Jean Claude Tardif

Summary

Country: Canada

Publications

  1. ncbi Impact of residual plaque burden after balloon angioplasty in the MultiVitamins and Probucol (MVP) trial
    J C Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 17:49-55. 2001
  2. ncbi Two-year angiographic follow-up of intracoronary Sr90 therapy for restenosis prevention after balloon angioplasty
    David Meerkin
    Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 106:539-43. 2002
  3. ncbi Antioxidants and atherosclerosis: emerging drug therapies
    Jean Claude Tardif
    MHI Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Curr Atheroscler Rep 7:71-7. 2005
  4. doi Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
    Reza Wakili
    Department of Medicine and Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 3:530-41. 2010
  5. ncbi Insights into oxidative stress and atherosclerosis
    J C Tardif
    Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 16:2D-4D. 2000
  6. ncbi Design features of the Avasimibe and Progression of coronary Lesions assessed by intravascular UltraSound (A-PLUS) clinical trial
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 144:589-96. 2002
  7. ncbi Effects of AGI-1067 and probucol after percutaneous coronary interventions
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    Circulation 107:552-8. 2003
  8. ncbi Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Curr Opin Lipidol 14:615-20. 2003
  9. ncbi Economic impact of contrast stress echocardiography on the diagnosis and initial treatment of patients with suspected coronary artery disease
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Soc Echocardiogr 15:1335-45. 2002
  10. ncbi Vascular protectants for the treatment of atherosclerosis
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Expert Rev Cardiovasc Ther 1:385-92. 2003

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. ncbi Impact of residual plaque burden after balloon angioplasty in the MultiVitamins and Probucol (MVP) trial
    J C Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 17:49-55. 2001
    ..Restenosis occurred in 40% of patients not treated with probucol and in 20% of those in the probucol alone group...
  2. ncbi Two-year angiographic follow-up of intracoronary Sr90 therapy for restenosis prevention after balloon angioplasty
    David Meerkin
    Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 106:539-43. 2002
    ..Postcoronary angioplasty vascular brachytherapy (VBT) has emerged as a successful intervention for restenosis prevention in some clinical scenarios. Longer-term follow-up after VBT in de novo nonstented lesions has not been reported...
  3. ncbi Antioxidants and atherosclerosis: emerging drug therapies
    Jean Claude Tardif
    MHI Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Curr Atheroscler Rep 7:71-7. 2005
    ....
  4. doi Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
    Reza Wakili
    Department of Medicine and Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 3:530-41. 2010
    ..Action potential (AP)-prolonging drugs are reported to normalize atrial hypocontractility caused by atrial tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility...
  5. ncbi Insights into oxidative stress and atherosclerosis
    J C Tardif
    Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 16:2D-4D. 2000
    ....
  6. ncbi Design features of the Avasimibe and Progression of coronary Lesions assessed by intravascular UltraSound (A-PLUS) clinical trial
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 144:589-96. 2002
    ..In addition to ACAT inhibitor monotherapy, combination of a statin with an ACAT inhibitor may be a promising approach to further prevent the progression of atherosclerosis...
  7. ncbi Effects of AGI-1067 and probucol after percutaneous coronary interventions
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    Circulation 107:552-8. 2003
    ..In a multicenter trial, we studied whether AGI-1067 reduces restenosis assessed by intravascular ultrasound (IVUS) after percutaneous coronary intervention (PCI) compared with placebo and probucol used as a positive control...
  8. ncbi Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Curr Opin Lipidol 14:615-20. 2003
    ....
  9. ncbi Economic impact of contrast stress echocardiography on the diagnosis and initial treatment of patients with suspected coronary artery disease
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Soc Echocardiogr 15:1335-45. 2002
    ..To estimate the impact of contrast stress echocardiography on resource use in the treatment of patients with suspected coronary artery disease (CAD)...
  10. ncbi Vascular protectants for the treatment of atherosclerosis
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Expert Rev Cardiovasc Ther 1:385-92. 2003
    ....
  11. ncbi Reliability of mechanical and phased-array designs for serial intravascular ultrasound examinations--animal and clinical studies in stented and non-stented coronary arteries
    J C Tardif
    Interventional Cardiology Laboratories, Montreal Heart Institute, Quebec, Canada
    Int J Card Imaging 16:365-75. 2000
    ..Determination of the reproducibility of measurements is critical before a given system can be used in studies such as regression of atherosclerosis trials...
