B M Feldman

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi Safety of intravenous immunoglobulin in the treatment of juvenile dermatomyositis: adverse reactions are associated with immunoglobulin A content
    Cedric Manlhiot
    Division of Rheumatology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 121:e626-30. 2008
  2. ncbi Haemophilia prophylaxis: how can we justify the costs?
    B M Feldman
    Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, Institute of Health Policy Management and Evaluation, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    Haemophilia 18:680-4. 2012
  3. ncbi Implementing musculoskeletal outcome assessments in clinical practice
    B M Feldman
    Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada
    Haemophilia 18:120-4. 2012
  4. ncbi Increased serum levels of TGFbeta1 in children with localized scleroderma
    Yosef Uziel
    Divisions of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Pediatr Rheumatol Online J 5:22. 2007
  5. ncbi Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
    B M Feldman
    Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    J Thromb Haemost 4:1228-36. 2006
  6. ncbi Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood
    Brian M Feldman
    Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 371:2201-12. 2008
  7. ncbi Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: validity of the hemophilia joint health score
    Brian M Feldman
    University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:223-30. 2011
  8. ncbi The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) symposium
    B M Feldman
    Department of Pediatrics, University of Toronto, and Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Haemophilia 13:745-9. 2007
  9. ncbi Proceedings of the International Haemophilia Prophylaxis Study Group Meeting, November 2003, Montreal, PQ, Canada
    B M Feldman
    Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Hospital for Sick Children, Bloorview MacMillan Children's Centre, Toronto, ON, Canada
    Haemophilia 11:58-63. 2005
  10. ncbi Efficacy of intravenous Ig therapy in juvenile dermatomyositis
    Catherine G Lam
    Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Rheum Dis 70:2089-94. 2011

Detail Information

Publications97

  1. ncbi Safety of intravenous immunoglobulin in the treatment of juvenile dermatomyositis: adverse reactions are associated with immunoglobulin A content
    Cedric Manlhiot
    Division of Rheumatology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 121:e626-30. 2008
    ....
  2. ncbi Haemophilia prophylaxis: how can we justify the costs?
    B M Feldman
    Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, Institute of Health Policy Management and Evaluation, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    Haemophilia 18:680-4. 2012
    ..In an era of rising health care costs, there is a strong research agenda to establish the factors that determine the value of expensive therapies for rare diseases like haemophilia...
  3. ncbi Implementing musculoskeletal outcome assessments in clinical practice
    B M Feldman
    Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada
    Haemophilia 18:120-4. 2012
    ..Because of their potential complexity, measures must be chosen that are practical for use in clinic. Future research should be focussed on the best ways to implement the use of standardized outcome measures in haemophilia practice...
  4. ncbi Increased serum levels of TGFbeta1 in children with localized scleroderma
    Yosef Uziel
    Divisions of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Pediatr Rheumatol Online J 5:22. 2007
    ..Monitoring is done almost exclusively by clinical assessment. Our aim was to determine whether serum concentrations of TGFbeta1 are a good biomarker of disease activity in children with LS...
  5. ncbi Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
    B M Feldman
    Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    J Thromb Haemost 4:1228-36. 2006
    ..We studied an inception cohort of 25 boys using a tailored prophylaxis approach to see if clotting factor use could be reduced with acceptable outcomes...
  6. ncbi Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood
    Brian M Feldman
    Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 371:2201-12. 2008
    ..Disease outcome, if treatment is initiated early, is generally good. Randomised controlled trials are needed to define the most effective treatments...
  7. ncbi Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: validity of the hemophilia joint health score
    Brian M Feldman
    University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:223-30. 2011
    ..The HJHS has been shown to be highly reliable. We compared its validity and sensitivity to the WFH scale...
  8. ncbi The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) symposium
    B M Feldman
    Department of Pediatrics, University of Toronto, and Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Haemophilia 13:745-9. 2007
  9. ncbi Proceedings of the International Haemophilia Prophylaxis Study Group Meeting, November 2003, Montreal, PQ, Canada
    B M Feldman
    Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Hospital for Sick Children, Bloorview MacMillan Children's Centre, Toronto, ON, Canada
    Haemophilia 11:58-63. 2005
  10. ncbi Efficacy of intravenous Ig therapy in juvenile dermatomyositis
    Catherine G Lam
    Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Rheum Dis 70:2089-94. 2011
    ..Patients requiring IVIg are generally expected to have poorer outcomes, leading to confounding by indication in observational studies. Few studies have evaluated IVIg efficacy in JDM...
