Binita M Kamath

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome
    Binita M Kamath
    The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada Electronic address
    J Pediatr 167:390-6.e3. 2015
  2. pmc Renal anomalies in Alagille syndrome: a disease-defining feature
    Binita M Kamath
    Division of Gastroenterology, Hepatology and Nutrition at The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Med Genet A 158:85-9. 2012
  3. pmc Pancreatic insufficiency is not a prevalent problem in Alagille syndrome
    Binita M Kamath
    Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 55:612-4. 2012
  4. doi request reprint Outcomes of liver transplantation for patients with Alagille syndrome: the studies of pediatric liver transplantation experience
    Binita M Kamath
    Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, Toronto, Canada
    Liver Transpl 18:940-8. 2012
  5. doi request reprint Liver transplantation in children: update 2010
    Binita M Kamath
    Department of Pediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada
    Pediatr Clin North Am 57:401-14, table of contents. 2010
  6. doi request reprint Medical management of Alagille syndrome
    Binita M Kamath
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 50:580-6. 2010
  7. pmc A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome
    Binita M Kamath
    Division of Gastroenterology, Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 50:526-30. 2010
  8. pmc Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3
    Melissa Leyva-Vega
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Med Genet A 152:886-95. 2010
  9. pmc Alagille syndrome in a Vietnamese cohort: mutation analysis and assessment of facial features
    Henry C Lin
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet A 158:1005-13. 2012
  10. pmc SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation
    Binita M Kamath
    Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Hum Mutat 30:371-8. 2009

