B L Tepperman

Summary

Country: Canada

Publications

  1. ncbi Protein kinase C mediates lipopolysaccharide- and phorbol-induced nitric-oxide synthase activity and cellular injury in the rat colon
    B L Tepperman
    Department of Physiology, University of Western Ontario, London, Ontario, Canada
    J Pharmacol Exp Ther 295:1249-57. 2000
  2. pmc The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells
    B L Tepperman
    Department of Physiology, University of Western Ontario, London Ontario, Canada, N6A 5C1
    Br J Pharmacol 128:1268-74. 1999
  3. ncbi The effect of protein kinase C activation on colonic epithelial cellular integrity
    B L Tepperman
    Department of Physiology, University of Western Ontario, London, Ontario, Canada
    Eur J Pharmacol 389:131-40. 2000
  4. ncbi The role of protein kinase C isozymes in TNF-alpha-induced cytotoxicity to a rat intestinal epithelial cell line
    Q Chang
    Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Gastrointest Liver Physiol 280:G572-83. 2001
  5. ncbi Colonic production and expression of IL-4, IL-6, and IL-10 in neonatal suckling rats after LPS challenge
    J K Adams
    Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Gastrointest Liver Physiol 280:G755-62. 2001
  6. pmc Effect of selective PKC isoform activation and inhibition on TNF-alpha-induced injury and apoptosis in human intestinal epithelial cells
    Q Chang
    Department of Physiology and Pharmacology, University of Western Ontario, Medical Sciences Building, Room M226, London, Ontario, Canada N6A 5C1
    Br J Pharmacol 140:41-52. 2003
  7. pmc Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity
    B L Tepperman
    Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada
    Br J Pharmacol 110:229-34. 1993

Collaborators

  • Q Chang
  • J K Adams

Detail Information

Publications7

  1. ncbi Protein kinase C mediates lipopolysaccharide- and phorbol-induced nitric-oxide synthase activity and cellular injury in the rat colon
    B L Tepperman
    Department of Physiology, University of Western Ontario, London, Ontario, Canada
    J Pharmacol Exp Ther 295:1249-57. 2000
    ..These data suggest that PKC mediates iNOS activation and subsequent colonic cell injury in response to LPS administration. The delta- and epsilon-isozymes appear to be most closely associated with these responses...
  2. pmc The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells
    B L Tepperman
    Department of Physiology, University of Western Ontario, London Ontario, Canada, N6A 5C1
    Br J Pharmacol 128:1268-74. 1999
    ..01-10 microM). 6 These data suggest that the PKC-epsilon isoform of the enzyme mediates NO-induced damage to colonic mucosal cells. This response may occur, at least in part, due to peroxynitrite formation...
  3. ncbi The effect of protein kinase C activation on colonic epithelial cellular integrity
    B L Tepperman
    Department of Physiology, University of Western Ontario, London, Ontario, Canada
    Eur J Pharmacol 389:131-40. 2000
    ..Furthermore, oxidant-mediated damage to these cells also involves protein kinase C activation...
  4. ncbi The role of protein kinase C isozymes in TNF-alpha-induced cytotoxicity to a rat intestinal epithelial cell line
    Q Chang
    Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Gastrointest Liver Physiol 280:G572-83. 2001
    ..Furthermore, inhibition of caspase-3 activity reduced apoptosis. These data suggest that activation of selective PKC isoforms mediate the effects of TNF-alpha on intestinal epithelial cell injury...
  5. ncbi Colonic production and expression of IL-4, IL-6, and IL-10 in neonatal suckling rats after LPS challenge
    J K Adams
    Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Gastrointest Liver Physiol 280:G755-62. 2001
    ..Furthermore, neutrophils may be implicated in colonic cytokine expression after LPS challenge in rats...
  6. pmc Effect of selective PKC isoform activation and inhibition on TNF-alpha-induced injury and apoptosis in human intestinal epithelial cells
    Q Chang
    Department of Physiology and Pharmacology, University of Western Ontario, Medical Sciences Building, Room M226, London, Ontario, Canada N6A 5C1
    Br J Pharmacol 140:41-52. 2003
    ..PKCdelta and epsilon primarily mediate the release of mitochondrial cytochrome c and degradation of I-kappaBalpha and hence mobilization of NF-kappaB, which are responsible for the pathway leading to cell injury...
  7. pmc Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity
    B L Tepperman
    Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada
    Br J Pharmacol 110:229-34. 1993
    ..The effects may be mediated at least in part by changes in gastric mucosal blood flow. Salivary glands and EGF may mediate these effects to some extent via changes in mucosal NO biosynthesis...