Chi chung Hui
Affiliation: The Hospital for Sick Children
Yin W, Satkunendran T, Mo R, Morrissy S, Zhang X, Huang E, et al
. Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma. Dev Cell. 2018;: pubmed publisher
..Overall, our work establishes the dual role of SUFU in SHH MB and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis. ..
Adolphe C, Nieuwenhuis E, Villani R, Li Z, Kaur P, Hui C, et al
. Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol. 2014;134:1981-1990 pubmed publisher
..In general, our findings implicate Ptch receptor redundancy as a key issue in elucidating the cellular origin of Hh-induced tumors. ..
Li D, Sakuma R, Vakili N, Mo R, Puviindran V, Deimling S, et al
. Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014;29:233-40 pubmed publisher
..Our data provide genetic evidence supporting the concept of early specification and progressive determination of anterior limb pattern. ..
Hui C, Angers S. Gli proteins in development and disease. Annu Rev Cell Dev Biol. 2011;27:513-37 pubmed publisher
..In this review, we describe the regulation of Gli proteins during development and discuss possible mechanisms for their abnormal activation during tumorigenesis. ..
Zhulyn O, Nieuwenhuis E, Liu Y, Angers S, Hui C. Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015;397:191-202 pubmed publisher