Chi chung Hui

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling
    Kelvin King Lo Law
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
    PLoS ONE 7:e50193. 2012
  2. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
  3. ncbi request reprint Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
  4. doi request reprint Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
    Zhu Juan Li
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Development 139:4152-61. 2012
  5. pmc Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    Pleasantine Mill
    Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Genes Dev 17:282-94. 2003
  6. doi request reprint Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    Jinny J Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:1825-36. 2011
  7. ncbi request reprint Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
  8. pmc The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 23:8216-25. 2003
  9. pmc Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia
    Erica Nieuwenhuis
    Program in Developmental Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, MARS Building, East Tower, Room 13 314, Toronto, Ontario M5G 1L7, Canada
    Mol Cell Biol 26:6609-22. 2006
  10. ncbi request reprint Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
    Leigh Coultas
    Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, Ontario, Canada
    Blood 116:653-60. 2010

Collaborators

Detail Information

Publications33

  1. pmc Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling
    Kelvin King Lo Law
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
    PLoS ONE 7:e50193. 2012
    ....
  2. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
    ..In this review, we describe the regulation of Gli proteins during development and discuss possible mechanisms for their abnormal activation during tumorigenesis...
  3. ncbi request reprint Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
    ..These findings demonstrate that Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation...
  4. doi request reprint Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
    Zhu Juan Li
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Development 139:4152-61. 2012
    ..These studies establish Sufu and Kif7 as crucial components in the regulation of Gli2 localization and activity, and illustrate their overlapping functions in skin development and tumor suppression...
  5. pmc Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    Pleasantine Mill
    Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Genes Dev 17:282-94. 2003
    ..Together, our results suggest that Shh-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators...
  6. doi request reprint Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    Jinny J Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:1825-36. 2011
    ..Together, our data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner...
  7. ncbi request reprint Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
    ..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
  8. pmc The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 23:8216-25. 2003
    ..Further studies of mutant mice of other Irx genes as well as compound mutant mice will be necessary to uncover the functional roles of these evolutionarily conserved transcriptional regulators in development and disease...
  9. pmc Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia
    Erica Nieuwenhuis
    Program in Developmental Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, MARS Building, East Tower, Room 13 314, Toronto, Ontario M5G 1L7, Canada
    Mol Cell Biol 26:6609-22. 2006
    ..While functional compensation by Ptc1 might account for the lack of a strong mutant phenotype in Ptc2-deficient mice, our results suggest that normal Ptc2 function is required for adult skin homeostasis...
  10. ncbi request reprint Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
    Leigh Coultas
    Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, Ontario, Canada
    Blood 116:653-60. 2010
    ..These findings establish that Hh uses both VEGF- and Notch-dependent and -independent mechanisms to pattern specific events in early blood vascular development...
  11. ncbi request reprint GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    Ming Chang Hu
    Program in Developmental Biology, Hospital for Sick Children, University of Toronto, Canada
    Development 133:569-78. 2006
    ..Together, these results demonstrate that SHH-SMO signaling controls renal morphogenesis via transcriptional control of Gli, renal patterning and cell cycle regulator genes in a manner that is opposed by GLI3...
  12. pmc Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
    Lijun Chi
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e65448. 2013
    ..Together, our data demonstrate that Kif3a controls nephron number via distinct cell lineage-specific mechanisms...
  13. ncbi request reprint Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Development 138:3791-801. 2011
    ..Furthermore, Kif7 also inhibits Gli transcriptional activity in the chondrocytes when Sufu function is absent. Therefore, Kif7 regulates the activity of Gli transcription factors through both Sufu-dependent and -independent mechanisms...
  14. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
    ..Thus, GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret...
  15. pmc Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 287:36222-8. 2012
    ..Pthlh regulates chondrocyte differentiation and Gli activity in a Sufu-dependent manner, with Sufu acting as a molecular switch in its regulation of differentiation...
  16. ncbi request reprint A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers
    Olena Zhulyn
