L Attisano

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Signal transduction by members of the transforming growth factor-beta superfamily
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Cytokine Growth Factor Rev 7:327-39. 1996
  2. pmc Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    E Labbe
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Proc Natl Acad Sci U S A 97:8358-63. 2000
  3. ncbi request reprint Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    E Labbe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Mol Cell 2:109-20. 1998
  4. ncbi request reprint Smads as transcriptional co-modulators
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Curr Opin Cell Biol 12:235-43. 2000
  5. ncbi request reprint The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling
    L Attisano
    Department of Anatomy and Cell Biology, Medical Sciences Building, Rm 6336, 1 King s College Circle, University of Toronto, ON, M5S 1A8, Toronto, Canada
    Mol Cell Endocrinol 180:3-11. 2001
  6. ncbi request reprint SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
  7. pmc Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis
    A Rebbapragada
    Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Biol 23:7230-42. 2003
  8. ncbi request reprint Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways
    A Letamendia
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    J Bone Joint Surg Am 83:S31-9. 2001
  9. ncbi request reprint TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    S Abdollah
    Program in Developmental Biology and Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    J Biol Chem 272:27678-85. 1997
  10. ncbi request reprint MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    P A Hoodless
    Program in Developmental Biology, Hospital for Sick Children Toronto, Ontario, Canada
    Cell 85:489-500. 1996

Collaborators

  • J L Wrana
  • H Li
  • A Martin
  • H Kim
  • I L Andrulis
  • Marcy Wong
  • Joan Massague
  • Rotraud Wieser
  • Janet Rossant
  • L L Dobens
  • DOUGLAS A contact MARCHUK
  • EDWIN FERGUSON
  • J N Berg
  • Stuart Newfeld
  • Yulong L Chen
  • P A Hoodless
  • E Labbe
  • F Blanchette
  • A Letamendia
  • A Rebbapragada
  • V Subramaniam
  • S Abdollah
  • T Tsukazaki
  • T Sanchez-Elsner
  • F Grondin
  • C M Dubois
  • P Rudd
  • M Macias-Silva
  • M B O'Connor
  • A Lux
  • J R Carlyle
  • A Mehra
  • R G Wisotzkey
  • A Seth
  • H Benchabane
  • A M Burger
  • R Kitching
  • J Zubovits
  • A J Celeste
  • S A Holley
  • K Eppert
  • R Pirone
  • D W Johnson
  • A Corbi
  • L M Botella
  • C Bernabeu
  • M Pye
  • B Velasco
  • C Chazaud
  • N Rivard
  • F W Tsui
  • J C Zuniga-Pflucker
  • T A Chiang
  • C Dohrmann
  • A F Davison
  • A Penton
  • L A Raftery
  • J Carcamo
  • C Silvestri
  • D J Sutherland
  • X Liu
  • T J Brummel
  • H Hayashi
  • P Hoodless
  • S W Scherer
  • I Marondel
  • M Speer
  • C J Gallione
  • Y Sasai
  • M Estevez
  • H Ozcelik
  • M E Porteous
  • J L Neul
  • S J Yoon
  • S R Childs
  • M A Baldwin
  • A Diamond
  • M Stapleton
  • B Bapat
  • G H Thomsen
  • T Haerry
  • M A Pericak-Vance
  • S Gallinger
  • C E Jackson
  • R Kucherlapati
  • A E Guttmacher
  • T T Stenzel
  • L C Tsui
  • E M De Robertis
  • F M Weis

