Anne M Griffiths

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Struggles, strengths, and strategies: an ethnographic study exploring the experiences of adolescents living with an ostomy
    David B Nicholas
    Faculty of Social Work, Central and Northern Region, University of Calgary, Edmonton, Alberta, Canada
    Health Qual Life Outcomes 6:114. 2008
  2. ncbi request reprint Specificities of inflammatory bowel disease in childhood
    Anne M Griffiths
    IBD Program, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont M5G 1X8, Canada
    Best Pract Res Clin Gastroenterol 18:509-23. 2004
  3. doi request reprint Mechanisms of growth impairment in pediatric Crohn's disease
    Thomas D Walters
    Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Gastroenterol Hepatol 6:513-23. 2009
  4. ncbi request reprint Enteral feeding in inflammatory bowel disease
    Anne M Griffiths
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 9:314-8. 2006
  5. doi request reprint Growth retardation in early-onset inflammatory bowel disease: should we monitor and treat these patients differently?
    Anne M Griffiths
    Division of Gastroenterology Nutrition, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Dig Dis 27:404-11. 2009
  6. ncbi request reprint Esophageal, Gastric, and Duodenal Manifestations of IBD and the Role of Upper Endoscopy in IBD Diagnosis
    Dan Turner
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada
    Curr Gastroenterol Rep 11:234-7. 2009
  7. ncbi request reprint Enteral nutrition in the management of Crohn's disease
    Anne M Griffiths
    Inflammatory Bowel Disease Program, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    JPEN J Parenter Enteral Nutr 29:S108-12; discussion S112-7, S184-8. 2005
  8. ncbi request reprint A review of activity indices and end points for clinical trials in children with Crohn's disease
    Anne M Griffiths
    Hospital for Sick Children, Toronto, Ontario, Canada
    Inflamm Bowel Dis 11:185-96. 2005
  9. doi request reprint Replication of genetic variation in the MYO9B gene in Crohn's disease
    Victorien M Wolters
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Hum Immunol 72:592-7. 2011
  10. doi request reprint Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype
    Cynthia H Seow
    Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1426-34. 2009

Detail Information

Publications51

  1. pmc Struggles, strengths, and strategies: an ethnographic study exploring the experiences of adolescents living with an ostomy
    David B Nicholas
    Faculty of Social Work, Central and Northern Region, University of Calgary, Edmonton, Alberta, Canada
    Health Qual Life Outcomes 6:114. 2008
    ..This study aimed to explore adolescents' experiences and quality of life following ostomy surgery...
  2. ncbi request reprint Specificities of inflammatory bowel disease in childhood
    Anne M Griffiths
    IBD Program, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont M5G 1X8, Canada
    Best Pract Res Clin Gastroenterol 18:509-23. 2004
    ..Key contributing factors have been defined; better immunomodulatory therapy and emerging biologic agents will potentially reduce its prevalence...
  3. doi request reprint Mechanisms of growth impairment in pediatric Crohn's disease
    Thomas D Walters
    Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Gastroenterol Hepatol 6:513-23. 2009
    ..As our understanding of the mechanisms that underlie growth impairment advance, so too should the opportunity for developing further novel and targeted therapies...
  4. ncbi request reprint Enteral feeding in inflammatory bowel disease
    Anne M Griffiths
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 9:314-8. 2006
    ....
  5. doi request reprint Growth retardation in early-onset inflammatory bowel disease: should we monitor and treat these patients differently?
    Anne M Griffiths
    Division of Gastroenterology Nutrition, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Dig Dis 27:404-11. 2009
    ..For all therapies, there is a window of opportunity to achieve normal growth before puberty is too advanced...
  6. ncbi request reprint Esophageal, Gastric, and Duodenal Manifestations of IBD and the Role of Upper Endoscopy in IBD Diagnosis
    Dan Turner
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada
    Curr Gastroenterol Rep 11:234-7. 2009
    ..Infliximab therapy for upper GI-CD seems as effective as that seen for more distal GI inflammation...
