Hai Ling Margaret Cheng

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Effect of hyperoxia and hypercapnia on tissue oxygen and perfusion response in the normal liver and kidney
    Hai Ling Margaret Cheng
    Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    PLoS ONE 7:e40485. 2012
  2. doi request reprint Monitoring tissue development in acellular matrix-based regeneration for bladder tissue engineering: multiexponential diffusion and T2* for improved specificity
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    NMR Biomed 25:418-26. 2012
  3. doi request reprint Improved correlation to quantitative DCE-MRI pharmacokinetic parameters using a modified initial area under the uptake curve (mIAUC) approach
    Hai Ling Margaret Cheng
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Magn Reson Imaging 30:864-72. 2009
  4. doi request reprint The acellular matrix (ACM) for bladder tissue engineering: A quantitative magnetic resonance imaging study
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 64:341-8. 2010
  5. doi request reprint Quantitative magnetic resonance imaging assessment of matrix development in cell-seeded natural urinary bladder smooth muscle tissue-engineered constructs
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Tissue Eng Part C Methods 16:643-51. 2010
  6. doi request reprint Investigation and optimization of parameter accuracy in dynamic contrast-enhanced MRI
    Hai Ling Margaret Cheng
    Research Institute, Department of Diagnostic Imaging, Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
    J Magn Reson Imaging 28:736-43. 2008
  7. ncbi request reprint Dynamic contrast-enhanced MRI in oncology drug development
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Clin Pharmacol 2:111-22. 2007
  8. doi request reprint MRI and contrast-enhanced ultrasound monitoring of prostate microwave focal thermal therapy: an in vivo canine study
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, Canada
    J Magn Reson Imaging 28:136-43. 2008
  9. ncbi request reprint Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 25:137-45. 2007
  10. ncbi request reprint Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneity
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging and The Research Institute, The Hospital for Sick Children, Toronto, Canada
    Magn Reson Med 55:566-74. 2006