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Dev Cell 29:241-9. 2014
    ....
  17. ncbi request reprint Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, Room 13 314, Toronto Medical Discovery Tower, Ontario, Canada
    Dev Biol 302:345-55. 2007
    ..Taken together, these observations indicate that Gli2 and Gli3 perform rhombomere-specific function during DV patterning of the hindbrain...
  18. ncbi request reprint The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development
    Chi Wa Cheng
    Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Dev Biol 287:48-60. 2005
    ..These results indicate that there are at least two distinct genetic pathways (Irx5-dependent and Vsx1-dependent) regulating the development of Type 2 and Type 3 cone bipolar cells...
  19. ncbi request reprint Mutations in SUFU predispose to medulloblastoma
    Michael D Taylor
    Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
    Nat Genet 31:306-10. 2002
    ..SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism...
  20. ncbi request reprint Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    Paul C Barnfield
    Hospital for Sick Children, Program in Developmental Biology, 101 College Street, TMDT, Rm 13 314, Toronto, ON, Canada M5G 1L7
    Differentiation 73:397-405. 2005
    ..Together, these observations reveal that Su(fu) regulates the activity of Gli1 and Gli2 through distinct cytoplasmic and nuclear mechanisms...
  21. pmc The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient
    Danny L Costantini
    Program in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cell 123:347-58. 2005
    ..Thus, an Irx5 repressor gradient negatively regulates potassium-channel-gene expression in the heart, forming an inverse I(to,f) gradient that ensures coordinated cardiac repolarization while also preventing arrhythmias...
  22. ncbi request reprint Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling
    DanYi Li
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON MS5 1A8, Canada
    Dev Cell 29:233-40. 2014
    ..Our data provide genetic evidence supporting the concept of early specification and progressive determination of anterior limb pattern. ..
  23. ncbi request reprint Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling
    Michael D Taylor
    The Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Oncogene 23:4577-83. 2004
    ..Our results suggest that loss of function of SUFU results in overactivity of both the Sonic Hedgehog, and the WNT signaling pathways, leading to excessive proliferation and failure to differentiate resulting in MB...
  24. pmc Cbl-3-deficient mice exhibit normal epithelial development
    Emily K Griffiths
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Mol Cell Biol 23:7708-18. 2003
    ..Moreover, Cbl-3 was not required for attenuation of epidermal growth factor-stimulated Erk activation in primary keratinocytes. Thus, Cbl-3 is dispensable for normal epithelial development and function...
  25. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..In sum, these results demonstrate that Lfng functions to enhance Notch signaling in myofibroblast precursor cells and thereby to coordinate differentiation and mobilization of myofibroblasts required for alveolar septation...
  26. ncbi request reprint A dermal niche for multipotent adult skin-derived precursor cells
    Karl J L Fernandes
    Department of Cancer Research, Hospital for Sick Children Research Institute, Ontario, Canada
    Nat Cell Biol 6:1082-93. 2004
    ..We propose that SKPs represent an endogenous embryonic precursor cell that arises in peripheral tissues such as skin during development and maintains multipotency into adulthood...
  27. ncbi request reprint Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1
    Erica Nieuwenhuis
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Towers, 101 College Street, Toronto, Ontario, Canada M5G1L7
    Dev Biol 308:547-60. 2007
    ..Increased expression of regulators of epidermal homeostasis, c-Myc and p63, was also observed in Ptc1(mes/mes) adult skin. These results suggest that the CTD of Ptc1 is involved in regulating epidermal homeostasis in mature skin...
  28. doi request reprint Iroquois homeodomain transcription factors in heart development and function
    Kyoung Han Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Circ Res 110:1513-24. 2012
    ..The molecular mechanisms by which Irx proteins regulate gene expression and the clinical relevance of Irx functions in the heart are discussed...
  29. ncbi request reprint Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
    Kazuko Koshiba-Takeuchi
    Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nat Genet 38:175-83. 2006
    ..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
  30. pmc Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality
    Siyi Zhang
    Research Institute, Program in Genetics and Genomic Biology, Room 15 313 TMDT, 101 College Street, East Tower, Toronto, Ontario M5G 1L7, Canada
    Mol Cell Biol 26:6656-63. 2006
    ..Sbds is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation...
  31. ncbi request reprint The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
    Helen Oi Lam Cheung
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Sci Signal 2:ra29. 2009
    ..Thus, Kif7 is a missing component of the mammalian Hh signaling machinery, implying a greater commonality between the Drosophila and mammalian system than the prevailing view suggests...
  32. pmc A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme
    Yoshiro Maezawa
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 7:e40547. 2012
    ..In summary, we report the generation and validation of a new Cre driver strain that provides robust excision in metanephric mesenchyme...
  33. pmc Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...