  7. ncbi request reprint Enteral nutrition in the management of Crohn's disease
    Anne M Griffiths
    Inflammatory Bowel Disease Program, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    JPEN J Parenter Enteral Nutr 29:S108-12; discussion S112-7, S184-8. 2005
    ..Factors influencing efficacy, including duration, location of intestinal inflammation, and formula composition require consideration...
  8. ncbi request reprint A review of activity indices and end points for clinical trials in children with Crohn's disease
    Anne M Griffiths
    Hospital for Sick Children, Toronto, Ontario, Canada
    Inflamm Bowel Dis 11:185-96. 2005
    ....
  9. doi request reprint Replication of genetic variation in the MYO9B gene in Crohn's disease
    Victorien M Wolters
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Hum Immunol 72:592-7. 2011
    ..Because the direction of association of MYO9B in this Canadian study was not consistent with European studies, further studies are needed to elucidate the role of MYO9B in IBD...
  10. doi request reprint Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype
    Cynthia H Seow
    Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1426-34. 2009
    ....
  11. pmc Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis
    Matti Waterman
    Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, ON, Canada
    Inflamm Bowel Dis 17:1936-42. 2011
    ..We evaluated the overlap between CD and UC genetic loci stratified by pathogenetic pathways and by disease location...
  12. pmc NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Gut 61:1028-35. 2012
    ..The aim of this study is to determine if polymorphisms in NOX2 NADPH oxidase complex genes that do not cause CGD are associated with the development of inflammatory bowel disease (IBD)...
  13. doi request reprint Mathematical weighting of a clinimetric index (Pediatric Ulcerative Colitis Activity Index) was superior to the judgmental approach
    Dan Turner
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Clin Epidemiol 62:738-44. 2009
    ..We aimed to compare the judgmental and mathematical approaches in weighting the Pediatric Ulcerative Colitis Activity Index (PUCAI)...
  14. doi request reprint Serum antibodies associated with complex inflammatory bowel disease
    Abdul A Elkadri
    The Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Inflamm Bowel Dis 19:1499-505. 2013
    ....
  15. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...
  16. doi request reprint Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics
    Eric I Benchimol
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital of Sick Children, Toronto, Canada
    Am J Gastroenterol 103:1524-31. 2008
    ..This study assessed the clinical and radiologic characteristics of TMC in children with IBD...
  17. doi request reprint Infliximab-induced psoriasis and psoriasiform skin lesions in pediatric Crohn disease and a potential association with IL-23 receptor polymorphisms
    Mary E Sherlock
    Division of Gastroenterology, and Nutrition, McMaster Children s Hospital, Hamilton, Ontario, Canada
    J Pediatr Gastroenterol Nutr 56:512-8. 2013
    ..Paradoxically, there have been numerous reports of new-onset psoriasis following tumor necrosis factor-α antagonist therapy in adult patients with inflammatory bowel disease, but pediatric data are sparse...
  18. ncbi request reprint Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study
    Dan Turner
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Gastroenterology 133:423-32. 2007
    ..Colonoscopic appearance, the primary measure of disease activity in adult ulcerative colitis, is less acceptable to children. Our aim was to develop a noninvasive activity index of pediatric ulcerative colitis...
  19. pmc Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 141:633-41. 2011
    ..Chronic inflammatory bowel diseases are associated with dysregulation of immune defenses. We studied the role of RAC1 in inflammatory bowel diseases using human genetic and functional studies and animal models of colitis...
  20. ncbi request reprint Functional variants of OCTN cation transporter genes are associated with Crohn disease
    Vanya D Peltekova
    Department of Medicine, University of Toronto, and Department of Immunology, Mount Sinai Hospital Samuel Lunenfeld Research Institute, Ontario, Canada
    Nat Genet 36:471-5. 2004
    ..These results suggest that SLC22A4, SLC22A5 and CARD15 act in a common pathogenic pathway to cause Crohn disease...
  21. doi request reprint Changes to surgical and hospitalization rates of pediatric inflammatory bowel disease in Ontario, Canada (1994-2007)
    Eric I Benchimol
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Inflamm Bowel Dis 17:2153-61. 2011
    ..We aimed to describe trends in medication use, associated health services, and outcomes (hospitalization and surgical rates) between 1994-2007 in children with IBD...