  12. ncbi The future of intravascular ultrasound in the detection and management of coronary artery disease
    J C Tardif
    Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 16:12D-15D. 2000
    ..The precise assessment of plaque burden by IVUS makes it the ideal tool for a clinical trial of progression and regression of atherosclerosis...
  13. ncbi Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression
    Colin Berry
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Circulation 115:1851-7. 2007
    ..To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical trial population...
  14. ncbi Quantification of the risk and predictors of hyperkalemia in patients with left ventricular dysfunction: a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trials
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Am Heart J 152:705-12. 2006
    ..Limited data are available to predict the occurrence of hyperkalemia. Risk assessment is complicated by the lack of consistency of definition between trials...
  15. ncbi Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction: insight from the Studies Of Left Ventricular Dysfunction (SOLVD) trials
    Emmanuelle Vermes
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Circulation 107:2926-31. 2003
    ....
  16. ncbi Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
    ..The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis. This study was designed to investigate the effects of avasimibe on human coronary atherosclerosis...
  17. ncbi Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy
    Marie Claude Aubin
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 47:702-10. 2006
    ..In conclusion, the antioxidant probucol limited the development and induced the regression of LVH and the associated coronary endothelial dysfunction...
  18. ncbi Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model
    Olivier Malo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 59:501-11. 2003
    ..The objective of this study was to assess the effect of L-arginine, BH(4) and the combination of two antioxidants, superoxide dismutase and catalase, on endothelium-dependent relaxations in a swine left ventricular hypertrophy model...
  19. doi Perioperative intravenous amiodarone does not reduce the burden of atrial fibrillation in patients undergoing cardiac valvular surgery
    Yanick Beaulieu
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Anesthesiology 112:128-37. 2010
    ....
  20. ncbi Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease
    Anil Nigam
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 92:395-9. 2003
    ..An increase in large conduit vessel stiffness may represent either a cause or consequence of endothelial dysfunction and may explain why elevated pulse pressure is a new cardiovascular risk factor...
  21. ncbi Effect of atherosclerotic regression on total luminal size of coronary arteries as determined by intravascular ultrasound
    Jean Claude Tardif
    Department of Medicine and Research Center of the Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Am J Cardiol 98:23-7. 2006
    ..This reverse vascular remodeling may be responsible for the "regression paradox," whereby secondary prevention is associated with clinical benefits despite minimal improvement in coronary lumen dimensions...
  22. ncbi Incidence and significance of abnormal hepatic venous Doppler flow velocities before cardiac surgery
    Maïté Carricart
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 19:751-8. 2005
    ..The purpose of this study was to determine the incidence and significance of abnormal hepatic Doppler venous flow velocities as signs of an abnormal right ventricular filling pattern before cardiac surgery...
  23. ncbi Mineralocorticoid receptor antagonists and cardiovascular mortality in patients with atrial fibrillation and left ventricular dysfunction: insights from the Atrial Fibrillation and Congestive Heart Failure Trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal Heart Institute Coordinating Center, and Université de Montréal, Montreal, QC, Canada
    Circ Heart Fail 5:586-93. 2012
    ..Our primary objective was to assess the impact of mineralocorticoid receptor antagonists on cardiovascular mortality in patients with AF and HF enrolled in the Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial...
  24. doi Unique quantitative trait loci in synergy permanently improve diastolic dysfunction
    Cristina Chauvet
    Research Centre, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 29:1302-9. 2013
    ..We previously demonstrated that diastolic dysfunction and left ventricular hypertrophy (LVH) in Dahl salt-sensitive rats can be ameliorated by quantitative trait loci (QTLs)...
  25. ncbi Identification of atrial tissue in pulmonary veins using intravascular ultrasound
    Peter G Guerra
    Department of Medicine, Montreal Heart Institute
    J Am Soc Echocardiogr 16:982-7. 2003
    ..Ectopic beats initiating AF always originated from these areas. PVs without thickening on IVUS did not have these potentials...