  11. ncbi Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus
    Sylvia Ota
    Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
    Pediatr Rheumatol Online J 6:5. 2008
    ..One of the first projects undertaken by this network was to define, by consensus, research priorities for the group, and if possible a first group-sponsored clinical trial in which all members could participate...
  12. ncbi Health-related quality of life (HRQL) scores reported from parents and their children with chronic illness differed depending on utility elicitation method
    L Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 57:1161-6. 2004
    ..To describe the relationship between health-related quality of life (HRQL) as measured by utility when elicited from parents and their children with chronic illness...
  13. ncbi The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids
    A V Ramanan
    Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Arthritis Rheum 52:3570-8. 2005
    ..CONCLUSION: Use of MTX in conjunction with an aggressively tapered course of prednisone may be as effective as traditional long-term corticosteroid therapy for children with DM, while decreasing the cumulative dose of corticosteroids...
  14. ncbi Risk of new-onset uveitis in patients with juvenile idiopathic arthritis treated with anti-TNFalpha agents
    R K Saurenmann
    Division of Rheumatology, the Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 149:833-6. 2006
    ..To determine whether treatment with tumor necrosis factor alpha (TNFalpha)-blocking agents alters the incidence of new-onset uveitis in patients with juvenile idiopathic arthritis (JIA)...
  15. ncbi Validity of a modified standard gamble elicited from parents of a hospital-based cohort of children
    L Sung
    Division of Hematology/Oncology, and Population Health Sciences, Hospital for Sick Children, Toronto, Ontario, M5G 1X8
    J Clin Epidemiol 56:848-55. 2003
    ..49; P<.01 for both). Both Mod SG and SG were moderately correlated with TTO (r=0.47 and r=0.05, P<0.002 for both). CONCLUSION: The Mod SG did not perform better than SG. Two nonoverlapping groups of HRQL measures were demonstrated...
  16. ncbi The arthritis of inflammatory childhood myositis syndromes
    S Tse
    Department of Pediatrics, Medicine, Immunology, Diagnostic Imaging, and Public Health Sciences, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Rheumatol 28:192-7. 2001
    ..In a significant proportion of JDM cases, arthritis is the major sequela and may warrant further medical therapy or intraarticular corticosteroid injections...
  17. ncbi Cost-utility analysis of Canadian tailored prophylaxis, primary prophylaxis and on-demand therapy in young children with severe haemophilia A
    N Risebrough
    HOPE Research Centre, Division of Clinical Pharmacology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Haemophilia 14:743-52. 2008
    ..In conclusion, prophylaxis will substantially improve clinical outcomes and quality of life compared to Demand treatment, but with substantial cost...
  18. ncbi Recommendations for reporting economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf of the Economics Expert Working Group of The International Prophylaxis Study Group
    A Nicholson
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 14:127-32. 2008
    ..The need for clearly reported studies evaluating the cost of prophylaxis and its overall outcomes has been recommended from previous literature...
  19. ncbi Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach
    A V Ramanan
    Department of Pediatrics, Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
    Rheumatology (Oxford) 44:1574-8. 2005
    ..As a next step, the measurement properties of these items will be tested to help develop a disease activity tool...
  20. ncbi What does "active disease" mean? patient and parent perceptions of disease activity in the systemic arthritis form of juvenile idiopathic arthritis (SO-JIA)
    M Batthish
    Division of Rheumatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Rheumatology (Oxford) 44:796-9. 2005
    ..We sought to elicit specific items reflecting their perceptions of active disease that may be considered for inclusion in a disease activity measure for SO-JIA...
  21. ncbi The Gap Study (GapS) interview--developing a process to determine the meaning and determinants of quality of life in children with arthritis and rheumatic disease
    G W K Gong
    Division of Rheumatology, Research Institute, The Hospital for Sick Children, and Department of Pediatrics, University of Toronto, Ontario, Canada
    Clin Exp Rheumatol 25:486-93. 2007
    ..We performed this study to develop items and methods for measuring and valuing these gaps in order to better determine individual QOL for children with rheumatic diseases...
