G Koren

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc The effect of Acid-reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Obstet Gynecol Int 2009:585269. 2009
  2. pmc A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk
    Lauren E Kelly
    Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e70073. 2013
  3. pmc Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population
    Kaitlyn Delano
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e82647. 2013
  4. pmc The role of social media in recruiting for clinical trials in pregnancy
    Mahvash Shere
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada
    PLoS ONE 9:e92744. 2014
  5. pmc Meconium fatty acid ethyl esters as biomarkers of late gestational ethanol exposure and indicator of ethanol-induced multi-organ injury in fetal sheep
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 8:e59168. 2013
  6. ncbi request reprint The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women
    Gideon Koren
    Motherisk Program, Department of Pediatrics, The Hospital for Sick Children, and the University of Toronto, Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e161-2. 2013
  7. doi request reprint Systematic review of the effects of maternal hypertension in pregnancy and antihypertensive therapies on child neurocognitive development
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, 555 Univeristy Ave, Toronto, ON M5G 1X8, Canada
    Reprod Toxicol 39:1-5. 2013
  8. ncbi request reprint The maternal drinking history guide: development of a national educational tool
    Gideon Koren
    Motherisk Program, Hospital for Sick Children, University of Toronto
    J Popul Ther Clin Pharmacol 20:e42-3. 2013
  9. doi request reprint Selective serotonin reuptake inhibitors and malformations: case closed?
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Semin Fetal Neonatal Med 18:19-22. 2013
  10. ncbi request reprint Depression in pregnancy: time to stop terrifying pregnant women
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada
    J Popul Ther Clin Pharmacol 19:e369-70. 2012

Collaborators

Detail Information

Publications204 found, 100 shown here

  1. pmc The effect of Acid-reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Obstet Gynecol Int 2009:585269. 2009
    ..72, P < .001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP...
  2. pmc A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk
    Lauren E Kelly
    Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e70073. 2013
    ..The primary objective of this study was to prospectively evaluate the effectiveness of these guidelines in ensuring neonatal safety...
  3. pmc Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population
    Kaitlyn Delano
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e82647. 2013
    ..This study aims to determine the effectiveness of MMT engagement in high-risk pregnant women in reducing polydrug use by objective laboratory examination of neonatal meconium...
  4. pmc The role of social media in recruiting for clinical trials in pregnancy
    Mahvash Shere
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada
    PLoS ONE 9:e92744. 2014
    ..This study aims to assess the effectiveness of social media as a recruitment tool through the comparison of diverse recruitment techniques in two different phases of the trial...
  5. pmc Meconium fatty acid ethyl esters as biomarkers of late gestational ethanol exposure and indicator of ethanol-induced multi-organ injury in fetal sheep
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 8:e59168. 2013
    ..Our objective was to measure meconium FAEE in fetal sheep following daily, relatively moderate-dose ethanol exposure in late gestation, and to evaluate their utility in identifying fetal organ-system injury...
  6. ncbi request reprint The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women
    Gideon Koren
    Motherisk Program, Department of Pediatrics, The Hospital for Sick Children, and the University of Toronto, Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e161-2. 2013
    ..This review highlights the milestones of this antiemetic agent over the last 40 years...
  7. doi request reprint Systematic review of the effects of maternal hypertension in pregnancy and antihypertensive therapies on child neurocognitive development
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, 555 Univeristy Ave, Toronto, ON M5G 1X8, Canada
    Reprod Toxicol 39:1-5. 2013
    ..The confounding effects by indication must be addressed in future studies...
  8. ncbi request reprint The maternal drinking history guide: development of a national educational tool
    Gideon Koren
    Motherisk Program, Hospital for Sick Children, University of Toronto
    J Popul Ther Clin Pharmacol 20:e42-3. 2013
    ..We describe the steps of development and implementation of a knowledge translation program for health care providers. The slide presentation is attached in English and French to allow its maximal use...