Detail Information

Publications35

  1. ncbi request reprint Signal transduction by members of the transforming growth factor-beta superfamily
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Cytokine Growth Factor Rev 7:327-39. 1996
    ..Recent advances, particularly in our understanding of the function of Mothers against dpp-related (MADR) proteins, are providing new insights into how the TGF beta superfamily signals its diverse biological activities...
  2. pmc Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    E Labbe
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Proc Natl Acad Sci U S A 97:8358-63. 2000
    ..Thus, our results show that TGFbeta and Wnt signaling pathways can independently or cooperatively regulate LEF1/TCF target genes and suggest a model for how these pathways can synergistically activate target genes...
  3. ncbi request reprint Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    E Labbe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Mol Cell 2:109-20. 1998
    ..Thus, we describe a mechanism whereby Smad2 and Smad3 positively and negatively regulate a TGF beta/activin target gene...
  4. ncbi request reprint Smads as transcriptional co-modulators
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Curr Opin Cell Biol 12:235-43. 2000
    ..Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression...
  5. ncbi request reprint The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling
    L Attisano
    Department of Anatomy and Cell Biology, Medical Sciences Building, Rm 6336, 1 King s College Circle, University of Toronto, ON, M5S 1A8, Toronto, Canada
    Mol Cell Endocrinol 180:3-11. 2001
    ..Thus, it is the interaction of Smads with a wide range of specific transcriptional partners that is important for the generation of diverse biological responses to TGFbeta superfamily members...
  6. ncbi request reprint SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
    ..These results thus define SARA as a component of the TGFbeta pathway that brings the Smad substrate to the receptor...
  7. pmc Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis
    A Rebbapragada
    Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Biol 23:7230-42. 2003
    ..Thus, our results reveal a strikingly specific antagonism of BMP7-mediated processes by myostatin and suggest that myostatin is an important regulator of adipogenesis...
  8. ncbi request reprint Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways
    A Letamendia
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    J Bone Joint Surg Am 83:S31-9. 2001
    ..This suggests that the cooperation between these pathways may be important for the specification of cell fates during development...
  9. ncbi request reprint TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    S Abdollah
    Program in Developmental Biology and Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    J Biol Chem 272:27678-85. 1997
    ..These results indicate that receptor-dependent phosphorylation of Smad2 on serines 465 and 467 is required in mammalian cells to permit association with Smad4 and to propagate TGF-beta signals...
  10. ncbi request reprint MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    P A Hoodless
    Program in Developmental Biology, Hospital for Sick Children Toronto, Ontario, Canada
    Cell 85:489-500. 1996
    ..BMP2 treatment results in accumulation of MADR1 in the nucleus. MAD proteins may thus define a novel class of signaling molecules with nuclear function in Ser/Thr kinase receptor signaling pathways...
  11. ncbi request reprint Mads and Smads in TGF beta signalling
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Curr Opin Cell Biol 10:188-94. 1998
    ..This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases...
  12. ncbi request reprint Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
    J R Carlyle
    Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 162:5917-23. 1999
    ..The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function...
  13. pmc The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase
    V Subramaniam
    Laboratory of Molecular Pathology and Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
    Br J Cancer 89:1538-44. 2003
    ..Smurf2 plays an active role in the repression of TGFbeta signalling, and our data indicate that overexpression of RNF11, through its interaction with Smurf2, can restore TGFbeta responsiveness in transfected cells...
  14. ncbi request reprint MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    K Eppert
    Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 86:543-52. 1996
    ..These findings suggest that MADR2 is a tumor suppressor and that mutations acquired in colorectal carcinomas may function to disrupt TGFbeta signaling...
  15. pmc The Smads
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Genome Biol 2:REVIEWS3010. 2001
    ..Smads therefore play an essential role in mediating TGFbeta-superfamily signals in development and disease...
  16. ncbi request reprint The Smad pathway
    J L Wrana
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1075, 600 University Avenue, Toronto, Canada
    Cytokine Growth Factor Rev 11:5-13. 2000
    ..In addition, we will summarize recent findings on the role of Smads as transcriptional co-modulators...
  17. ncbi request reprint Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation
    F Blanchette
    Immunology Division, Faculty of Medicine, , Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 276:33986-94. 2001
    ..Such an uncovered mechanism may be a key determinant for the regulation of furin in embryogenesis and growth-related physiopathological conditions...
  18. ncbi request reprint Involvement of Smads in TGFbeta1-induced furin (fur) transcription
    F Blanchette