  22. ncbi Working out the kinks: testing the feasibility of an electronic pain diary for adolescents with arthritis
    J N Stinson
    The Hospital for Sick Children, Toronto, Canada
    Pain Res Manag 13:375-82. 2008
    ..A real-time data capture approach using electronic diaries has been proposed as a new standard for pain measurement. However, there is limited information available regarding the development and feasibility of this approach in children...
  23. ncbi Definitions for haemophilia prophylaxis and its outcomes: the Canadian consensus study
    S Ota
    Research program in Child Health Evaluation Sicenses, The Hospital for Sick Children, Toronto, Canada
    Haemophilia 13:12-20. 2007
    ..Further refinement from members of the international haemophilia community will ensure that comprehensive standard definitions can be used in multicentre studies in the future...
  24. ncbi Pilot study of fitness training and exercise testing in polyarticular childhood arthritis
    D Singh-Grewal
    Division of Rheumatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Arthritis Rheum 55:364-72. 2006
    ..CONCLUSION: This study suggests that it is safe, feasible, and acceptable for children with arthritis, in the absence of severe hip involvement, to participate in formal exercise testing and structured fitness programs...
  25. ncbi Acute renal failure in paediatric systemic lupus erythematosus: treatment and outcome
    S M Benseler
    Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada
    Rheumatology (Oxford) 48:176-82. 2009
    ..To determine the outcome of paediatric SLE (pSLE) patients with nephritis who developed acute renal failure (ARF). Efficacy and safety of treatment regimens were compared...
  26. ncbi Tumour necrosis factor alpha inhibitors in the treatment of childhood uveitis
    R K Saurenmann
    Division of Rheumatology, Hospital for Sick Children, Toronto, Canada
    Rheumatology (Oxford) 45:982-9. 2006
    ..To describe the efficacy of anti-TNF-alpha agents in the treatment of childhood uveitis...
  27. ncbi Health-related quality-of-life treatments for severe haemophilia: utility measurements using the Standard Gamble technique
    V S Naraine
    Faculty of Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Haemophilia 8:112-20. 2002
    ....
  28. ncbi Effect of intracranial bleeds on the neurocognitive, academic, behavioural and adaptive functioning of boys with haemophilia
    B S Miles
    Psychology Department, Dufferin Peel Catholic District School Board, Mississauga, ON, Canada
    Haemophilia 18:229-34. 2012
    ..Early neuropsychological assessment may be indicated when there is a history of ICH. Investigation of age at ICH and quantitative measures of brain in relation to neurocognitive outcomes in larger groups of boys with ICH would be useful...
  29. ncbi Hemophilia joint health score reliability study
    P Hilliard
    Department of Rehabilitation Service, The Division of Rheumatology, The Hospital for Sick Children, University of Toronto, Canada
    Haemophilia 12:518-25. 2006
    ..To address these concerns, the Hemophilia Joint Health Score (HJHS) was developed by modifying existing scores...
  30. ncbi Assessment of an infectious disease history preceding juvenile dermatomyositis symptom onset
    C Manlhiot
    Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Rheumatology (Oxford) 47:526-9. 2008
    ..We sought to correlate preceding infectious symptoms with onset and outcomes of JDM...
  31. ncbi The clinical meaning of functional outcome scores in children with juvenile arthritis
    H Dempster
    University of Toronto, Ontario, Canada
    Arthritis Rheum 44:1768-74. 2001
    ..CONCLUSION: Clinicians, as well as researchers setting protocols, should aim for a mimimum improvement of 0.13 in the CHAQ score when treating pediatric patients with arthritis...
  32. ncbi Cost-utility analysis in evaluating prophylaxis in haemophilia
    M Carcao
    Department of Paediatrics, Divisions of Haematology Oncology, Hospital for Sick Children, Toronto, Canada
    Haemophilia 10:50-7. 2004
    ..Ultimately CUA may provide a tool to allow societies to decide if prophylaxis is worth the cost and how the costs and benefits of prophylaxis compare to other healthcare interventions for other disease entities...