  9. doi request reprint Selective serotonin reuptake inhibitors and malformations: case closed?
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Semin Fetal Neonatal Med 18:19-22. 2013
    ..These data strongly support the view that SSRIs do not increase the risk of cardiovascular malformations...
  10. ncbi request reprint Depression in pregnancy: time to stop terrifying pregnant women
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada
    J Popul Ther Clin Pharmacol 19:e369-70. 2012
    ..Yet, physicians and epidemiologists continue to terrify women who are at serious life threatening risks if not treated pharmacologically, with non evidence-based information. This paper calls for immediate stop of such practice...
  11. ncbi request reprint Antidepressant use during pregnancy: the benefit-risk ratio
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Obstet Gynecol 207:157-63. 2012
    ....
  12. doi request reprint More codeine fatalities after tonsillectomy in North American children
    Lauren E Kelly
    Schulich School of Medicine, University of Western Ontario, London, Canada
    Pediatrics 129:e1343-7. 2012
    ..These cases demonstrate that analgesia with codeine or other opioids that use the CYP2D6 pathway after adenotonsillectomy may not be safe in young children with obstructive sleep apnea syndrome...
  13. ncbi request reprint Pharmacokinetics in pregnancy; clinical significance
    Gideon Koren
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    J Popul Ther Clin Pharmacol 18:e523-7. 2011
    ..To ensure that women are not orphaned from advances in drug therapy, much more research is needed into the determinants of pharmacokinetic and pharmacodynamic changes in pregnancy...
  14. pmc The effect of acyclovir on the tubular secretion of creatinine in vitro
    Patrina Gunness
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    J Transl Med 8:139. 2010
    ..Our objective was to determine whether acyclovir inhibits the tubular secretion of creatinine...
  15. pmc Health-related quality of life of Canadian children and youth prenatally exposed to alcohol
    Brenda C Stade
    Department of Paediatrics, St, Michael s Hospital, Toronto, Canada
    Health Qual Life Outcomes 4:81. 2006
    ..Caused by prenatal exposure to alcohol, FASD is the leading cause of neuro-developmental disabilities among Canadian children, and youth...
  16. pmc Effect of iron content on the tolerability of prenatal multivitamins in pregnancy
    Patricia Nguyen
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    BMC Pregnancy Childbirth 8:17. 2008
    ....
  17. pmc How physicians perceive and utilize information from a teratogen information service: the Motherisk Program
    Adrienne Einarson
    The Motherisk Program, The Hospital for Sick Children Toronto, Canada
    BMC Med Educ 4:6. 2004
    ..Our primary objective was to evaluate the perception and utilization of information received from us by physicians. Our secondary objective was to examine their information seeking behavior, in particular regarding teratogen information...
  18. pmc Seroprevalence of Toxoplasma gondii infection among veterinary staff in Ontario, Canada (2002): implications for teratogenic risk
    Samar Shuhaiber
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    BMC Infect Dis 3:8. 2003
    ..gondii antibody among veterinary staff, to ascertain whether they have an increased risk through occupational exposure. Our secondary objective was to examine their practices regarding cats, toxoplasma infection, and pregnancy...
  19. pmc A survey of physicians knowledge regarding awareness of maternal alcohol use and the diagnosis of FAS
    Alexandra C Nevin
    The University of Toronto Medical School
    BMC Fam Pract 3:2. 2002
    ..The objectives of this study were twofold: 1) to evaluate the experience, knowledge and confidence of family physicians with respect to the diagnosis of FAS and 2) to evaluate physicians awareness of maternal drinking patterns...
  20. ncbi request reprint Understanding fetal alcohol spectrum disorder--bringing schools and teachers on board
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Popul Ther Clin Pharmacol 18:e242-4. 2011
    ..A new approach to the educational aspects of FASD will help educational experts to be better prepared for students affected by this challenging condition...
