Affiliation: The Hospital for Sick Children
- Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5CDaria Grafodatskaya
Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
BMC Med Genomics 6:1. 2013..Identification of epigenetic alterations occurring in these disorders could shed light on molecular pathways relevant to neurodevelopment...
- Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and designSylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
BMC Public Health 10:590. 2010..The objective of this report is to present the methodology and design of this study...
- Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trialJill Hamilton
Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
Diabetes Care 26:138-43. 2003....
- Early onset of severe diabetes mellitus-related microvascular complicationsJill Hamilton
Departments of Pediatrics and Medicine, the Hospital for Sick Children and University Health Network, University of Toronto, Toronto, Ontario, Canada
J Pediatr 144:281-3. 2004..We speculate on potential mechanisms that may have contributed to the rapid development of diabetes mellitus-related complications...
- Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of ageJill K Hamilton
Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
Obesity (Silver Spring) 18:340-6. 2010..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
- Science and art: in harmonyJill Hamilton
Division of Endocrinology, The Hospital for Sick Children, Toronto, Canada, and Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
Pediatr Diabetes 7:336-40. 2006
- Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngiomaJudith Simoneau-Roy
Division of Endocrinology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
Clin Endocrinol (Oxf) 72:364-70. 2010..It has been suggested that abnormalities of insulin secretion and/or insulin action due to hypothalamic injury may be associated with weight gain and the metabolic syndrome in this population...
- Type 2 diabetes in children and adolescentsShazhan Amed
The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
Expert Rev Cardiovasc Ther 8:393-406. 2010..Here, we highlight the epidemiology, pathophysiology, risk factors, clinical presentation and diagnosis, treatment and public health impact of T2D in children and adolescents...
- Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controlsClodagh S O'Gorman
Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
J Clin Endocrinol Metab 95:2211-8. 2010..Retrospective studies suggest that adolescents with craniopharyngioma and hypothalamic obesity have increased sleep-disordered breathing (SDB)...
- Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesityMichal Cohen
Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada
Eur J Endocrinol 168:845-52. 2013..We aimed to study autonomic activity using heart rate variability (HRV) and biochemical measures in youth with CRHO compared with controls and to explore relationships between obesity and autonomic indices...
- Potential adjunctive therapies in adolescents with type 1 diabetes mellitusCraig A Jefferies
Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
Treat Endocrinol 3:337-43. 2004....
- Deteriorating diabetes control during adolescence: physiological or psychosocial?Jill Hamilton
Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada
J Pediatr Endocrinol Metab 15:115-26. 2002..In this review, we examine the impact of physiological and psychosocial changes during puberty in type 1 DM, highlight treatment strategies aimed at modifying these factors, and suggest further interventions that warrant evaluation...
- Skeletal muscle abnormalities in girls and adolescents with Turner syndromeGreg D Wells
Faculty of Kinesiology and Physical Education, McMaster University, Hamilton, Ontario L8S 4L8, Canada
J Clin Endocrinol Metab 98:2521-7. 2013..Individuals with TS report lower levels of physical activity than healthy control (HC) subjects. Cardiorespiratory limitations may contribute to the observed reduction in physical activity...
- Nutrition education program design for youth with type 2 diabetes mellitusJennifer Buccino
Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada
Can J Diet Pract Res 69:192-7. 2008..Together with program development strategies, a summary of relevant content and mode of delivery is presented for a nutrition education program intended specifically for youth with T2DM at The Hospital for Sick Children...
- Variation in growth hormone immunoassays in clinical practice in CanadaShazhan Amed
Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Ont, Canada
Horm Res 69:290-4. 2008..The objective of this study was to determine the variability of GH assays used at Canadian pediatric hospitals...
- Outcome after bariatric surgery in two adolescents with hypothalamic obesity following treatment of craniopharyngiomaDiane Rottembourg
Department of Pediatrics, Divisions of Endocrinology, CHU Sainte Justine, Universite de Montreal, Montreal, PQ, Canada
J Pediatr Endocrinol Metab 22:867-72. 2009....
- Final height in children with idiopathic growth hormone deficiency treated with a fixed dose of recombinant growth hormoneMarianna Rachmiel
Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Horm Res 68:236-43. 2007..51; p < 0.005). Treatment of children with idiopathic GHD with a fixed dose of 0.18 mg/kg/week rhGH is sufficient to reach FAH within 2 SDS of the normal population range (84%) with an average FAH within -0.5 SDS of midparental height...
