Sheena A Josselyn

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi request reprint Infantile amnesia: a neurogenic hypothesis
    Sheena A Josselyn
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada M5G 1X8
    Learn Mem 19:423-33. 2012
  2. pmc Continuing the search for the engram: examining the mechanism of fear memories
    Sheena A Josselyn
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, and the Department of Physiology and Institute of Medical Sciences, University of Toronto, Toronto, Ont, Canada
    J Psychiatry Neurosci 35:221-8. 2010
  3. ncbi request reprint CREB, synapses and memory disorders: past progress and future challenges
    Sheena A Josselyn
    Program in Integrative Biology and Brain and Behaviour, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Curr Drug Targets CNS Neurol Disord 4:481-97. 2005
  4. ncbi request reprint The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior
    Sheena A Josselyn
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT, USA
    Neuropsychopharmacology 30:17-26. 2005
  5. ncbi request reprint MEF2 negatively regulates learning-induced structural plasticity and memory formation
    Christina J Cole
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Neurosci 15:1255-64. 2012
  6. ncbi request reprint Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition
    Ameet S Sengar
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 33:4055-65. 2013
  7. pmc p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior
    Gonzalo I Cancino
    Programs in Cell Biology, Developmental and Stem Cell Biology, and Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 33:12569-85. 2013
  8. ncbi request reprint Hippocampal neurogenesis regulates forgetting during adulthood and infancy
    Katherine G Akers
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada
    Science 344:598-602. 2014
  9. doi request reprint Age-dependent effects of hippocampal neurogenesis suppression on spatial learning
    Alonso Martinez-Canabal
    Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 23:66-74. 2013
  10. doi request reprint Selective erasure of a fear memory
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Science 323:1492-6. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint Infantile amnesia: a neurogenic hypothesis
    Sheena A Josselyn
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada M5G 1X8
    Learn Mem 19:423-33. 2012
    ..We propose that high neurogenesis levels negatively regulate the ability to form enduring memories, most likely by replacing synaptic connections in preexisting hippocampal memory circuits...
  2. pmc Continuing the search for the engram: examining the mechanism of fear memories
    Sheena A Josselyn
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, and the Department of Physiology and Institute of Medical Sciences, University of Toronto, Toronto, Ont, Canada
    J Psychiatry Neurosci 35:221-8. 2010
    ..These findings are the first to show disruption of a specific memory by disrupting select neurons within a distributed network...
  3. ncbi request reprint CREB, synapses and memory disorders: past progress and future challenges
    Sheena A Josselyn
    Program in Integrative Biology and Brain and Behaviour, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Curr Drug Targets CNS Neurol Disord 4:481-97. 2005
    ..Therefore, we explore the possibility of targeting CREB function in developing novel treatment strategies. Finally, we highlight areas of research on CREB that are ripe for further advancement...
  4. ncbi request reprint The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior
    Sheena A Josselyn
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT, USA
    Neuropsychopharmacology 30:17-26. 2005
    ....
  5. ncbi request reprint MEF2 negatively regulates learning-induced structural plasticity and memory formation
    Christina J Cole
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Neurosci 15:1255-64. 2012
    ..These bidirectional effects indicate that MEF2 is a key regulator of plasticity and that relieving the suppressive effects of MEF2-mediated transcription permits memory formation...
  6. ncbi request reprint Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition
    Ameet S Sengar
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 33:4055-65. 2013
    ..Thus, coincident with the acquisition of additional signaling domains, vertebrate Itsn1 has been functionally repurposed to also facilitate interhemispheric connectivity essential for high order cognitive functions...
  7. pmc p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior
    Gonzalo I Cancino
    Programs in Cell Biology, Developmental and Stem Cell Biology, and Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 33:12569-85. 2013
    ..These results indicate that p63 regulates the numbers of adult NPCs and adult-born neurons as well as neural stem cell-dependent cognitive functions, and that it does so, at least in part, by inhibiting p53-dependent cell death. ..
