Research Topics
Genomes and GenesSpecies | B L BanwellSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Detail Information
Publications
Pediatric tumefactive demyelination: case series and review of the literatureLaura C McAdam
Department of Pediatrics, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada
Pediatr Neurol 26:18-25. 2002..We describe the neuroimaging characteristics and clinical presentation of tumefactive demyelination and how these features may be used in differentiating demyelination from other mass lesions...
Safety and tolerability of interferon beta-1b in pediatric multiple sclerosisB Banwell
The Hospital for Sick Children, University of Toronto, Ontario, Canada
Neurology 66:472-6. 2006..Although at least 5% of all patients with MS experience the clinical onset of their disease prior to age 18 years, the available literature on safety and tolerability of immunomodulatory therapies for pediatric-onset MS is limited...
Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directionsBrenda Banwell
Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Lancet Neurol 6:887-902. 2007..Understanding the immunological consequences of these putative exposures will shed light on the early pathological changes in MS...
Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort studyBrenda Banwell
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Lancet Neurol 10:436-45. 2011....
MRI features of pediatric multiple sclerosisB Banwell
Departments of Paediatrics Neurology, The Hospital for Sick Children, Toronto, ON, Canada
Neurology 68:S46-53. 2007..Although MRI has also been used to aid in the diagnosis and care of children with MS, the MRI features of MS in children are less well understood...
The clinical features, MRI findings, and outcome of optic neuritis in childrenM Wilejto
Department of Neuroradiology, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
Neurology 67:258-62. 2006..Optic neuritis (ON) in childhood is thought to be more likely bilateral and less likely to lead to multiple sclerosis (MS) vs ON in adults...
Treatment of children and adolescents with multiple sclerosisBrenda Banwell
University of Toronto, Pediatric Multiple Sclerosis Clinic, ON, Canada
Expert Rev Neurother 5:391-401. 2005..Future directions in multiple sclerosis therapeutics and specific issues relating to pediatric multiple sclerosis are discussed...
Therapies for multiple sclerosis: considerations in the pediatric patientBrenda Banwell
Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
Nat Rev Neurol 7:109-22. 2011....
The cognitive burden of multiple sclerosis in childrenBrenda L Banwell
Research Institute, Multiple Sclerosis Clinic, The Hospital for Sick Children, Toronto, Ontario, Canada
Neurology 64:891-4. 2005..Cognitive impairment occurs in children with MS, and those with longer disease duration and younger age at MS onset appear to be at greatest risk...
Pediatric multiple sclerosisBrenda L Banwell
Department of Pediatrics Neurology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Curr Neurol Neurosci Rep 4:245-52. 2004..The rationale and importance of future studies in pediatric MS is highlighted...
Muscle weakness in critically ill childrenB L Banwell
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
Neurology 61:1779-82. 2003..To establish the incidence of muscle weakness in critically ill children...
Incidence of acquired demyelination of the CNS in Canadian childrenB Banwell
Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8 Canada
Neurology 72:232-9. 2009..It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS)...
Clinical features and viral serologies in children with multiple sclerosis: a multinational observational studyBrenda Banwell
Division of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
Lancet Neurol 6:773-81. 2007..Our aim was to determine some of these characteristics in children with MS...
MRI in the diagnosis of pediatric multiple sclerosisD J A Callen
Division of Pediatric Neurology, Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, Canada
Neurology 72:961-7. 2009....
Factors associated with emotional and behavioral outcomes in adolescents with multiple sclerosisC Till
Department of Psychology, York University, Toronto, Canada
Mult Scler 18:1170-80. 2012..Objective: We aimed to examine the prevalence and risk factors associated with emotional and behavioral outcomes in adolescents with MS...
Magnetic resonance imaging predictors of executive functioning in patients with pediatric-onset multiple sclerosisC Till
Department of Psychology, York University, Toronto, Canada
Arch Clin Neuropsychol 27:495-509. 2012..Working memory and attention switching are at greatest risk of impairment. Results support the inclusion of neuropsychological assessment alongside parent-report measures of EF skills in childhood-onset MS...
Role of MRI in the differentiation of ADEM from MS in childrenD J A Callen
Division of Pediatric Neurology, Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, Canada
Neurology 72:968-73. 2009..Quantitative analyses of MRI images from children with monophasic ADEM have yet to be compared with those from children with MS, and MRI criteria capable of distinguishing ADEM from MS at onset have yet to be derived...
