Yaron Finkelstein

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Toxico-surveillance of infant and toddler poisonings in the United States
    Yaron Finkelstein
    Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Med Toxicol 8:263-6. 2012
  2. doi request reprint Colchicine poisoning: the dark side of an ancient drug
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Toxicol (Phila) 48:407-14. 2010
  3. doi request reprint Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children
    Yaron Finkelstein
    Department of Pediatrics, Divisions of Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 128:723-8. 2011
  4. doi request reprint Predisposition to epilepsy--does the ABCB1 gene play a role?
    Laila Nurmohamed
    Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 51:1882-5. 2010
  5. pmc Methadone exposure during lactation
    Miguel Marcelo Glatstein
    Motherisk Team, Hospital for Sick Children, Toronto, ON, Canada
    Can Fam Physician 54:1689-90. 2008
  6. doi request reprint Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study
    Yaron Finkelstein
    Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:2738-43. 2007
  7. ncbi request reprint Severe bullous hypersensitivity reactions after exposure to carbamazepine in a Han-Chinese child with a positive HLA-B*1502 and negative in vitro toxicity assays: evidence for different pathophysiological mechanisms
    Abdelbaset A Elzagallaai
    Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Ontario, Canada
    J Popul Ther Clin Pharmacol 18:e1-9. 2011
  8. ncbi request reprint Inactive pharmaceutical ingredients : implications for pregnancy
    Yaron Finkelstein
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 14:e17-28. 2007
  9. doi request reprint Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns
    Gal Dubnov-Raz
    Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
    Pediatrics 122:e710-5. 2008
  10. pmc Exposure to alcohol-containing medications during pregnancy
    Facundo Garcia-Bournissen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Can Fam Physician 52:1067-8. 2006

