Victor Blanchette

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Childhood chronic immune thrombocytopenic purpura: unresolved issues
    Victor S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Pediatr Hematol Oncol 25:S28-33. 2003
  2. pmc Cross-cultural adaptation of the CHO-KLAT for boys with hemophilia in rural and urban China
    Runhui Wu
    Department of Haematology, Beijing Children s Hospital and Capital Medical University, Beijing, China
    Health Qual Life Outcomes 10:112. 2012
  3. pmc Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation
    Victoria E Price
    Division of Pediatric Hematology Oncology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada
    Health Qual Life Outcomes 7:92. 2009
  4. doi request reprint Childhood immune thrombocytopenic purpura: diagnosis and management
    Victor Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Pediatr Clin North Am 55:393-420, ix. 2008
  5. doi request reprint Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients
    V S Blanchette
    Hospital for Sick Children, University of Toronto, ON, Canada
    J Thromb Haemost 6:1319-26. 2008
  6. ncbi request reprint Childhood acute immune thrombocytopenic purpura: 20 years later
    Victor S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Semin Thromb Hemost 29:605-17. 2003
  7. ncbi request reprint A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto and the Department of Pediatrics, University of Toronto, Ontario, Canada
    Haemophilia 9:19-26; discussion 26. 2003
  8. doi request reprint Childhood immune thrombocytopenic purpura: diagnosis and management
    Victor Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Hematol Oncol Clin North Am 24:249-73. 2010
  9. doi request reprint Meeting unmet needs in inhibitor patients
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    Haemophilia 16:46-51. 2010
  10. doi request reprint Prophylaxis in the haemophilia population
    V S Blanchette
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 16:181-8. 2010

Detail Information

Publications45

  1. ncbi request reprint Childhood chronic immune thrombocytopenic purpura: unresolved issues
    Victor S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Pediatr Hematol Oncol 25:S28-33. 2003
    ..The presence of an accessory spleen should be sought and removal considered if present. The role of newer treatment modalities such as anti-CD 20 remains to be established...
  2. pmc Cross-cultural adaptation of the CHO-KLAT for boys with hemophilia in rural and urban China
    Runhui Wu
    Department of Haematology, Beijing Children s Hospital and Capital Medical University, Beijing, China
    Health Qual Life Outcomes 10:112. 2012
    ..Quality of life (QoL) is increasingly recognized as an important outcome measure in clinical trials. The Canadian Hemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT) shows promise for use in China...
  3. pmc Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation
    Victoria E Price
    Division of Pediatric Hematology Oncology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada
    Health Qual Life Outcomes 7:92. 2009
    ..e. children with a rare disorder...
  4. doi request reprint Childhood immune thrombocytopenic purpura: diagnosis and management
    Victor Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Pediatr Clin North Am 55:393-420, ix. 2008
    ..This review focuses on the diagnosis and management of children who have acute and chronic ITP. Emphasis is placed on areas of controversy and new therapies...
  5. doi request reprint Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients
    V S Blanchette
    Hospital for Sick Children, University of Toronto, ON, Canada
    J Thromb Haemost 6:1319-26. 2008
    ..The pharmacokinetics of factor VIII replacement therapy in preschool previously treated patients (PTPs) with hemophilia A have not been well characterized...
  6. ncbi request reprint Childhood acute immune thrombocytopenic purpura: 20 years later
    Victor S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Semin Thromb Hemost 29:605-17. 2003
    ....
  7. ncbi request reprint A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto and the Department of Pediatrics, University of Toronto, Ontario, Canada
    Haemophilia 9:19-26; discussion 26. 2003
    ..These data offer a basis for projecting long-term factor concentrate needs for persons with haemophilia living in North America...
  8. doi request reprint Childhood immune thrombocytopenic purpura: diagnosis and management
    Victor Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Hematol Oncol Clin North Am 24:249-73. 2010
    ..This review focuses on the diagnosis and management of children who have acute and chronic ITP. Emphasis is placed on areas of controversy and new therapies...