  26. ncbi Sustained elevation of serum CD40 ligand levels one month after coronary angioplasty predicts angiographic restenosis
    Philippe L L'Allier
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 21:495-500. 2005
    ..The intensity of such a reaction as measured by high-sensitivity C-reactive protein has been correlated with recurrent ischemic events, but its association with restenosis remains uncertain...
  27. ncbi Angiotensin-converting enzyme inhibition in hypertensive patients is associated with a reduction in the occurrence of atrial fibrillation
    Philippe L L'Allier
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Coll Cardiol 44:159-64. 2004
    ..The objective of this study was to determine the effects of angiotensin-converting enzyme inhibition (ACEI) versus long-acting calcium-channel blockade (CCB) on atrial fibrillation (AF) in patients with hypertension...
  28. ncbi Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial
    Jean Claude Tardif
    Montreal Heart Institute and the Montreal Heart Institute Coordinating Center, Universite de Montreal, Montreal, Quebec, Canada
    JAMA 297:1675-82. 2007
    ..High-density lipoprotein (HDL) cholesterol is an inverse predictor of coronary atherosclerotic disease. Preliminary data have suggested that HDL infusions can induce atherosclerosis regression...
  29. ncbi Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs
    Kaori Shinagawa
    Department of Medicine, Montreal Heart Institute, and University of Montreal, Montreal, Canada
    Circulation 105:2672-8. 2002
    ..Clinical atrial fibrillation (AF) often results from pathologies that cause atrial structural remodeling. The reversibility of arrhythmogenic structural remodeling on removal of the underlying stimulus has not been studied systematically...
  30. doi Preliminary experience in the use of preoperative echo-guided left stellate ganglion block in patients undergoing cardiac surgery
    Sébastien Y Garneau
    Department of Anesthesiology, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 25:78-84. 2011
    ..Thus, the goal of the study was to test the hypothesis that echo-guided left SGB, performed before the induction of general anesthesia, could prevent PA pressure increases during CPB weaning...
  31. doi T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice
    Khai Le Quang
    Department of Medicine and Research Centre, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 6:799-808. 2013
    ..The role of T-type Ca(2+) channels in pacemaking outside the sinus node is unknown. We investigated the role of T-type Ca(2+) channels in escape rhythms and bradycardia-related ventricular tachyarrhythmias after AVB in mice...
  32. ncbi Left and right ventricular diastolic dysfunction as predictors of difficult separation from cardiopulmonary bypass
    Andre Y Denault
    Department of Anesthesia, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    Can J Anaesth 53:1020-9. 2006
    ....
  33. doi Atorvastatin worsens left ventricular diastolic dysfunction and endothelial dysfunction of epicardial coronary arteries in normocholesterolemic porcine with left ventricular hypertrophy
    Jessica Forcillo
    Cardiac Surgery, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 58:295-306. 2011
    ..05). In this swine model of LVH, atorvastatin did not prevent LVH development or coronary endothelial dysfunction and resulted in worsening of the LV diastolic dysfunction...
  34. ncbi Milrinone enhances systolic, but not diastolic function during coronary artery bypass grafting surgery
    Pierre Couture
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Can J Anaesth 54:509-22. 2007
    ..To evaluate the effect of milrinone on diastolic function during coronary artery bypass grafting surgery (CABG)...
  35. ncbi Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure
    Yanfen Shi
    Montreal Heart Institute, Research Center and Department of Medicine, 5000 Belanger Street East, Montreal HlT 1C8 Quebec, Canada
    Cardiovasc Res 54:456-61. 2002
    ..There have been no studies performed to assess the effects of ACE inhibitors on atrial dimensions and emptying function in relationship to vulnerability to AF in the setting of experimental CHF...
  36. ncbi Effects of plaque composition on vascular remodelling after angioplasty in the MultiVitamins and Probucol (MVP) trial
    Hai Shiang Lee
    Department of Medicine, Montreal Heart Institute, Quebec
    Can J Cardiol 18:271-5. 2002
    ..The antioxidant probucol reduced coronary restenosis in the MultiVitamins and Probucol (MVP) trial by improving vascular remodelling. Whether calcification limits the extent of adaptive vessel enlargement is not known...
