Research Topics
| Laurie J MorrisonSummaryAffiliation: Sunnybrook Health Sciences Centre Country: Canada Publications
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Detail Information
Publications
A randomized controlled feasibility trial comparing safety and effectiveness of prehospital pacing versus conventional treatment: 'PrePACE'Laurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook Health Sciences Centre, Toronto, Ont, Canada
Resuscitation 76:341-9. 2008..To evaluate the feasibility of a prehospital randomized controlled trial comparing transcutaneous pacing (TCP) with dopamine for unstable bradycardia...
Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac ArrestLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5
Resuscitation 78:161-9. 2008..To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest...- Inter-rater reliability and comfort in the application of a basic life support termination of resuscitation clinical prediction rule for out of hospital cardiac arrestLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Resuscitation 74:150-7. 2007.... - Derivation and evaluation of a termination of resuscitation clinical prediction rule for advanced life support providersLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
Resuscitation 74:266-75. 2007..Validation of a rule for termination of resuscitation in out-of-hospital cardiac arrest. N Engl J Med 2006;355(5):478-87] on the same cohort of patients for comparison purposes... - Validation of a universal prehospital termination of resuscitation clinical prediction rule for advanced and basic life support providersLaurie J Morrison
Prehospital and Transport Medicine Research Program, Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Resuscitation 80:324-8. 2009..We sought to externally validate each rule on a prospective cohort of prehospital cardiac arrest patients to determine if either rule could be proposed as a universal prehospital termination of resuscitation rule... - Termination of resuscitation: a guide to interpreting the literatureLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Resuscitation 79:387-90. 2008..Very few publish the EMS transport rate when the rule is applied; the outcome of interest to EMS services... - The Toronto prehospital hypertonic resuscitation--head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trialLaurie J Morrison
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Ontario, Canada
J Crit Care 26:363-72. 2011..The aim of the study was to evaluate the feasibility of a prehospital trial comparing hypertonic saline and dextran (HSD) with normal saline (NS) in blunt head injury patients... 
Knowledge translation in emergency medical services: a qualitative survey of barriers to guideline implementationBlair L Bigham
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
Resuscitation 81:836-40. 2010..The American Heart Association (AHA) released guidelines to improve survival rates from out-of-hospital cardiac arrest in 2005. We sought to identify what barriers delayed the implementation of these guidelines in EMS agencies...- Validation of a rule for termination of resuscitation in out-of-hospital cardiac arrestLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ont, Canada
N Engl J Med 355:478-87. 2006..CONCLUSIONS: The use of a clinical prediction rule for the termination of resuscitation may help clinicians decide whether to terminate basic life support resuscitative efforts in patients having an out-of-hospital cardiac arrest... - Cardiac arrest survival did not increase in the Resuscitation Outcomes Consortium after implementation of the 2005 AHA CPR and ECC guidelinesBlair L Bigham
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B1W8, Canada
Resuscitation 82:979-83. 2011..We examined the effect of the 2005 American Heart Association guidelines on survival in the Resuscitation Outcomes Consortium (ROC) Cardiac Arrest Epistry... - Out-of-hospital cardiac arrest rectilinear biphasic to monophasic damped sine defibrillation waveforms with advanced life support intervention trial (ORBIT)Laurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, Institute for Clinical and Evaluative Sciences, Department of Medicine, University of Toronto, Toronto, Ont, Canada
Resuscitation 66:149-57. 2005..This effectiveness study compared monophasic and biphasic defibrillation waveform for conversion of ventricular arrhythmias in all OHCA treated with advance life support (ALS)... - Rationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)Warren J Cantor
Southlake Regional Health Centre, Newmarket, Ontario, Canada
Am Heart J 155:19-25. 2008..The role of routine early PCI after fibrinolysis, using stents and contemporary pharmacotherapy, has not been studied in a large adequately powered randomized trial... - Emergency department gridlock and out-of-hospital delays for cardiac patientsMichael J Schull