  21. pmc Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gaps
    Gideon Koren
    Department of Medicine, Division of Endocrinology and Metabolism, Lombardi Cancer Center
    Ther Drug Monit 28:12-3. 2006
    ..This knowledge gap must be filled to ensure fetal safety...
  22. ncbi request reprint Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis
    Gideon Koren
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    Ann Pharmacother 40:824-9. 2006
    ..An evaluation of the risk of premature closure of the ductus arteriosus is useful in determining the safety of NSAIDs at different stages of pregnancy...
  23. ncbi request reprint Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
    Gideon Koren
    Motherisk Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Lancet 368:704. 2006
  24. ncbi request reprint Perpetuating fears: bias against the null hypothesis in fetal safety of drugs as expressed in scientific citations
    Gideon Koren
    The Motherisk Program and the Medical Library, Hospital for Sick Children, Toronto, Canada
    J Popul Ther Clin Pharmacol 18:e28-32. 2011
    ..e., those showing no issues with fetal safety of drugs) may cause distorted interpretation with apparently safe drugs being labeled as teratogenic, causing women to terminate pregnancy or not to treat serious medical conditions...
  25. pmc Fetal alcohol spectrum disorder
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children and University of Toronto, Toronto, Ont
    CMAJ 169:1181-5. 2003
  26. ncbi request reprint Validation studies of the Pregnancy Unique-Quantification of Emesis (PUQE) scores
    G Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, University of Toronto, Canada
    J Obstet Gynaecol 25:241-4. 2005
    ..PUQE has been validated through 4 independent clinical outcomes of direct importance and relevance for NVP. The simplicity of PUQE and the ease of its execution make it a practical tool for both clinical follow-up and research...
  27. ncbi request reprint Recall bias of the symptoms of nausea and vomiting of pregnancy
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Obstet Gynecol 190:485-8. 2004
    ..The purpose of this study was to assess the accuracy of recall by women of their symptoms of nausea and vomiting of pregnancy...
  28. ncbi request reprint Use of healthy children as volunteers in drug studies: the ethical debate
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Clin Pharmacol Ther 73:147-52. 2003
  29. pmc Is maternal use of selective serotonin reuptake inhibitors in the third trimester of pregnancy harmful to neonates?
    Gideon Koren
    Motherisk Program, The Hospital for Sick Children and University of Toronto, Toronto, Ont
    CMAJ 172:1457-9. 2005
  30. ncbi request reprint Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum
    G Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children Toronto, University of Toronto, Canada
    J Obstet Gynaecol 24:530-3. 2004
    ..Women who have experienced severe NVP in a previous pregnancy may benefit from taking antiemetics before, or immediately at the start of symptoms in a subsequent pregnancy...
  31. ncbi request reprint Healthy children as subjects in pharmaceutical research
    Gideon Koren
    Division of Clinical Pharmacology and Toxicology, Toronto, ON, Canada
    Theor Med Bioeth 24:149-59. 2003
    ..In this paper, I review the ethical and scientific issues and the arguments in favor and against this new practice...
  32. pmc DEET-based insect repellents: safety implications for children and pregnant and lactating women
    Gideon Koren
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children and University of Toronto, Toronto, Ont
    CMAJ 169:209-12. 2003
    ..In this article, we review the available evidence on the effectiveness and safety of DEET-based products. The evidence does not support increased risk in young children...
  33. ncbi request reprint The effect of ascertainment bias in evaluating gestational antidepressant exposure
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, and the University of Toronto
    J Popul Ther Clin Pharmacol 18:e174-5. 2011
    ..Hence, there is much higher chance to identify VSD in their babies than among healthy controls. Moreover, paroxetine has been used more specifically than other SSRI for anxiety, further increasing the chance of  ascertainment bias...
  34. pmc Generic isotretinoin: a new risk for unborn children
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and Sunnybrook and Women s College Health Sciences Centre and the University of Toronto, Toronto, Ont
    CMAJ 170:1567-8. 2004
  35. ncbi request reprint Cancer chemotherapy in young children: challenges and solutions
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 49:1091-2. 2007
    ..Each drug should be studied by itself before rational cancer therapy for young children can be offered. Much more focus on this age group is needed to improve survival, while ensuring their long-term quality of life of these children...
