Jill Hamilton

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experience
    Michal Cohen
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto Toronto, ON, Canada
    Front Endocrinol (Lausanne) 2:81. 2011
  2. pmc Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy
    Jill K Hamilton
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8
    Int J Pediatr Endocrinol 2011:417949. 2011
  3. pmc Impact of maternal physical activity and infant feeding practices on infant weight gain and adiposity
    Lisa Chu
    The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Int J Endocrinol 2012:293821. 2012
  4. pmc Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
    Daria Grafodatskaya
    Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
    BMC Med Genomics 6:1. 2013
  5. pmc Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    BMC Public Health 10:590. 2010
  6. doi request reprint Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
    Jill K Hamilton
    Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:340-6. 2010
  7. ncbi request reprint Science and art: in harmony
    Jill Hamilton
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Canada, and Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
    Pediatr Diabetes 7:336-40. 2006
  8. ncbi request reprint Early onset of severe diabetes mellitus-related microvascular complications
    Jill Hamilton
    Departments of Pediatrics and Medicine, the Hospital for Sick Children and University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 144:281-3. 2004
  9. ncbi request reprint Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial
    Jill Hamilton
    Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
    Diabetes Care 26:138-43. 2003
  10. doi request reprint Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma
    Judith Simoneau-Roy
    Division of Endocrinology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 72:364-70. 2010

