardiologists, and medical charts...
  91. ncbi Echocardiographic and electrocardiographic trends in children with acute Kawasaki disease
    Matthew A Crystal
    Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada
    Can J Cardiol 24:776-80. 2008
    ..Many patients are noted to have ventricular dilation on initial echocardiography; however, functional and structural measurements may remain within the normal range...
  92. ncbi Noninvasive analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 18:461-7. 2005
  93. ncbi Randomized clinical trial of tacrolimus- vs cyclosporine-based immunosuppression in pediatric heart transplantation: preliminary results at 15-month follow-up
    Stacey M Pollock-Barziv
    Division of Cardiology, Department of Pediatrics and Immunology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:190-4. 2005
    ..CONCLUSIONS: Further studies are required to establish pharmacokinetic parameters to enhance therapeutic monitoring of these patients to minimize side effects and enhance outcomes...
  94. ncbi Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery
    Colleen E Gruenwald
    Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Canada
    J Extra Corpor Technol 42:9-19. 2010
    ..However, this review article clearly establishes that further studies are necessary to obtain evidence-based protocols for the proper management of anticoagulation of children undergoing cardiopulmonary bypass...
  95. ncbi Cor triatriatum sinistrum in childhood. A single institution's experience
    Tilman Humpl
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario
    Can J Cardiol 26:371-6. 2010
    ..Cor triatriatum sinistrum (CTS) is a rare congenital cardiac defect that can present with a wide range of symptoms and may be associated with other structural cardiac defects. Very limited data are available for pediatric patients...
  96. ncbi Evaluation of computerized interpretation of the pediatric electrocardiogram
    Christine C Chiu
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    J Electrocardiol 40:139-43. 2007
    ..9). Although CAI is helpful, pediatric cardiologists were more likely to disagree with the computer in rhythm diagnosis, recognition of bundle branch block, hypertrophy, and QT interval analysis...
  97. ncbi Usability assessment of pacemaker programmers
    Christine C Chiu
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pacing Clin Electrophysiol 27:1388-98. 2004
    ..This impacts on the safe and effective use of programmers. Guidelines in programmer design should be established, particularly with respect to labeling, location, and operation of critical controls...
  98. ncbi Reconstituted fresh whole blood improves clinical outcomes compared with stored component blood therapy for neonates undergoing cardiopulmonary bypass for cardiac surgery: a randomized controlled trial
    Colleen E Gruenwald
    Labatt Family Heart Centre, Department of Perfusion, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 136:1442-9. 2008
    ..This study compared the effects of reconstituted fresh whole blood against standard blood component therapy in neonates undergoing cardiac surgery...
  99. ncbi Outcomes of 829 neonates with complete transposition of the great arteries 12-17 years after repair
    William G Williams
    Congenital Heart Surgeons Society Data Center, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Eur J Cardiothorac Surg 24:1-9; discussion 9-10. 2003
    ..We sought to examine the intermediate outcomes and their associated risk factors in neonates repaired during the era of transition...
  100. ncbi A prospective study of dobutamine stress echocardiography for the assessment of cardiac allograft vasculopathy in pediatric heart transplant recipients
    Anne I Dipchand
    Labatt Family Heart Centre, Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 12:570-6. 2008
    ..Patients transplanted at an older age and those with a greater history of rejection were at higher risk of a positive DSE and may require increased surveillance for CAV...
  101. ncbi Outcomes of tricuspid atresia in the Fontan era
    Rekwan Sittiwangkul
    Departments of Pediatrics and Surgery, Divisions of Cardiology and Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 77:889-94. 2004
    ..CONCLUSIONS: Improvements in outcomes with tricuspid atresia will require attention to management and risk factors before Fontan...