Eric Bouffet

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi request reprint Salvage chemotherapy for metastatic and recurrent ependymoma of childhood
    Eric Bouffet
    Paediatric Neuro Oncology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G1X8, Canada
    Childs Nerv Syst 25:1293-301. 2009
  2. doi request reprint Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation
    Eric Bouffet
    Department of Hematology Oncology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 83:1541-8. 2012
  3. doi request reprint Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma
    Eric Bouffet
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 30:1358-63. 2012
  4. doi request reprint The 2008 annual meeting of the International Society for Pediatric Neurosurgery: highlights of the oncology session
    Eric Bouffet
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Expert Rev Neurother 9:43-5. 2009
  5. doi request reprint The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors
    Eric Bouffet
    Neuro Oncology Program, Department of Hematology Oncology, The Hospital for Sick Children, Ontario, Canada
    Pediatr Blood Cancer 54:644-6. 2010
  6. ncbi request reprint Possibilities of new therapeutic strategies in brain tumors
    Eric Bouffet
    The Hospital for Sick Children, Toronto, Canada
    Cancer Treat Rev 36:335-41. 2010
  7. doi request reprint Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy
    Tal Finkelstein-Shechter
    Bone Marrow Transplant Program, Hospital for Sick Children, Toronto, Canada
    J Pediatr Hematol Oncol 32:e182-6. 2010
  8. ncbi request reprint Natural history and outcome of optic pathway gliomas in children
    Gary Nicolin
    Pediatric Brain Tumor Program, Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 53:1231-7. 2009
  9. doi request reprint Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas
    Katrin Scheinemann
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Pediatr Blood Cancer 57:84-8. 2011
  10. ncbi request reprint Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience
    Lucie Lafay-Cousin
    Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 112:892-9. 2008

Detail Information

Publications86

  1. doi request reprint Salvage chemotherapy for metastatic and recurrent ependymoma of childhood
    Eric Bouffet
    Paediatric Neuro Oncology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G1X8, Canada
    Childs Nerv Syst 25:1293-301. 2009
    ..At the time of recurrence, the role of chemotherapy is also ill defined and the choice of chemotherapeutic agents is often arbitrary, based on anecdotal data and personal experience...
  2. doi request reprint Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation
    Eric Bouffet
    Department of Hematology Oncology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 83:1541-8. 2012
    ..The outcome of recurrent ependymoma in children is dismal. Reirradiation has been proposed as an effective modality for ependymoma at relapse. However, the toxicity and outcome benefits of this approach have not been well established...
  3. doi request reprint Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma
    Eric Bouffet
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 30:1358-63. 2012
    ..To evaluate the efficacy of single-agent vinblastine in pediatric patients with recurrent or refractory low-grade glioma...
  4. doi request reprint The 2008 annual meeting of the International Society for Pediatric Neurosurgery: highlights of the oncology session
    Eric Bouffet
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Expert Rev Neurother 9:43-5. 2009
    ..This year's 36th annual meeting took place in Cape Town, South Africa, and focused on different topics, including pediatric neuro-oncology, which is the subject of this report...
  5. doi request reprint The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors
    Eric Bouffet
    Neuro Oncology Program, Department of Hematology Oncology, The Hospital for Sick Children, Ontario, Canada
    Pediatr Blood Cancer 54:644-6. 2010
    ..These promising results have led some cooperative groups to incorporate in their protocols a high dose chemotherapy component for newly diagnosed patients with high-risk features or poor response to initial chemotherapy...
  6. ncbi request reprint Possibilities of new therapeutic strategies in brain tumors
    Eric Bouffet
    The Hospital for Sick Children, Toronto, Canada
    Cancer Treat Rev 36:335-41. 2010
    ..The role of molecularly targeted agents is still unclear and a number of phase I and II trials are ongoing to better define the future of these new therapies in pediatric brain tumors...
  7. doi request reprint Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy
    Tal Finkelstein-Shechter
    Bone Marrow Transplant Program, Hospital for Sick Children, Toronto, Canada
    J Pediatr Hematol Oncol 32:e182-6. 2010
    ..To retrospectively review an institutional experience in managing atypical teratoid/rhabdoid tumors (AT/RT) of the Central Nervous System with high-dose chemotherapy in infants and children less than 4 years old...