  9. doi request reprint Meeting unmet needs in inhibitor patients
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    Haemophilia 16:46-51. 2010
    ....
  10. doi request reprint Prophylaxis in the haemophilia population
    V S Blanchette
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 16:181-8. 2010
    ..The role of novel long-acting factor concentrates for prophylaxis will also need to be evaluated...
  11. ncbi request reprint Optimizing factor prophylaxis for the haemophilia population: where do we stand?
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada
    Haemophilia 10:97-104. 2004
    ..Such studies should incorporate outcome measures such as health-related quality-of-life and economic analyses...
  12. ncbi request reprint Chronic immune thrombocytopenic purpura in children: a survey of the canadian experience
    Mark Belletrutti
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Stollery Children s Hospital, University of Alberta, Alberta, Canada
    J Pediatr Hematol Oncol 29:95-100. 2007
    ..To better understand the natural history of chronic ITP and detect response trends and outcomes of therapy, we conducted a 10-year retrospective survey of children from age 1 to 18 years with a diagnosis of chronic ITP...
  13. doi request reprint The use of prophylaxis in 2663 children and adults with haemophilia: results of the 2006 Canadian national haemophilia prophylaxis survey
    T T Biss
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 14:923-30. 2008
    ..Prophylaxis is being started earlier in boys with severe haemophilia A...
  14. ncbi request reprint Health-related quality-of-life treatments for severe haemophilia: utility measurements using the Standard Gamble technique
    V S Naraine
    Faculty of Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Haemophilia 8:112-20. 2002
    ....
  15. ncbi request reprint Clinical and cost implications of target joints in Canadian boys with severe hemophilia A
    Melissa Kern
    Division of Hematology Oncology, The Hospital for Sick Children, Ontario, Canada
    J Pediatr 145:628-34. 2004
    ..To compare target joint-associated costs incurred by boys with severe hemophilia A 1 year before and 1 year after development of a target joint (pre-TJ, post-TJ)...
  16. ncbi request reprint Canadian multi-institutional survey of immune tolerance therapy (ITT) -- experience with the use of recombinant factor VIII for ITT
    C Barnes
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Haemophilia 12:1-6. 2006
    ..3% (23/29), which is comparable with the results of immune tolerance registries. Our results suggest that the success rate of ITT using rFVIII is not inferior to the results with pdFVIII...
  17. ncbi request reprint Rituximab for congenital haemophiliacs with inhibitors: a Canadian experience
    M Carcao
    Division of Haematology Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Haemophilia 12:7-18. 2006
    ..Our five cases suggest that rituximab may hold promise in the eradication of inhibitors. Prospective randomized studies are required to determine the value of this agent in inhibitor management...
  18. ncbi request reprint Proceedings of the International Haemophilia Prophylaxis Study Group Meeting, November 2003, Montreal, PQ, Canada
    B M Feldman
    Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Hospital for Sick Children, Bloorview MacMillan Children s Centre, Toronto, ON, Canada
    Haemophilia 11:58-63. 2005
  19. ncbi request reprint Comparing two measures of quality of life for children with haemophilia: the CHO-KLAT and the Haemo-QoL
    C S Bradley
    Department of Rehabilitation Services, The Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 12:643-53. 2006
    ..The present recommendation is that the measures be run independently, but preferably concurrently in studies of children with haemophilia...
  20. ncbi request reprint Central venous catheter-related thrombosis presenting as superior vena cava syndrome in a haemophilic patient with inhibitors
    M D Carcao
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Haemophilia 9:578-83. 2003
    ..The appropriate management of TEs in such a setting is unknown...
  21. ncbi request reprint Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
    B M Feldman
    Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    J Thromb Haemost 4:1228-36. 2006
    ..We studied an inception cohort of 25 boys using a tailored prophylaxis approach to see if clotting factor use could be reduced with acceptable outcomes...