- Weight gain in craniopharyngioma--a model for hypothalamic obesityAlexandra Ahmet
Divisions of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Endocrinol Metab 19:121-7. 2006..To evaluate (1) the pattern of post-operative weight gain and (2) the risk factors associated with the development of post-operative weight gain and obesity in children treated for craniopharyngioma...
- Thyroid cancer in childhood: a retrospective review of childhood courseClodagh S O'Gorman
The Hospital for Sick Children, Toronto, Canada
Thyroid 20:375-80. 2010..The objectives of this study were to describe the demographics and outcomes in children with TC treated at The Hospital for Sick Children, Toronto, from 1983 to 2006. We hypothesized that childhood TC was increasing at our institution...
- Impaired endothelial function in pediatric patients with turner syndrome and healthy controls: a case-control studyClodagh S O'Gorman
Divisions of Endocrinology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
Int J Pediatr Endocrinol 2012:5. 2012..abstract:..
- Longitudinal evaluation of sleep-disordered breathing in children with Prader-Willi Syndrome during 2 years of growth hormone therapySuhail Al-Saleh
University of Toronto, Toronto, Ontario, Canada
J Pediatr 162:263-8.e1. 2013..To review longitudinal polysomnography data to assess sleep-related disordered breathing (SRDB) before and up to 2 years after initiation of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS)...
- Clinical management of the physically active patient with type 1 diabetesLisa Chu
School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Diabetes Unit, York University, Toronto, Ontario, Canada
Phys Sportsmed 39:64-77. 2011..This article highlights challenges and key strategies for diabetes management in the active individual with type 1 diabetes, including the application of the most recent diabetes technologies...
- Quality of life and anxiety in adolescents with differentiated thyroid cancerAsaf Oren
Division of Endocrinology The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
J Clin Endocrinol Metab 97:E1933-7. 2012..Although adult DTC survivors have similar or slightly worse quality of life (QOL), this has not been evaluated in the pediatric population...
- Dopaminergic resistant prolactinomas in the peripubertal populationCarol Huang
Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children and University of Toronto, Ontario, Canada
J Pediatr Endocrinol Metab 19:951-3. 2006..Both required surgical debulking, and one has received growth hormone treatment with no increase in tumor size...
- Growth hormone deficiency in Costello syndromeRobert I Stein
Department of Paediatrics, Division of Endocrinology, Children s Hospital of Western Ontario, University of Western Ontario, London, Canada
Am J Med Genet A 129:166-70. 2004..We review the pathophysiology of Costello syndrome and highlight the recent recommendations of tumor screening and cardiac surveillance in this population, of particular relevance to those receiving GH therapy...
- Finasteride for the treatment of hidradenitis suppurativa in children and adolescentsHarkamal Kaur Randhawa
Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
JAMA Dermatol 149:732-5. 2013..Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients...
- Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experienceMichal Cohen
Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto Toronto, ON, Canada
Front Endocrinol (Lausanne) 2:81. 2011....
- Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011Michal Cohen
Division of Endocrinology, The Hospital for Sick Children, 555 University Ave Toronto, Ontario, Canada M5G1X8
Neuro Oncol 15:767-74. 2013..We aimed to review the long-term outcomes of children treated for craniopharyngioma in our institution over the past decade and describe trends in treatment and outcomes over the past 3 decades...
- Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and designBeverly Walpole
Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
BMC Public Health 11:459. 2011....
- Recurrent anaphylaxis associated with gonadotropin-releasing hormone analogs: case report and review of the literatureCatherine Lam
Department of General Paediatrics, University of Toronto, Toronto, Ontario, Canada
Pharmacotherapy 26:1811-5. 2006..Clinicians should be aware of the potential association of GnRH analogs with systemic reactions. They should also recognize that recurrent anaphylaxis may occur due to the long half-life of these therapeutic agents in tissue...
- Skeletal muscle metabolic dysfunction in obesity and metabolic syndromeGreg D Wells
Department of Anesthesia, The Hospital for Sick Children, Toronto General Hospital, University of Toronto, Toronto, Canada
Can J Neurol Sci 35:31-40. 2008..A physiological model of the effect of intramyocellular lipid accumulation on oxidative metabolism and insulin mediated glucose uptake is proposed...
- The efficacy of trimethoprim in wound healing of patients with epidermolysis bullosa: a feasibility trialIrene Lara-Corrales
Hospital for Sick Children, Toronto, Ontario, Canada
J Am Acad Dermatol 66:264-70. 2012..There are no systemic therapies known to facilitate wound healing in patients with recessive dystrophic epidermolysis bullosa (RDEB)...