  22. doi request reprint Outcomes of pediatric inflammatory bowel disease: socioeconomic status disparity in a universal-access healthcare system
    Eric I Benchimol
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Pediatr 158:960-967.e1-4. 2011
    ..To examine healthcare utilization according to family income in children with inflammatory bowel disease (IBD)...
  23. ncbi request reprint Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease
    Dan Turner
    Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Am J Gastroenterol 102:2804-12; quiz 2803, 2813. 2007
    ..We report outcomes with methotrexate treatment in pediatric patients previously refractory to or intolerant of thiopurines...
  24. doi request reprint Development and use of reporting guidelines for assessing the quality of validation studies of health administrative data
    Eric I Benchimol
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Clin Epidemiol 64:821-9. 2011
    ..We created reporting guidelines for studies validating administrative data identification algorithms and used them to assess the quality of reporting of validation studies in the literature...
  25. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
    ..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
  26. ncbi request reprint Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression
    Dan Turner
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Canada
    Clin Gastroenterol Hepatol 5:103-10. 2007
    ..We aimed to systematically review studies that reported the short-term colectomy rate in severe UC or reported variables that could predict treatment failure...
  27. ncbi request reprint Esophageal, gastric, and duodenal manifestations of IBD and the role of upper endoscopy in IBD diagnosis
    Dan Turner
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada
    Curr Gastroenterol Rep 9:475-8. 2007
    ..Infliximab therapy for upper GI-CD seems as effective as that seen for more distal GI inflammation...
  28. doi request reprint Budesonide for Crohn's disease
    Cynthia H Seow
    Mount Sinai Hospital, C O Room 445, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Expert Opin Drug Metab Toxicol 5:971-9. 2009
    ..However, budesonide is not effective in maintaining remission in patients with Crohn's disease...
  29. doi request reprint Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn's disease: results of the REACH study
    Meena Thayu
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19014, USA
    Clin Gastroenterol Hepatol 6:1378-84. 2008
    ....
  30. doi request reprint Increased Effectiveness of Early Therapy With Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease
    Thomas D Walters
    Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 146:383-91. 2014
    ..We compared the effectiveness of early (≤3 mo after diagnosis) treatment with an anti-tumor necrosis factor (TNF)α with that of an immunomodulator in attaining clinical remission and facilitating growth of pediatric patients...
  31. doi request reprint Medical therapy for pediatric inflammatory bowel disease
    Mary E Sherlock
    Division of Gastroenterology, McMaster Children s Hospital, Hamilton, Canada
    Curr Gastroenterol Rep 14:166-73. 2012
    ..Optimal patient selection and timing of anti-TNF therapy requires clinical judgment. Attention must be paid to sustaining responsiveness safely...
  32. ncbi request reprint Use of 6-mercapturine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: con
    Anne M Griffiths
    University of Toronto, Toronto, Canada
    Inflamm Bowel Dis 11:200-2. 2005
  33. ncbi request reprint Linear growth improves during infliximab therapy in children with chronically active severe Crohn's disease
    Thomas D Walters
    Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Inflamm Bowel Dis 13:424-30. 2007
    ..The efficacy of infliximab as maintenance therapy in patients with otherwise chronically active Crohn's disease (CD) is well established. Data concerning the linear growth response are sparse and can only be accrued in children...
  34. doi request reprint Use of C-reactive protein in children with newly diagnosed inflammatory bowel disease
    Anne Tsampalieros
    Department of Pediatrics, University of Ottawa and Children s Hospital of Eastern Ontario Ottawa, Ontario, Canada
    J Pediatr 159:340-2. 2011
    ..Evaluation of CRP level helped identify additional patients found to have inflammatory bowel disease at endoscopy, although a sizeable number of patients with mild ulcerative colitis had a normal CRP level...
  35. pmc Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository
    Mamatha Bhat
    Division of Gastroenterology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Am J Gastroenterol 104:2233-40. 2009
    ..The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America...
