Martin J Yaffe

Summary

Affiliation: Sunnybrook Health Sciences Centre
Country: Canada

Publications

  1. doi request reprint Risk of radiation-induced breast cancer from mammographic screening
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, Room S6 57, Toronto, ON, Canada M4N 3M5
    Radiology 258:98-105. 2011
  2. ncbi request reprint Quality control for digital mammography: part II. Recommendations from the ACRIN DMIST trial
    Martin J Yaffe
    Imaging Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 33:737-52. 2006
  3. doi request reprint Mammographic density, response to hormones, and breast cancer risk
    Norman F Boyd
    DSC, Ontario Cancer Institute, 610 University Ave, Room 10 415, Toronto, Ontario, Canada
    J Clin Oncol 29:2985-92. 2011
  4. pmc Effects of partner proteins on BCA2 RING ligase activity
    Stephanie Bacopulos
    Sunnybrook Research Institute, Toronto, ON, Canada
    BMC Cancer 12:63. 2012
  5. doi request reprint Technical developments in mammography
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Health Phys 95:599-611. 2008
  6. pmc Mammographic density. Measurement of mammographic density
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Breast Cancer Res 10:209. 2008
  7. ncbi request reprint Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
  8. ncbi request reprint Quality control for digital mammography in the ACRIN DMIST trial: part I
    Aili K Bloomquist
    Imaging Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 33:719-36. 2006
  9. doi request reprint Is mammography adequate for screening women with inherited BRCA mutations and low breast density?
    Rachel Z Bigenwald
    Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:706-11. 2008
  10. doi request reprint Is mammographic breast density a breast cancer risk factor in women with BRCA mutations?
    Kavitha Passaperuma
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 28:3779-83. 2010

Collaborators

Detail Information

Publications79

  1. doi request reprint Risk of radiation-induced breast cancer from mammographic screening
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, Room S6 57, Toronto, ON, Canada M4N 3M5
    Radiology 258:98-105. 2011
    ....
  2. ncbi request reprint Quality control for digital mammography: part II. Recommendations from the ACRIN DMIST trial
    Martin J Yaffe
    Imaging Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 33:737-52. 2006
    ....
  3. doi request reprint Mammographic density, response to hormones, and breast cancer risk
    Norman F Boyd
    DSC, Ontario Cancer Institute, 610 University Ave, Room 10 415, Toronto, Ontario, Canada
    J Clin Oncol 29:2985-92. 2011
    ..We have examined the magnitude of the association of hormone exposure with PMD according to subsequent breast cancer risk...
  4. pmc Effects of partner proteins on BCA2 RING ligase activity
    Stephanie Bacopulos
    Sunnybrook Research Institute, Toronto, ON, Canada
    BMC Cancer 12:63. 2012
    ..We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2...
  5. doi request reprint Technical developments in mammography
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Health Phys 95:599-611. 2008
    ..Nevertheless, imaging should be conducted with careful attention to efficient use of the radiation. New techniques, currently under development and evaluation, promise to add further to the value of mammography...
  6. pmc Mammographic density. Measurement of mammographic density
    Martin J Yaffe
    Imaging Research Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Breast Cancer Res 10:209. 2008
    ..In this article, the techniques for measurement of density are reviewed and some consideration is given to their strengths and limitations...
  7. ncbi request reprint Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
    ..Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown...
  8. ncbi request reprint Quality control for digital mammography in the ACRIN DMIST trial: part I
    Aili K Bloomquist
    Imaging Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 33:719-36. 2006
    ..Because of the relatively short duration of this study further, investigation of the long-term failure characteristics of these systems is advisable...
  9. doi request reprint Is mammography adequate for screening women with inherited BRCA mutations and low breast density?
    Rachel Z Bigenwald
    Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:706-11. 2008
    ..We sought to determine the extent to which the low sensitivity of mammography is due to greater breast density...
  10. doi request reprint Is mammographic breast density a breast cancer risk factor in women with BRCA mutations?
    Kavitha Passaperuma
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 28:3779-83. 2010
    ..We present the results of a nested case-control screening study investigating the relationship between breast density and breast cancer incidence in this population...