  22. ncbi request reprint The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) symposium
    B M Feldman
    Department of Pediatrics, University of Toronto, and Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Haemophilia 13:745-9. 2007
  23. doi request reprint Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study
    Yaron Finkelstein
    Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:2738-43. 2007
    ..However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain...
  24. ncbi request reprint Immune thrombocytopenia following successful treatment of cancer in children
    Victoria Price
    Department of Pediatrics, Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Canada
    Pediatr Blood Cancer 46:372-6. 2006
    ..2-8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co-incidental as chemotherapy may cause persistent immune dysfunction...
  25. ncbi request reprint Platelet activation and hypercoagulability following treatment with porcine factor VIII (HYATE:C)
    J Freedman
    Transfusion Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 69:192-9. 2002
    ....
  26. ncbi request reprint Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A
    A Sharathkumar
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Thromb Haemost 1:1228-36. 2003
    ..Inhibitors are rare in boys with mild hemophilia A (MHA; factor (F)VIII:C > 5%) but may arise following intense FVIII exposure, e.g. continuous infusion (CI)...
  27. ncbi request reprint A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia
    V E Price
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thromb Haemost 2:737-42. 2004
    ..Less frequently reported is CVC-related deep venous thrombosis (DVT). We conducted a prospective study to determine the frequency and outcome of this complication...
  28. doi request reprint Laparoscopic partial vs total splenectomy in children with hereditary spherocytosis
    Julia Morinis
    Department of Surgery, The Hospital for Sick Children, University of Toronto, Canada
    J Pediatr Surg 43:1649-52. 2008
    ..The purpose of the present study is to compare the outcomes in a group of patients undergoing laparoscopic partial splenectomy (LPS) with those in a group of children undergoing laparoscopic total splenectomy (LTS) over the same period...
  29. ncbi request reprint Immunoadsorption may provide a cost-effective approach to management of patients with inhibitors to FVIII
    John Freedman
    St Michael s Hospital and the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Transfusion 43:1508-13. 2003
    ..The procedure may be cost effective, given the expense of therapies used to treat patients with inhibitors, particularly in an acute setting...
  30. pmc Hemophilia during pregnancy
    Ran D Goldman
    Hospital for Sick Children, Toronto, Ont
    Can Fam Physician 49:1601-3. 2003
    ..Vaginal delivery is not contraindicated and has been proven during the last two decades to be as safe as cesarean section. Vacuum extraction should be avoided to minimize risk of intracranial hemolysis and severe cephalhematoma...
  31. ncbi request reprint Definitions for haemophilia prophylaxis and its outcomes: the Canadian consensus study
    S Ota
    Research program in Child Health Evaluation Sicenses, The Hospital for Sick Children, Toronto, Canada
    Haemophilia 13:12-20. 2007
    ..Further refinement from members of the international haemophilia community will ensure that comprehensive standard definitions can be used in multicentre studies in the future...
  32. doi request reprint Quantitation of bleeding symptoms in children with von Willebrand disease: use of a standardized pediatric bleeding questionnaire
    T T Biss
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Thromb Haemost 8:950-6. 2010
    ..A detailed bleeding history can distinguish children who may have an inherited bleeding disorder from those who are normal. There is a lack of standardization of such history taking in pediatric practise...
  33. ncbi request reprint Initial bone marrow aspiration in childhood idiopathic thrombocytopenia: decision analysis
    R J Klaassen
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Canada
    J Pediatr Hematol Oncol 23:511-8. 2001
    ..Bone marrow aspiration (BMA) is routinely performed before starting steroid therapy in children with idiopathic thrombocytopenia, primarily to rule out leukemia...
  34. ncbi request reprint Immune thrombocytopenic purpura
    Douglas B Cines
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 346:995-1008. 2002
  35. ncbi request reprint The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B
    Amy D Shapiro
    Indiana Hemophilia and Thrombosis Center, Indianapolis 46260, USA
    Blood 105:518-25. 2005
    ..rFIX was well tolerated, with no associated thrombotic events or evidence of viral transmission. These data indicate that rFIX is a safe and effective treatment for PUPs with hemophilia B...