  33. ncbi Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients
    L Sung
    Department of Paediatrics, University of Toronto, Toronto, Canada
    Eur J Cancer 43:1269-75. 2007
    ..3 with placebo. Topical vitamin E does not reduce doxorubicin-induced oral mucositis in children. The use of N-of-1 studies and Bayesian meta-analysis may facilitate the study of some therapies in paediatric oncology...
  34. ncbi Distinction of quality of life, health related quality of life, and health status in children referred for rheumatologic care
    B M Feldman
    Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Ontario, Canada
    J Rheumatol 27:226-33. 2000
    ..We investigated whether children referred for rheumatologic care differentiate between the concepts of health related quality of life (HRQOL), overall QOL, and health status...
  35. ncbi Seven items were identified for inclusion when reporting a Bayesian analysis of a clinical study
    Lillian Sung
    Division of Hematology Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Epidemiol 58:261-8. 2005
    ....
  36. ncbi Cost-effectiveness of biologics in polyarticular-course juvenile idiopathic arthritis patients unresponsive to disease-modifying antirheumatic drugs
    Wendy J Ungar
    The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:111-9. 2011
    ..Biologics are a new class of drugs increasingly used to treat JIA. The primary study objective was to determine the incremental costs of biologics per additional responder compared to conventional treatment (methotrexate)...
  37. ncbi Validation of the oral mucositis assessment scale in pediatric cancer
    Lillian Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 49:149-53. 2007
    ..Our objective was to examine the construct validity of the Oral Mucositis Assessment Scale (OMAS) in children receiving doxorubicin chemotherapy...
  38. ncbi An internet-based self-management program with telephone support for adolescents with arthritis: a pilot randomized controlled trial
    Jennifer N Stinson
    Child Health Evaluative Sciences, Chronic Pain Program, Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Rheumatol 37:1944-52. 2010
    ....
  39. ncbi e-Ouch: usability testing of an electronic chronic pain diary for adolescents with arthritis
    Jennifer N Stinson
    Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    Clin J Pain 22:295-305. 2006
    ..The aim of this study was to evaluate the usability of the e-Ouch electronic chronic pain diary in adolescents with juvenile idiopathic arthritis...
  40. ncbi Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin
    Irena Nulman
    Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:45-50, 50.e1-2. 2009
    ..To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment...
  41. ncbi Treating children with arthritis: towards an evidence-based culture
    Brian M Feldman
    Department of Pediatrics, Health Policy Management and Evaluation Unit, Public Health Sciences, University of Toronto, Canada
    J Rheumatol Suppl 72:33-5. 2005
    ..These groups might potentially lead the way to a new evidence-based culture for childhood arthritis...
  42. ncbi Construct validity of a multidimensional electronic pain diary for adolescents with arthritis
    Jennifer N Stinson
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ont, Canada
    Pain 136:281-92. 2008
    ..These findings provide evidence of the construct validity and feasibility of the e-Ouch(c) electronic diary in adolescents with JIA. Use of real-time data capture approaches should be considered in future studies of chronic arthritis...
  43. ncbi Use of complementary and alternative medicine by pediatric rheumatology patients
    Lorrie E M Hagen
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Rheum 49:3-6. 2003
    ..To assess how often the patients in The Hospital for Sick Children's rheumatology clinic use complementary and alternative medicine (CAM), and the type of CAM used...
  44. ncbi Inpatient versus outpatient management of low-risk pediatric febrile neutropenia: measuring parents' and healthcare professionals' preferences
    Lillian Sung
    Department of Pediatrics, University of Toronto, Ontario, Canada
    J Clin Oncol 22:3922-9. 2004
    ..Our secondary objective was to identify predictors of strength of preference for oral outpatient treatment...
  45. ncbi Asking the experts: exploring the self-management needs of adolescents with arthritis
    Jennifer N Stinson
    University of Toronto and Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Rheum 59:65-72. 2008
    ..To explore the self-management needs of adolescents with juvenile idiopathic arthritis and the acceptability of a Web-based program of self-management aimed at improving quality of life...
  46. ncbi N-of-1 trials: innovative methods to evaluate complementary and alternative medicines in pediatric cancer
    Lillian Sung
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 28:263-6. 2006
    ..The use of N-of-1 RCTs may be very beneficial in evaluating CAM therapies in pediatric cancer. However, careful consideration of the advantages and disadvantages of such a design should be undertaken prior to initiating an N-of-1 RCT...