  37. pmc Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice
    Virginie Bolduc
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 301:H2081-92. 2011
    ..In conclusion, HR-dependent mechanical stress contributes to carotid artery wall stiffening in severely dyslipidemic mice while cerebrovascular compliance is mostly regulated by the endothelium...
  38. ncbi Temporal increases in subclinical levels of inflammation are associated with adverse clinical outcomes in patients with left ventricular dysfunction
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Card Fail 12:353-9. 2006
    ..The role of temporal changes of more conventional markers of inflammation, such as the white blood cell (WBC) count, on clinical outcomes remains largely unknown...
  39. ncbi Effects of angiotensin-converting enzyme inhibitor plus irbesartan on maximal and submaximal exercise capacity and neurohumoral activation in patients with congestive heart failure
    Martine Blanchet
    Department of Medicine, Division of Cardiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 149:938.e1-7. 2005
    ....
  40. pmc Critical appraisal of C-reactive protein throughout the spectrum of cardiovascular disease
    Raed Osman
    Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Vasc Health Risk Manag 2:221-37. 2006
    ..Therapeutic interventions to decrease circulating levels of CRP are also reviewed...
  41. doi Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome
    Jean Claude Tardif
    Department of Medicine, Radiology, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Cardiovasc Imaging 3:298-307. 2010
    ..Production of leukotrienes by 5-lipoxygenase (5-LO) has been linked to unstable atherosclerotic plaques and cardiovascular events. VIA-2291 is a potent 5-LO inhibitor...
  42. ncbi Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD)
    Emmanuelle Vermes
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Circulation 107:1291-6. 2003
    ....
  43. doi A single bout of high-intensity interval exercise does not increase endothelial or platelet microparticles in stable, physically fit men with coronary heart disease
    Thibaut Guiraud
    Cardiovascular Prevention Centre, Montreal Heart Institute, Montreal, Quebec, Canada Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Sante et de la Recherche Medicale, UMR 1048, Paul Sabatier University, Toulouse, France
    Can J Cardiol 29:1285-91. 2013
    ....
  44. ncbi Absence of association between infectious agents and endothelial function in healthy young men
    Paul Khairy
    Department of Medicine, Montreal Heart Institute, University of Montreal, Quebec, Canada
    Circulation 107:1966-71. 2003
    ..This study assessed whether infection with Chlamydia pneumoniae (CP), cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Helicobacter pylori (HP) is associated with decreased endothelial function...
  45. doi Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure
    Sophie Cardin
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1027-35. 2012
    ..The present study examined the potential role of miR-21 in the atrial AF substrate resulting from experimental heart failure after myocardial infarction (MI)...
  46. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
    ....
  47. ncbi Mitral Doppler indices are superior to two-dimensional echocardiographic and hemodynamic variables in predicting responsiveness of cardiac output to a rapid intravenous infusion of colloid
    Robert Lattik
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Anesth Analg 94:1092-9, table of contents. 2002
    ..We conclude that the MF Doppler filling pattern is an important factor to predict the increase in CO after intravascular fluid challenge in patients undergoing coronary artery bypass grafting...
  48. ncbi Biventricular diastolic filling patterns after coronary artery bypass graft surgery
    Yanfen Shi
    Department of Medicine, Montreal Heart Institute, and University of Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 131:1080-6. 2006
    ..We sought to study the evolution of biventricular filling properties after coronary artery bypass grafting...
  49. doi Atherosclerosis imaging and the Canadian Atherosclerosis Imaging Network
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 29:297-303. 2013
    ..The benefits are expected to appear in the next 2 to 3 years. CAIN will drive innovation in imaging technology within the field of cardiology and neurology and improve health outcomes in Canada and worldwide...
  50. doi Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models
    Kunihiro Nishida
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1168-75. 2012
    ..This study assessed effects of AF-related remodeling on the atrial thrombogenic milieu by using radiofrequency ablation (RFA) to create a quantifiable prothrombotic nidus...
  51. ncbi Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
    Ariel Diaz
    Department of Medicine, Research Center, Montreal Heart Institute, 5000 Belanger Street E, H1T 1C8 Montreal, Canada
    Eur Heart J 26:967-74. 2005
    ..Heart rate reduction is the cornerstone of the treatment of angina. The purpose of this study was to explore the prognostic value of heart rate in patients with stable coronary artery disease (CAD)...