  8. ncbi request reprint Natural history and outcome of optic pathway gliomas in children
    Gary Nicolin
    Pediatric Brain Tumor Program, Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 53:1231-7. 2009
    ..The optimal management of optic pathway gliomas (OPGs) is complicated by their variable natural history, the association with neurofibromatosis type 1 (NF1) and difficulties in defining progression and response to treatment...
  9. doi request reprint Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas
    Katrin Scheinemann
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Pediatr Blood Cancer 57:84-8. 2011
    ..Treatment modalities for further progression are not clearly established. The aim of the study was to determine the feasibility and long-term outcome of repeated chemotherapy for children with recurrent LGG...
  10. ncbi request reprint Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience
    Lucie Lafay-Cousin
    Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 112:892-9. 2008
    ..Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy...
  11. ncbi request reprint Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent
    Vijay Ramaswamy
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Pediatr Blood Cancer 61:1190-4. 2014
    ..In light of the recent discovery of distinct medulloblastoma subgroups, we sought to define the initial presentation of childhood medulloblastoma in a subgroup specific manner...
  12. ncbi request reprint Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem
    Milind Ronghe
    Pediatric Brain Tumor Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 55:471-7. 2010
    ..The majority of the published experience is in children with hypothalamic/optic chiasmatic lesions and little information is available regarding its use in LGG of the brainstem...
  13. pmc Chemotherapy versus supportive care alone in pediatric palliative care for cancer: comparing the preferences of parents and health care professionals
    Deborah Tomlinson
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont
    CMAJ 183:E1252-8. 2011
    ..We compared the strength of these preferences by considering children's quality of life and survival time as key attributes. In addition, we identified factors associated with the reported preferences...
  14. ncbi request reprint Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma
    Uri Tabori
    Pediatric Brain Tumor Program, The Hospital for Sick Children, Toronto, and Department of Hematology Oncology, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 64:402-7. 2006
    ..To report the clinical course of adolescents with medulloblastoma, with specific emphasis on prognosis and pattern of relapse...
  15. doi request reprint A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma
    Julia R Sharp
    Department of Paediatrics Division of Haematology Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Eur J Cancer 46:3271-9. 2010
    ..This study aimed to evaluate the safety and efficacy of this regimen in paediatric DIBSG patients...
  16. doi request reprint Long-term quality of life in children treated for posterior fossa brain tumors
    Abhaya V Kulkarni
    Divisions of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 12:235-40. 2013
    ..The authors' objective was to assess the long-term QOL in survivors of PFBT...
  17. doi request reprint Core neurocognitive functions in children treated for posterior fossa tumors
    Donald J Mabbott
    Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuropsychology 22:159-68. 2008
    ..The authors consider information processing speed to be an excellent candidate mechanism in understanding the impact of cranial radiation on intellectual outcome...
  18. pmc Optic pathway gliomas in adolescence--time to challenge treatment choices?
    Amy Lee Chong
    The Hospital for Sick Children, Division of Haematology Oncology, 555 University Avenue, Toronto, ON, Canada
    Neuro Oncol 15:391-400. 2013
    ..National trials have focused on younger children and excluded adolescents from studies evaluating the role of chemotherapy...
  19. pmc Clinical and neuroanatomical predictors of cerebellar mutism syndrome
    Nicole Law
    Program in Neuroscience and Mental Health, Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada
    Neuro Oncol 14:1294-303. 2012
    ..Our findings may be relevant for surgical planning and speech-language therapy to mitigate symptoms of CMS...
  20. doi request reprint Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations
    Uri Tabori
    Divisions of Haematology Oncology, The LabattBrain Tumor Research Centre, TheHospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 28:1345-50. 2010
    ....
  21. pmc Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 123:615-26. 2012
    ....