  36. ncbi request reprint Corticosteroids versus intravenous immune globulin for the treatment of acute immune thrombocytopenic purpura in children: a systematic review and meta-analysis of randomized controlled trials
    Carolyn E Beck
    Division of Paediatric Medicine, The Hospital for Sick Children, and the University of Toronto, Toronto, Ontario, Canada
    J Pediatr 147:521-7. 2005
    ..To compare the effectiveness of corticosteroids with intravenous immune globulin (IVIG) for the initial treatment of children with acute immune thrombocytopenic purpura (ITP)...
  37. ncbi request reprint How well does the Canadian Haemophilia Outcomes-Kids' Life Assessment Tool (CHO-KLAT) measure the quality of life of boys with haemophilia?
    Nancy L Young
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:305-11. 2006
    ..This paper describes the final phase of development of a disease-specific measure of QoL for boys with haemophilia: the Canadian Haemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT)...
  38. ncbi request reprint DDAVP challenge tests in boys with mild/moderate haemophilia A
    Shoshana Revel-Vilk
    Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Br J Haematol 117:947-51. 2002
    ..Age and FVIII:C association with DDAVP response are both important in boys with mild/moderate haemophilia A. Absence of response to DDAVP should therefore be confirmed by later re-challenge...
  39. ncbi request reprint Fcgamma receptor IIa and IIIa polymorphisms in childhood immune thrombocytopenic purpura
    Manuel D Carcao
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Br J Haematol 120:135-41. 2003
    ..These observations underscore the importance of Fcgamma receptor-mediated cell clearance in childhood ITP...
  40. ncbi request reprint Self-reported initial management of childhood idiopathic thrombocytopenic purpura: results of a survey of members of the American Society of Pediatric Hematology/Oncology, 2001
    Sara K Vesely
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Pediatr Hematol Oncol 25:130-3. 2003
    ..This information provides the basis for designing a randomized clinical trial to compare the effect of different management strategies on the outcomes of bleeding symptoms, side effects of therapy, costs, and quality of life...
  41. ncbi request reprint Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100)
    Manuel D Carcao
    Divisions of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Br J Haematol 117:961-4. 2002
    ..Further investigations are warranted to more fully understand the relationships among platelet function as measured by the PFA-100 in standard/experimental modes, bleeding and transfusion outcome in thrombocytopenia...
  42. ncbi request reprint Desmopressin (DDAVP) responsiveness in children with von Willebrand disease
    Shoshana Revel-Vilk
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 25:874-9. 2003
    ..To determine the pattern and predictors of response to desmopressin (DDAVP) in children with von Willebrand disease (VWD)...
  43. ncbi request reprint The prevention and treatment of bacterial infections in children with asplenia or hyposplenia: practice considerations at the Hospital for Sick Children, Toronto
    Victoria E Price
    Department of Pediatrics, Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 46:597-603. 2006
    ..Many experts continue prophylaxis indefinitely although prophylaxis of the penicillin allergic child remains suboptimal...
  44. ncbi request reprint Validity, reliability, and responsiveness of a new measure of health-related quality of life in children with immune thrombocytopenic purpura: the Kids' ITP Tools
    Robert J Klaassen
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    J Pediatr 150:510-5, 515.e1. 2007
    ..To refine the disease-specific health-related quality of life measure in immune (idiopathic) thrombocytopenic purpura (ITP) and to determine its validity, reliability, and responsiveness to change...
  45. ncbi request reprint The prevention and management of infections in children with asplenia or hyposplenia
    Victoria E Price
    Division of Hematology Oncology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850 5980 University Ave, P O Box 9700, Halifax, Canada, B3K 6R8 Halifax, Canada
    Infect Dis Clin North Am 21:697-710, viii-ix. 2007
    ..This article reviews the current literature on the prevention and management of severe infections in children with underlying asplenia or hyposplenia...