  52. doi Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy
    Kimberley Crespo
    Research Centre, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Hypertens 31:927-35. 2013
    ..We previously showed in principle that diastolic function in Dahl salt-sensitive rats (DSS) can be genetically determined by quantitative trait loci (QTLs) that also modulate blood pressure (BP)...
  53. ncbi Prevention of restenosis with antioxidants: mechanisms and implications
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Am J Cardiovasc Drugs 2:323-34. 2002
    ....
  54. ncbi Right ventricular myocardial performance index predicts perioperative mortality or circulatory failure in high-risk valvular surgery
    Francois Haddad
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Soc Echocardiogr 20:1065-72. 2007
    ..The main objective of this study is to assess the prognostic value of RVMPI and RVFAC in predicting postoperative mortality or circulatory failure...
  55. ncbi Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    J Thorac Cardiovasc Surg 133:1604-11. 2007
    ..The MEND-CABG trial tested the hypothesis that MC-1 reduces cardiovascular morbidity and mortality after coronary artery bypass graft...
  56. ncbi Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial
    Jean Claude Tardif
    Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 197:480-6. 2008
    ..The present study originally intended to study restenosis as a primary endpoint but was subsequently modified to primarily investigate the effects of AGI-1067 on coronary atherosclerosis...
  57. ncbi Specific alterations of endothelial signal transduction pathways of porcine epicardial coronary arteries in left ventricular hypertrophy
    Olivier Malo
    Research Center, Department of Pharmacology, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    J Cardiovasc Pharmacol 42:275-86. 2003
    ..8% +/- 0.2% to 1.2% +/- 0.1% (P < 0.05 versus control). Chronic pressure-overload LVH is associated with an endothelial dysfunction involving both Gi and Gq protein-mediated relaxations in coronary arteries as well as the EDHF pathway...
  58. ncbi Poor correlation between hemodynamic and echocardiographic indexes of left ventricular performance in the operating room and intensive care unit
    Marie Josée Bouchard
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Crit Care Med 32:644-8. 2004
    ..To compare hemodynamic and echocardiographic indexes of left ventricular performance...
  59. ncbi Long-term safety of intravascular ultrasound in nontransplant, nonintervened, atherosclerotic coronary arteries
    Antoine Guédès
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Coll Cardiol 45:559-64. 2005
    ..The goal of this study was to demonstrate that intravascular ultrasound (IVUS) examination of native coronary arteries does not result in an acceleration of the atherosclerotic process...
  60. doi Heart rate recovery after exercise and long-term prognosis in patients with coronary artery disease
    Mathieu Gayda
    Montreal Heart Institute Cardiovascular and Prevention Centre Centre ÉPIC, Montreal, Quebec, Canada
    Can J Cardiol 28:201-7. 2012
    ..The long-term prognostic value of heart rate recovery (HRR) has been incompletely documented in patients with coronary artery disease (CAD). We sought to confirm the prognostic value of HRR in a large cohort with stable CAD...
  61. ncbi Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Eur Heart J 26:2529-36. 2005
    ..Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic effects of ivabradine and the beta-blocker atenolol...
  62. doi Enlargement of catheter ablation lesions in infant hearts with cryothermal versus radiofrequency energy: an animal study
    Paul Khairy
    Electrophysiology Service and Research Center, Montreal Heart Institute, Universite de Montreal, Canada
    Circ Arrhythm Electrophysiol 4:211-7. 2011
    ..It remains unknown whether cryothermal ablation lesions display a similar pattern of growth...
  63. doi Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis
    David Busseuil
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Cardiology 117:234-42. 2010
    ..To determine if heart rate (HR) reduction with ivabradine (IVA), a selective inhibitor of the pacemaker I(f) current, prevents cardiac dysfunction associated with dyslipidemia...