  22. doi request reprint Spinal cord tumors in children under the age of 3 years: a retrospective Canadian review
    Shayna Zelcer
    Division of Oncology, Children s Hospital, London Health Sciences Center, London, Ontario, N6C 2V5, Canada
    Childs Nerv Syst 27:1089-94. 2011
    ..The objectives of our study were to describe the demographic characteristics of spinal cord tumors (SCT) in children less than 3 years of age at diagnosis and to review their treatment and outcome...
  23. doi request reprint Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory
    Nicole Law
    Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuroimage 56:2238-48. 2011
    ..Identifying differences in the structural integrity of white matter for specific pathways is an essential step in attempting to localize the effects of posterior fossa tumors and their treatment methods...
  24. pmc TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
    Marc Remke
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 126:917-29. 2013
    ..TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes...
  25. doi request reprint Successful treatment of a recurrent choroid plexus carcinoma with surgery followed by high-dose chemotherapy and stem cell rescue
    Othman Mosleh
    Neuro Oncology Program, Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Hematol Oncol 30:386-91. 2013
    ..Remarkably the patient remains without evidence of recurrence 5 years after completion of therapy. Additional studies are necessary to determine the role of HDC and stem cell rescue in patients with recurrent CPC...
  26. doi request reprint Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma
    Pawel Buczkowicz
    Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada
    Brain Pathol 23:244-53. 2013
    ..Our data highlight Aurora B as a potential therapeutic target in DIPG...
  27. doi request reprint Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature
    Anita Villani
    Division of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    J Neurooncol 88:309-14. 2008
    ..Based on an unusual case of a basal ganglia germinoma in a 13-year-old Caucasian male, we highlight the diagnostic challenges and discuss treatment considerations in this disease...
  28. doi request reprint Favorable outcome with conservative treatment for children with low grade brainstem tumors
    Iris Fried
    Pediatric Brain Tumor Program, Division of Pediatric Hematology and Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 58:556-60. 2012
    ..In order to better define risk groups and evaluate treatment options for pediatric BST, we performed a comprehensive analysis of all BST patients treated in our hospital during the MRI era...
  29. doi request reprint Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood
    Donald J Mabbott
    Department of Psychology, The Hospital for Sick Children, Toronto, Canada
    Cancer 117:5402-11. 2011
    ..Knowledge about neurocognitive outcome in these patients is limited. Longitudinal neurocognitive outcome in CNS GCT patients seen for neuropsychological evaluation at a single institution was explored...
  30. pmc The role of telomere maintenance in the spontaneous growth arrest of pediatric low-grade gliomas
    Uri Tabori
    Division of Hematology Oncology, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Neoplasia 8:136-42. 2006
    ..Our findings provide a plausible biologic mechanism to explain the tendency of PLGG to exhibit growth arrest and spontaneous regression. Telomere maintenance may therefore represent the first known biologic prognostic marker in PLGG...
  31. ncbi request reprint Medulloblastoma in children under the age of three years: a retrospective Canadian review
    Donna L Johnston
    Division of Oncology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa K1H 8L1, Ontario, Canada
    J Neurooncol 94:51-6. 2009
    ....
  32. doi request reprint Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy
    Samina Afzal
    Division of Haematology Oncology Neuro Oncology, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    J Neurooncol 97:393-9. 2010
    ..The role of these agents in the management of ICGT should be carefully evaluated and guidelines for management of DI established...
  33. pmc Neurocognitive function in same-sex twins following focal radiation for medulloblastoma
    Donald J Mabbott
    Department of Psychology, Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    Neuro Oncol 9:460-4. 2007
    ....
  34. doi request reprint TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors
    Uri Tabori
    The Hospital for Sick Children, Division of Hematology Oncology, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada
    J Clin Oncol 28:1995-2001. 2010
    ..CONCLUSION Patients with CPC who have low tumor TSV and absence of TP53 dysfunction have a favorable prognosis and can be successfully treated without radiation therapy...
  35. ncbi request reprint Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma
    Uri Tabori
    Division of Hematology Oncology, The Hospital for Sick Children and the University of Toronto, Toronto, Canada
    J Clin Oncol 24:1522-8. 2006
    ....
