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Genomes and Genes | J BelikSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Publications
Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouseJaques Belik
Department of Paediatrics, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 1X8, Canada
Free Radic Biol Med 51:2227-33. 2011..01) in hph-1 compared to wild-type mice. In conclusion, our data suggest that pulmonary hypertension is present from birth in the GTPCH1-deficient mice, not as a result of impaired vasodilation, but secondary to vascular remodeling...
Bronchial epithelium-associated pulmonary arterial muscle relaxation in the rat is absent in the fetus and suppressed by postnatal hypoxiaJ Belik
Canadian Institute of Health Research Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 288:L384-9. 2005..These results suggest that the BrEpRF may be involved in postnatal adaptation of the pulmonary circulation and that its suppression may contribute to hypoxic pulmonary vasoconstriction...- Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn ratJaques Belik
Lung Biology Programme, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Free Radic Biol Med 37:1384-92. 2004..This unique response potentially renders the newborn more susceptible to ONOO- -induced pulmonary hypertension than older animals... - Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscleJaques Belik
Department of Pediatrics, Hospital for Sick Children, 555 Univ Ave, Toronto, ON, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 292:L699-703. 2007..01). In conclusion, the bronchial smooth muscle cGMP-, but not cAMP-dependent, relaxant response is developmentally regulated and significantly reduced in the adult rat... - Developmental changes in arginase expression and activity in the lungJaques Belik
Department of Pediatrics, Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, and University of Toronto, 555 University Ave, Toronto, Ontario, M5G 1X8 Canada
Am J Physiol Lung Cell Mol Physiol 294:L498-504. 2008..We speculate that the maintenance of a high pulmonary vascular resistance and decreased lung NO production prenatally may, in part, be dependent on increased arginase expression and/or activity... - Fetal and neonatal effects of maternal drug treatment for depressionJaques Belik
The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CA
Semin Perinatol 32:350-4. 2008..The pharmacological effects of SSRI on the fetus and newborn, available treatment, and prevention strategies are discussed in this review... - A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn ratJ Belik
Hospital for Sick Children, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Toronto, Ontario, Canada M5G 1X8
J Appl Physiol 96:1399-405. 2004..We speculate that such a mechanism may be operative in vivo and plays an important role in control of pulmonary vascular resistance in the early postnatal period... - Chronic O2 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostaneJ Belik
Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
J Appl Physiol 96:725-30. 2004..We speculate that impaired pulmonary vascular tissue NO metabolism after chronic O2 exposure potentiates 8-iso-PGF(2alpha)-induced vasoconstriction in the newborn rat, thus contributing to pulmonary hypertension... - Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endotheliumJ Belik
Canadian Institutes of Health Research Group in Lung Development, Lung Biology and Integrative Biology Programmes, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
J Appl Physiol 95:1979-85. 2003..This phenomenon may contribute to the maintenance of a higher pulmonary vascular resistance in the early postnatal period... - Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn ratJaques Belik
Physiology and Experimental Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 297:L777-84. 2009..This mechanism may explain some of the beneficial effects of chronic hypercapnia on experimental pulmonary hypertension... - Airway smooth muscle changes in the nitrofen-induced congenital diaphragmatic hernia rat modelJaques Belik
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada
Pediatr Res 53:737-43. 2003..This is the first report of airway smooth muscle abnormalities in the nitrofen-induced fetal rat model of CDH. We speculate that congenital airway muscle changes may be present in the human form of this disease... - Chronic O2 exposure enhances vascular and airway smooth muscle contraction in the newborn but not adult ratJ Belik
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