  36. ncbi request reprint The way women perceive teratogenic risk
    Gideon Koren
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Clin Pharmacol 14:e10-6. 2007
  37. pmc Insulin glargine safety in pregnancy: a transplacental transfer study
    Erika K Pollex
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Diabetes Care 33:29-33. 2010
    ..Therefore, the objective of this study was to determine whether insulin glargine crosses the human placenta using the human perfused placental lobule technique...
  38. pmc Ribavirin in the treatment of SARS: A new trick for an old drug?
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ont
    CMAJ 168:1289-92. 2003
  39. doi request reprint Novel methods for the detection of drug and alcohol exposure during pregnancy: implications for maternal and child health
    G Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Pharmacol Ther 83:631-4. 2008
    ..Despite extensive evidence of fetal and neonatal risk, a large number of pregnant women are involved in excessive alcohol and drug abuse, such as with cocaine, methamphetamine, opioids, and cannabinoids...
  40. doi request reprint Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter
    Gideon Koren
    From the Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 31:1-2. 2009
    ..A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter...
  41. doi request reprint Hair nicotine:cotinine metabolic ratio in pregnant women: a new method to study metabolism in late pregnancy
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 30:246-8. 2008
    ..This phenomenon may explain why many pregnant women feel the urge to continue smoking and why standard-dose nicotine replacement therapy has not been effective in reducing smoking during pregnancy in several clinical trials...
  42. ncbi request reprint The global alliance for pediatric pharmacology: the future is here and now
    Gideon Koren
    The Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:4-5. 2009
    ..This is also true for pharmacokinetic and pharmacodynamic studies, as well as for the development of pediatric formulations. Finding simple ways to inform the world about existing data may save time and facilitate efforts...
  43. ncbi request reprint Training clinicians in pediatric pharmacology-toxicology: the Toronto model
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children and University of Toronto, Ontario, Canada
    Paediatr Drugs 11:60-2. 2009
    ..The program will continue to prepare pediatricians for the rapidly changing challenges of rational drug therapy for children...
  44. ncbi request reprint Adverse effects in neonates exposed to SSRIs and SNRI in late gestation--Motherisk Update 2008
    Gideon Koren
    The Motherisk Program, The Hospital for Sick Children, Toronto
    Can J Clin Pharmacol 16:e66-7. 2009
    ..Preliminary evidence suggests that the very early respiratory symptoms may not be part of discontinuation but rather part of a reversible form of persistent pulmonary hypertension of the newborn (PPHN)...
  45. ncbi request reprint Reviewers' bias against the null hypothesis: the reproductive hazard of binge drinking
    Gideon Koren
    The Ivey Chair in Molecular Toxicology, Department of Medicine, University of Western Ontario, London, Canada
    J Popul Ther Clin Pharmacol 17:e281-3. 2010
    ..Scientific journals should make an effort to eliminate this source of bias against negative results...
  46. doi request reprint Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial
    Gideon Koren
    Motherisk Program, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 203:571.e1-7. 2010
    ..To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy...
  47. ncbi request reprint Drugs in pregnancy: acknowledging challenges--finding solutions
    Gideon Koren
    The Motherisk Program, Toronto and Ivey Chair in Molecular Toxicology, University of Western Ontario
    Can J Clin Pharmacol 14:e2-4. 2007
  48. doi request reprint Pregnancy and commonly used drugs in hematology practice
    Gideon Koren
    Motherisk Program, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Hematology Am Soc Hematol Educ Program 2010:160-5. 2010
    ..It is critical to always balance the potential fetal risks of the drug in question against the maternal and fetal risks of the untreated hematological condition...