Department of Emergency Services, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Acad Emerg Med 10:709-16. 2003..To determine the effect of simultaneous ambulance diversion at multiple emergency departments (EDs) (gridlock) on transport delays for patients with chest pain... - Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patientsShawn G Rhind
Defence Research and Development Canada, Toronto, Canada
J Neuroinflammation 7:5. 2010..This study examined the impact of hypertonic fluids on inflammatory/coagulation cascades in isolated head injury... - Emergency department contributors to ambulance diversion: a quantitative analysisMichael J Schull
Clinical Epidemiology Unit and the Department of Emergency Services, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Ann Emerg Med 41:467-76. 2003..CONCLUSION: Admitted patients in the ED are important determinants of ambulance diversion, whereas nurse hours and most emergency physicians are not. Reducing the volume of walk-in patients is unlikely to lessen the use of diversion... - A citywide prehospital protocol increases access to stroke thrombolysis in TorontoDavid J Gladstone
North and East GTA Ontario Regional Stroke Centre and Division of Neurology, Department of Medicine, and Brain Sciences Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Stroke 40:3841-4. 2009..This report describes the initial impact of the activation protocol at our regional stroke center... - Prehospital triage and direct transport of patients with ST-elevation myocardial infarction to primary percutaneous coronary intervention centres: a systematic review and meta-analysisSteven C Brooks
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
CJEM 11:481-92. 2009..We sought to determine whether direct transport of adult STEMI patients by emergency medical services to primary PCI centres improves 30-day all-cause mortality when compared with a strategy of transportation to the closest hospital... - Efficacy of early invasive management post-fibrinolysis in men versus women with ST-elevation myocardial infarction: a subgroup analysis from Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial InfarctioVineet Bhan
Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
Am Heart J 164:343-50. 2012..However, it is not clear whether treatment efficacy differs between men and women... - Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 2: rationale and methodology for "Analyze Later vs. Analyze Early" protocolIan G Stiell
Ottawa, Ontario, Canada
Resuscitation 78:186-95. 2008.... - Delayed prehospital implementation of the 2005 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiac careBlair L Bigham
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B1W8
Prehosp Emerg Care 14:355-60. 2010..In 2005, the American Heart Association (AHA) released guidelines to improve survival rates from out-of-hospital cardiac arrest (OHCA)... - Prehospital evaluation and economic analysis of different coronary syndrome treatment strategies--PREDICT--rationale, development and implementationLaurie J Morrison
Rescue, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
BMC Emerg Med 11:4. 2011..The main objective is to compare prehospital care strategies for time to treatment and survival outcomes as well as cost effectiveness... - Patient safety in emergency medical services: a systematic review of the literatureBlair L Bigham
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Prehosp Emerg Care 16:20-35. 2012.... - Measuring the EMS patient access time interval and the impact of responding to high-rise buildingsLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
Prehosp Emerg Care 9:14-8. 2005.... - Derivation of a termination-of-resuscitation guideline for emergency medical technicians using automated external defibrillatorsP Richard Verbeek
Division of Prehospital Care, Department of Emergency Services, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Acad Emerg Med 9:671-8. 2002.... - Perceived barriers to therapeutic hypothermia for patients resuscitated from cardiac arrest: a qualitative study of emergency department and critical care workersAlina Toma
Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
Crit Care Med 38:504-9. 2010..Despite scientific evidence to support therapeutic hypothermia for resuscitated cardiac arrest patients, it is inconsistently and at times inadequately used... - Use of personal protective equipment during infectious disease outbreak and nonoutbreak conditions: a survey of emergency medical techniciansLaura M Visentin
Dalla Lana School of Public Health, University of Toronto, Toronto, Ont
CJEM 11:44-56. 2009.... - The Toronto prehospital hypertonic resuscitation-head injury and multi organ dysfunction trial (TOPHR HIT)--methods and data collection toolsLaurie J Morrison
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond St, Toronto Ontario, Canada