  47. ncbi Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy
    L Sung
    Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada
    Br J Cancer 88:1185-90. 2003
    ..1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete...
  48. ncbi Quality of randomized clinical trials in juvenile idiopathic arthritis
    L Abrahamyan
    The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Rheumatology (Oxford) 47:640-5. 2008
    ..We evaluated the quality of randomized clinical trials (RCTs) of therapy for juvenile idiopathic arthritis (JIA) using an individual component approach and assessed temporal changes...
  49. ncbi Clinical relevance of the risk factors for coronary artery inflammation in Kawasaki disease
    V E A Honkanen
    Division of Rheumatology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Pediatr Cardiol 24:122-6. 2003
    ..We could not distinguish a group at such a low risk that these patients could be left untreated. Young patients with low albumin run a very high risk for CALs...
  50. ncbi Minimal difference in pain associated with change in quality of life in children with rheumatic disease
    Sonny Dhanani
    The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 47:501-5. 2002
    ..CONCLUSION: Our results suggest that future studies of the assessment and treatment of pain in this population should aim for a minimum reduction in pain score of 0.82 cm on a 10-cm VAS to achieve clinical improvement in quality of life...
  51. ncbi Predictors of disease course and remission in systemic juvenile idiopathic arthritis: significance of early clinical and laboratory features
    D Singh-Grewal
    The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 54:1595-601. 2006
    ..Features at 3 and 6 months are predictive of the disease course and time to remission...
  52. ncbi Clinical outcomes in juvenile dermatomyositis
    A V Ramanan
    Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Opin Rheumatol 14:658-62. 2002
    ..Functional outcomes have become good with modern treatments, but the disease remains chronic in a large number of children and sequelae are often seen...
  53. ncbi A pilot study of ondansetron plus metopimazine vs. ondansetron monotherapy in children receiving highly emetogenic chemotherapy: a Bayesian randomized serial N-of-1 trials design
    P C Nathan
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Support Care Cancer 14:268-76. 2006
    ..The present study was designed to assess its efficacy in children with cancer, a group in which it has not been studied previously...
  54. ncbi A three-stage clinical trial design for rare disorders
    V E Honkanen
    Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada
    Stat Med 20:3009-21. 2001
    ..In situations where patient numbers are limited, a three-stage clinical trial design may be a more powerful design than the traditional randomized trial for detecting clinical benefits...
  55. ncbi Validation of the Childhood Health Assessment Questionnaire in the juvenile idiopathic myopathies. Juvenile Dermatomyositis Disease Activity Collaborative Study Group
    A M Huber
    Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Rheumatol 28:1106-11. 2001
    ..We conclude that the CHAQ is a valid measure of physical function in juvenile IIM, appropriate for use in therapeutic trials, and potentially in the clinical care of these patients...
  56. ncbi The Quality of My Life questionnaire: the minimal clinically important difference for pediatric rheumatology patients
    Grace W K Gong
    Division of Rheumatology, Population Health Sciences Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Rheumatol 34:581-7. 2007
    ..To establish construct validity of the QoML questionnaire. To determine the minimal clinically important difference (MCID) for the Quality of Life (QOL) and Health-Related Quality of Life (HRQOL) scales...
  57. ncbi Fitting marginal structural models: estimating covariate-treatment associations in the reweighted data set can guide model fitting
    Eleanor M Pullenayegum
    Department of Clinical Epidemiology and Biostatistics, Biostatistics Unit, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 61:875-81. 2008
    ..Often treatment effect estimates will be sensitive to the choice of weights. A framework within which to explore reasons for this sensitivity and to select a good weighting scheme is suggested...
  58. ncbi Innovative strategies for trial design
    B M Feldman
    Department of Paediatrics, University of Toronto, Ontario, Canada
    J Rheumatol Suppl 58:4-7. 2000
    ..For treatments that may permanently affect the disease course, I propose the randomized placebo phase design as one way of increasing study acceptability and accrual...
  59. ncbi Clinical and cost implications of target joints in Canadian boys with severe hemophilia A
    Melissa Kern
    Division of Hematology/Oncology, The Hospital for Sick Children, Ontario, Canada
    J Pediatr 145:628-34. 2004
    ..This finding provides further support for more aggressive treatment aimed at reducing target joints-either more aggressive treatment of joint bleeds or institution of primary prophylactic therapy at an early age...