  36. ncbi request reprint Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary
    Anne M Griffiths
    Pediatrics, IBD Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Inflamm Bowel Dis 9:389-91; discussion 392-3. 2003
  37. pmc Challenges and strategies of children and adolescents with inflammatory bowel disease: a qualitative examination
    David B Nicholas
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Health Qual Life Outcomes 5:28. 2007
    ..The aims of this study were to understand the lived experience and elements of quality of life as depicted by children and adolescents with inflammatory bowel disease (IBD)...
  38. ncbi request reprint CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease
    Bill Newman
    Department of Medicine, University of Toronto, Toronto, Canada
    Am J Gastroenterol 99:306-15. 2004
    ..Crohn's disease (CD) is a chronic inflammatory disease of the gut associated with allelic variants of CARD15 and HLA-DRB1 genes. We investigated the prevalence and effects of these variants in a Canadian CD cohort...
  39. ncbi request reprint Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America
    Athos Bousvaros
    J Pediatr Gastroenterol Nutr 44:653-74. 2007
    ....
  40. ncbi request reprint The IMPACT questionnaire: a valid measure of health-related quality of life in pediatric inflammatory bowel disease
    Anthony Otley
    Division of Gastroenterology, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia Canada
    J Pediatr Gastroenterol Nutr 35:557-63. 2002
    ..This study sought to assess the feasibility, reliability, and validity of the instrument...
  41. ncbi request reprint Inflammatory bowel disease: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Simon H Murch
    J Pediatr Gastroenterol Nutr 39:S647-54. 2004
  42. ncbi request reprint Pediatricians overestimate importance of physical symptoms upon children's health concerns
    Hester J Loonen
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, The Netherlands
    Med Care 40:996-1001. 2002
    ..To compare the importance of issues of concern ranked by physicians and children with inflammatory bowel disease (IBD)...
  43. ncbi request reprint Nutrition support for pediatric patients with inflammatory bowel disease: a clinical report of the North American Society for Pediatric Gastroenterology, Hepatology And Nutrition
    Ronald E Kleinman
    NASPGHAN, Flourtown, PA, USA
    J Pediatr Gastroenterol Nutr 39:15-27. 2004
    ..The following is a Clinical Report from the Nutrition and Inflammatory Bowel Disease Committees of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition...
  44. ncbi request reprint Design issues and outcomes in IBD clinical trials
    Bruce E Sands
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Inflamm Bowel Dis 11:S22-8. 2005
    ..Careful subject selection, standardization of disease activity indices, and precise outcome measurement are the keys to continued improvement of the inflammatory bowel disease research process...
  45. ncbi request reprint Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease
    Anthony R Otley
    FRCPC, Division of Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada
    Inflamm Bowel Dis 12:684-91. 2006
    ..The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis...
  46. ncbi request reprint Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Gastroenterol 101:572-80. 2006
    ..The purpose of this study was to assess phenotypic subsets that contribute to the major IBD susceptibility loci...
  47. ncbi request reprint Effects of serum from children with newly diagnosed Crohn disease on primary cultures of rat osteoblasts
    Samuel Varghese
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA
    J Pediatr Gastroenterol Nutr 35:641-8. 2002
    ..We therefore examined the effects of serum from newly diagnosed, untreated children with CD on osteoblasts in culture and the role of interleukin-6 (IL-6), a cytokine present in excess in active CD that also has direct effects on bone...
  48. pmc Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    John D Rioux
    Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
    Nat Genet 39:596-604. 2007
    ..Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease...
  49. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  50. ncbi request reprint Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
    Francisco A Sylvester
    Division of Gastroenterology and Nutrition, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Inflamm Bowel Dis 13:42-50. 2007
    ..In children with inflammatory bowel disease (IBD) it is not known whether reductions in bone mineral density (BMD) are a consequence of bone turnover alterations and if BMD improves with treatment...
  51. ncbi request reprint Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort
    Geoffrey C Nguyen
    Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 101:1012-23. 2006
    ..This study was undertaken to characterize racial differences in disease phenotype in a predominantly adult population...