Trials 10:105. 2009..We describe a feasibility study of randomizing head injured patients to hypertonic saline and dextran vs. normal saline administration in the out of hospital setting... - Prehospital transcutaneous cardiac pacing for symptomatic bradycardia or bradyasystolic cardiac arrest: a systematic reviewJonathan Sherbino
Division of Emergency Medicine, Department of Medicine, University of Toronto, and Sunnybrook Osler Centre for Prehospital Care, Toronto, Ont, Canada
Resuscitation 70:193-200. 2006..There is inadequate evidence to determine the efficacy of prehospital TCP in the treatment of symptomatic bradycardia... - What is the role of chest compression depth during out-of-hospital cardiac arrest resuscitation?Ian G Stiell
Department of Emergency Medicine and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Crit Care Med 40:1192-8. 2012..We sought to study patterns of cardiopulmonary resuscitation compression depth and their associations with patient outcomes in out-of-hospital cardiac arrest cases treated by the 2005 guideline standards... - Out-of-hospital cardiac arrests occurring in southern Ontario health care clinics: bystander cardiopulmonary resuscitation and automated external defibrillator useSteven C Brooks
Rescu, St Michael s Hospital, 30 Bond St, Toronto, ON M5B 1W8, Canada
Can Fam Physician 56:e213-8. 2010.... - Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhageChristopher B Allard
Department of Surgery and or Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
J Trauma 67:959-67. 2009..ICH commonly increases in size and coagulopathy has been implicated in such progression. We investigated the association between coagulopathy diagnosed by routine laboratory tests and ICH progression... - Prehospital 12-lead electrocardiography impact on acute myocardial infarction treatment times and mortality: a systematic reviewLaurie J Morrison
Department of Emergency Services, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Acad Emerg Med 13:84-9. 2006..The authors systematically reviewed the literature to report whether mortality or treatment time intervals improved when compared with standard care... - Responses to written notification during out-of-hospital care trials using waiver of informed consentJulia M Spence
Centre for Research on Inner City Health, Department of Emergency Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Acad Emerg Med 12:1099-103. 2005..Resuscitation research has been allowed to proceed using waiver of consent when compliance with guidelines is assured. In these circumstances, institutional review boards (IRBs) may request notification of enrolled patients... - Development of a data dictionary for the Strategies for Post Arrest Resuscitation Care (SPARC) network for post cardiac arrest researchSteve Lin
Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Resuscitation 82:419-22. 2011..However, collection of many of these variables poses significant practical challenges. In addition, several important variables in post resuscitation research are missing... - Out-of-hospital cardiac arrest frequency and survival: evidence for temporal variabilitySteven C Brooks
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Resuscitation 81:175-81. 2010..Some cardiac phenomena demonstrate temporal variability. We evaluated temporal variability in out-of-hospital cardiac arrest (OHCA) frequency and outcome... - Evaluating paramedic comfort with field pronouncement: development and validation of an outcome measureLaurie J Morrison
Department of Emergency Services, Sunnybrook and Women s Health Sciences Center, Division of Emergency Medicine, Department of Medicine, University of Toronto, Ontario, Canada
Acad Emerg Med 10:633-7. 2003..The authors developed and evaluated the reliability and validity of a survey instrument measuring paramedic comfort with field pronouncement... - Emergency department overcrowding and ambulance transport delays for patients with chest painMichael J Schull
Department of Emergency Services, Toronto, ON, Canada
CMAJ 168:277-83. 2003..Emergency department overcrowding sometimes results in diversion of ambulances to other locations. We sought to determine the resulting prehospital delays for cardiac patients... - Implementation of therapeutic hypothermia guidelines for post-cardiac arrest syndrome at a glacial pace: seeking guidance from the knowledge translation literatureSteven C Brooks
Division of Emergency Medicine, Department of Medicine, University of Toronto, Canada
Resuscitation 77:286-92. 2008..We will review the underlying phenomenon of research implementation into practice, specific barriers to guideline implementation and interventions that may improve therapeutic hypothermia uptake... - Patient safety in emergency medical services: executive summary and recommendations from the Niagara SummitBlair L Bigham
University of Toronto, Toronto, Canada
CJEM 13:13-8. 2011.... - Management of cardiac arrest in pregnancy: a systematic reviewFarida M Jeejeebhoy
