Research Topics
| Hai Ling Margaret ChengSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Detail Information
Publications
Effect of hyperoxia and hypercapnia on tissue oxygen and perfusion response in the normal liver and kidneyHai Ling Margaret Cheng
Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
PLoS ONE 7:e40485. 2012..The objective of this study was to elucidate organ-specific physiological responses to gas challenge underlying MR measurements by investigating oxygenation and perfusion changes in the normal liver and kidney cortex...
Monitoring tissue development in acellular matrix-based regeneration for bladder tissue engineering: multiexponential diffusion and T2* for improved specificityHai Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
NMR Biomed 25:418-26. 2012..These findings are important for further development of more specific MRI methods for the monitoring of regeneration in tissue-engineered systems...- Improved correlation to quantitative DCE-MRI pharmacokinetic parameters using a modified initial area under the uptake curve (mIAUC) approachHai Ling Margaret Cheng
The Research Institute and Diagnostic Imaging, The Hospital for Sick Children and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
J Magn Reson Imaging 30:864-72. 2009..To propose a modified initial area under the uptake curve (mIAUC) dynamic contrast-enhanced (DCE)-MRI approach to achieve better distinction of underlying physiology... - Investigation and optimization of parameter accuracy in dynamic contrast-enhanced MRIHai Ling Margaret Cheng
Research Institute, Department of Diagnostic Imaging, Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
J Magn Reson Imaging 28:736-43. 2008.... 
Dynamic contrast-enhanced MRI in oncology drug developmentHai Ling Margaret Cheng
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
Curr Clin Pharmacol 2:111-22. 2007..We conclude with an outlook on the future of DCE-MRI, including its role in the emerging field of imaging molecular markers of angiogenesis for target-specific therapy...- MRI and contrast-enhanced ultrasound monitoring of prostate microwave focal thermal therapy: an in vivo canine studyHai Ling Margaret Cheng
Department of Diagnostic Imaging, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, Canada
J Magn Reson Imaging 28:136-43. 2008.... - The acellular matrix (ACM) for bladder tissue engineering: A quantitative magnetic resonance imaging studyHai Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Magn Reson Med 64:341-8. 2010.... - Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weightsHai Ling Margaret Cheng
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
J Magn Reson Imaging 25:137-45. 2007..To compare Gadomer, a macromolecular magnetic resonance (MR) contrast agent, and gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) for quantifying angiogenesis in tissue-engineered bladder constructs... - Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneityHai Ling Margaret Cheng
Department of Diagnostic Imaging and The Research Institute, The Hospital for Sick Children, Toronto, Canada
Magn Reson Med 55:566-74. 2006..A rapid B(1) (+) mapping sequence was employed in all phantom experiments and high-field in vivo brain scans. Experimental results confirmed the theory and validated the accuracy of the proposed method... - Dynamic Gd-DTPA enhanced MRI as a surrogate marker of angiogenesis in tissue-engineered bladder constructs: a feasibility study in rabbitsHai Ling Margaret Cheng
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
J Magn Reson Imaging 21:415-23. 2005.... - Usefulness of contrast kinetics for predicting and monitoring tissue changes in muscle following thermal therapy in long survival studiesHai Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
J Magn Reson Imaging 19:329-41. 2004..To investigate Gd-DTPA kinetics as indicators of subacute and subchronic histopathological changes following focused ultrasound (FUS) thermal therapy for improved evaluation... - Quantitative magnetic resonance imaging assessment of matrix development in cell-seeded natural urinary bladder smooth muscle tissue-engineered constructsHai Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Toronto, Canada
Tissue Eng Part C Methods 16:643-51. 2010..We conclude that quantitative MRI may provide specific information on cell-matrix interaction and is a promising noninvasive approach to understand and monitor cell-seeded natural scaffold-based regeneration... - Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRIJeff D Winter
Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
J Magn Reson Imaging 34:608-15. 2011..Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney... - A general dual-bolus approach for quantitative DCE-MRILucy E Kershaw
The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
Magn Reson Imaging 29:160-6. 2011..To present a dual-bolus technique for quantitative dynamic contrast-enhanced MRI (DCE-MRI) and show that it can give an arterial input function (AIF) measurement equivalent to that from a single-bolus protocol... - Monitoring angiogenesis in soft-tissue engineered constructs for calvarium bone regeneration: an in vivo longitudinal DCE-MRI studyMarine Beaumont