  49. ncbi request reprint Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 24:23-5. 2002
    ..The identification of biologic markers of intrauterine exposure to xenobiotics will allow better understanding of etiology and dose-response relationships...
  50. ncbi request reprint Training clinicians in Maternal-Fetal Pharmacology: closing a conceptual gap
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:72-3. 2009
    ..The novel Summer Institute in Maternal-Fetal Pharmacology is presented, with preliminary indications that it fulfils its mandate...
  51. ncbi request reprint Critical appraisal rounds: a new training model for clinical pharmacologists
    Gideon Koren
    The Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Can J Clin Pharmacol 14:e81-5. 2007
    ..Formal evaluation of this model by trainees revealed high marks for "critical thinking", "learning study design", and "how to write/not to write"...
  52. ncbi request reprint Drug-induced nephrotoxicity in children: pharmacologically based prevention of long-term impairment
    Gideon Koren
    Division of Clinical Pharmacology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Paediatr Drugs 9:139-42. 2007
  53. ncbi request reprint Preconception counseling: rational, practice and challenges
    A Walfisch
    Hospital for Sick Children, Department of Pharmacology, University of Toronto, Ontario, Canada
    Minerva Ginecol 63:411-9. 2011
    ..In addition, specific topics are reviewed in depth including folic acid supplementation, obesity, depression, seizure disorders, and drug therapy during pregnancy...
  54. ncbi request reprint Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada
    P Mazzotta
    The Motherisk Program, Department of Pediatrics and Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Int J Gynaecol Obstet 70:359-65. 2000
    ..In Canada, a generic form of Bendectin (Diclectin; a doxylamine/pyridoxine combination) has continued to be available, with increasing use over the last few years...
  55. ncbi request reprint Combined analgesia and local anesthesia to minimize pain during circumcision
    A Taddio
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 154:620-3. 2000
    ..Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers...
  56. ncbi request reprint Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta
    C Gedeon
    University of Toronto, Department of Pharmacology, Toronto, Ontario, Canada
    Placenta 29:39-43. 2008
    ..Our study also indicates that BCRP likely effluxes substrates in the fetal to maternal direction in the human placenta...
  57. ncbi request reprint Pregnancy outcome following gestational exposure to venlafaxine: a multicenter prospective controlled study
    A Einarson
    The Motherisk Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:1728-30. 2001
    ..Because there are no studies available on the safety of venlafaxine during pregnancy, the authors' goal in this study was to determine whether venlafaxine increases the risk for major malformations...
  58. ncbi request reprint Recent developments in meconium and hair testing methods for the confirmation of gestational exposures to alcohol and tobacco smoke
    Daphne Chan
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Biochem 37:429-38. 2004
    ..The latest developments and novel applications of meconium and hair testing for the confirmation of prenatal alcohol and tobacco exposure are discussed in this review...
  59. ncbi request reprint Neurodevelopment of adopted children exposed in utero to cocaine: the Toronto Adoption Study
    I Nulman
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ont
    Clin Invest Med 24:129-37. 2001
    ..Follow-up into school years is warranted to evaluate the extent of these effects...
  60. ncbi request reprint Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits
    P Madadi
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Pharmacol Ther 88:792-5. 2010
    ..Thirty-three percent of the participants wished to withhold these results from their physicians. Participants' expectations seem to dictate the extent of transparency of pharmacogenetic research results...
  61. ncbi request reprint Opioid detection in maternal and neonatal hair and meconium: characterization of an at-risk population and implications to fetal toxicology
    Monique Moller
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 32:318-23. 2010
    ..657, P = 0.03). Understanding the addiction profiles of these women may lead to better clinical and social management and may largely benefit an at-risk population...
  62. ncbi request reprint Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6)
    R Bishai
    The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 7:138-43. 2000
    ..The present review aims to refute the unsubstantiated beliefs that Diclectin is unsafe when used in the treatment of nausea and vomiting of pregnancy...