  36. pmc Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
    Vijay Ramaswamy
    Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 14:1200-7. 2013
    ..Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We sought to delineate subgroup-specific differences in medulloblastoma recurrence patterns...
  37. doi request reprint Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor
    Meihua Li
    Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
    Cancer Genet 205:220-31. 2012
    ..Our data suggest that CDK/CYCLIND gene amplification may represent important mechanisms for functional inactivation of pRB in medulloblastoma and sPNET...
  38. doi request reprint Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets
    Maryam Zarghooni
    Division of Pathology andHaematology, The Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 28:1337-44. 2010
    ..Herein, we address this lack of knowledge by performing the first high-resolution single nucleotide polymorphism (SNP) -based DNA microarray analysis of a series of DIPGs...
  39. pmc Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes
    Kim Edelstein
    Psychosocial Oncology and Palliative Care, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
    Neuro Oncol 13:536-45. 2011
    ..It will become increasingly important to identify factors that contribute to risk and resilience in this growing population...
  40. ncbi request reprint Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood
    Donald J Mabbott
    Paediatric Brain Tumor Program, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada
    J Clin Oncol 23:2256-63. 2005
    ..To evaluate academic and behavioral outcome in radiated survivors of posterior fossa (PF) tumors...
  41. doi request reprint Neural correlates of delayed visual-motor performance in children treated for brain tumours
    Colleen Dockstader
    The Hospital for Sick Children, Department of Psychology, Toronto, ON, Canada
    Cortex 49:2140-50. 2013
    ..This is the first study to investigate neural function in real-time during cognitive performance in paediatric brain tumour patients. ..
  42. doi request reprint Chronic residual lesions in metastatic medulloblastoma patients
    Iris Fried
    Neuro Oncology Program, Division of Paediatric Haematology and Oncology, The Hospital for Sick Children, University of Toronto Department of Radiation Oncology, Princess Margaret Hospital Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada Department of Pediatrics, Hadassah Medical Center, Division of Pediatric Hematology and Oncology, Jerusalem, Israel
    J Pediatr Hematol Oncol 36:71-5. 2014
    ..Despite persistent magnetic resonance imaging findings, the patients are alive and well 13 and 7 years after diagnosis with no further treatment applied. The nature of these residual abnormalities is discussed. ..
  43. ncbi request reprint Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma
    Iska Moxon-Emre
    Iska Moxon Emre, Eric Bouffet, Michael D Taylor, Nadia Scantlebury, Nicole Law, Brenda J Spiegler, David Malkin, Laura Janzen, and Donald Mabbott, Hospital for Sick Children Iska Moxon Emre, Michael D Taylor, Normand Laperriere, Brenda J Spiegler, David Malkin, and Laura Janzen, University of Toronto and Normand Laperriere, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Oncol 32:1760-8. 2014
    ....
  44. ncbi request reprint Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
    Nataliya Zhukova
    University of Toronto, Toronto, Canada
    J Clin Oncol 31:2927-35. 2013
    ..Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles...
  45. doi request reprint Pulmonary hypertensive vasculopathy following tandem autologous transplantation in pediatric patients with central nervous system tumors
    Tal Schechter
    Blood and Marrow Transplantation Section, Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Biol Blood Marrow Transplant 19:235-9. 2013
    ..There is an urgent need to evaluate PAH as a potential complication after each cycle of high-dose chemotherapy when using such regimens in pediatric patients with CNS tumors...
  46. pmc Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis
    Daniel Picard
    Division of Hematology Oncology, Arthur and Sonia Labatt Brain Tumour Research Centre, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 13:838-48. 2012
    ..We assessed a large cohort of these rare tumours to identify molecular markers to enhance clinical management of this disease...
  47. ncbi request reprint Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management: a Canadian Pediatric Brain Tumor Consortium Study
    Uri Tabori
    Pediatric Brain Tumor Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 103:1874-80. 2005
    ..To consider the feasibility of this approach in adolescents, the authors studied their clinical course with specific emphasis on toxicity, tolerability, and prognosis...