Collaborators

Detail Information

Publications39

  1. pmc Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experience
    Michal Cohen
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto Toronto, ON, Canada
    Front Endocrinol (Lausanne) 2:81. 2011
    ....
  2. pmc Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy
    Jill K Hamilton
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8
    Int J Pediatr Endocrinol 2011:417949. 2011
    ..96, P = .009). Conclusion. Combined diazoxide-metformin therapy was associated with reduced weight gain in patients with hypothalamic obesity. AUC(ins) at study commencement predicted effectiveness of the treatment...
  3. pmc Impact of maternal physical activity and infant feeding practices on infant weight gain and adiposity
    Lisa Chu
    The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Int J Endocrinol 2012:293821. 2012
    ..4 g (t = 3.97, P < 0.001) and weight-for-length z-score by 0.08 (t = 2.59, P = 0.01). Maternal pregravid physical activity and exclusive breastfeeding duration are associated with weight gain and adiposity as early as 1 year of age...
  4. pmc Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
    Daria Grafodatskaya
    Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
    BMC Med Genomics 6:1. 2013
    ..Identification of epigenetic alterations occurring in these disorders could shed light on molecular pathways relevant to neurodevelopment...
  5. pmc Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    BMC Public Health 10:590. 2010
    ..The objective of this report is to present the methodology and design of this study...
  6. doi request reprint Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
    Jill K Hamilton
    Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:340-6. 2010
    ..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
  7. ncbi request reprint Science and art: in harmony
    Jill Hamilton
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Canada, and Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
    Pediatr Diabetes 7:336-40. 2006
  8. ncbi request reprint Early onset of severe diabetes mellitus-related microvascular complications
    Jill Hamilton
    Departments of Pediatrics and Medicine, the Hospital for Sick Children and University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 144:281-3. 2004
    ..We speculate on potential mechanisms that may have contributed to the rapid development of diabetes mellitus-related complications...
  9. ncbi request reprint Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial
    Jill Hamilton
    Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
    Diabetes Care 26:138-43. 2003
    ....
  10. doi request reprint Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma
    Judith Simoneau-Roy
    Division of Endocrinology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 72:364-70. 2010
    ..It has been suggested that abnormalities of insulin secretion and/or insulin action due to hypothalamic injury may be associated with weight gain and the metabolic syndrome in this population...
  11. doi request reprint Type 2 diabetes in children and adolescents
    Shazhan Amed
    The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Expert Rev Cardiovasc Ther 8:393-406. 2010
    ..Here, we highlight the epidemiology, pathophysiology, risk factors, clinical presentation and diagnosis, treatment and public health impact of T2D in children and adolescents...
  12. doi request reprint Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls
    Clodagh S O'Gorman
    Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 95:2211-8. 2010
    ..Retrospective studies suggest that adolescents with craniopharyngioma and hypothalamic obesity have increased sleep-disordered breathing (SDB)...
  13. ncbi request reprint Weight gain in craniopharyngioma--a model for hypothalamic obesity
    Alexandra Ahmet
    Divisions of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Endocrinol Metab 19:121-7. 2006
    ..To evaluate (1) the pattern of post-operative weight gain and (2) the risk factors associated with the development of post-operative weight gain and obesity in children treated for craniopharyngioma...
  14. pmc Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011
    Michal Cohen
    Division of Endocrinology, The Hospital for Sick Children, 555 University Ave Toronto, Ontario, Canada M5G1X8
    Neuro Oncol 15:767-74. 2013
    ..We aimed to review the long-term outcomes of children treated for craniopharyngioma in our institution over the past decade and describe trends in treatment and outcomes over the past 3 decades...
  15. doi request reprint Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity
    Michal Cohen
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Eur J Endocrinol 168:845-52. 2013
    ..We aimed to study autonomic activity using heart rate variability (HRV) and biochemical measures in youth with CRHO compared with controls and to explore relationships between obesity and autonomic indices...
  16. ncbi request reprint Potential adjunctive therapies in adolescents with type 1 diabetes mellitus
    Craig A Jefferies
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Treat Endocrinol 3:337-43. 2004
    ....
  17. ncbi request reprint Deteriorating diabetes control during adolescence: physiological or psychosocial?
    Jill Hamilton
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada
    J Pediatr Endocrinol Metab 15:115-26. 2002
    ..In this review, we examine the impact of physiological and psychosocial changes during puberty in type 1 DM, highlight treatment strategies aimed at modifying these factors, and suggest further interventions that warrant evaluation...
  18. ncbi request reprint Ectopic fat in youth: The contribution of hepatic and pancreatic fat to metabolic disturbances
    Michal Cohen
    Division of Endocrinology, The Hospital for Sick Children, and the University of Toronto, ON, Canada
    Obesity (Silver Spring) 22:1280-6. 2014
    ..To study the relationships between parameters of glucose and insulin metabolism and visceral and abdominal ectopic fat in youth...
  19. doi request reprint Clinical management of the physically active patient with type 1 diabetes
    Lisa Chu
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Phys Sportsmed 39:64-77. 2011
    ..This article highlights challenges and key strategies for diabetes management in the active individual with type 1 diabetes, including the application of the most recent diabetes technologies...
  20. pmc Impaired endothelial function in pediatric patients with turner syndrome and healthy controls: a case-control study
    Clodagh S O'Gorman
    Divisions of Endocrinology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
    Int J Pediatr Endocrinol 2012:5. 2012
    ..abstract:..
  21. doi request reprint Skeletal muscle abnormalities in girls and adolescents with Turner syndrome
    Greg D Wells
    Faculty of Kinesiology and Physical Education, McMaster University, Hamilton, Ontario L8S 4L8, Canada
    J Clin Endocrinol Metab 98:2521-7. 2013
    ..Individuals with TS report lower levels of physical activity than healthy control (HC) subjects. Cardiorespiratory limitations may contribute to the observed reduction in physical activity...