  63. ncbi request reprint The role of the placenta in variability of fetal exposure to cocaine and cannabinoids: a twin study
    R Boskovic
    Department of Pediatrics and Research Institute, The Hospital for Sick Children, The University of Toronto, ON, Canada
    Can J Physiol Pharmacol 79:942-5. 2001
    ..Given that twins are theoretically exposed to similar maternal drug levels, our findings suggest that the placenta may have a major role in modulating the amounts of drug reaching the fetus...
  64. ncbi request reprint The role of acetaldehyde in pregnancy outcome after prenatal alcohol exposure
    M L Hard
    Division of Clinical Pharmacology and Toxicology, University of Toronto, Ontario, Canada
    Ther Drug Monit 23:427-34. 2001
    ..The similar frequencies of high acetaldehyde levels among alcoholics and the rates of ARBD among alcoholic women provide epidemiologic support to the hypothesis that acetaldehyde may play a major role in the cause of ARBD...
  65. ncbi request reprint The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy
    G Atanackovic
    Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Canada
    J Clin Pharmacol 41:842-5. 2001
    ..If needed, Diclectin can be given at doses higher than 4 tablets/day to normalize for body weight or optimize efficacy...
  66. doi request reprint Adverse effects of antidepressant use in pregnancy: an evaluation of fetal growth and preterm birth
    A Einarson
    The Motherisk Program, The Hospital for Sick Children, Toronto, Canada
    Depress Anxiety 27:35-8. 2010
    ..To compare the rates of low birth weight, preterm delivery and small for gestational age (SGA), in pregnancy outcomes among women who were exposed and nonexposed to antidepressants during pregnancy...
  67. doi request reprint The transfer of ethyl glucuronide across the dually perfused human placenta
    J N Matlow
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Placenta 34:369-73. 2013
    ..Therefore, the objective of this study was to determine if EtG crosses the human placenta...
  68. doi request reprint Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta
    C Gedeon
    Department of Clinical Pharmacology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Obstet Gynaecol 28:485-9. 2008
    ..These results pose other ABC transporters, such as likely candidates for the placental transfer of glyburide...
  69. doi request reprint Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology
    J R Hutson
    Insitute of Medical Sciences, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Placenta 31:351-7. 2010
    ....
  70. ncbi request reprint Neurodevelopment after in utero amiodarone exposure
    L A Magee
    Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    Neurotoxicol Teratol 21:261-5. 1999
    ..There may be neurotoxicity associated with transplacental exposure to amiodarone. Follow-up is warranted, although most mothers were happy with the development of their children...
  71. doi request reprint Solid-phase microextraction for the detection of codeine, morphine and 6-monoacetylmorphine in human hair by gas chromatography-mass spectrometry
    M Moller
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Forensic Sci Int 196:64-9. 2010
    ....
  72. ncbi request reprint Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
    ..Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD...
  73. ncbi request reprint Determinants of women's decision making on whether to treat nausea and vomiting of pregnancy pharmacologically
    Anne Baggley
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Midwifery Womens Health 49:350-4. 2004
    ..Of the women who did use Diclectin, the most convincing reassuring information that it was safe to use came from friends and family. Many other factors play a large role in a women's decision making...
  74. ncbi request reprint Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes
    Josephine Djulus
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1280-4. 2006
    ..Currently, apart from a few case reports and case series in the literature, there are no studies evaluating the safety of this drug during pregnancy...
  75. ncbi request reprint Discrepancy between CYP2D6 phenotype and genotype derived from post-mortem dextromethorphan blood level
    B Bailey
    Department of Pediatrics, Division of Clinical Pharmacology and Toxicology, H opital Ste Justine, 3175 Cote St Catherine, Montr eal, Qu ebec, Canada
    Forensic Sci Int 110:61-70. 2000
    ..To describe the death of a toddler after a therapeutic dose of dextromethorphan and its investigation...