Collaborators

Detail Information

Publications30

  1. pmc Effect of hyperoxia and hypercapnia on tissue oxygen and perfusion response in the normal liver and kidney
    Hai Ling Margaret Cheng
    Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    PLoS ONE 7:e40485. 2012
    ..The objective of this study was to elucidate organ-specific physiological responses to gas challenge underlying MR measurements by investigating oxygenation and perfusion changes in the normal liver and kidney cortex...
  2. doi request reprint Monitoring tissue development in acellular matrix-based regeneration for bladder tissue engineering: multiexponential diffusion and T2* for improved specificity
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    NMR Biomed 25:418-26. 2012
    ..These findings are important for further development of more specific MRI methods for the monitoring of regeneration in tissue-engineered systems...
  3. doi request reprint Improved correlation to quantitative DCE-MRI pharmacokinetic parameters using a modified initial area under the uptake curve (mIAUC) approach
    Hai Ling Margaret Cheng
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Magn Reson Imaging 30:864-72. 2009
    ..To propose a modified initial area under the uptake curve (mIAUC) dynamic contrast-enhanced (DCE)-MRI approach to achieve better distinction of underlying physiology...
  4. doi request reprint The acellular matrix (ACM) for bladder tissue engineering: A quantitative magnetic resonance imaging study
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 64:341-8. 2010
    ....
  5. doi request reprint Quantitative magnetic resonance imaging assessment of matrix development in cell-seeded natural urinary bladder smooth muscle tissue-engineered constructs
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Tissue Eng Part C Methods 16:643-51. 2010
    ..We conclude that quantitative MRI may provide specific information on cell-matrix interaction and is a promising noninvasive approach to understand and monitor cell-seeded natural scaffold-based regeneration...
  6. doi request reprint Investigation and optimization of parameter accuracy in dynamic contrast-enhanced MRI
    Hai Ling Margaret Cheng
    Research Institute, Department of Diagnostic Imaging, Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
    J Magn Reson Imaging 28:736-43. 2008
    ....
  7. ncbi request reprint Dynamic contrast-enhanced MRI in oncology drug development
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Clin Pharmacol 2:111-22. 2007
    ..We conclude with an outlook on the future of DCE-MRI, including its role in the emerging field of imaging molecular markers of angiogenesis for target-specific therapy...
  8. doi request reprint MRI and contrast-enhanced ultrasound monitoring of prostate microwave focal thermal therapy: an in vivo canine study
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, Canada
    J Magn Reson Imaging 28:136-43. 2008
    ....
  9. ncbi request reprint Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 25:137-45. 2007
    ..To compare Gadomer, a macromolecular magnetic resonance (MR) contrast agent, and gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) for quantifying angiogenesis in tissue-engineered bladder constructs...
  10. ncbi request reprint Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneity
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging and The Research Institute, The Hospital for Sick Children, Toronto, Canada
    Magn Reson Med 55:566-74. 2006
    ..A rapid B(1) (+) mapping sequence was employed in all phantom experiments and high-field in vivo brain scans. Experimental results confirmed the theory and validated the accuracy of the proposed method...
  11. ncbi request reprint Dynamic Gd-DTPA enhanced MRI as a surrogate marker of angiogenesis in tissue-engineered bladder constructs: a feasibility study in rabbits
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 21:415-23. 2005
    ....
  12. ncbi request reprint Usefulness of contrast kinetics for predicting and monitoring tissue changes in muscle following thermal therapy in long survival studies
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
    J Magn Reson Imaging 19:329-41. 2004
    ..To investigate Gd-DTPA kinetics as indicators of subacute and subchronic histopathological changes following focused ultrasound (FUS) thermal therapy for improved evaluation...
  13. ncbi request reprint Prediction of subtle thermal histopathological change using a novel analysis of Gd-DTPA kinetics
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    J Magn Reson Imaging 18:585-98. 2003
    ..To investigate Gd-DTPA kinetics as predictors of histopathological changes following focused ultrasound (FUS) thermal ablation for improved planning and assessment...
  14. doi request reprint Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI
    Jeff D Winter
    Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 34:608-15. 2011
    ..Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney...
  15. doi request reprint Normal tissue quantitative T1 and T2* MRI relaxation time responses to hypercapnic and hyperoxic gases
    Jeff D Winter
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Acad Radiol 18:1159-67. 2011
    ..The objective for this study was to quantify independent effects of inhaled O(2) and CO(2) on normal tissue T(1) and T(2)* in rabbit liver, kidney, and paraspinal muscle...
  16. ncbi request reprint Dynamic contrast-enhanced MRI to quantify VEGF-enhanced tissue-engineered bladder graft neovascularization: pilot study
    Lisa Cartwright
    The Hospital for Sick Children, Division of Urology, University of Toronto, Toronto, Ontario, Canada
    J Biomed Mater Res A 77:390-5. 2006