  11. doi request reprint Improvement in DCIS detection rates by MRI over time in a high-risk breast screening study
    Ellen Warner
    Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Breast J 17:9-17. 2011
    ..MRI-guided biopsy capability is essential for a high-risk screening program. In experienced centers the increased sensitivity of MRI relative to mammography is at least as high for DCIS as it is for invasive breast cancer...
  12. pmc Breast tissue composition and susceptibility to breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Room 10 415 610 University Ave, Toronto, ON, Canada M5G2M9
    J Natl Cancer Inst 102:1224-37. 2010
    ....
  13. ncbi request reprint The dependence of the modulation transfer function on the blocking layer thickness in amorphous selenium x-ray detectors
    David M Hunter
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, M4N 3M5, Canada
    Med Phys 34:3358-73. 2007
    ....
  14. doi request reprint Tumor characteristics associated with mammographic detection of breast cancer in the Ontario breast screening program
    Victoria A Kirsh
    Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON M5G 2L7, Canada
    J Natl Cancer Inst 103:942-50. 2011
    ..Few studies have compared the prognostic value of tumor characteristics by type of breast cancer diagnosed in the interval between mammographic screenings with screen-detected breast cancers...
  15. doi request reprint Family history, mammographic density, and risk of breast cancer
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 19:456-63. 2010
    ..The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease...
  16. ncbi request reprint A CdZnTe slot-scanned detector for digital mammography
    James G Mainprize
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 29:2767-81. 2002
    ..70 +/- 0.02 at 7.1 x 10(-6) C/kg (27 mR) exposure to the detector, despite its relatively poor charge collection efficiency...
  17. doi request reprint Anatomical noise in contrast-enhanced digital mammography. Part II. Dual-energy imaging
    Melissa L Hill
    Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 40:081907. 2013
    ..The influence on the anatomical noise of the presence of iodine in the breast, the timing of imaging postcontrast administration, and the x-ray energy used for acquisition are each evaluated...
  18. ncbi request reprint Lag and ghosting in a clinical flat-panel selenium digital mammography system
    Aili K Bloomquist
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Med Phys 33:2998-3005. 2006
    ..Modifications in the technology of the selenium detectors appear to have resulted in a marked decrease in both lag and ghosting effects in more recent systems...
  19. doi request reprint Mammographic density: a heritable risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Methods Mol Biol 472:343-60. 2009
    ....
  20. ncbi request reprint Mammographic density: a hormonally responsive risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Br Menopause Soc 12:186-93. 2006
    ..A better understanding of the factors that influence the response of breast tissue to these hormonal exposures may lead to an improved understanding of the aetiology of mammographic density and of breast cancer...
  21. ncbi request reprint A solid iodinated phantom material for use in tomographic x-ray imaging
    Melissa L Hill
    Imaging Research, Sunnybrook Health Sciences Centre, S6 35, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:4409-20. 2009
    ..This material can be molded or machined into a desired shape to create a test object or for use in an anthropomorphic phantom...
  22. pmc Evaluation of scatter effects on image quality for breast tomosynthesis
    Gang Wu
    Imaging Research, Sunnybrook Health Sciences Centre, S 657, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:4425-32. 2009
    ....
  23. doi request reprint Digital compared with screen-film mammography: performance measures in concurrent cohorts within an organized breast screening program
    Anna M Chiarelli
    Department of Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON, Canada
    Radiology 268:684-93. 2013
    ..To evaluate the performance of digital direct radiography (DR) and computed radiography (CR) compared with that of screen-film mammography (SFM) in large concurrent cohorts...
  24. doi request reprint Anatomical noise in contrast-enhanced digital mammography. Part I. Single-energy imaging
    Melissa L Hill
    Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 40:051910. 2013
    ..The results are presented in a two-part report, with SE CEDM described here, and DE CEDM in Part II...
  25. doi request reprint The relationship between anatomic noise and volumetric breast density for digital mammography
    James G Mainprize
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 39:4660-8. 2012
    ..Here, a large study is performed to investigate the variations in β in a clinical population and to indicate the relationship between β and breast density...
  26. ncbi request reprint Resolution at oblique incidence angles of a flat panel imager for breast tomosynthesis
    James G Mainprize
    Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Med Phys 33:3159-64. 2006
    ..The impact of this blur is likely to cause misregistration and increased relative noise in tomosynthesis reconstructed images...