  60. ncbi Clinical features and outcomes of juvenile dermatomyositis and other childhood onset myositis syndromes
    A V Ramanan
    Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Rheum Dis Clin North Am 28:833-57. 2002
    ....
  61. ncbi Shifting our thinking about uncommon disease trials: the case of methotrexate in scleroderma
    Sindhu R Johnson
    Division of Rheumatology, Toronto Western Hospital, Ground Floor, East Wing, 399 Bathurst Street, Toronto, ON M5T 2S8
    J Rheumatol 36:323-9. 2009
    ..05 as "negative." Our study demonstrates how Bayesian analysis conveys more relevant information to clinicians - using the example of methotrexate (MTX) in systemic sclerosis (SSc)...
  62. ncbi Predicting the course of juvenile dermatomyositis: significance of early clinical and laboratory features
    Elizabeth Stringer
    The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 58:3585-92. 2008
    ..The aims of this study were to describe the clinical course of juvenile DM and to determine whether early clinical and laboratory features can be used to predict the time to remission and/or the disease course...
  63. ncbi Comparison of patients with juvenile psoriatic arthritis and nonpsoriatic juvenile idiopathic arthritis: how different are they?
    Yonatan Aviel Butbul
    Division of Rheumatology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Rheumatol 36:2033-41. 2009
    ..To compare the clinical features and outcome between patients with juvenile psoriatic arthritis (JPsA) and non-JPsA juvenile idiopathic arthritis (JIA)...
  64. ncbi Eye findings in patients with juvenile dermatomyositis
    Jonathan D Akikusa
    Department of Pediatrics, Division of Rheumatology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Rheumatol 32:1986-91. 2005
    ..As lid lesions and cataracts are easily detected by non-ophthalmologists, and retinal lesions are rare, we feel that JDM patients without visual symptoms do not require routine formal ophthalmologic assessment for disease manifestations...
  65. ncbi A qualitative study of fitness instructors' experiences leading an exercise program for children with juvenile idiopathic arthritis
    Carolyn E Hutzal
    Hospital for Sick Children, Toronto, Canada
    Phys Occup Ther Pediatr 29:409-25. 2009
    ....
  66. ncbi A valid and reliable belief elicitation method for Bayesian priors
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Clin Epidemiol 63:370-83. 2010
    ..The objectives of this study were to evaluate the feasibility, validity, and reliability of a belief elicitation method for Bayesian priors...
  67. ncbi Differences in the profiles of circulating levels of soluble tumor necrosis factor receptors and interleukin 1 receptor antagonist reflect the heterogeneity of the subgroups of juvenile rheumatoid arthritis
    Mohammed A Muzaffer
    Division of Rheumatology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Rheumatol 29:1071-8. 2002
    ..Our results suggest that cytokines have differing roles in JRA subtypes and likely reflect JRA subtype heterogeneity...
  68. ncbi Sleep and fatigue and the relationship to pain, disease activity and quality of life in juvenile idiopathic arthritis and juvenile dermatomyositis
    Yonatan Butbul Aviel
    Department of Pediatrics, Technion Institution, Pediatric Department Rheumatology Unit, Technion Faculty of Medicine, Meyer Children s Hospital of Haifa, Haifa, Israel
    Rheumatology (Oxford) 50:2051-60. 2011
    ..To determine and compare the prevalence of disturbed sleep in JIA and JDM and the relationship of sleep disturbance to pain, function, disease activity and medications...
  69. ncbi Predictors of hip disease in the systemic arthritis subtype of juvenile idiopathic arthritis
    Michelle Batthish
    Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Rheumatol 38:954-8. 2011
    ..Patients with systemic JIA (sJIA) are affected most frequently. The aim of our study was to investigate the predictors of clinical hip disease and radiographic hip damage in sJIA...
  70. ncbi Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: results of a randomized controlled pilot trial
    Samantha Stephens
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Rheum 59:1399-406. 2008
    ....
  71. ncbi Methods to elicit beliefs for Bayesian priors: a systematic review
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Clin Epidemiol 63:355-69. 2010
    ..We review belief-elicitation methods for Bayesian analysis and determine if any of them had an incremental value over the others based on its validity, reliability, and responsiveness...