    ..This preliminary work demonstrates improved neovascularization of bladder constructs with VEGF fortification of ACM-HA and the feasibility of MRI as a non-invasive method to assume angiogenesis in tissue engineered constructs...
  17. doi request reprint Monitoring angiogenesis in soft-tissue engineered constructs for calvarium bone regeneration: an in vivo longitudinal DCE-MRI study
    Marine Beaumont
    The Research Institute, The Hospital for Sick Children, Toronto, Canada
    NMR Biomed 23:48-55. 2010
    ....
  18. doi request reprint A general dual-bolus approach for quantitative DCE-MRI
    Lucy E Kershaw
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Magn Reson Imaging 29:160-6. 2011
    ..To present a dual-bolus technique for quantitative dynamic contrast-enhanced MRI (DCE-MRI) and show that it can give an arterial input function (AIF) measurement equivalent to that from a single-bolus protocol...
  19. ncbi request reprint Tissue thermal conductivity by magnetic resonance thermometry and focused ultrasound heating
    Hai Ling Margaret Cheng
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
    J Magn Reson Imaging 16:598-609. 2002
    ..To investigate the combined use of magnetic resonance (MR) temperature imaging and focused ultrasound (FUS) for the noninvasive determination of tissue thermal properties...
  20. doi request reprint Impact of motion on T1 mapping acquired with inversion recovery fast spin echo and rapid spoiled gradient recalled-echo pulse sequences for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in volunteers
    Ueli Studler
    Department of Medical Imaging, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada
    J Magn Reson Imaging 32:394-8. 2010
    ....
  21. ncbi request reprint T1 measurement of flowing blood and arterial input function determination for quantitative 3D T1-weighted DCE-MRI
    Hai Ling Margaret Cheng
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Magn Reson Imaging 25:1073-8. 2007
    ..To propose a simple, accurate method for measuring T(1) in flowing blood and the arterial input function (AIF), and to evaluate the impact on dynamic contrast-enhanced MRI (DCE-MRI) quantification of pharmacokinetic parameters...
  22. doi request reprint Accurate liver T2 measurement of iron overload: a simulations investigation and in vivo study
    Marine Beaumont
    The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Magn Reson Imaging 30:313-20. 2009
    ....
  23. doi request reprint Quantitative MRI assessment of VX2 tumour oxygenation changes in response to hyperoxia and hypercapnia
    Jeff D Winter
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    Phys Med Biol 56:1225-42. 2011
    ..This observation supports the predominance of dissolved O(2) on R(1) sensitivity and demonstrates the value of R(1) over R(2)* for tissue oxygenation measures...
  24. doi request reprint A technique for rapid single-echo spin-echo T2 mapping
    Marshall S Sussman
    Medical Imaging, University Health Network, Toronto, Ontario, Canada
    Magn Reson Med 64:536-45. 2010
    ..g., immunity to stimulated echo effects, robustness to static field inhomogeneity, flexibility in the number and choice of echo times) in a considerably reduced amount of time and is readily implemented on any clinical scanner...
  25. doi request reprint Temporal resolution and SNR requirements for accurate DCE-MRI data analysis using the AATH model
    Lucy E Kershaw
    The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    Magn Reson Med 64:1772-80. 2010
    ..A 10% error in the measured height of the arterial input function first pass peak resulted in an error of at most 10% in each model parameter...
  26. pmc Ultrashort echo time for improved positive-contrast manganese-enhanced MRI of cancer
    Joris Tchouala Nofiele
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    PLoS ONE 8:e58617. 2013
    ..To overcome these limitations, this study investigates the use of ultrashort echo time (UTE) and subtraction UTE (SubUTE) imaging for more sensitive and specific determination of Mn accumulation...
  27. ncbi request reprint Human aortic endothelial cell labeling with positive contrast gadolinium oxide nanoparticles for cellular magnetic resonance imaging at 7 Tesla
    Yasir Loai
    Department of Physiology and Experimental Medicine, The Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
    Mol Imaging 11:166-75. 2012
    ..26 to 34.1 pg Gd/cell). Cell viability and proliferation were unaffected at the concentrations tested and up to at least 3 days postlabeling. Gd₂O₃ is a promising sensitive and stable positive contrast agent for cellular MRI at 7 T...
  28. doi request reprint Delayed gadolinium-enhanced MR imaging of articular cartilage: three-dimensional T1 mapping with variable flip angles and B1 correction
    Gustav Andreisek
    Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    Radiology 252:865-73. 2009
    ....
  29. doi request reprint Practical medical applications of quantitative MR relaxometry
    Hai Ling Margaret Cheng
    Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
    J Magn Reson Imaging 36:805-24. 2012
    ..It concludes with three case studies of quantitative relaxometry applied to studying multiple sclerosis, liver iron, and acute myocardial infarction...
  30. pmc Concurrent dual contrast for cellular magnetic resonance imaging using gadolinium oxide and iron oxide nanoparticles
    Yasir Loai
    Physiology and Experimental Medicine, The Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Int J Mol Imaging 2012:230942. 2012
    ..Conclusion. It is feasible to use Gd oxide and Fe oxide for dual contrast and concurrent discrimination of two colocalized cell populations on MRI at 7 tesla...