Collaborators

Detail Information

Publications22

  1. pmc Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome
    Binita M Kamath
    The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada Electronic address
    J Pediatr 167:390-6.e3. 2015
    ..To assess health-related quality of life (HRQOL) in children with Alagille syndrome (ALGS) in comparison with healthy and other liver disease cohorts, and to identify determinants of HRQOL in patients with ALGS...
  2. pmc Renal anomalies in Alagille syndrome: a disease-defining feature
    Binita M Kamath
    Division of Gastroenterology, Hepatology and Nutrition at The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Med Genet A 158:85-9. 2012
    ..These data also suggest that renal involvement be considered the sixth defining criterion for ALGS...
  3. pmc Pancreatic insufficiency is not a prevalent problem in Alagille syndrome
    Binita M Kamath
    Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 55:612-4. 2012
    ..FE measurements were normal (>200  μg/g) in 40 (95%) and indeterminate (100-200  μg/g) in 2 (5%). As FE is the most reliable screen for PI, these data suggest that PI is not a prevalent problem in ALGS...
  4. doi request reprint Outcomes of liver transplantation for patients with Alagille syndrome: the studies of pediatric liver transplantation experience
    Binita M Kamath
    Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, Toronto, Canada
    Liver Transpl 18:940-8. 2012
    ..Although the 1-year survival rate was modestly lower for the ALGS patients versus the BA patients, the clustering of deaths within the first 30 days is notable and warrants increased vigilance and further investigation...
  5. doi request reprint Liver transplantation in children: update 2010
    Binita M Kamath
    Department of Pediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada
    Pediatr Clin North Am 57:401-14, table of contents. 2010
    ..These issues require constant collaboration between pediatricians, transplant hepatologists, transplant surgeons, nurses, dieticians, social workers, psychologists, and other supporting services...
  6. doi request reprint Medical management of Alagille syndrome
    Binita M Kamath
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 50:580-6. 2010
    ..Furthermore, the liver disease in particular requires an appreciation of the natural history and evolution of the profound cholestasis...
  7. pmc A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome
    Binita M Kamath
    Division of Gastroenterology, Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 50:526-30. 2010
    ..This poses a challenge to the clinician in terms of timing therapies. The study aim was to identify laboratory markers present in children younger than 5 years that could predict the ultimate outcome of liver disease in AGS...
  8. pmc Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3
    Melissa Leyva-Vega
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Med Genet A 152:886-95. 2010
    ..The overlapping 1.76 Mb deletion on chromosome 2q37.3 from 240,936,900 to 242,692,820 constitutes the critical region and the genes within this region could be candidates for susceptibility to BA...
  9. pmc Alagille syndrome in a Vietnamese cohort: mutation analysis and assessment of facial features
    Henry C Lin
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet A 158:1005-13. 2012
    ..This is the first report of mutations and phenotypic spectrum of ALGS in a Vietnamese population...
  10. pmc SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation
    Binita M Kamath
    Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Hum Mutat 30:371-8. 2009
    ..Deletions of the short arm of chromosome 20 are associated with relatively mild and limited clinical anomalies. The use of SNP arrays provides accurate high-resolution definition of genomic abnormalities...
  11. doi request reprint Renal involvement and the role of Notch signalling in Alagille syndrome
    Binita M Kamath
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Nat Rev Nephrol 9:409-18. 2013
    ..Increased awareness of Alagille syndrome amongst nephrologists may lead to more diagnoses of Alagille syndrome in patients with apparently isolated renal disease...
  12. doi request reprint Abnormal Liver Biochemistry Is Common in Pediatric Inflammatory Bowel Disease: Prevalence and Associations
    Pamela L Valentino
    Division of Gastroenterology, Hepatology, and Nutrition, The University of Toronto, ON, Canada Department of Pediatrics, The University of Toronto, Toronto, ON, Canada Institute of Health Policy, Management and Evaluation, The University of Toronto, Toronto, ON, Canada Child Health Evaluative Sciences, Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada and Division of Rheumatology, The University of Toronto, Toronto, ON, Canada
    Inflamm Bowel Dis 21:2848-56. 2015
    ..Liver enzymes (LEs) abnormalities associated with pediatric inflammatory bowel diseases (IBD) are understudied. We undertook to describe the development and associations of abnormal LEs in pediatric IBD...
  13. pmc Pathologic lower extremity fractures in children with Alagille syndrome
    Christina B Bales
    Department of Pediatrics, The Department of Biostatistics and Epidemiology at the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 51:66-70. 2010
    ..In this retrospective study, we aimed to determine the incidence and distribution of fractures in patients with Alagille syndrome, 1 of the leading inherited causes of pediatric cholestatic liver disease...
  14. ncbi request reprint Intracranial vascular abnormalities in patients with Alagille syndrome
    Karan M Emerick
    Division of Gastroenterology, The Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Pediatr Gastroenterol Nutr 41:99-107. 2005
    ....
  15. doi request reprint Alagille syndrome and liver transplantation
    Binita M Kamath
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 50:11-5. 2010
    ....
  16. doi request reprint Solitary Hepatic Nodule Adjacent to the Right Portal Vein: A Common Finding of Alagille Syndrome?
    Abdullah Alhammad
    Department of Diagnostic Imaging Division of Gastroenterology, Hepatology and Nutrition Department of Pediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 62:226-32. 2016
    ..Hepatic lesions have been described in Alagille syndrome (ALGS) in isolated case reports, and most of these have been reported to be hepatocellular carcinoma...
  17. doi request reprint A screening algorithm for the efficient exclusion of biliary atresia in infants with cholestatic jaundice
    Tim Jancelewicz
    Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Surgery, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Pediatr Surg 50:363-70. 2015
    ..An optimal diagnostic approach to reduce risk, cost, and delay has yet to be defined. The purpose of this study was to develop an algorithm that rapidly and accurately excludes BA for infants with cholestatic jaundice...
  18. doi request reprint Enteral energy and macronutrients in end-stage liver disease
    Marialena Mouzaki
    Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto Department of Paediatrics, University of Toronto, Toronto
    JPEN J Parenter Enteral Nutr 38:673-81. 2014
    ..A summary of recommendations is provided. ..
  19. doi request reprint The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children
    Pamela L Valentino
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children SickKids, Toronto, Ontario, Canada Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Liver Int 34:227-34. 2014
    ..The role of liver biopsy in children for the diagnosis of FNH is unclear. This study investigates the diagnostic accuracy of DI for FNH in children without comorbidities, compared to liver biopsy...
  20. doi request reprint Hepatotoxicity caused by methotrexate therapy in children with inflammatory bowel disease: a systematic review and meta-analysis
    Pamela L Valentino
    1Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada 2Neonatal Intensive Care Unit, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Toronto, ON, Canada and 4Division of Rheumatology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Inflamm Bowel Dis 20:47-59. 2014
    ..However, MTX use is associated with liver toxicity. We aimed to systematically review and meta-analyze the incidence of hepatotoxicity with MTX use among children with IBD...
  21. doi request reprint Gadobenate-dimeglumine-enhanced magnetic resonance imaging for hepatic lesions in children
    Govind B Chavhan
    Department of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, 555 University Ave, Toronto, Canada, M5G 1X8
    Pediatr Radiol 44:1266-74. 2014
    ..Magnetic resonance imaging enhanced by hepatocyte-specific contrast media has been found useful to characterize liver lesions in adults and children...
  22. pmc Glatiramer acetate-induced acute hepatotoxicity in an adolescent with MS
    Naila Makhani
    Hospital for Sick Children, Canada
    Neurology 81:850-2. 2013
    ..Here, we report GA-induced hepatotoxicity in a pediatric patient with multiple sclerosis (MS). ..