  48. ncbi request reprint Limited-field radiation for bifocal germinoma
    Lucie Lafay-Cousin
    Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 65:486-92. 2006
    ..To report the incidence, characteristics, treatment, and outcomes of bifocal germinomas treated with chemotherapy followed by focal radiation...
  49. ncbi request reprint Role of spinal MRI in the follow-up of children treated for medulloblastoma
    Ute Bartels
    Division of Haematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 107:1340-7. 2006
    ..The purpose of the current study was to describe the usefulness of spinal magnetic resonance imaging (MRI) in children with medulloblastoma or primitive neuroectodermal tumor (PNET) of the posterior fossa...
  50. pmc Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
    Pawel Buczkowicz
    1 Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada 2 Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada 3 Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 4
    Nat Genet 46:451-6. 2014
    ..Our results highlight distinct molecular subgroups and novel therapeutic targets for this incurable pediatric cancer. ..
  51. ncbi request reprint Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction
    Lucie Lafay-Cousin
    Hospital for Sick Children, Toronto, Canada
    Cancer 103:2636-42. 2005
    ..Desensitization has been the recommended approach for HSR. However, no guidelines have existed to aid physicians when carboplatin desensitization techniques fail...
  52. doi request reprint Post mortem examinations in diffuse intrinsic pontine glioma: challenges and chances
    Paola Angelini
    Division of Paediatric Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurooncol 101:75-81. 2011
    ..The families derived comfort from the hope that scientific breakthroughs could be made and felt that they were helping to make a difference in the future management of DIPG...
  53. pmc Clonal selection drives genetic divergence of metastatic medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nature 482:529-33. 2012
    ..Failure to account for the bicompartmental nature of metastatic medulloblastoma could be a major barrier to the development of effective targeted therapies...
  54. doi request reprint A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours
    Sylvain Baruchel
    Department of Paediatrics Division of Haematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Eur J Cancer 45:2352-9. 2009
    ..To evaluate the safety, efficacy and pharmacokinetics of imatinib in children with recurrent or refractory central nervous system (CNS) tumours expressing KIT and/or PDGFRA...
  55. doi request reprint Diffuse intrinsic brainstem tumors in neonates. Report of two cases
    Niketa C Shah
    Division of Hematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg Pediatr 1:382-5. 2008
    ..The rapid tumor progression in both cases indicates that where a diagnostic procedure may pose significant risks, supportive observation can aid in distinguishing malignant from benign tumor growth...
  56. doi request reprint BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
    Cynthia Hawkins
    Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Cancer Res 17:4790-8. 2011
    ..However, the clinical significance of this genetic alteration is yet to be determined. We aimed to test the prognostic role of the B-K fusion in progression of incompletely resected PLGA...
  57. ncbi request reprint Vascularity and angiogenesis as predictors of growth in optic pathway/hypothalamic gliomas
    Ute Bartels
    Division of Hematology Oncology, Pediatric Brain Tumor Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 104:314-20. 2006
    ..The authors' aim in conducting this study was to investigate retrospectively the prognostic significance of angiogenic features in optic pathway/hypothalamic gliomas (OPHGs) in children...
  58. doi request reprint Favorable survival and metabolic outcome for children with diencephalic syndrome using a radiation-sparing approach
    John Paul Kilday
    Division of Haematology Oncology, Department of Pediatric Neuro Oncology, Hospital for Sick Children, University Avenue, University of Toronto, Toronto, ON, M5G 1X8, Canada
    J Neurooncol 116:195-204. 2014
    ..Continued surveillance is mandatory to prevent significant weight gain and support affected children with clinical sequelae...
  59. pmc Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    Paul A Northcott
    Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Nature 488:49-56. 2012
    ..Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy...
  60. ncbi request reprint Primary central nervous system sarcomas in children: clinical, radiological, and pathological features
    Mubarak Al-Gahtany
    Division of Neurosurgery, Suite 1502, Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Canada
    Childs Nerv Syst 19:808-17. 2003
    ..Fourteen children (87%) had an intracranial sarcoma, and 2 (13%) had intraspinal tumors. Nine intracranial tumors (60%) were supratentorial. The parietal and temporal regions were the most frequently involved sites...
  61. doi request reprint Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
    ..We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups...