  72. ncbi Clinical assessment of conjunctival and episcleral vessel tortuosity in juvenile dermatomyositis
    Tara A Young
    Department of Ophthalmology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J AAPOS 6:238-40. 2002
    ..The appearance of conjunctival and episcleral vessels should be assessed in the context of other ocular and periocular findings of patients with juvenile dermatomyositis...
  73. ncbi Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis
    Athimalaipet V Ramanan
    Department of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 31:2068-70. 2004
    ..In 2 recently reported case series of MAS in SoJRA, renal involvement appeared to be associated with poor prognosis. We describe 3 children with SoJRA who had renal involvement complicating MAS and had a favorable outcome...
  74. ncbi Vitamin E: the evidence for multiple roles in cancer
    Lillian Sung
    Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nutr Cancer 46:1-14. 2003
    ..The therapeutic role of vitamin E is poorly understood. Further research will be required before routine use of vitamin E in patients with cancer can be advocated in the clinical setting...
  75. ncbi Advances in the treatment of juvenile dermatomyositis
    Elizabeth Stringer
    Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Curr Opin Rheumatol 18:503-6. 2006
    ....
  76. ncbi Sinus bradycardia after intravenous pulse methylprednisolone
    Jonathan D Akikusa
    Division of Rheumatology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 119:e778-82. 2007
    ..Sinus bradycardia after repeated administration of high-dose pulse methylprednisolone in children may be more common than previously appreciated...
  77. ncbi Classification criteria for systemic sclerosis subsets
    Sindhu R Johnson
    Division of Rheumatology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1855-63. 2007
    ..To evaluate the measurement properties of criteria for systemic sclerosis (SSc) subsets for classification of patients in SSc trials, and to determine if any one criteria set confers measurement advantage over others...
  78. ncbi Inflammatory myopathies in children
    Sandrine Compeyrot-Lacassagne
    Division of Rheumatology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Pediatr Clin North Am 52:493-520, vi-vii. 2005
    ..Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy. This article describes a recent patient who presented with typical JDM and uses her case to discuss aspects of the childhood inflammatory myopathies...
  79. ncbi Classification criteria in rheumatic diseases: a review of methodologic properties
    Sindhu R Johnson
    University Health Network, Toronto, Ontario, Canada
    Arthritis Rheum 57:1119-33. 2007
    ..To identify classification criteria for the rheumatic diseases and to evaluate their measurement properties and methodologic rigor using current measurement standards...
  80. ncbi The effects of vigorous exercise training on physical function in children with arthritis: a randomized, controlled, single-blinded trial
    Davinder Singh Grewal
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Rheum 57:1202-10. 2007
    ....
  81. ncbi Revised versions of the Childhood Health Assessment Questionnaire (CHAQ) are more sensitive and suffer less from a ceiling effect
    Catherine Lam
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 51:881-9. 2004
    ..By being more sensitive at differentiating patients, the revised versions of the CHAQ will allow fewer subjects to be studied and will be more able to detect differences between patients in the clinic...
  82. ncbi Reliability of exercise testing and functional activity questionnaires in children with juvenile arthritis
    Samantha Stephens
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Arthritis Rheum 57:1446-52. 2007
    ..To determine the reliability of formal exercise testing and the reliability of functional and activity questionnaires in children with juvenile idiopathic arthritis (JIA)...
  83. ncbi Preliminary validation and clinical meaning of the Cutaneous Assessment Tool in juvenile dermatomyositis
    Adam M Huber
    Division of Pediatric Rheumatology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Arthritis Rheum 59:214-21. 2008
    ..To provide preliminary validation of the Cutaneous Assessment Tool (CAT), a new tool to assess cutaneous manifestations of juvenile dermatomyositis (DM), and to explore the clinical meaning of CAT scores...
  84. ncbi Corticosteroid treatment of refractory Kawasaki disease
    Bianca A Lang
    Canadian Pediatric Rheumatology Association, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada
    J Rheumatol 33:803-9. 2006
    ..To review the indications for corticosteroids in patients with Kawasaki disease (KD) treated by pediatric rheumatologists in Canada and to determine their efficacy on fever in patients with refractory KD...