  76. ncbi request reprint Outcomes of infants exposed to multiple antidepressants during pregnancy: results of a cohort study
    A Einarson
    The Motherisk Program, The Hospital for Sick Children, Toronto, Canada
    J Popul Ther Clin Pharmacol 18:e390-6. 2011
    ..A single study has been published documenting an increased risk for adverse pregnancy outcomes following use of more than one antidepressant during pregnancy...
  77. doi request reprint Pharmacokinetics of disappearance of cocaine from hair after discontinuation of drug use
    F Garcia-Bournissen
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada
    Forensic Sci Int 189:24-7. 2009
    ..We aimed to evaluate the kinetics of disappearance of cocaine and its metabolite, benzoylecgonine (BE), from hair after discontinuation of drug use...
  78. pmc Methamphetamine detection in maternal and neonatal hair: implications for fetal safety
    F Garcia-Bournissen
    G Koren, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, 555 University Avenue, 8th Floor, Black Wing, Toronto, Canada ON, USA
    Arch Dis Child Fetal Neonatal Ed 92:F351-5. 2007
    ..Methamphetamine misuse is a serious health problem of epidemic proportions. Use of this drug, particularly during pregnancy, is difficult to ascertain. Sparse information is available on gestational exposure...
  79. pmc Hair analysis provides a historical record of cortisol levels in Cushing's syndrome
    S Thomson
    Department of Physiology and Pharmacology, University of Western Ontario, Ontario, Canada N6A4V2
    Exp Clin Endocrinol Diabetes 118:133-8. 2010
    ....
  80. doi request reprint Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study
    P Madadi
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 85:31-5. 2009
    ..Breastfed infants of mothers who are CYP2D6 UMs combined with the UGT2B7*2/*2 are at increased risk of potentially life-threatening CNS depression...
  81. ncbi request reprint Identifying the behavioural phenotype in Fetal Alcohol Spectrum Disorder: sensitivity, specificity and screening potential
    K Nash
    Psychology Department, The Hospital for Sick Children, Toronto, Cananda
    Arch Womens Ment Health 9:181-6. 2006
    ..Since access to psychological testing is typically limited or non-existent in remote areas, other diagnostic methods are needed to provide necessary interventions...
  82. ncbi request reprint A novel method for the evaluation of the severity of nausea and vomiting of pregnancy
    G Koren
    The Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, The CIBC World Market Children's Miracle Foundation Chair in Child Health Research, University of Toronto, ON, Burlington, Canada
    Eur J Obstet Gynecol Reprod Biol 94:31-6. 2001
    ..Unlike the Rhode's score, this simple method can be used clinically to evaluate the severity and changes in NVP...
  83. ncbi request reprint A method for meta-analysis of epidemiological studies
    T R Einarson
    Department of Pediatrics, Hospital for Sick Children, Toronto, ON
    Drug Intell Clin Pharm 22:813-24. 1988
    ..62-1.45. For case-control studies, the summary odds ratio was 1.27 with a 95 percent confidence interval of 0.83-1.94. The corresponding chi-square values were not statistically significant at the p = 0.05 level...
  84. ncbi request reprint Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children
    D L Halperin
    Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
    Pediatrics 84:281-4. 1989
    ....
  85. pmc Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling
    A Einarson
    Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, 555 University Ave, Toronto ON 5G 1X8
    J Psychiatry Neurosci 26:44-8. 2001
    ..To assess the consequences to mother and baby of abruptly discontinuing antidepressant or benzodiazepine medication during pregnancy and to assess the impact of our counselling...
  86. ncbi request reprint The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta
    E Pollex
    The Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada
    Placenta 29:743-7. 2008
    ..32+/-0.06 (p=0.04). These data indicate that nicardipine partially blocked the transfer of glyburide across the whole placenta through its inhibition of BCRP. This is the first ex vivo evidence that BCRP actively transports glyburide...
  87. doi request reprint An assessment of cortisol analysis in hair and its clinical applications
    R Gow
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Forensic Sci Int 196:32-7. 2010
    ..This review uses emerging evidence to describe the usefulness of hair analysis for cortisol and discusses the current methods used...
