Walter H A Kahr

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi request reprint Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome
    Walter H A Kahr
    Department of Paediatrics, University of Toronto, Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 43:738-40. 2011
  2. doi request reprint Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA
    Walter H A Kahr
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Thromb Haemost 102:1241-50. 2009
  3. pmc The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis
    Denisa Urban
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Blood 120:5032-40. 2012
  4. doi request reprint Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice
    Walter H A Kahr
    Department of Paediatrics, University of Toronto, Division of Haematology Oncology, and
    Blood 122:3349-58. 2013
  5. doi request reprint Platelet-associated complement factor H in healthy persons and patients with atypical HUS
    Christoph Licht
    Department of Paediatrics, Division of Nephrology, Program in Cell Biology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Blood 114:4538-45. 2009
  6. doi request reprint Idiopathic suppurative pylephlebitis: interventional radiological diagnosis and management
    Conor O Bogue
    Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Cardiovasc Intervent Radiol 32:1304-7. 2009
  7. ncbi request reprint Liver biopsy complicated by hemorrhage in a patient with ARC syndrome
    Jason A Hayes
    Department of Anesthesia, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada
    Paediatr Anaesth 14:960-3. 2004
  8. ncbi request reprint Exercise-induced deep vein thrombosis of the upper extremity. 2. A case series in children
    Leonardo R Brandao
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont, Canada
    Acta Haematol 115:221-9. 2006
  9. ncbi request reprint Exercise-induced deep vein thrombosis of the upper extremity. 1. Literature review
    Leonardo R Brandao
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont, Canada
    Acta Haematol 115:214-20. 2006
  10. doi request reprint Interstitial deletion of 11q-implicating the KIRREL3 gene in the neurocognitive delay associated with Jacobsen syndrome
    Andrea Guerin
    Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Med Genet A 158:2551-6. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome
    Walter H A Kahr
    Department of Paediatrics, University of Toronto, Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 43:738-40. 2011
    ..NBEAL2 encodes a protein containing a BEACH domain that is predicted to be involved in vesicular trafficking and may be critical for the development of platelet α-granules...
  2. doi request reprint Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA
    Walter H A Kahr
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Thromb Haemost 102:1241-50. 2009
    ....
  3. pmc The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis
    Denisa Urban
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Blood 120:5032-40. 2012
    ..We conclude that VPS16B, similar to its binding partner VPS33B, is essential for megakaryocyte and platelet α-granule biogenesis...
  4. doi request reprint Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice
    Walter H A Kahr
    Department of Paediatrics, University of Toronto, Division of Haematology Oncology, and
    Blood 122:3349-58. 2013
    ....
  5. doi request reprint Platelet-associated complement factor H in healthy persons and patients with atypical HUS
    Christoph Licht
    Department of Paediatrics, Division of Nephrology, Program in Cell Biology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Blood 114:4538-45. 2009
    ..This CFH-dependent response did not involve P-selectin mobilization, indicating a complement-induced platelet response distinct from alpha-granule secretion...
  6. doi request reprint Idiopathic suppurative pylephlebitis: interventional radiological diagnosis and management
    Conor O Bogue
    Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Cardiovasc Intervent Radiol 32:1304-7. 2009
    ..Our aim is to increase the awareness of this entity and stress the importance of early diagnosis and appropriate therapy...
  7. ncbi request reprint Liver biopsy complicated by hemorrhage in a patient with ARC syndrome
    Jason A Hayes
    Department of Anesthesia, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada
    Paediatr Anaesth 14:960-3. 2004
    ..The evaluation and management of unexpected hemorrhage in pediatric patients as a result of undiagnosed congenital bleeding problems is discussed...
  8. ncbi request reprint Exercise-induced deep vein thrombosis of the upper extremity. 2. A case series in children
    Leonardo R Brandao
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont, Canada
    Acta Haematol 115:221-9. 2006
    ..Adolescents with UEDVT treated only with anticoagulation seem to have a poor outcome...
  9. ncbi request reprint Exercise-induced deep vein thrombosis of the upper extremity. 1. Literature review
    Leonardo R Brandao
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont, Canada
    Acta Haematol 115:214-20. 2006
    ..Similarly, the best therapeutic option has not been established and in the lack of evidence-based guidelines, treatment may be extremely challenging especially in children, in whom long-term complications can be particularly disabling...
  10. doi request reprint Interstitial deletion of 11q-implicating the KIRREL3 gene in the neurocognitive delay associated with Jacobsen syndrome
    Andrea Guerin
    Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Med Genet A 158:2551-6. 2012
    ....
  11. doi request reprint The cell motility modulator Slit2 is a potent inhibitor of platelet function
    Sajedabanu Patel
    The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Circulation 126:1385-95. 2012
    ..The effects of Slit2 on platelet function and thrombus formation have never been explored...
  12. doi request reprint Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
    Hong Yang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 114:425-36. 2009
    ..Since human fibrinogen levels vary significantly in normal and diseased populations, P-selectin as an activation marker on platelets should be used with caution...
  13. ncbi request reprint Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis
    Bryan Lo
    Department of Paediatrics, Division of Clinical and Metabolic Genetics, Programme in Cell Biology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada
    Blood 106:4159-66. 2005
    ..We conclude that like other Sec1/Munc18 proteins, VPS33B is involved in intracellular vesicle trafficking, being essential for the development of platelet alpha-granules but not for granule secretion...
  14. doi request reprint Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene
    Roberto Mendoza-Londono
    Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 158:1344-54. 2012
    ..Furthermore, we ruled out the contribution of intrinsic platelet factors to the bleeding diathesis observed in some affected individuals...
  15. doi request reprint Congenital thrombocytopenia: clinical manifestations, laboratory abnormalities, and molecular defects of a heterogeneous group of conditions
    Riten Kumar
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Hematol Oncol Clin North Am 27:465-94. 2013
    ....
  16. ncbi request reprint Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder
    Prameet M Sheth
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 90:293-8. 2003
    ..The QPD is the only known bleeding disorder associated with chronic, intracellular activation of the fibrinolytic cascade...
  17. doi request reprint The use of elastic compression stockings for post-thrombotic syndrome in a child
    Tina T Biss
    Department of Haematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Blood Cancer 53:462-3. 2009
    ..The presented case highlights the subtle nature of symptoms, potential benefits and limitations of ECS use for PTS, and current lack of evidence in children...