  22. ncbi request reprint Nutrition education program design for youth with type 2 diabetes mellitus
    Jennifer Buccino
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Diet Pract Res 69:192-7. 2008
    ..Together with program development strategies, a summary of relevant content and mode of delivery is presented for a nutrition education program intended specifically for youth with T2DM at The Hospital for Sick Children...
  23. ncbi request reprint Outcome after bariatric surgery in two adolescents with hypothalamic obesity following treatment of craniopharyngioma
    Diane Rottembourg
    Department of Pediatrics, Divisions of Endocrinology, CHU Sainte Justine, Universite de Montreal, Montreal, PQ, Canada
    J Pediatr Endocrinol Metab 22:867-72. 2009
    ....
  24. ncbi request reprint Final height in children with idiopathic growth hormone deficiency treated with a fixed dose of recombinant growth hormone
    Marianna Rachmiel
    Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Horm Res 68:236-43. 2007
    ..51; p < 0.005). Treatment of children with idiopathic GHD with a fixed dose of 0.18 mg/kg/week rhGH is sufficient to reach FAH within 2 SDS of the normal population range (84%) with an average FAH within -0.5 SDS of midparental height...
  25. doi request reprint Variation in growth hormone immunoassays in clinical practice in Canada
    Shazhan Amed
    Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Ont, Canada
    Horm Res 69:290-4. 2008
    ..The objective of this study was to determine the variability of GH assays used at Canadian pediatric hospitals...
  26. doi request reprint Thyroid cancer in childhood: a retrospective review of childhood course
    Clodagh S O'Gorman
    The Hospital for Sick Children, Toronto, Canada
    Thyroid 20:375-80. 2010
    ..The objectives of this study were to describe the demographics and outcomes in children with TC treated at The Hospital for Sick Children, Toronto, from 1983 to 2006. We hypothesized that childhood TC was increasing at our institution...
  27. ncbi request reprint Childhood obesity prevention: opportunities in healthcare
    Catherine S Birken
    Catherine S Birken, MD, FRCPC, MSc, is a member of the Division of Paediatric Medicine, Department of Pediatrics, University of Toronto, The Hospital for Sick Children She can be contacted at 1 416 813 6933 or by e mail at
    Healthc Q 15:48-53. 2012
    ..This article reviews approaches to obesity prevention in children, with a focus on the healthcare setting, incorporating both primary and secondary preventions. ..
  28. pmc Clinically important age-related differences in sleep related disordered breathing in infants and children with prader-willi syndrome
    Michal Cohen
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada The University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e101012. 2014
    ..However data on the patterns of SDB and their management, particularly in infants in this population, is lacking...
  29. doi request reprint Longitudinal evaluation of sleep-disordered breathing in children with Prader-Willi Syndrome during 2 years of growth hormone therapy
    Suhail Al-Saleh
    University of Toronto, Toronto, Ontario, Canada
    J Pediatr 162:263-8.e1. 2013
    ..To review longitudinal polysomnography data to assess sleep-related disordered breathing (SRDB) before and up to 2 years after initiation of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS)...
  30. doi request reprint Quality of life and anxiety in adolescents with differentiated thyroid cancer
    Asaf Oren
    Division of Endocrinology The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
    J Clin Endocrinol Metab 97:E1933-7. 2012
    ..Although adult DTC survivors have similar or slightly worse quality of life (QOL), this has not been evaluated in the pediatric population...
  31. ncbi request reprint Dopaminergic resistant prolactinomas in the peripubertal population
    Carol Huang
    Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children and University of Toronto, Ontario, Canada
    J Pediatr Endocrinol Metab 19:951-3. 2006
    ..Both required surgical debulking, and one has received growth hormone treatment with no increase in tumor size...
  32. ncbi request reprint Growth hormone deficiency in Costello syndrome
    Robert I Stein
    Department of Paediatrics, Division of Endocrinology, Children s Hospital of Western Ontario, University of Western Ontario, London, Canada
    Am J Med Genet A 129:166-70. 2004
    ..We review the pathophysiology of Costello syndrome and highlight the recent recommendations of tumor screening and cardiac surveillance in this population, of particular relevance to those receiving GH therapy...
  33. pmc The CANadian Pediatric Weight Management Registry (CANPWR): Study protocol
    Katherine M Morrison
    Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, ON, Canada
    BMC Pediatr 14:161. 2014
    ..Characterize the individual-, family-, and program-level determinants of change in anthropometric and obesity-related co-morbidities;3. Examine the individual-, family-, and program-level determinants of program attrition...
  34. doi request reprint Use of local data to enhance uptake of published recommendations: an example from the diagnostic evaluation of precocious puberty
    Jennifer Harrington
    Division of Endocrinology, The Departments of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Arch Dis Child 99:15-20. 2014
    ..However, in clinical practice, gonadotropin-releasing hormone (GnRH) stimulation tests are frequently still used...
  35. doi request reprint Finasteride for the treatment of hidradenitis suppurativa in children and adolescents
    Harkamal Kaur Randhawa
    Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    JAMA Dermatol 149:732-5. 2013
    ..Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients...
  36. pmc Motivational interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: methodology and design
    Beverly Walpole
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    BMC Public Health 11:459. 2011
    ....
  37. ncbi request reprint Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome
    Greg D Wells
    Department of Anesthesia, The Hospital for Sick Children, Toronto General Hospital, University of Toronto, Toronto, Canada
    Can J Neurol Sci 35:31-40. 2008
    ..A physiological model of the effect of intramyocellular lipid accumulation on oxidative metabolism and insulin mediated glucose uptake is proposed...
  38. ncbi request reprint Recurrent anaphylaxis associated with gonadotropin-releasing hormone analogs: case report and review of the literature
    Catherine Lam
    Department of General Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Pharmacotherapy 26:1811-5. 2006
    ..Clinicians should be aware of the potential association of GnRH analogs with systemic reactions. They should also recognize that recurrent anaphylaxis may occur due to the long half-life of these therapeutic agents in tissue...
  39. doi request reprint The efficacy of trimethoprim in wound healing of patients with epidermolysis bullosa: a feasibility trial
    Irene Lara-Corrales
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Acad Dermatol 66:264-70. 2012
    ..There are no systemic therapies known to facilitate wound healing in patients with recessive dystrophic epidermolysis bullosa (RDEB)...