Affiliation: The Hospital for Sick Children
- Langerhans cell histiocytosis: Current concepts and treatmentsOussama Abla
Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Cancer Treat Rev 36:354-9. 2010..Due to the rarity of LCH in children and adults, patients must be enrolled on multi-national clinical trials, whenever possible, to advance our knowledge of the optimal therapeutic strategies and long-term outcomes...
- Leptomeningeal precursor B-cell lymphoblastic lymphoma in a child with minimal bone marrow involvementOussama Abla
University of Toronto, Division of Hematology Oncology, The Hospital for Sick Children, ON, Canada
J Pediatr Hematol Oncol 26:469-72. 2004..This patient was treated on a high-risk ALL protocol with intensive systemic/intrathecal chemotherapy plus cranial irradiation, and he remained in complete remission 6 months after his initial diagnosis...
- A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiationOussama Abla
Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Blood Cancer 47:880-5. 2006..To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT)...
- bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infectionOussama Abla
The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Hematol Oncol 28:98-9. 2006..He died 8 months after transplant due to idiopathic pneumonia syndrome, but without evidence of relapsed disease...
- Primary CNS lymphoma in children and adolescents: a descriptive analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG)Oussama Abla
Division of Haematology Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
Clin Cancer Res 17:346-52. 2011..To describe the demographic and clinical features and outcomes for children and adolescents with primary CNS lymphoma (PCNSL)...
- Anaplastic large cell lymphoma of the ovary in a pediatric patientAmy Lee Chong
Department of Paediatrics Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Hematol Oncol 31:702-4. 2009..We describe the unusual case of a 14-year-old adolescent with a locally disseminated ovarian anaplastic large-cell lymphoma, treated with surgery followed by chemotherapy, and who remains disease free at 2 years after diagnosis...
- Hemophagocytic lymphohistiocytosis onset during induction therapy for precursor B-cell acute lymphoblastic leukemiaVicky R Breakey
Division of Pediatric Haematology and Oncology, Department of Paediatric Medicine, Hospital for Sick Children, Toronto, Canada
J Pediatr Hematol Oncol 30:956-8. 2008..His symptoms improved significantly after an increased dosage of steroids...
- Isolated central nervous system relapse in childhood acute promyelocytic leukemiaKatrin Scheinemann
Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Hematol Oncol 30:160-2. 2008..The patient remains in molecular remission at 9 months after autologous stem cell transplant. Prognostic factors of CNS relapse in children with APL are needed to define the indications for CNS prophylaxis in this group of patients...
- Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipientsAdam Gassas
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Oncol 22:1222-7. 2004....
- Human metapneumovirus (hMPV) infection in children with cancerMuhammad Ali
Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
J Pediatr Hematol Oncol 35:444-6. 2013..Infections may result in significant disease but is usually not fatal. In the absence of specific anti-viral drug, good symptomatic therapy appears to be the optimal therapy. ..
- Association between obesity at diagnosis and weight change during induction and survival in pediatric acute lymphoblastic leukemiaMarie Chantal Ethier
Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
Leuk Lymphoma 53:1677-81. 2012..74-0.90; p <0.0001). Obese pediatric patients with ALL have inferior survival while increased weight during induction may be associated with better survival. Causes of weight loss during induction should be aggressively managed...
- Risk factors for infection-related outcomes during induction therapy for childhood acute lymphoblastic leukemiaSamina Afzal
Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Infect Dis J 28:1064-8. 2009..The secondary objectives were to describe risk factors for microbiologically documented infections and for patients with a febrile episode, to identify risk factors for recurrence of fever or reinitiation of antibiotics...
- Primary central nervous system lymphoma in childrenOussama Abla
Division of Hematology Oncology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Ontario, Canada
Neurosurg Focus 21:E8. 2006..Further progress in the management of childhood PCNSL will require prospective multinational studies...
- Lumbar spinal fluid collections in children treated with intrathecal chemotherapy: elevated CSF protein as a diagnostic clueFahd Almanjomi
Division of Haematology Oncology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Blood Cancer 51:295-8. 2008..Awareness and detection of this complication by imaging is important because of its potential to interfere with effective CNS-directed chemotherapy of ALL...
- Sevelamer hydrochloride: a novel treatment of hyperphosphatemia associated with tumor lysis syndrome in childrenShaker Abdullah
Divisions of Hematology Oncology, The Hospital for Sick Children, Toronto, Canada
Pediatr Blood Cancer 51:59-61. 2008..Sevelamer is a phosphate-binder used effectively for the treatment of hyperphosphatemia in patients treated with dialysis...
- Features at presentation predict children with acute lymphoblastic leukemia at low risk for tumor lysis syndromeTony H Truong
Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Cancer 110:1832-9. 2007..The objectives of the current study were 1) to describe the prevalence and predictors of TLS in childhood ALL and 2) to develop a sensitive prediction rule to identify patients at lower risk of TLS...
- Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23)Mohamed Abdelhaleem
Division of Haematopathology, Department of Paediatric Laboratory Medicine, Room 3691, Atrium, Hospital for Sick Children, Toronto, Ontario, Canada
Cancer Genet Cytogenet 178:141-3. 2007..3) and t(14;17)(q32;q23), not previously described in childhood acute leukemia. The patient achieved morphological remission following myeloid-based leukemia therapy...
- Hepatitis-associated aplastic anemia presenting as a familial bone marrow failure syndromeVicky Rowena Breakey
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Pediatr Hematol Oncol 31:884-7. 2009..These familial cases raise the possibility of an inherited bone marrow failure syndrome and suggest that severe hepatitis-associated aplastic anemia may not be always an acquired condition...
- Hepatosplenic gammadelta T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantationAdam Gassas
Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Hematol 75:113-4. 2004..Conventional multi-agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymphoma in a boy less than 15 years old treated with hematopoietic stem cell transplantation (HSCT)...
- Coadministration of propofol and remifentanil for lumbar puncture in children: dose-response and an evaluation of two dose combinationsJason A Hayes
Department of Anesthesia, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Anesthesiology 109:613-8. 2008..The authors undertook a two-part study to evaluate coadministration of propofol and remifentanil as an anesthetic technique for lumbar puncture in children...
- Childhood acute lymphoblastic leukaemia simulating multifocal osteomyelitisSandip Bartakke
Paediatric Haematology Oncology, Hospital for Sick Children, Toronto, ON, Canada
Br J Haematol 139:2. 2007
- Severe neutropenia at time of port insertion is not a risk factor for catheter-associated infections in children with acute lymphoblastic leukemiaBeatriz L P Junqueira
Department of Diagnostic Imaging Image Guided Therapy Center, The Hospital for Sick Children, Toronto, Ontario, Canada
Cancer 116:4368-75. 2010..The objective of this study was to determine whether severe neutropenia on the day of port-a-catheter (PORT) insertion was a risk factor for catheter-associated infection (CAI) in children with acute lymphoblastic leukemia (ALL)...
- TEL-AML1 fusion in acute lymphoblastic leukemia with L3 morphologyMohamed Abdelhaleem
Pediatr Blood Cancer 49:217. 2007
- Translocation (X;10) in a child with therapy-related acute myeloid leukemia following chemotherapy for Ewing's SarcomaOussama Abla
Cancer Genet Cytogenet 178:168-9. 2007
- Acute lymphoblastic leukemia with massive myelofibrosisOussama Abla
J Pediatr Hematol Oncol 28:633-4. 2006