Chi chung Hui

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
  2. pmc Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    Pleasantine Mill
    Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Genes Dev 17:282-94. 2003
  3. doi request reprint Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
    Zhu Juan Li
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Development 139:4152-61. 2012
  4. doi request reprint Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    Jinny J Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:1825-36. 2011
  5. pmc The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 23:8216-25. 2003
  6. ncbi request reprint Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
  7. doi request reprint Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
    Leigh Coultas
    Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, Ontario, Canada
    Blood 116:653-60. 2010
  8. pmc Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 287:36222-8. 2012
  9. pmc Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling
    Kelvin King Lo Law
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
    PLoS ONE 7:e50193. 2012
  10. doi request reprint Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Development 138:3791-801. 2011

Collaborators

Detail Information

Publications22

  1. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
    ..In this review, we describe the regulation of Gli proteins during development and discuss possible mechanisms for their abnormal activation during tumorigenesis...
  2. pmc Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    Pleasantine Mill
    Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Genes Dev 17:282-94. 2003
    ..Together, our results suggest that Shh-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators...
  3. doi request reprint Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
    Zhu Juan Li
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Development 139:4152-61. 2012
    ..These studies establish Sufu and Kif7 as crucial components in the regulation of Gli2 localization and activity, and illustrate their overlapping functions in skin development and tumor suppression...
  4. doi request reprint Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    Jinny J Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:1825-36. 2011
    ..Together, our data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner...
  5. pmc The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 23:8216-25. 2003
    ..Further studies of mutant mice of other Irx genes as well as compound mutant mice will be necessary to uncover the functional roles of these evolutionarily conserved transcriptional regulators in development and disease...
  6. ncbi request reprint Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
    ..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
  7. doi request reprint Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
    Leigh Coultas
    Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, Ontario, Canada
    Blood 116:653-60. 2010
    ..These findings establish that Hh uses both VEGF- and Notch-dependent and -independent mechanisms to pattern specific events in early blood vascular development...
  8. pmc Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 287:36222-8. 2012
    ..Pthlh regulates chondrocyte differentiation and Gli activity in a Sufu-dependent manner, with Sufu acting as a molecular switch in its regulation of differentiation...
  9. pmc Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling
    Kelvin King Lo Law
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
    PLoS ONE 7:e50193. 2012
    ....
  10. doi request reprint Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu
    Shu Hsuan C Hsu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Development 138:3791-801. 2011
    ..Furthermore, Kif7 also inhibits Gli transcriptional activity in the chondrocytes when Sufu function is absent. Therefore, Kif7 regulates the activity of Gli transcription factors through both Sufu-dependent and -independent mechanisms...
  11. ncbi request reprint Mutations in SUFU predispose to medulloblastoma
    Michael D Taylor
    Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
    Nat Genet 31:306-10. 2002
    ..SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism...
  12. ncbi request reprint Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling
    Michael D Taylor
    The Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Oncogene 23:4577-83. 2004
    ..Our results suggest that loss of function of SUFU results in overactivity of both the Sonic Hedgehog, and the WNT signaling pathways, leading to excessive proliferation and failure to differentiate resulting in MB...
  13. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
    ..Thus, GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret...
  14. ncbi request reprint Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
    ..These findings demonstrate that Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation...
  15. doi request reprint Iroquois homeodomain transcription factors in heart development and function
    Kyoung Han Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Circ Res 110:1513-24. 2012
    ..The molecular mechanisms by which Irx proteins regulate gene expression and the clinical relevance of Irx functions in the heart are discussed...
  16. pmc A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme
    Yoshiro Maezawa
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 7:e40547. 2012
    ..In summary, we report the generation and validation of a new Cre driver strain that provides robust excision in metanephric mesenchyme...
  17. ncbi request reprint Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    Paul C Barnfield
    Hospital for Sick Children, Program in Developmental Biology, 101 College Street, TMDT, Rm 13 314, Toronto, ON, Canada M5G 1L7
    Differentiation 73:397-405. 2005
    ..Together, these observations reveal that Su(fu) regulates the activity of Gli1 and Gli2 through distinct cytoplasmic and nuclear mechanisms...
  18. pmc Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
    Lijun Chi
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e65448. 2013
    ..Together, our data demonstrate that Kif3a controls nephron number via distinct cell lineage-specific mechanisms...
  19. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..In sum, these results demonstrate that Lfng functions to enhance Notch signaling in myofibroblast precursor cells and thereby to coordinate differentiation and mobilization of myofibroblasts required for alveolar septation...
  20. pmc Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...
  21. pmc The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient
    Danny L Costantini
    Program in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cell 123:347-58. 2005
    ..Thus, an Irx5 repressor gradient negatively regulates potassium-channel-gene expression in the heart, forming an inverse I(to,f) gradient that ensures coordinated cardiac repolarization while also preventing arrhythmias...
  22. ncbi request reprint Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
    Kazuko Koshiba-Takeuchi
    Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nat Genet 38:175-83. 2006
    ..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...