Johann K Hitzler

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
    Johann K Hitzler
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada
    Blood 101:4301-4. 2003
  2. ncbi request reprint Origins of leukaemia in children with Down syndrome
    Johann K Hitzler
    Department of Pediatrics, Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Rev Cancer 5:11-20. 2005
  3. ncbi request reprint CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation
    Paul C Nathan
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children Research Institute, The University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 42:24-9. 2004
  4. ncbi request reprint Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate
    Brenda J Spiegler
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:3858-64. 2006
  5. ncbi request reprint A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes
    Adam Gassas
    Divisions of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada
    J Pediatr Hematol Oncol 27:192-6. 2005
  6. ncbi request reprint Acute megakaryoblastic leukemia in Down syndrome
    Johann K Hitzler
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ont, Canada M5G 1X8
    Pediatr Blood Cancer 49:1066-9. 2007
  7. ncbi request reprint GATA1--a player in normal and leukemic megakaryopoiesis
    Johann K Hitzler
    Division of Hematology Oncology and Program for Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada
    Pediatr Res 52:831. 2002
  8. ncbi request reprint Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo
    Akira Inoue
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 2:279-88. 2002
  9. pmc Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes
    Bo Cen
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Mol Cell Biol 23:6597-608. 2003
  10. ncbi request reprint Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc(-/-) mouse model, while long-term treatment is ineffective
    Madeleine Carreau
    Unité de Génétique Humaine et Moléculaire, CHUQ Hôpital St François d Assise, Laval University, Quebec, QC, Canada
    Blood 100:1499-501. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
    Johann K Hitzler
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada
    Blood 101:4301-4. 2003
    ..These findings suggest a model of malignant transformation in Down syndrome AMKL in which GATA1 mutations are an early event and AMKL arises from latent TL clones following initial apparent remission...
  2. ncbi request reprint Origins of leukaemia in children with Down syndrome
    Johann K Hitzler
    Department of Pediatrics, Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Rev Cancer 5:11-20. 2005
    ..Leukaemia that specifically arises in the context of constitutional trisomy 21 and somatic GATA1 mutations is a unique biological model of the incremental process of leukaemic transformation...
  3. ncbi request reprint CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation
    Paul C Nathan
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children Research Institute, The University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 42:24-9. 2004
    ..We conducted a retrospective cohort study to determine the effect on survival of substituting HD-MTX for CRT in young children with T-ALL, a group that faces a high risk of long-term sequelae from CRT...
  4. ncbi request reprint Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate
    Brenda J Spiegler
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:3858-64. 2006
    ..The impact of chemotherapy-only protocols on neurocognitive outcomes is unclear, and the importance of systemic MTX dose has not been established...
  5. ncbi request reprint A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes
    Adam Gassas
    Divisions of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada
    J Pediatr Hematol Oncol 27:192-6. 2005
    ..The authors found that all the cases could be easily classified. MPS in children is different from adult-type MPS in terms of biology, categories, classification, and prognosis...
  6. ncbi request reprint Acute megakaryoblastic leukemia in Down syndrome
    Johann K Hitzler
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ont, Canada M5G 1X8
    Pediatr Blood Cancer 49:1066-9. 2007
    ..The distinct phenotypes of megakaryoblastic leukemia in DS are a unique biological model of the incremental process of leukemic transformation...
  7. ncbi request reprint GATA1--a player in normal and leukemic megakaryopoiesis
    Johann K Hitzler
    Division of Hematology Oncology and Program for Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada
    Pediatr Res 52:831. 2002
  8. ncbi request reprint Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo
    Akira Inoue
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 2:279-88. 2002
    ..These results implicate Slug in a novel survival pathway that protects hematopoietic progenitors from apoptosis after DNA damage...
  9. pmc Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes
    Bo Cen
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Mol Cell Biol 23:6597-608. 2003
    ....
  10. ncbi request reprint Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc(-/-) mouse model, while long-term treatment is ineffective
    Madeleine Carreau
    Unité de Génétique Humaine et Moléculaire, CHUQ Hôpital St François d Assise, Laval University, Quebec, QC, Canada
    Blood 100:1499-501. 2002
    ..These results suggest that cytokine treatment may be beneficial only in the short-term, while long-term treatment is not protective for BM aplasia...