  85. ncbi Clinical responsiveness of self-report functional assessment measures for children with juvenile idiopathic arthritis undergoing intraarticular corticosteroid injections
    G Ted Brown
    Monash University, Frankston, Victoria, Australia
    Arthritis Rheum 53:897-904. 2005
    ..The choice of which measure to use should therefore be based on the time available for completion, the intended clinical/research use, and the depth of content required...
  86. ncbi Long-term outcomes in juvenile dermatomyositis: how did we get here and where are we going?
    Adam Huber
    Division of Pediatric Rheumatology, IWK Health Centre, Halifax, Nova Scotia, Canada
    Curr Rheumatol Rep 7:441-6. 2005
    ..Current efforts to identify key outcomes and validate measures for those outcomes will allow researchers in the future to provide this much needed information...
  87. ncbi Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials
    Adam M Huber
    Division of Pediatric Rheumatology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    J Rheumatol 34:1125-32. 2007
    ..intervention? (2) Compared to placebo, how likely is it that low-dose amitriptyline therapy in children aged 10-18 years with active polyarticular-course juvenile idiopathic arthritis (JIA) results in a significant improvement in pain?..
  88. ncbi The role of aggressive corticosteroid therapy in patients with juvenile dermatomyositis: a propensity score analysis
    Roopa Seshadri
    Feinberg School of Medicine, Northwestern University, and Children s Memorial Research Center, Chicago, Illinois, USA
    Arthritis Rheum 59:989-95. 2008
    ..To compare outcomes at 36 months in patients newly diagnosed with juvenile dermatomyositis (DM) treated with aggressive versus standard therapy...
  89. ncbi International consensus guidelines for trials of therapies in the idiopathic inflammatory myopathies
    Chester V Oddis
    University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 52:2607-15. 2005
  90. ncbi Item weightings for the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Disease Damage Index using Rasch analysis do not lead to an important improvement
    Hermine I Brunner
    William Rowe Division of Rheumatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Rheumatol 30:292-7. 2003
    ....
  91. ncbi Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damage
    Hermine I Brunner
    Division of Rheumatology, Children s Hospital Medical Center, University of Cincinnati, PAV2 129, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Arthritis Rheum 46:436-44. 2002
    ....
  92. ncbi Effect of intracranial bleeds on the health and quality of life of boys with hemophilia
    Shoshana Revel-Vilk
    Pediatric Hematology/Oncology Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
    J Pediatr 144:490-5. 2004
    ..CONCLUSION: The poorer long-term outcomes of boys with hemophilia appropriately treated for ICH, especially in the domain of QoL, suggest that new strategies to prevent ICH and to manage ICH effectively in this population are needed...
  93. ncbi Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies
    Adam M Huber
    IWK Health Centre and Dalhousie University, 5850 University Avenue, Halifax, Nova Scotia B3J 3G9, Canada
    Arthritis Rheum 50:1595-603. 2004
    ....
  94. ncbi Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis
    Nicolino Ruperto
    IRCCS G Gasalini, Pediatria II, Genova, Italy
    Rheumatology (Oxford) 42:1452-9. 2003
    ..To identify preliminary core sets of outcome variables for disease activity and damage assessment in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM)...
  95. ncbi Normal scores for nine maneuvers of the Childhood Myositis Assessment Scale
    Robert M Rennebohm
    Division of Pediatric Rheumatolgy, Columbus Children s Hospital and The Ohio State University, 43205, USA
    Arthritis Rheum 51:365-70. 2004
    ..To document and evaluate the scores that normal, healthy children achieve when performing 9 maneuvers of the Childhood Myositis Assessment Scale (CMAS)...
  96. ncbi European Consensus Lupus Activity Measurement is sensitive to change in disease activity in childhood-onset systemic lupus erythematosus
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA
    Arthritis Rheum 49:335-41. 2003
    ..To confirm the construct validity and to characterize the measurement properties of the ECLAM by assessing its ability to predict damage and steroid requirements...
  97. ncbi Alternative scoring of the Cutaneous Assessment Tool in juvenile dermatomyositis: results using abbreviated formats
    Adam M Huber
    Izaak Walton Killam Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Arthritis Rheum 59:352-6. 2008
    ..The goal of this study was to determine whether alternative scoring methods would shorten the CAT without compromising its measurement characteristics...