  27. ncbi request reprint Influence of patterns of hormone replacement therapy use and mammographic density on breast cancer detection
    Anna M Chiarelli
    Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada M5G 2L7
    Cancer Epidemiol Biomarkers Prev 15:1856-62. 2006
    ..This study explores this relationship further by examining the influence of patterns of HRT use and the percentage of mammographic density on the detection of breast cancer by classification of interval cancer...
  28. doi request reprint Diffuse optical imaging for monitoring treatment response in breast cancer patients
    Omar Falou
    Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada
    Conf Proc IEEE Eng Med Biol Soc 2012:3155-8. 2012
    ..Patient response to the treatment was evaluated from clinical and pathological response using whole-mount pathology after mastectomy...
  29. ncbi request reprint Cascaded analysis of signal and noise propagation through a heterogeneous breast model
    James G Mainprize
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 37:5243-50. 2010
    ..Here, the analytic forms of the signal and noise transfer are derived to obtain an exact expression for any input random distribution and the "power law" filter used to generate the texture of the tissue distribution...
  30. ncbi request reprint Accurate estimation of compressed breast thickness in mammography
    Gordon E Mawdsley
    Room S657, Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:577-86. 2009
    ..On the systems tested, the estimated value of VBD obtained using this method is significantly reduced from that determined using the constant thickness reported by the mammography machine...
  31. ncbi request reprint Evidence that breast tissue stiffness is associated with risk of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    PLoS ONE 9:e100937. 2014
    ..We here use measurements of the volume and the projected area of the compressed breast during mammography to derive estimates of breast tissue stiffness and examine the relationship of stiffness to risk of breast cancer...
  32. doi request reprint Towards a nanoscale mammographic contrast agent: development of a modular pre-clinical dual optical/x-ray agent
    Melissa L Hill
    Physical Sciences, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Phys Med Biol 58:5215-35. 2013
    ..Furthermore, the QDs can be removed from the PFOB agent without affecting its x-ray attenuation or structural properties for expedited translation of optimized PFOB droplet formulations into patients. ..
  33. doi request reprint Characterization of a constrained paired-view technique in iterative reconstruction for breast tomosynthesis
    Gang Wu
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada and Sunnybrook Research Institute, S 657, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 Canada
    Med Phys 40:101901. 2013
    ..Furthermore, a new normalization method is presented. It produces more accurate reconstructions with reduced artifacts comparing to the standard method of sequential ordering...
  34. doi request reprint Comparative performance of modern digital mammography systems in a large breast screening program
    Martin J Yaffe
    Physical Sciences Division, Sunnybrook Research Institute, Departments of Medical Biophysics and Medical Imaging, University of Toronto, Ontario M4N 3M5, Canada
    Med Phys 40:121915. 2013
    ..To examine qualitatively differences in these measures and differences in clinical cancer detection rates between CR and DR among sites within that program...
  35. pmc Mammographic density and breast cancer risk: current understanding and future prospects
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Room 10 415, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Breast Cancer Res 13:223. 2011
    ..Future prospects for the application of PMD include mammographic screening, risk prediction in individuals, breast cancer prevention research, and clinical decision making...
  36. doi request reprint Spectral analysis of mammographic images using a multitaper method
    Gang Wu
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Med Phys 39:801-10. 2012
    ..The performance of the multitaper approach will be evaluated in terms of spectral stability, variance reduction, bias, and frequency precision. The ultimate goal is the development of a useful tool for image quality assurance...
  37. ncbi request reprint Measurement of compressed breast thickness by optical stereoscopic photogrammetry
    Albert H Tyson
    Room S657, Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:569-76. 2009
    ..This measurement tool will allow us to characterize paddle surface deformations, deflections and calibration offsets for mammographic units...
  38. doi request reprint Differences in measured mammographic density in the menstrual cycle
    Gayane Hovhannisyan
    Ontario Cancer Institute University Health Network, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 18:1993-9. 2009
    ..To examine this possible effect, we compared mammographic density in premenopausal women who had mammograms at different phases of the menstrual cycle...