  88. ncbi request reprint Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal Guinea pig
    James F Brien
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada
    Ther Drug Monit 28:345-50. 2006
    ....
  89. ncbi request reprint Reference values for hair cotinine as a biomarker of active and passive smoking in women of reproductive age, pregnant women, children, and neonates: systematic review and meta-analysis
    Ana Florescu
    Public Health Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Ther Drug Monit 29:437-46. 2007
    ..These new values should facilitate clinical diagnosis of active and passive exposure to tobacco smoke. Such diagnosis is critical in pregnancy and in a large number of tobacco-induced medical conditions...
  90. ncbi request reprint Child neurodevelopmental outcome and maternal occupational exposure to solvents
    Dionne Laslo-Baker
    Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 158:956-61. 2004
    ..Animal toxicological studies and human case reports demonstrate that high exposure to solvents causes neurodevelopmental toxicity in exposed offspring. Data from occupationally exposed women and their children are few...
  91. ncbi request reprint Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study
    Kate McKenna
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 66:444-9; quiz 546. 2005
    ..Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy...
  92. ncbi request reprint Risks and benefits of beta-receptor blockers for pregnancy hypertension: overview of the randomized trials
    L A Magee
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ont, Canada
    Eur J Obstet Gynecol Reprod Biol 88:15-26. 2000
    ..Examine the benefits/risks of beta-blockers for pregnancy hypertension...
  93. pmc The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancy
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
    Can J Gastroenterol 23:270-2. 2009
    ..Heartburn (HB) and acid reflux (RF) in the nonpregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severity of symptoms...
  94. ncbi request reprint Prenatal exposure to organic solvents and child neurobehavioral performance
    C Till
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Neurotoxicol Teratol 23:235-45. 2001
    ..The findings suggest that maternal occupational exposure to organic solvents during pregnancy is associated with poorer outcome in selective aspects of cognitive and neuromotor functioning in offspring...
  95. ncbi request reprint Fetal exposure to isotretinoin-an international problem
    Facundo Garcia-Bournissen
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Reprod Toxicol 25:124-8. 2008
    ..Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at minimizing isotretinoin exposure in pregnancy have been implemented in North America with limited success...
  96. doi request reprint Hair analysis of fatty acid ethyl esters in the detection of excessive drinking in the context of fetal alcohol spectrum disorders
    Vivian Kulaga
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Ther Drug Monit 31:261-6. 2009
    ..Our results suggest that FAEE hair analysis may be a powerful tool in detecting excessive alcohol use in the perinatal period...
  97. ncbi request reprint Fetal exposure to alcohol as evidenced by fatty acid ethyl esters in meconium in the absence of maternal drinking history in pregnancy
    Daphne Chan
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 26:474-81. 2004
    ..Meconium FAEE are emerging biologic markers that can potentially facilitate earlier diagnosis and intervention for less apparent forms of alcohol-related disabilities that cannot be confirmed in the absence of maternal drinking history...
  98. ncbi request reprint Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy
    Galina Portnoi
    The Motherisk Program, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Obstet Gynecol 189:1374-7. 2003
    ..The primary objective of our study was to examine the safety and the secondary objective was to examine the effectiveness of ginger for nausea and vomiting of pregnancy (NVP)...
  99. ncbi request reprint Fatty acid ethyl esters (FAEE); comparative accumulation in human and guinea pig hair as a biomarker for prenatal alcohol exposure
    Vivian Kulaga
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Alcohol Alcohol 41:534-9. 2006
    ..To compare the incorporation rate (ICR) of fatty acid ethyl esters (FAEE) in hair between guinea pigs and humans, and to assess the relationship between ethanol exposure and FAEE concentrations in hair...
  100. ncbi request reprint Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis
    Cameron Gilbert
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Fertil Steril 86:658-63. 2006
    ....