Cyclophosphamide therapy in pediatric multiple sclerosisN Makhani
The Hospital for Sick Children, University of Toronto, Canada
Neurology 72:2076-82. 2009..To review our multicenter experience with cyclophosphamide in the treatment of children with multiple sclerosis (MS)...
MRI correlates of cognitive impairment in childhood-onset multiple sclerosisC Till
Department of Psychology, York University, Toronto, Ontario, Canada
Neuropsychology 25:319-32. 2011..Brain MRI measures were correlated with neuropsychological function in 35 pediatric-onset multiple sclerosis (MS) patients and 33 age- and sex-matched healthy controls...
Becker muscular dystrophy caused by an intronic mutation reducing the efficiency of the splice donor site of intron 26 of the dystrophin geneBerivan Baskin
Division of Molecular Genetics, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada
Neuromuscul Disord 19:189-92. 2009..We highlight the importance of mRNA analysis for determination of pathogenicity in patients with ambiguous sequence variants in the DMD gene...
Duchenne muscular dystrophy: Canadian paediatric neuromuscular physicians surveyHugh J McMillan
Division of Neurology, Department of Paediatrics, Children s Hospital of Eastern Ontario, Ottawa
Can J Neurol Sci 37:195-205. 2010..Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy in childhood...
Pediatric multiple sclerosisSunita Venkateswaran
Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
Neurologist 16:92-105. 2010..Pediatric multiple sclerosis (MS), once considered a rare childhood illness, has been increasingly identified as an important childhood acquired neurologic disease requiring early recognition and intervention...
Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetesBrenda Banwell
Division of Neurology, Department of Pediatrics and the Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Ann Neurol 63:98-111. 2008..Our objectives were to determine the presence, pattern, and specificity of abnormal T-cell reactivities to such antigens in the earliest stages of the multiple sclerosis process...
Multiple sclerosis in childrenTerrence Thomas
Pediatric Multiple Sclerosis Clinic, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Semin Neurol 28:69-83. 2008..Finally, this article presents recent research studies performed in an MS population for whom disease onset occurs in unique temporal proximity to the events involved in MS pathogenesis...
Update on emerging therapies for multiple sclerosisEppie M Yiu
The Hospital for Sick Children, Toronto, Canada
Expert Rev Neurother 10:1259-62. 2010..This meeting report focuses on the latest therapies in the treatment of multiple sclerosis (MS)...
Hidden focal EEG seizures during prolonged suppressions and high-amplitude bursts in early infantile epileptic encephalopathyAmna Al-Futaisi
Division of Neurology, The Hospital for Sick Children, Toronto, Ont, Canada
Clin Neurophysiol 116:1113-7. 2005..SIGNIFICANCE: Digital EEG sensitivity can reveal covert electrical activity during suppression periods in epileptic neonates and infants...
Neurocognitive outcome after acute disseminated encephalomyelitisCecil D Hahn
Division of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
Pediatr Neurol 29:117-23. 2003....
Starting early: MRI evidence of gray matter atrophy in children with multiple sclerosisBrenda L Banwell
Neurology 70:1065-6. 2008
The long (-itudinally extensive) and the short of it: transverse myelitis in childrenBrenda L Banwell
Neurology 68:1447-9. 2007
Into the looking glass: predicting MS in children experiencing a first demyelinating eventBrenda L Banwell
Neurology 71:962-3. 2008
Through the eyes of a child: research insights gained through the study of childhood multiple sclerosisBrenda L Banwell
Mult Scler 14:4-5. 2008
Novel truncating RAPSN mutations causing congenital myasthenic syndrome responsive to 3,4-diaminopyridineBrenda L Banwell
Department of Pediatrics Neurology, The Hospital for Sick Children, University of Toronto, Canada
Neuromuscul Disord 14:202-7. 2004....
MRI criteria for multiple sclerosis: Evaluation in a pediatric cohortCecil D Hahn
Division of Neurology, Department of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Ontario, Canada
Neurology 62:806-8. 2004..The authors thus suggest that MRI criteria for adult MS be applied cautiously to pediatric MS patients...