  8. ncbi request reprint Hippocampal neurogenesis regulates forgetting during adulthood and infancy
    Katherine G Akers
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada
    Science 344:598-602. 2014
    ..Consistent with reduced levels of postnatal hippocampal neurogenesis, infant guinea pigs and degus did not exhibit forgetting. However, increasing neurogenesis after memory formation induced infantile amnesia in these species. ..
  9. doi request reprint Age-dependent effects of hippocampal neurogenesis suppression on spatial learning
    Alonso Martinez-Canabal
    Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 23:66-74. 2013
    ..These findings suggest that during juvenility, suppression of neurogenesis may alter hippocampal development, whereas during adulthood and aging, pre-existing neurons may compensate for the lack of new hippocampal neurons...
  10. doi request reprint Selective erasure of a fear memory
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Science 323:1492-6. 2009
    ..These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace...
  11. ncbi request reprint Chronic over-expression of TGFβ1 alters hippocampal structure and causes learning deficits
    Alonso Martinez-Canabal
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 23:1198-211. 2013
    ..Together, our data indicate that chronic upregulation of TGFβ1 negatively impacts hippocampal structure and, even in the absence of disease, impairs hippocampus-dependent learning...
  12. doi request reprint Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice
    Derya Sargin
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Neurobiol Learn Mem 103:39-49. 2013
    ..These results provide the first in vivo evidence that Jag1-Notch signaling is critical for memory formation in the adult brain...
  13. doi request reprint Posttraining ablation of adult-generated neurons degrades previously acquired memories
    Maithe Arruda-Carvalho
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada
    J Neurosci 31:15113-27. 2011
    ..These retrograde effects suggest that adult-generated neurons form a critical and enduring component of hippocampal memory traces...
  14. doi request reprint Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality
    Melanie J Sekeres
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 32:17857-68. 2012
    ..CREB overexpression produced strikingly similar effects. Therefore, increasing CRTC1 or CREB function is sufficient to enhance the strength of new, as well as established reactivated, memories without compromising memory quality...
  15. doi request reprint Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    J Neurosci 31:13469-84. 2011
    ..Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory...
  16. doi request reprint Reprint of: disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice
    Derya Sargin
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8 Department of Psychology, University of Toronto, Toronto, ON, Canada M5G 1X8 Department of Physiology, University of Toronto, Toronto, ON, Canada M5G 1X8 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada M5G 1X8
    Neurobiol Learn Mem 105:20-30. 2013
    ..These results provide the first in vivo evidence that Jag1-Notch signaling is critical for memory formation in the adult brain. ..
  17. pmc Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Learn Mem 15:443-53. 2008
    ..Not only do these findings refine our knowledge of the circuitry underlying fear memory but they also provide novel insights into the neural substrates that govern the degree to which acquired fear of a tone generalizes to other tones...
  18. doi request reprint Ontogeny of contextual fear memory formation, specificity, and persistence in mice
    Katherine G Akers
    Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada, M5G 1X8
    Learn Mem 19:598-604. 2012
    ....
  19. ncbi request reprint Neuronal competition and selection during memory formation
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Science 316:457-60. 2007
    ..Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning...
  20. doi request reprint Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning
    Jason P Lerch
    Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuroimage 54:2086-95. 2011
    ....
  21. ncbi request reprint Dorsal hippocampal CREB is both necessary and sufficient for spatial memory
    Melanie J Sekeres
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Learn Mem 17:280-3. 2010
    ....
  22. doi request reprint Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure
    Anne L Wheeler
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada
    J Neurosci 33:1797-803a. 2013
    ..These results suggest that altered brain structure following 1 month of abstinence may contribute to these persistent drug-related behaviors, and identify cocaine exposure as the cause of these morphological changes...
  23. pmc Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory
    Gisella Vetere
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 108:8456-60. 2011
    ..Together, these data strengthen the causal link between cortical structural remodeling and memory consolidation and, further, identify MEF2 as a key regulator of these processes...