  39. ncbi request reprint Detectors for digital mammography
    Martin J Yaffe
    Imaging Research Program, Sunnybrook and Women s College, Health Sciences Centre, University of Toronto, Room S6 57, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5
    Technol Cancer Res Treat 3:309-24. 2004
    ..Here, some of the considerations related to the detector technology for digital mammography will be discussed and systems currently available will be described...
  40. ncbi request reprint Design and characterization of a digital image acquisition system for whole-specimen breast histopathology
    Gina M Clarke
    Imaging Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Phys Med Biol 51:5089-103. 2006
    ..The tests demonstrate that the system is largely adequate for the imaging task, although further optimizations are required to reduce the degradation of coverage incurred by seam artefact...
  41. ncbi request reprint Contrast-enhanced digital mammography: initial clinical experience
    Roberta A Jong
    Department of Medical Imaging, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Ave, MG178, Toronto, Ontario, Canada M4N 3M5
    Radiology 228:842-50. 2003
    ..To investigate the potential of using intravenous contrast material with full-field digital mammography to facilitate the detection and characterization of lesions in the breast...
  42. ncbi request reprint A volumetric method for estimation of breast density on digitized screen-film mammograms
    Olga Pawluczyk
    Imaging Bioengineering Research, Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 30:352-64. 2003
    ..Clinical studies are ongoing to evaluate whether VBD can be a better indicator for breast cancer risk...
  43. ncbi request reprint Effect of scatter and an antiscatter grid on the performance of a slot-scanning digital mammography system
    Sam Z Shen
    Imaging Research, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Ave, Room SG12, Toronto, Ontario, M4N 3M5, Canada
    Med Phys 33:1108-15. 2006
    ..It is possible that greater benefit could be achieved by using a grid with a higher Tp, such as obtained using air-core technology...
  44. ncbi request reprint Spatial resolution requirements for acquisition of the virtual screening slide for digital whole-specimen breast histopathology
    Gina M Clarke
    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5
    Hum Pathol 38:1764-71. 2007
    ..Factors related to the readers may have also affected performance in this study. Based on these results, a more comprehensive study should examine pixel sizes between 0.7 and 1.9 microm...
  45. ncbi request reprint Early prediction of therapy responses and outcomes in breast cancer patients using quantitative ultrasound spectral texture
    Ali Sadeghi-Naini
    Imaging Research Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Oncotarget 5:3497-511. 2014
    ..002). Such early prediction permits offering effective alternatives to standard treatment, or switching to a salvage therapy, for refractory patients. ..
  46. doi request reprint Increasing specimen coverage using digital whole-mount breast pathology: implementation, clinical feasibility and application in research
    Gina M Clarke
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Comput Med Imaging Graph 35:531-41. 2011
    ....
  47. doi request reprint Development and evaluation of a robust algorithm for computer-assisted detection of sentinel lymph node micrometastases
    Gina M Clarke
    Imaging Research, Sunnybrook Health Sciences Centre, Department of Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Histopathology 59:116-28. 2011
    ..To make serial sectioning feasible, we have developed an algorithm for computer-assisted detection (CAD) with digitized lymph node sections...
  48. ncbi request reprint Mammographic breast density as an intermediate phenotype for breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Lancet Oncol 6:798-808. 2005
    ....
  49. ncbi request reprint Digital mammography: 2005
    Roberta A Jong
    Department of Medical Imaging, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON
    Can Assoc Radiol J 56:319-23. 2005
  50. ncbi request reprint Point/Counterpoint. Film mammography for breast cancer screening in younger women is no longer appropriate because of the demonstrated superiority of digital mammography for this age group
    Martin J Yaffe
    Sunnybrook and Women s College Health Sciences Centre and Department of Medical Imaging, University of Toronto, Toronto, Canada
    Med Phys 33:3979-82. 2006
  51. ncbi request reprint Dependence of image quality on geometric factors in breast tomosynthesis
    James G Mainprize
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 38:3090-103. 2011
    ..The sensitivity of image reconstruction to geometric inaccuracies is investigated by simulation of image formation and reconstruction for a DBT system...
  52. doi request reprint A novel, automated technology for multiplex biomarker imaging and application to breast cancer
    Gina M Clarke
    Sunnybrook Research Institute, Toronto, ON, Canada
    Histopathology 64:242-55. 2014
    ....