J Appl Physiol 94:2303-12. 2003..The present findings also suggest that the newborn is more susceptible to airway hyperresponsiveness after chronic O(2) exposure... - Riociguat, an oral soluble guanylate cyclase stimulator for the treatment of pulmonary hypertensionJaques Belik
University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
Curr Opin Investig Drugs 10:971-9. 2009.... - Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous miceJ Belik
The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 297:L1170-8. 2009..To the extent that these mice mimic human HHT1, age-associated pulmonary vascular eNOS uncoupling may explain the late childhood and adult onset of clinical lung manifestations... - Isoprostanes in fetal and neonatal health and diseaseJaques Belik
Department of Pediatrics, University of Toronto and Physiology and Experimental Medicine Program of the Research Institute, The Hospital for Sick Children, Toronto, Canada
Free Radic Biol Med 48:177-88. 2010..Although its existence has been recognized for almost 20 years, little is known about the critical importance of isoprostanes during fetal life and immediate neonatal period. This review is an attempt to bridge this knowledge gap... - Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn ratsJaques Belik
Physiology and Experimental Medicine Program, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada
Free Radic Biol Med 49:1306-14. 2010.... - Rat pulmonary arterial smooth muscle myosin light chain kinase and phosphatase activities decrease with ageJ Belik
Department of Pediatrics, Hospital for Sick Children, Univ of Toronto, Div of Neonatology, Hospital for Sick Children, 555 Univ Ave, Toronto, Ontario M5G 1X8, Canada
Am J Physiol Lung Cell Mol Physiol 290:L509-16. 2006..During fetal life, the lung pulmonary arterial MLCK- and MLCP-specific activities are highest and appear to be related to Rho-kinase activation during lung morphogenesis... - Myogenic response in large pulmonary arteries and its ontogenesisJ Belik
Department of Pediatrics, University of Manitoba, Winnipeg, Canada
Pediatr Res 36:34-40. 1994..We conclude that the large pulmonary arterial vessels of the guinea pig exhibit a powerful stretch-induced myogenic response that is greater in the newborn period.(ABSTRACT TRUNCATED AT 250 WORDS).. - Airway epithelial-derived factor relaxes pulmonary vascular smooth muscleOmar R Farah
The Hospital for Sick Children, 555 Univ Ave, Toronto, Ontario, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 296:L115-20. 2009..We speculate that under physiological conditions, the maintenance of a low pulmonary vascular resistance, postnatally, is in part modulated by the airway epithelium... - Human meconium has a pulmonary vascular and airway smooth muscle relaxant effectRogerio Tessler
Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
Pediatr Res 64:24-8. 2008..In addition, it contains plasmatic proteins such as alpha1-antitripsin and phospholipase A2 (4,5)... - Pulmonary and systemic vascular tissue collagen, growth factor, and cytokine gene expression in the rabbitJ Belik
Department of Pediatrics, University of Calgary, Alberta, Canada
Can J Physiol Pharmacol 78:400-6. 2000..We conclude that circulation specific developmental regulation of collagen gene expression is present in the rabbit in a pattern that is unrelated to the intravascular pressure... - Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal ratsRobert P Jankov
Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Center, 76 Grenville Street, Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 294:L233-45. 2008..Due to the potential for adverse effects on normal growth, targeting XO may represent a superior "antioxidant" strategy to ROS scavengers for neonates with pulmonary hypertension... - Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal ratV E Fabris
Department of Pediatrics, University of Manitoba at Winnipeg, Manitoba, Canada
Pediatr Pulmonol 31:344-53. 2001..We speculate that lung growth in late gestation is adversely affected by pulmonary hypertension... - Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levelsF E Martinez
Department of Pediatrics, University of Calgary, Alberta, Canada
Inflamm Res 49:727-31. 2000.... - Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the ratEnrica Fornaro
Lung Biology Research Group, Physiology and Experimental Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Respir Crit Care Med 176:1035-40. 2007..The mechanism responsible for this effect is unclear and paradoxical, considering the current evidence of a pulmonary hypertension protective fluoxetine effect in adult rodents... - Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal ratsAzhar Masood