    Immunology Division, Faculty of Medicine, , Sherbrooke QC, Canada
    J Cell Physiol 188:264-73. 2001
    ..This represents the first detailed study of the transcriptional regulation of the fur gene...
  19. ncbi request reprint Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    T Sanchez-Elsner
    Centro de Investigaciones Biologicas, CSIC, Velazquez 144, 28006 Madrid, Spain
    J Biol Chem 276:38527-35. 2001
    ..These results demonstrate that both TGF-beta and hypoxia signaling pathways can synergize in the regulation of VEGF gene expression at the transcriptional level...
  20. ncbi request reprint Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1
    A Lux
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:9984-92. 1999
    ..These data suggest that HHT pathogenesis involves disruption of a complex network of positive and negative angiogenic factors, involving TGF-beta, a new unknown ligand, and their corresponding receptors...
  21. pmc FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
    P A Hoodless
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 15:1257-71. 2001
    ..These results show that FoxH1 functions in an activin/nodal-Smad signaling pathway that acts upstream of Foxa2 and is required specifically for patterning the APS and node in the mouse...
  22. ncbi request reprint Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
    R G Wisotzkey
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 125:1433-45. 1998
    ..We propose that this provides a general model for Smad4/MEDEA function in signaling by the TGF-beta family...
  23. ncbi request reprint Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
    A Penton
    McArdle Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison 53706
    Cell 78:239-50. 1994
    ..Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E...
  24. ncbi request reprint Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
    T J Brummel
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Cell 78:251-61. 1994
    ..Thus, there is at least partial functional overlap of the sax and tkv receptors in vivo. We consider these observations in terms of possible ligand-receptor interactions during Drosophila development...
  25. ncbi request reprint Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors
    L Attisano
    Cell Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 75:671-80. 1993
    ..The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities...
  26. ncbi request reprint The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development
    M Estevez
    Molecular Biology Program, University of Missouri, Columbia 65211
    Nature 365:644-9. 1993
    ..When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family...
  27. ncbi request reprint The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
    S A Holley
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Cell 86:607-17. 1996
    ..These results suggest a mechanistic basis for the action of Spemann's organizer during Xenopus development and provide further support for the conservation of dorsal-ventral patterning mechanisms between arthropods and chordates...
  28. ncbi request reprint MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
    M Macias-Silva
    Program in Developmental Biology, Division of Gastroenterology, The Hospital for Sick Children, Toronto, ON, Canada
    Cell 87:1215-24. 1996
    ..Thus, transient association and phosphorylation of MADR2 by the TGFbeta receptor is necessary for nuclear accumulation and initiation of signaling...
  29. ncbi request reprint Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade
    S J Newfeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Development 124:3167-76. 1997
    ..From these observations, we discuss possible roles for MAD in a DPP-dependent serine-threonine kinase signal transduction cascade integral to the proper interpretation of DPP signals...
  30. ncbi request reprint Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
    L Attisano
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 68:97-108. 1992
    ..This receptor heterogeneity might underlie the sharply different responses that activin can elicit in a dose- or cell-specific manner...
  31. pmc Activation of signalling by the activin receptor complex
    L Attisano
    Cell Biology and Genetics Program and Howard Hughes Medical Institute, New York 10021 USA
    Mol Cell Biol 16:1066-73. 1996
    ..The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals...
  32. pmc Identification of a Drosophila activin receptor
    S R Childs
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Proc Natl Acad Sci U S A 90:9475-9. 1993
    ..During development, the highest levels of Atr-II transcript and protein are observed in the mesoderm and gut. The possible role of an activin signaling system in Drosophila development is discussed...
  33. ncbi request reprint Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
    D W Johnson
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 13:189-95. 1996
    ..We report three mutations in the coding sequence of the ALK1 gene in those families which show linkage of the ORW phenotype to chromosome 12. Our data suggest a critical role for ALK1 in the control of blood vessel development or repair...
  34. pmc Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex
    J L Wrana
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Mol Cell Biol 14:944-50. 1994
    ..melanogaster. These results indicate that the heteromeric kinase structure is a general feature of this receptor family...
  35. pmc Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
    J Carcamo
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Mol Cell Biol 14:3810-21. 1994
    ..Hence, we conclude that the type I receptor subunits are primary specifiers of signals sent by TGF-beta and activin receptor complexes...