The Research Institute, The Hospital for Sick Children, Toronto, Canada
NMR Biomed 23:48-55. 2010.... - Normal tissue quantitative T1 and T2* MRI relaxation time responses to hypercapnic and hyperoxic gasesJeff D Winter
The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
Acad Radiol 18:1159-67. 2011..The objective for this study was to quantify independent effects of inhaled O(2) and CO(2) on normal tissue T(1) and T(2)* in rabbit liver, kidney, and paraspinal muscle... - T1 measurement of flowing blood and arterial input function determination for quantitative 3D T1-weighted DCE-MRIHai Ling Margaret Cheng
Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
J Magn Reson Imaging 25:1073-8. 2007..To propose a simple, accurate method for measuring T(1) in flowing blood and the arterial input function (AIF), and to evaluate the impact on dynamic contrast-enhanced MRI (DCE-MRI) quantification of pharmacokinetic parameters... - Impact of motion on T1 mapping acquired with inversion recovery fast spin echo and rapid spoiled gradient recalled-echo pulse sequences for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in volunteersUeli Studler
Department of Medical Imaging, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada
J Magn Reson Imaging 32:394-8. 2010.... - Prediction of subtle thermal histopathological change using a novel analysis of Gd-DTPA kineticsHai-Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Toronto, Canada
J Magn Reson Imaging 18:585-98. 2003..CONCLUSION: Our results suggest Gd-DTPA kinetics can predict different histopathological changes following FUS ablation and may be valuable for early prediction... - A technique for rapid single-echo spin-echo T2 mappingMarshall S Sussman
Medical Imaging, University Health Network, Toronto, Ontario, Canada
Magn Reson Med 64:536-45. 2010..g., immunity to stimulated echo effects, robustness to static field inhomogeneity, flexibility in the number and choice of echo times) in a considerably reduced amount of time and is readily implemented on any clinical scanner... - Temporal resolution and SNR requirements for accurate DCE-MRI data analysis using the AATH modelLucy E Kershaw
The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
Magn Reson Med 64:1772-80. 2010..A 10% error in the measured height of the arterial input function first pass peak resulted in an error of at most 10% in each model parameter... - Accurate liver T2 measurement of iron overload: a simulations investigation and in vivo studyMarine Beaumont
The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
J Magn Reson Imaging 30:313-20. 2009.... - Tissue thermal conductivity by magnetic resonance thermometry and focused ultrasound heatingHai-Ling Margaret Cheng
Department of Medical Biophysics, University of Toronto, Sunnybrook and Women's College Health Sciences Center, Toronto, Canada
J Magn Reson Imaging 16:598-609. 2002..This capability is relevant in thermal therapy planning of tumor ablation using MR-guided FUS systems... - Human aortic endothelial cell labeling with positive contrast gadolinium oxide nanoparticles for cellular magnetic resonance imaging at 7 TeslaYasir Loai
Department of Physiology and Experimental Medicine, The Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Mol Imaging 11:166-75. 2012..26 to 34.1 pg Gd/cell). Cell viability and proliferation were unaffected at the concentrations tested and up to at least 3 days postlabeling. Gd₂O₃ is a promising sensitive and stable positive contrast agent for cellular MRI at 7 T... - Delayed gadolinium-enhanced MR imaging of articular cartilage: three-dimensional T1 mapping with variable flip angles and B1 correctionGustav Andreisek
Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
Radiology 252:865-73. 2009.... - Dynamic contrast-enhanced MRI to quantify VEGF-enhanced tissue-engineered bladder graft neovascularization: pilot studyLisa Cartwright
The Hospital for Sick Children, Division of Urology, University of Toronto, Toronto, Ontario, Canada
J Biomed Mater Res A 77:390-5. 2006..This preliminary work demonstrates improved neovascularization of bladder constructs with VEGF fortification of ACM-HA and the feasibility of MRI as a non-invasive method to assume angiogenesis in tissue engineered constructs... - Practical medical applications of quantitative MR relaxometryHai Ling Margaret Cheng
Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
J Magn Reson Imaging 36:805-24. 2012..It concludes with three case studies of quantitative relaxometry applied to studying multiple sclerosis, liver iron, and acute myocardial infarction... - Quantitative MRI assessment of VX2 tumour oxygenation changes in response to hyperoxia and hypercapniaJeff D Winter
The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
Phys Med Biol 56:1225-42. 2011..This observation supports the predominance of dissolved O(2) on R(1) sensitivity and demonstrates the value of R(1) over R(2)* for tissue oxygenation measures...