Detail Information

Publications31

  1. pmc Toxico-surveillance of infant and toddler poisonings in the United States
    Yaron Finkelstein
    Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Med Toxicol 8:263-6. 2012
    ..These data could be used to target specific preventive interventions...
  2. doi request reprint Colchicine poisoning: the dark side of an ancient drug
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Toxicol (Phila) 48:407-14. 2010
    ..Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome...
  3. doi request reprint Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children
    Yaron Finkelstein
    Department of Pediatrics, Divisions of Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 128:723-8. 2011
    ..To report clinical course, etiology, management, and long-term outcomes of children suffering from Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN)...
  4. doi request reprint Predisposition to epilepsy--does the ABCB1 gene play a role?
    Laila Nurmohamed
    Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 51:1882-5. 2010
    ..No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34). ABCB1 genotyping for epileptic patients is not warranted...
  5. pmc Methadone exposure during lactation
    Miguel Marcelo Glatstein
    Motherisk Team, Hospital for Sick Children, Toronto, ON, Canada
    Can Fam Physician 54:1689-90. 2008
    ..One of my patients is currently using methadone for maintenance of opioid dependence. She wants to breastfeed. Is breastfeeding safe for her infant?..
  6. doi request reprint Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study
    Yaron Finkelstein
    Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:2738-43. 2007
    ..However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain...
  7. ncbi request reprint Severe bullous hypersensitivity reactions after exposure to carbamazepine in a Han-Chinese child with a positive HLA-B*1502 and negative in vitro toxicity assays: evidence for different pathophysiological mechanisms
    Abdelbaset A Elzagallaai
    Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Ontario, Canada
    J Popul Ther Clin Pharmacol 18:e1-9. 2011
    ..The aim of this study was to investigate the genetic and metabolic bases of DHS development to help predict patient susceptibility...
  8. ncbi request reprint Inactive pharmaceutical ingredients : implications for pregnancy
    Yaron Finkelstein
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 14:e17-28. 2007
  9. doi request reprint Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns
    Gal Dubnov-Raz
    Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
    Pediatrics 122:e710-5. 2008
    ..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring...
  10. pmc Exposure to alcohol-containing medications during pregnancy
    Facundo Garcia-Bournissen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Can Fam Physician 52:1067-8. 2006
    ..Caution is advisable when prescribing ethanol-containing elixirs to pregnant women, as is informing them about the alcohol content...
  11. doi request reprint Safety of anticoagulants in children with arterial ischemic stroke
    Tal Schechter
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Blood 119:949-56. 2012
    ..3507). We conclude that ACT is relatively safe in children with AIS, with a 4% risk of symptomatic ICH. Based on the safety of ACT in our study, clinical trials of ACT in childhood AIS are warranted...
  12. pmc Use of hypoglycemic drugs during lactation
    Miguel Marcelo Glatstein
    Hospital for Sick Children, Toronto, Ontario
    Can Fam Physician 55:371-3. 2009
    ..Can sulfonylureas cross into human milk and, if so, is it safe for her to breastfeed her infant?..
  13. doi request reprint Daclizumab therapy for children with corticosteroid-resistant acute graft-vs.-host disease
    Tal Schechter
    Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Transplant 13:332-7. 2009
    ..We conclude that daclizumab is effective in the treatment of children with corticosteroid-resistant aGVHD, especially in patients with gut involvement...
  14. doi request reprint Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic
    Laila Nurmohamed
    Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 205:533.e1-3. 2011
    ..The objective of this study was to report the outcomes of intrauterine pregnancies misdiagnosed as ectopic and exposed to methotrexate, a major teratogen...
  15. ncbi request reprint Establishing causality in pediatric adverse drug reactions: use of the Naranjo probability scale
    Marina Avner
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Paediatr Drugs 9:267-70. 2007
    ..Our analysis reveals that this method is useful, but also highlights potential areas for its improvement...
  16. doi request reprint Pharmacokinetic and pharmacogenetic determinants and considerations in chemotherapy selection and dosing in infants
    Janine R Hutson
    University of Toronto, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto ON, M5G 1X8, Canada
    Expert Opin Drug Metab Toxicol 8:709-22. 2012
    ....
  17. ncbi request reprint Discrepancies in pharmacokinetic analysis results obtained by using two standard population pharmacokinetics software programs
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
    Fundam Clin Pharmacol 23:53-7. 2009
    ..7 h vs. 206.9 h, respectively). When considering the results reported from a population PK analysis, validation of the results by different software should be considered, especially when extreme, unexpected values are obtained...
  18. doi request reprint Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis
    Facundo Garcia Bournissen
    Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 50:898-903. 2009
    ....
  19. doi request reprint Hypoglycemia in a healthy toddler
    Miguel Glatstein
    Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Ther Drug Monit 31:173-7. 2009
    ..We stress the need to consider potential child abuse or neglect in a hypoglycaemic patient with sulphonylurea-using caregivers...
  20. ncbi request reprint Pharmacokinetic disposition and clinical outcomes in infants and children receiving intravenous busulfan for allogeneic hematopoietic stem cell transplantation
    Tal Schechter
    Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 13:307-14. 2007
    ..v. busulfan doses were adjusted to achieve a target AUC. The influence of factors other than busulfan disposition on transplantation outcomes, such as genetic polymorphisms, should be evaluated...
  21. doi request reprint Eosinophilic myocarditis temporally associated with conjugate meningococcal C and hepatitis B vaccines in children
    Michelle Barton
    Division of Infectious Diseases, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 27:831-5. 2008
    ..Time of onset of cardiac symptoms in all patients ranged from 1 to 30 days postimmunization...
  22. ncbi request reprint Generalized seizures following topical lidocaine administration during circumcision: establishing causation
    Massoud Rezvani
    Division of Clinical Pharmacology Toxicology and Clinical Biochemistry, The Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Drugs 9:125-7. 2007
    ..The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local anesthetics in infants to avoid life-threatening seizures...
  23. doi request reprint Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children
    Stacey M Pollock-Barziv
    SickKids Transplant Centre, Department of Pediatrics, The Hospital for Sick Children and University of Toronto Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 14:968-75. 2010
    ..003). In conclusion, high s.d. in serial tacrolimus concentrations associated with increased risk of late rejection and graft loss in pediatric organ transplant recipients, providing opportunities for screening and interventions...
  24. ncbi request reprint A randomized controlled trial of a vancomycin loading dose in children
    Alicia Demirjian
    From the Department of Medicine, Division of Infectious Diseases Clinical Pharmacology Research Program, Division of Emergency Medicine, Boston Children s Hospital, Boston, MA Division of Emergency Medicine Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Pharmacy and Department of Laboratory Medicine, Boston Children s Hospital, Boston, MA
    Pediatr Infect Dis J 32:1217-23. 2013
    ..Our objective was to assess whether a loading dose of vancomycin would increase the proportion of children reaching target trough concentrations 8 hours after initiation of therapy...
  25. doi request reprint Ondansetron dosing in pediatric gastroenteritis: a prospective cohort, dose-response study
    Stephen B Freedman
    Division of Pediatric Emergency Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Paediatr Drugs 12:405-10. 2010
    ..Ondansetron is increasingly used to prevent emesis in children with acute gastroenteritis; however, the optimal dose is unknown...
  26. ncbi request reprint Smoke screen: increase in movie stars' smoking on the big screen and its effect on teen smoking
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Ther Drug Monit 27:547-8. 2005
    ..Several recent studies show an increase in movie stars' smoking on the big screen, leading to an increased rate of teen smoking...
  27. ncbi request reprint Back to basics: understanding drugs in children: pharmacokinetic maturation
    Maria Tetelbaum
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics and Population Health Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Rev 26:321-8. 2005
  28. ncbi request reprint Motherisk rounds. Warfarin embryopathy following low-dose maternal exposure
    Yaron Finkelstein
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON
    J Obstet Gynaecol Can 27:702-6. 2005
  29. ncbi request reprint Clopidogrel use in children
    Yaron Finkelstein
    Division of Clinical Pharmacology, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario
    J Pediatr 147:657-61. 2005
    ..To review a pediatric experience with the antiplatelet agent clopidogrel and suggest a dosage regimen...
  30. doi request reprint Palatability, adherence and prescribing patterns of antiretroviral drugs for children with human immunodeficiency virus infection in Canada
    Daren Lin
    Division of Emergency Medicine, Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada
    Pharmacoepidemiol Drug Saf 20:1246-52. 2011
    ..To assess the impact of perceived palatability of antiretroviral drugs on adherence to therapy of children infected by human immunodeficiency virus and on prescribing patterns by their caring physicians...
  31. pmc Pregnancy after stem cell transplantation
    Tal Schechter
    Hospital for Sick Children, Toronto, Ont
    Can Fam Physician 51:817-8. 2005
    ..There is increased risk of prematurity, low birth weight, and spontaneous abortion. Pregnancy should be managed as high risk...