  62. ncbi request reprint Neuroradiological findings of bleomycin leakage in cystic craniopharyngioma. Report of three cases
    Lucie Lafay-Cousin
    Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 107:318-23. 2007
    ..In the authors' experience, the toxicity to bleomycin was transient. Management of the toxicity using high-dose steroid administration appears to contribute to controlling the bleomycin-induced inflammatory process...
  63. doi request reprint Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 122:231-40. 2011
    ..Collectively, our data demonstrate that pediatric and adult Shh-medulloblastomas are clinically, transcriptionally, genetically, and prognostically distinct...
  64. ncbi request reprint Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy
    Rodrigo V Ozelame
    Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatr Radiol 36:325-30. 2006
    ..The association of cerebral and/or brain stem atrophy with basal ganglia germinoma on CT and MRI is found in 33% of the cases...
  65. ncbi request reprint White matter growth as a mechanism of cognitive development in children
    Donald J Mabbott
    Brain and Behavior Program, Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, ON, Toronto, Ontario, Canada M5G 1X8
    Neuroimage 33:936-46. 2006
    ....
  66. doi request reprint Anaplastic medulloblastoma in a child with Duchenne muscular dystrophy
    Machiel van den Akker
    Division of Haematology Oncology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 10:21-4. 2012
    ..This is the second report of a malignant brain tumor in a boy with DMD. The possible link between the 2 conditions is discussed, as are ethical considerations regarding the management of medulloblastoma in children with DMD...
  67. ncbi request reprint A clinicobiological model predicting survival in medulloblastoma
    Amit Ray
    Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Cancer Res 10:7613-20. 2004
    ..The purpose of this study was to determine the relative contributions of biological and clinical predictors of survival in patients with medulloblastoma (MB)...
  68. ncbi request reprint Evaluation of dietetic intervention in children with medulloblastoma or supratentorial primitive neuroectodermal tumors
    Jaimie Bakish
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cancer 98:1014-20. 2003
    ..The goal of the current study was to evaluate the effect of dietetic intervention in a cohort of children treated for medulloblastoma and supratentorial primitive neuroectodermal tumors (PNET) over a 10-year period...
  69. doi request reprint Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors
    Catherine Lam
    Division of Haematology Oncology, Neuro Oncology Program, The Hospital for Sick Children, Toronto, Canada
    Pediatr Blood Cancer 54:476-9. 2010
    ..We summarize our institutional experience and literature review that highlight potential benefits and hazards of rapamycin therapy, for TSC patients with SEGA, and other syndromal brain tumors...
  70. doi request reprint Intracerebral malignant peripheral nerve sheath tumor in a child with neurofibromatosis Type 1 and middle cerebral artery aneurysm treated with endovascular coil embolization
    Michael J Ellis
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 8:346-52. 2011
    ..While patients with NF1 represent a population with genetic susceptibility to radiation-induced tumors, the pathogenesis of intracerebral MPNSTs remains poorly understood...
  71. ncbi request reprint Imaging findings in primary intracranial atypical teratoid/rhabdoid tumors
    Hemant Parmar
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Pediatr Radiol 36:126-32. 2006
    ..Imaging features are often considered non-specific. However, correct diagnosis of AT/RT is important because these tumors have a markedly different clinical prognosis and require more aggressive therapy...
  72. ncbi request reprint Massive plexiform neurofibromas in childhood: natural history and management issues
    Demitre Serletis
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 106:363-7. 2007
    ..The authors review their experience with massive plexiform neurofibromas (PNs) in patients with pediatric neurofibromatosis Type 1 (NF1) to better characterize the natural history and management of these complex lesions...
  73. pmc Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: correlation with IQ
    Donald J Mabbott
    Brain and Behavior Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Neuro Oncol 8:244-52. 2006
    ..A novel finding was that microscopic damage in normal-appearing white matter, as indexed by higher ADC and lower FA, was related to poor intellectual outcome relative to age-matched controls...
  74. doi request reprint Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG
    Ute Bartels
    Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada
    J Neurooncol 105:119-25. 2011
    ..The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed...