Canadian Institutes of Health Research Group in Lung Development, Toronto, ON, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 297:L920-30. 2009..Inhaled 5.5% CO2 provided a significant degree of protection against parenchymal and vascular injury in an animal model of chronic neonatal lung injury likely due, at least in part, to its inhibition of a phagocyte influx... - Lung development and susceptibility to ventilator-induced lung injuryAlik Kornecki
Lung Biology Program, Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
Am J Respir Crit Care Med 171:743-52. 2005.... - Use of tolazoline to counteract vasospasm in peripheral arterial catheters in neonatesR P Lemke
Department of Pediatrics, Children s Hospital, Winnipeg, Manitoba, Canada
Acta Paediatr 85:1497-8. 1996..In this report, we describe the use of tolazoline (0.02 to 0.2 mg/kg/h) to counteract local arterial vasospasm in five critically ill neonates, where arterial access was vital for care but difficult to maintain... - High tidal volume ventilation causes different inflammatory responses in newborn versus adult lungIan B Copland
Lung Biology Program, Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada
Am J Respir Crit Care Med 169:739-48. 2004..In newborns, the inflammatory response is dependent on VT, duration, and supplemental O2. Thus, recommendations for VT limitation based on adult data may be inappropriate for newborns... - Volutrauma activates the clotting cascade in the newborn but not adult ratAnthony Chan
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 290:L754-L760. 2006..Compared with adults, newborn rats have a greater propensity for volutrauma-activated intravascular coagulation. These data suggest that mechanical ventilation promotes neonatal thrombosis via lung tissue factor release... - Regional pulmonary blood flow: Comparison of dynamic contrast-enhanced MR perfusion and phase-contrast MRJoshua F P van Amerom
Department of Medical Biophysics, University of Toronto and Hospital for Sick Children, Toronto, Ontario, Canada
Magn Reson Med 61:1249-54. 2009..A strong correlation (R(2) = 0.71, P < 0.01) was observed between the methods. In conclusion, DCE MR and PC MR provide a consistent measure of changes in regional pulmonary blood flow... - Early changes in lung gene expression due to high tidal volumeIan B Copland
Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 168:1051-9. 2003..the effects of HV are cumulative; (2). specific patterns of gene activation and suppression precede lung injury; and (3). alteration of gene expression after mechanical stretch is pathogenic... - Mechanical ventilation effect on surfactant content, function, and lung compliance in the newborn ratFrancisco Martinez
Department of Pediatics, University of Toronto, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
Pediatr Res 56:19-25. 2004.... - Bronchial muscle peristaltic activity in the fetal ratOmar Parvez
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada, M5G IX8
Pediatr Res 59:756-61. 2006..We conclude that the airway smooth muscle phasic activity is greatest in the fetus and tends to disappear post-natally with age suggesting an in utero role during lung development... - Sildenafil acutely reverses the hypoxic pulmonary vasoconstriction response of the newborn pigRogerio Tessler
Department of Pediatrics, Pontificia Universidade Catolica do Rio Grande do Sul, Rio Grande do Sul, Brazil
Pediatr Res 64:251-5. 2008..v. administration in a dose-dependent manner. In the presence of lung parenchymal disease, the use of i.v. sildenafil as a pulmonary vasodilator may worsen arterial oxygenation by reversing the HPV response in nonventilated lung units... - Tadalafil improves oxygenation in a model of newborn pulmonary hypertensionRogerio B Tessler
Department of Pediatrics, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
Pediatr Crit Care Med 9:330-2. 2008..Its hemodynamic effects on the newborn, however, have not been tested. The objective was to evaluate the effect of tadalafil on central hemodynamics and arterial oxygenation in a piglet model of acute pulmonary hypertension... - Chronic in ovo hypoxia decreases pulmonary arterial contractile reactivity and induces biventricular cardiac enlargement in the chicken embryoEduardo Villamor
Department of Pediatrics, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
Am J Physiol Regul Integr Comp Physiol 287:R642-51. 2004....