  53. doi request reprint Measured and calculated K-fluorescence effects on the MTF of an amorphous-selenium based CCD x-ray detector
    David M Hunter
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Med Phys 39:608-22. 2012
    ..This paper compares measured MTF changes above and below the Se K-edge of a CCD based a-Se x-ray detector with theoretical expectations...
  54. doi request reprint An improved processing method for breast whole-mount serial sections for three-dimensional histopathology imaging
    Laibao Sun
    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Canada
    Am J Clin Pathol 131:383-92. 2009
    ..No adverse effects of microwaves on morphologic features, antigenicity, or gross tissue dimensions were observed...
  55. ncbi request reprint Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination
    Ellen Warner
    Division of Medical Oncology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre and University of Toronto, Ontario, Canada
    JAMA 292:1317-25. 2004
    ..Magnetic resonance imaging (MRI) and ultrasound may improve the ability to detect breast cancer at an early stage...
  56. ncbi request reprint Mammographic density as a surrogate marker for the effects of hormone therapy on risk of breast cancer
    Norman F Boyd
    Ontario Cancer Institute, Room 10 415, 610 University Avenue, Toronto, Ontario, Canada M5G 2K9
    Cancer Epidemiol Biomarkers Prev 15:961-6. 2006
    ..This research was undertaken to determine whether the effect of hormone therapy on breast cancer risk is mediated by its effect on mammographic density...
  57. doi request reprint Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer
    Hany Soliman
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 16:2605-14. 2010
    ..In this study, we evaluated tumor DOS parameters and described their relationship to clinical and pathologic outcome in patients undergoing neoadjuvant therapy for locally advanced breast cancer...
  58. ncbi request reprint A slot-scanned photodiode-array/CCD hybrid detector for digital mammography
    James G Mainprize
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Med Phys 29:214-25. 2002
    ..For a 26 kVp spectrum, the DQE(0) was measured to be 0.75+/-0.02 for an exposure of 1.29 x 10(-5) C/kg (50 mR)...
  59. ncbi request reprint Development of contrast digital mammography
    Mia Skarpathiotakis
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Med Phys 29:2419-26. 2002
    ..The total x-ray dose from the procedure ranges between 1 and 3 mGy, similar to that from a conventional single view film mammogram. A clinical pilot study is currently being carried out to evaluate this technique...
  60. ncbi request reprint What should the burden of proof be for acceptance of a new breast-cancer screening technique?
    Martin J Yaffe
    Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada M4N 3M5
    Lancet 364:1111-2. 2004
  61. ncbi request reprint Method of measuring NEQ as a quality control metric for digital mammography
    Aili K Bloomquist
    Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 41:031905. 2014
    ..The purpose of this work is to explore use of a simple phantom to measure the components of the noise-equivalent quanta of digital mammography systems for use in routine quality control...
  62. pmc Evaluation of neoadjuvant chemotherapy response in women with locally advanced breast cancer using ultrasound elastography
    Omar Falou
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Imaging Research Physical Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Transl Oncol 6:17-24. 2013
    ..The aim of this study was to investigate the potential of ultrasound elastography for monitoring treatment response of locally advanced breast cancer patients undergoing neoadjuvant therapy...
  63. pmc Diffuse optical spectroscopy evaluation of treatment response in women with locally advanced breast cancer receiving neoadjuvant chemotherapy
    Omar Falou
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Transl Oncol 5:238-46. 2012
    ....
  64. doi request reprint In vitro assessment of poly-iodinated triglyceride reconstituted low-density lipoprotein: initial steps toward CT molecular imaging
    Melissa L Hill
    Imaging Research, Sunnybrook Health Sciences Centre, Room S6 57, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Acad Radiol 17:1359-65. 2010
    ..LDLs are targeted to the LDL cell surface receptor (LDLR), which is overexpressed in several tumor types. The LDL-LDLR pathway presents a high-capacity and self-renewing transport system for molecular imaging in CT...
  65. ncbi request reprint Heritability of mammographic density, a risk factor for breast cancer
    Norman F Boyd
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Canada
    N Engl J Med 347:886-94. 2002
    ..8 to 6.0 times that of women of the same age with little or no density. Menopausal status, weight, and parity account for 20 to 30 percent of the age-adjusted variation in the percentage of dense tissue...