Department of Medicine, University of Toronto, Division of Cardiology, Mount Sinai Hospital, Toronto, ON, Canada
Resuscitation 82:801-9. 2011..To describe the consensus on science pertaining to resuscitation of the pregnant patient... - Predictive validity of the Global Assessment Form used in a final-year undergraduate rotation in emergency medicineGlen W Bandiera
Department of Emergency Services, St Michael s Hospital, Toronto, Ontario, Canada
Acad Emerg Med 9:889-95. 2002.... - Immediate angioplasty after thrombolysis: a systematic reviewWarren J Cantor
Division of Cardiology, St Michael s Hospital, and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada
CMAJ 173:1473-81. 2005..We performed a systematic review of the related literature to determine whether thrombolysis followed by transfer for immediate or early PCI is safe, feasible and superior to conservative management... - Mechanical versus manual chest compressions for cardiac arrestSteven C Brooks
Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute at St Michael s Hospital and the Sunnybrook Health Sciences Centre Program for Trauma, Emergency and Critical Care, Division of Emergency Medicine, Department of Medicine, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
Cochrane Database Syst Rev 1:CD007260. 2011..Mechanical chest compression devices have been proposed to improve the effectiveness of cardiopulmonary resuscitation (CPR)... - Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patientsAndrew J Baker
Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
J Neurotrauma 26:1227-40. 2009..Pre-hospital resuscitation with HSD is associated with a reduction in serum S100B, NSE, and MBP concentrations, which are correlated with better outcome after severe TBI... - A knowledge translation collaborative to improve the use of therapeutic hypothermia in post-cardiac arrest patients: protocol for a stepped wedge randomized trialKatie N Dainty
RESCU Research Program, Keenan Research Centre, Li Ka Shing Knowledge Institute, St, Michael s Hospital Toronto, Canada
Implement Sci 6:4. 2011..Despite the strong evidence for its efficacy and the apparent simplicity of this intervention, recent surveys show that therapeutic hypothermia is delivered inconsistently, incompletely, and often with delay... - Defining the outcome measures for out-of-hospital trials in acute pulmonary edemaMichelle Welsford
Research Program, Division of Prehospital Care, Department of Emergency Services, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Acad Emerg Med 9:983-8. 2002..Clinicians appear to favor short-term and non-mortality outcomes for out-of-hospital interventions. The use of this set of APE outcome measures may improve the design and comparability of future out-of-hospital trials... - The Resuscitation Outcomes Consortium Epistry-Trauma: design, development, and implementation of a North American epidemiologic prehospital trauma registryCraig D Newgard
Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR 97239 3098, United States
Resuscitation 78:170-8. 2008..This data registry samples patients from 264 EMS agencies transporting to 287 acute care hospitals in both the United States and Canada... - Hypertonic resuscitation: design and implementation of a prehospital intervention trialKaren J Brasel
Department of Surgery, Division of Trauma Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Am Coll Surg 206:220-32. 2008..Trauma is the leading cause of death among North Americans between the ages of 1 and 44 years. Resuscitation with hypertonic saline (7.5%) solutions can reduce mortality in hypotensive and brain-injured patients... - Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement: a scientific statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Virginia Commonwealth University, USA
Circulation 116:2481-500. 2007 - Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement. A Scientific Statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Resuscitation 75:412-33. 2007 - Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC and CPR Science with Treatment Recommendations. A consensusRaúl J Gazmuri
Rosalind Franklin University of Medicine and Science, North Chicago Medical Center, Chicago, USA
Resuscitation 75:400-11. 2007 - Subcutaneous glucagon may be better than oral glucose for prehospital treatment of symptomatic hypoglycemiaMarian J Vermeulen
Diabetes Care 26:2472-3. 2003 - Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC [corrected] and CPR science with treatment recommendations:Raúl J Gazmuri
North Chicago VA and Rosalind Franklin University of Medicine and Science, USA
Circulation 116:2501-12. 2007 - Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility studyWarren J Cantor
Southlake Regional Health Centre, Newmarket, Canada
Can J Cardiol 22:1121-6. 2006..Urgent PCI after thrombolysis may optimize reperfusion and prevent reinfarction and recurrent ischemia...