  24. doi request reprint Hippocampal neurogenesis and forgetting
    Paul W Frankland
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada Department of Psychology, University of Toronto, Toronto, Ontario M5S 3GM, Canada Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada Electronic address
    Trends Neurosci 36:497-503. 2013
    ....
  25. doi request reprint Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region
    Yosuke Niibori
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Nat Commun 3:1253. 2012
    ..These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus...
  26. pmc Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease
    Adelaide P Yiu
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuropsychopharmacology 36:2169-86. 2011
    ..These parallel findings not only confirm that TgCRND8 mice accurately model key aspects of human AD, but furthermore, suggest the intriguing possibility that targeting CREB may be a useful therapeutic strategy in treating humans with AD...
  27. ncbi request reprint Patterns across multiple memories are identified over time
    Blake A Richards
    1 Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada 2 Department of Psychology, University of Toronto, Toronto, Ontario, Canada 3 Department of Physiology, University of Toronto, Toronto, Ontario, Canada 4 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada 5 Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada 6 Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Nat Neurosci 17:981-6. 2014
    ..These results indicate that pattern identification occurs over time, which can lead to conflicts between new information and existing knowledge that must be resolved, in part, by computations carried out in the mPFC. ..
  28. doi request reprint Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
    Alireza Mansouri
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurobiol Dis 47:201-9. 2012
    ..We conclude that PNP deficiency cause cerebellar abnormalities, including PC damage and progressive motor deficits. TAT-PNP treatment from birth can prevent the neurological abnormalities in PNP-KO mice...
  29. pmc Development and validation of a sensitive entropy-based measure for the water maze
    Hamid R Maei
    Program in Neurosciences and Mental Health, The Hospital for Sick Children Toronto, ON, Canada
    Front Integr Neurosci 3:33. 2009
    ..Together, these data indicate that H offers greater sensitivity than existing measures, most likely because it exploits the richness of the precise positional information of the mouse throughout the probe test...
  30. doi request reprint Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites
    David I Wasserman
    Department of Psychology, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 38:2774-85. 2013
    ..Conversely, enhancing M5 receptor gene expression on VTA DA neurons increased morphine-induced locomotion via cholinergic inputs. ..
  31. pmc MAPK, CREB and zif268 are all required for the consolidation of recognition memory
    Bruno Bozon
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, CNRS UMR 8620, Universite Paris Sud, 91405 Orsay, France
    Philos Trans R Soc Lond B Biol Sci 358:805-14. 2003
    ....
  32. ncbi request reprint Memory reconsolidation and extinction have distinct temporal and biochemical signatures
    Akinobu Suzuki
    Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
    J Neurosci 24:4787-95. 2004
    ..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms...
  33. ncbi request reprint Consolidation of CS and US representations in associative fear conditioning
    Paul W Frankland
    Departments of Neurobiology, Psychology and Psychiatry, University of California at Los Angeles, Los Angeles, California 90095 1761, USA
    Hippocampus 14:557-69. 2004
    ..Together, these data suggest that this approach is particularly suited for the characterization of molecular and cellular processes underlying the formation of stimulus representations...
  34. ncbi request reprint CREB required for the stability of new and reactivated fear memories
    Satoshi Kida
    Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Nat Neurosci 5:348-55. 2002
    ..The findings presented here delineate the memory processes that require CREB and demonstrate the power of LBD-inducible transgenic systems in the study of complex cognitive processes...
  35. doi request reprint p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease
    Monica K Wetzel
    Cell Biology, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
    Neuron 59:708-21. 2008
    ..Thus, p73 is essential for preventing neurodegeneration, and haploinsufficiency for p73 may be a susceptibility factor for AD and other neurodegenerative disorders...
  36. ncbi request reprint The molecules of forgetfulness
    Alcino J Silva
    Nature 418:929-30. 2002