  66. ncbi request reprint Direct conversion detectors: the effect of incomplete charge collection on detective quantum efficiency
    James G Mainprize
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Med Phys 29:976-90. 2002
    ..The optimization of detector thickness should be based not only on quantum efficiency but also on the charge collection statistics, which are influenced by bias field and polarity...
  67. ncbi request reprint A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density
    Joe H Lai
    Centre for Research in Women s Health, University of Toronto, 8790 Bay Street, Toronto, Ontario, M5G 1N8 Canada
    Cancer Epidemiol Biomarkers Prev 13:573-82. 2004
    ....
  68. pmc Experimental manipulation of radiographic density in mouse mammary gland
    Mehrdad Hariri
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, Toronto, Ontario, Canada
    Breast Cancer Res 6:R540-5. 2004
    ..Mouse models provide a powerful approach to the study of human diseases, but there is currently no model that is suited to the study of mammographic density...
  69. doi request reprint Intermixed normal tissue within prostate cancer: effect on MR imaging measurements of apparent diffusion coefficient and T2--sparse versus dense cancers
    Deanna L Langer
    Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network, University of Toronto, Rm 3 958, 610 University Ave, Toronto, ON, Canada M5G 2M9
    Radiology 249:900-8. 2008
    ..To investigate differences in apparent diffusion coefficient (ADC) and T2 values between dense and sparse regions in prostate cancer...
  70. ncbi request reprint The ACR's Mammography Accreditation Program: ten years of experience since MQSA
    Judy M Destouet
    Advanced Radiology
    J Am Coll Radiol 2:585-94. 2005
    ..In 2003, 88.3% of the units passed on their first attempts, indicating a marked improvement in the quality of mammography in the United States since MQSA went into effect 10 years ago...
  71. ncbi request reprint The heritability of mammographically dense and nondense breast tissue
    Jennifer Stone
    Centre for Molecular Environmental Genetic and Analytic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 15:612-7. 2006
    ..Our previous twin study showed that the heritability of PMD was 63%. This study determined the heritabilities of the components of PMD, the areas of dense and nondense tissue in the mammogram...
  72. doi request reprint A limitation of ACRIN DMIST
    Gordon L Hixson
    Radiology 248:702; author reply 702-3. 2008
  73. pmc Optimization of exposure parameters in full field digital mammography
    Mark B Williams
    Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Med Phys 35:2414-23. 2008
    ..In most cases, the AECs of the FFDM systems successfully identified exposure parameters resulting in FOM values near the maximum ones, however, there were several examples where AEC performance could be improved...
  74. pmc Diagnostic accuracy of digital versus film mammography: exploratory analysis of selected population subgroups in DMIST
    Etta D Pisano
    Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7510, USA
    Radiology 246:376-83. 2008
    ....
  75. ncbi request reprint Digital mammography
    Etta D Pisano
    Department of Radiology and Biomedical Engineering and UNC Lineberger Comprehensive Cancer Center, University of North Carolina, 515 Old Infirmary, CB 7510, Chapel Hill, NC 27599, USA
    Radiology 234:353-62. 2005
    ..In addition, several potentially useful applications that are being developed with digital mammography will be described...
  76. ncbi request reprint American College of Radiology Imaging Network digital mammographic imaging screening trial: objectives and methodology
    Etta D Pisano
    Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Radiology 236:404-12. 2005
    ....
  77. ncbi request reprint DMIST results: technologic or observer variability?
    Daniel B Kopans
    Radiology 248:703; author reply 703. 2008
  78. ncbi request reprint Image quality in digital mammography: image acquisition
    Mark B Williams
    University of Virginia, Charlottesville, VA 22908 1339, USA
    J Am Coll Radiol 3:589-608. 2006
    ....
  79. ncbi request reprint Reference values for diagnostic radiology: application and impact
    Joel E Gray
    Landauer, 2 Science Road, Glenwood, IL 60425, USA
    Radiology 235:354-8. 2005
    ..RVs are a useful tool for comparing patient radiation doses at institutions throughout the United States and for providing information about radiographic equipment performance...