  64. ncbi Detection of myocardial perfusion abnormalities after a recent acute coronary syndrome by quantitative Levovist myocardial contrast echocardiography: comparison with 99m Tc-Myoview SPECT imaging
    Luciana P Fernandes
    Division of Medicine, Montreal Heart Institute, Montreal, Quebec
    Can J Cardiol 19:251-6. 2003
    ..The value of stress harmonic power Doppler imaging (HPDI) for the evaluation of myocardial perfusion has never been assessed in patients after acute coronary syndrome (ACS)...
  65. ncbi Effect of intravenous nitroglycerin on cerebral saturation in high-risk cardiac surgery
    Dominique Piquette
    Department of Anesthesiology and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Can J Anaesth 54:718-27. 2007
    ..To determine whether or not intravenous nitroglycerin (IV NTG) can prevent a decrease in near-infrared spectroscopy (NIRS) values during cardiopulmonary bypass (CPB)...
  66. pmc Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Eur Heart J 30:540-8. 2009
    ..To evaluate the anti-anginal and anti-ischaemic efficacy of the selective I(f) current inhibitor ivabradine in patients with chronic stable angina pectoris receiving beta-blocker therapy...
  67. ncbi The metabolic syndrome and its components and the long-term risk of death in patients with coronary heart disease
    Anil Nigam
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 151:514-21. 2006
    ..We sought to assess the impact of the metabolic syndrome and its individual components on intermediate-term and long-term outcomes in patients with CHD...
  68. ncbi Coronary heart disease in patients with diabetes: part I: recent advances in prevention and noninvasive management
    Colin Berry
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 49:631-42. 2007
    ..Noncompliance, particularly with lifestyle measures, and underprescription of evidence-based therapies remain important unsolved problems...
  69. ncbi Intravascular ultrasound assessment of atherosclerosis
    Antoine Guédès
    Department of Medicine, Montreal Heart Institute, 5000 Belanger Street, Montreal H1T 1C8, Canada
    Curr Atheroscler Rep 6:219-24. 2004
    ..IVUS can also help to determine dose-response relationships in the development of novel pharmacologic agents. IVUS is currently the ideal imaging modality for clinical trials of atherosclerosis progression/regression...
  70. pmc Temporal variations in hematocrit values in patients with left ventricular dysfunction: Relationship with cause-specific mortality and morbidity and optimal monitoring--further insights from SOLVD
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    Can J Cardiol 24:45-8. 2008
    ..Currently, the relationship between temporal variations in hematocrit and specific causes of mortality and morbidity, as well as the most appropriate way to monitor changes in hematocrit, is unknown...
  71. ncbi Coronary heart disease in patients with diabetes: part II: recent advances in coronary revascularization
    Colin Berry
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 49:643-56. 2007
    ..Improvements in PCI and coronary artery bypass graft surgery are leading to better results in diabetic patients, and clinical trials are presently comparing contemporary PCI with surgery...
  72. ncbi Dynamic right ventricular outflow tract obstruction in cardiac surgery
    Andre Y Denault
    Department of Anesthesiology, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 132:43-9. 2006
    ..Right ventricular outflow tract obstruction can be a cause of hemodynamic instability but it has not been described in non-congenital cardiac surgery...
  73. ncbi Inhaled milrinone: a new alternative in cardiac surgery?
    Andre Y Denault
    Department of Cardiac Anesthesiology, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Semin Cardiothorac Vasc Anesth 10:346-60. 2006
    ..Therefore, this approach could represent an alternative to nitric oxide. This current state of knowledge of intravenous and inhaled milrinone is presented and summarized...
  74. doi Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice
    Khai Le Quang
    Research Center and Departments of Medicine, Université de Montréal and Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, Canada
    Cardiovasc Res 91:420-8. 2011
    ..To clarify the role of I(CaT) in cardiac remodelling, we studied mice with either of the principal cardiac I(CaT)-subunits (Cav3.1 or Cav3.2) knocked out...
  75. doi Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
    ..Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated...
  76. doi Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea
    Yu Ki Iwasaki
    Department of Medicine and Research Center, Montreal Heart Institute, Quebec, Canada
    Heart Rhythm 9:1409-16.e1. 2012
    ..Obesity and obstructive sleep apnea (OSA) are risk factors for atrial fibrillation (AF), but the underlying mechanisms are poorly understood...
  77. pmc Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure
    Andreanne Chabot
    Research Center, Montreal Heart Institute Université de Montréal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    BMC Cardiovasc Disord 11:72. 2011
    ..We hypothesized that aldosterone contributes to pulmonary remodelling and right ventricular (RV) dysfunction associated with CHF by stimulation of lung myofibroblasts (MYFs) proliferation...
  78. ncbi Intensity of lipid lowering with statins and brachial artery vascular endothelium reactivity after acute coronary syndromes (from the BRAVER trial)
    Jocelyn Dupuis
    The Research Center of the Montreal Heart Institute and the Department of Medicine of the University of Montreal, Montreal, Quebec, Canada
    Am J Cardiol 96:1207-13. 2005
    ..140) and NMD (p = 0.129). In conclusion, initiation of statin therapy soon after ACS is associated with improvements in endothelium-dependent and independent vascular reactivities after 4 months...
  79. ncbi Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies
    Martial G Bourassa
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada, H1T 1C8
    J Am Coll Cardiol 41:351-9. 2003
    ..Successful medical, interventional, or surgical therapy leads not only to marked improvement or normalization of these alterations but also relief of angina and ischemia...
  80. ncbi Retrospective longitudinal cohort study comparing the effects of angiotensin-converting enzyme inhibitors and long-acting calcium channel blockers on total and cardiovascular mortality in patients with hypertension
    Jean Claude Tardif
    Montreal Heart Institute, Montreal H1T IC8, Canada
    Clin Ther 26:1073-83. 2004
    ..There is controversy regarding the impact that different antihypertensive regimens, including modern combination therapy, have on the incidence of myocardial infarction, other cardiovascular events, and mortality...
  81. pmc Evaluation of coronary atheroma by 64-slice multidetector computed tomography: Comparison with intravascular ultrasound and angiography
    P Ugolini
    Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 25:641-7. 2009
    ..Previous studies have reported an underestimation of plaque burden by MDCT. Whether shorter scan times can allow correct assessment of plaque volume requires comparison with intravascular ultrasound (IVUS)...
  82. ncbi Rapid pacing rotational angiography with three-dimensional reconstruction: use and benefits in structural heart disease interventions
    Stephane Noble
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Canada
    EuroIntervention 5:244-9. 2009
    ..We describe a new imaging technique consisting of rotational angiography combined with rapid pacing to obtain real-time, high-quality, three-dimensional images in the catheterisation laboratory...
  83. doi Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress
    Joanna Rossi
    Dept of Chemical Engineering, McGill University, 3610 University Street, Montreal, QC, Canada
    Life Sci 87:92-9. 2010
    ..In this study, we investigated the combined effect of laminar shear stress (LSS) and statins on endothelial cell gene expression...
  84. ncbi Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
    Tae Joon Cha
    5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
    Circulation 109:412-8. 2004
    ..The relative importance of ionic versus structural remodeling in CHF-related atrial fibrillation (AF) is controversial...
  85. doi Single measurement of troponin T for early prediction of infarct size, congestive heart failure, and pulmonary hypertension in an animal model of myocardial infarction
    Bao Hua Jiang
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Pathol 20:e85-9. 2011
    ..Early prediction of infarct size and of the subsequent development of congestive heart failure (CHF) and pulmonary hypertension (PH) would be useful in therapeutic trials using the rat myocardial infarction (MI) model...
  86. doi Remodeling is a more important determinant of lumen size than atheroma burden in left main coronary artery disease
    Colin Berry
    Department of Medicine, Montreal Heart Institute Université de Montréal, Montreal, Quebec, Canada
    Am Heart J 160:188-194.e1. 2010
    ..Left main coronary artery (LMCA) disease influences survival; however, the predictors of LMCA changes over time are incompletely understood...
  87. doi Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors
    Ba Khoi Nguyen
    Cardiac Surgery, Montreal University Hospital Centre CHUM, Montreal, QC, Canada
    J Cardiovasc Transl Res 3:547-58. 2010
    ..MSC-derived growth factors injection (rather than MSC themselves) should be evaluated as a novel therapy to treat ischemic heart disease, avoiding many practical and technical issues of cell therapy...
  88. doi Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model
    Eduard Guasch
    Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 62:68-77. 2013
    ..The goal of this study was to assess mechanisms underlying atrial fibrillation (AF) promotion by exercise training in an animal model...
  89. doi Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 61:2048-55. 2013
    ..The study aimed to evaluate inclacumab for the reduction of myocardial damage during a percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction...
  90. doi Cardiac remodeling with rhythm versus rate control strategies for atrial fibrillation in patients with heart failure: insights from the AF-CHF echocardiographic sub-study
    Valérie Henrard
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Int J Cardiol 165:430-6. 2013
    ..This echocardiographic sub-study was designed to compare the effects of the two treatment strategies on LV ejection fraction (LVEF), chamber volumes and dimensions, valvular regurgitation and functional status...
  91. doi Real-time compared to off-line evaluation of segmental wall motion abnormalities with transesophageal echocardiography using dobutamine stress testing
    Pierre Couture
    Department of Anesthesiology, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 26:191-6. 2012
    ..To compare real-time (on-line) monitoring of myocardial ischemia with transesophageal echocardiography (TEE) with off-line reviewing during a dobutamine stress test in patients undergoing coronary artery bypass grafting (CABG)...
  92. doi Usefulness of self-reported leisure-time physical activity to predict long-term survival in patients with coronary heart disease
    Francisco Javier Apullan
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Am J Cardiol 102:375-9. 2008
    ..49, p = 0.03 for all-cause mortality; adjusted HR 1.25, 95% CI 0.99 to 1.57, p = 0.05 for CV mortality). In conclusion, leisure-time physical activity independently predicted long-term survival in men and women with chronic stable CHD...
  93. ncbi Is there an association between coronary atherosclerosis and airway responsiveness?
    Julie Turmel
    Laval Hospital Quebec Heart Lung Institute, Quebec City, Montreal, Canada
    Acta Cardiol 63:347-53. 2008
    ..Our objective was to assess the potential relationship between AHR and coronary atherosclerosis plaque volume as assessed by 3-dimensional intravascular ultrasound (IVUS)...
  94. pmc Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    Masahide Harada
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montre al, Montreal, Quebec, Canada
    Circulation 126:2051-64. 2012
    ..Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast regulation by Ca(2+)-permeable transient receptor potential canonical-3 (TRPC3) channels...
  95. pmc Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, Canada H1T 1C8
    Eur Heart J 32:2507-15. 2011
    ..The SHIFT echocardiographic substudy evaluated the effects of ivabradine on left ventricular (LV) remodelling in heart failure (HF)...
  96. ncbi Cardiac investigation in patients with diabetes
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec
    Can J Cardiol 22:38A-40A. 2006
    ..Official guidelines for appropriate and cost-effective cardiac investigation should help physicians manage diabetic patients...
  97. ncbi Vascular biomarkers and surrogates in cardiovascular disease
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 113:2936-42. 2006
    ..The information presented in the present report summarizes the authors' perspective distilled from these proceedings...
  98. doi Physiological stress responses in defensive individuals: age and sex matter
    Karine Levesque
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Psychophysiology 47:332-41. 2010
    ..02). In conclusion, greater defensiveness was associated with increased reactivity to stress in women whereas in older men, lower defensiveness was associated with elevated cardiovascular, autonomic, and endocrine responses to stress...
  99. pmc Fasting but not postprandial (postmeal) glycemia predicts the risk of death in subjects with coronary artery disease
    Anil Nigam
    Montreal Heart Institute, Universite de Montreal, Montreal, Canada
    Can J Cardiol 23:873-8. 2007
    ..Postprandial glycemia may be a stronger CAD risk factor than fasting glycemia in patients without documented heart disease...
  100. ncbi Three-dimensional trajectory assessment of an IVUS transducer from single-plane cineangiograms: a phantom study
    Denis Sherknies
    Department of Computer Science and Operations Research, University of Montreal, Montreal, QC H3T IJ4, Canada
    IEEE Trans Biomed Eng 52:543-9. 2005
    ..The method is described and validated on two helical vessel phantoms, giving on average a reconstructed path that is less than 2 mm distant from the true path when using full-perspective projection...
  101. ncbi Clinical results with AGI-1067: a novel antioxidant vascular protectant
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 91:41A-49A. 2003
    ....