  75. ncbi request reprint Pilomyxoid astrocytoma in a patient with neurofibromatosis
    Muhammad Faisal Khanani
    Department of Hematology Oncology, Paediatric Brain Tumor Programme, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 46:377-80. 2006
    ..The patient demonstrated a partial response to chemotherapy. The authors review the literature on PMA and discuss the specific issues associated with this diagnosis in the context of a child with neurofibromatosis...
  76. ncbi request reprint Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells
    Annie Huang
    Cancer Research Program, Canada
    Cancer Res 65:5607-19. 2005
    ....
  77. ncbi request reprint Parental decision making in pediatric cancer end-of-life care: using focus group methodology as a prephase to seek participant design input
    Deborah Tomlinson
    Population Health Sciences, Hospital for Sick Children, 123 Edward Street, Toronto, Ont, Canada M5G 1E2
    Eur J Oncol Nurs 10:198-206. 2006
    ..We found it was extremely beneficial to include a focus group pre-phase in a study that will interview parents in a high sensitivity area...
  78. pmc Intracystic therapies for cystic craniopharyngioma in childhood
    Ute Bartels
    Paediatric Brain Tumour Program, Division of Haematology Oncology, The Hospital for Sick Children Toronto, ON, Canada
    Front Endocrinol (Lausanne) 3:39. 2012
    ..The authors advocate for consensus on prospective data collection and standardized intracystic treatment strategies to allow reliable comparisons and herewith optimize treatment and outcome...
  79. ncbi request reprint Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma
    Mei Hua Li
    Arthur and Sonia Labatt Brain Tumor Research Centre, Cancer Research Program, Division of Hematology and Oncology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada
    Neurosurg Focus 19:E3. 2005
    ..Studies of the related but distinct pineoblastoma PNET are also reviewed...
  80. ncbi request reprint Tumors of the central nervous system in the first year of life
    Valerie Larouche
    Paediatric Brain Tumour Program, Division of Paediatric Oncology Haematology, Hospital for Sick Children, Toronto, Canada
    Pediatr Blood Cancer 49:1074-82. 2007
    ..While new techniques of radiation have been introduced in the management of infants, there is still reluctance to consider radiotherapy in this age group...
  81. ncbi request reprint Childhood brain tumour information on the Internet in the Chinese language
    Loretta Lau
    Paediatric Brain Tumour Programme, Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Childs Nerv Syst 22:346-51. 2006
    ....
  82. ncbi request reprint Change in neurocognitive functioning after treatment with cranial radiation in childhood
    Brenda J Spiegler
    Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    J Clin Oncol 22:706-13. 2004
    ..To evaluate the pattern of stability and change over time across multiple domains of neurocognitive function in radiated survivors of posterior fossa (PF) tumors...
  83. doi request reprint Nimotuzumab in pediatric glioma
    Catherine Lam
    The Hospital for Sick Children, Division for Haematology Oncology, Toronto, Canada
    Future Oncol 5:1349-61. 2009
    ..Emerging trials suggest a promising role for nimotuzumab as a therapeutic agent in patients with high-grade gliomas. This review attempts to provide a context for the evolving interest and evidence for nimotuzumab in pediatric glioma...
  84. ncbi request reprint Phase I study of fotemustine in pediatric patients with refractory brain tumors
    Darren R Hargrave
    New Agents and Innovative Therapy Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Cancer 95:1294-301. 2002
    ..Fotemustine is a nitrosourea with theoretic and preclinical advantages over the original analogs, carmustine and lomustine, in the treatment of brain tumors. This is the first pediatric Phase I study of fotemustine...
  85. ncbi request reprint Patients with primary brain tumors as organ donors: case report and review of the literature
    Angela S Punnett
    Pediatric Brain Tumor Program, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 43:73-7. 2004
    ..The transplantation team ultimately decides upon the use of organs from specific donors. Many families will appreciate the opportunity to donate specific tissues even if solid organ transplantation is prohibited...
  86. pmc Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors
    Meihua Li
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, ON M5G 0A3, Canada
    Cancer Cell 16:533-46. 2009
    ..Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus...