Nathan Herrmann

Summary

Affiliation: Sunnybrook and Women's College Health Sciences Centre
Country: Canada

Publications

  1. ncbi Do atypical antipsychotics cause stroke?
    Nathan Herrmann
    Division of Geriatric Psychiatry, University of Toronto, Toronto, Ontario, Canada
    CNS Drugs 19:91-103. 2005
  2. ncbi Panic disorder in later life: results from a national survey of Canadians
    Laurie M Corna
    Department of Public Health Sciences, University of Toronto, Canada
    Int Psychogeriatr 19:1084-96. 2007
  3. ncbi Current prescription patterns and safety profile of irreversible monoamine oxidase inhibitors: a population-based cohort study of older adults
    Kenneth I Shulman
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada
    J Clin Psychiatry 70:1681-6. 2009
  4. ncbi Comorbid depression and anxiety in later life: patterns of association, subjective well-being, and impairment
    John Cairney
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON
    Am J Geriatr Psychiatry 16:201-8. 2008
  5. ncbi Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury
    Krista L Lanctot
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Brain Inj 24:959-69. 2010
  6. ncbi Behavioral correlates of GABAergic disruption in Alzheimer's disease
    Krista L Lanctot
    Neuropharmacology Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int Psychogeriatr 19:151-8. 2007
  7. ncbi The relationship between inflammatory markers and post stroke cognitive impairment
    Lana S Rothenburg
    Neuropsychopharmacology Research Group, Toronto, Ontario, Canada
    J Geriatr Psychiatry Neurol 23:199-205. 2010
  8. ncbi Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 19:1026-33. 2011
  9. ncbi Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease
    Walter Swardfager
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Geriatr Soc 58:1519-25. 2010
  10. ncbi Apathy associated with Alzheimer disease: use of dextroamphetamine challenge
    Krista L Lanctot
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Geriatr Psychiatry 16:551-7. 2008

Collaborators

Detail Information

Publications96

  1. ncbi Do atypical antipsychotics cause stroke?
    Nathan Herrmann
    Division of Geriatric Psychiatry, University of Toronto, Toronto, Ontario, Canada
    CNS Drugs 19:91-103. 2005
    ..At the present time, this association is another factor that clinicians should consider when weighing the risks and benefits of treating behavioural and psychological disturbances in elderly dementia patients...
  2. ncbi Panic disorder in later life: results from a national survey of Canadians
    Laurie M Corna
    Department of Public Health Sciences, University of Toronto, Canada
    Int Psychogeriatr 19:1084-96. 2007
    ..To address this gap, we examined the prevalence, risk markers, and comorbidity of panic disorder defined using DSM-IV criteria among older adults...
  3. ncbi Current prescription patterns and safety profile of irreversible monoamine oxidase inhibitors: a population-based cohort study of older adults
    Kenneth I Shulman
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada
    J Clin Psychiatry 70:1681-6. 2009
    ..To determine the prescription pattern and safety profile for irreversible monoamine oxidase inhibitors (MAOIs) in older adults over the past decade...
  4. ncbi Comorbid depression and anxiety in later life: patterns of association, subjective well-being, and impairment
    John Cairney
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON
    Am J Geriatr Psychiatry 16:201-8. 2008
    ..In this study, the authors examine psychiatric comorbidity and associated impairment of four disorders (major depression, panic disorder, social phobia, and agoraphobia) in a community-based sample of adults aged 55 and older...
  5. ncbi Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury
    Krista L Lanctot
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Brain Inj 24:959-69. 2010
    ..To determine which serotonergic system-related single nucleotide polymorphisms (SNPs) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (TBI)...
  6. ncbi Behavioral correlates of GABAergic disruption in Alzheimer's disease
    Krista L Lanctot
    Neuropharmacology Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int Psychogeriatr 19:151-8. 2007
    ..Our objective was to assess the relationship between plasma GABA (pGABA) levels and specific BPSD in patients with severe AD...
  7. ncbi The relationship between inflammatory markers and post stroke cognitive impairment
    Lana S Rothenburg
    Neuropsychopharmacology Research Group, Toronto, Ontario, Canada
    J Geriatr Psychiatry Neurol 23:199-205. 2010
    ..Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of CRP, interleukin 6 (IL-6), and interferon gamma (IFN-gamma)...
  8. ncbi Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 19:1026-33. 2011
    ..To determine whether current antipsychotic use among older persons without diabetes is associated with a higher risk of hospital visits for hyperglycemia, as previous studies in this population have yielded conflicting results...
  9. ncbi Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease
    Walter Swardfager
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Geriatr Soc 58:1519-25. 2010
    ..To investigate the association between cardiopulmonary fitness and cognitive performance in subjects with coronary artery disease (CAD)...
  10. ncbi Apathy associated with Alzheimer disease: use of dextroamphetamine challenge
    Krista L Lanctot
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Geriatr Psychiatry 16:551-7. 2008
    ..To assess the role of the dopaminergic brain reward system (BRS) in apathy associated with Alzheimer disease (AD)...
  11. ncbi A population-based study of cholinesterase inhibitor use for dementia
    Nathan Herrmann
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Geriatr Soc 55:1517-23. 2007
    ....
  12. ncbi A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury
    Mark J Rapoport
    Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
    J Clin Psychiatry 71:1125-30. 2010
    ..This study examines whether continuation therapy with citalopram can prevent a relapse following remission of major depression due to traumatic brain injury...
  13. ncbi The effects of donepezil on computer-simulated driving ability among healthy older adults: a pilot study
    Mark J Rapoport
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Psychopharmacol 31:587-92. 2011
    ..This analysis does not support the use of donepezil to extend the period of safe driving among older adults, but further study is needed regarding its role among patients with cognitive disorders...
  14. ncbi Traumatic brain injury, Apolipoprotein E-epsilon4, and cognition in older adults: a two-year longitudinal study
    Mark Rapoport
    Sunnybrook Health Sciences Centre Geriatric Psychiatry, Toronto, Ontario, Canada
    J Neuropsychiatry Clin Neurosci 20:68-73. 2008
    ..Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-epsilon4 was not associated with cognition...
  15. ncbi Mental health-related drug utilization among older adults: prevalence, trends, and costs
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G119, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 13:892-900. 2005
    ..Authors assessed temporal changes in mental health-related drug utilization and costs in an older population...
  16. ncbi The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
    Allison B Gold
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Neuroinflammation 8:17. 2011
    ....
  17. ncbi Adverse drug events in cognitively impaired elderly patients
    Hooman Ganjavi
    Neuropharmacology Research, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Dement Geriatr Cogn Disord 23:395-400. 2007
    ..Adverse drug events (ADEs) are a frequent problem encountered in the elderly. The aim of this study was to elucidate the factors that influence ADEs in an elderly population with cognitive impairment...
  18. ncbi Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysis
    Elmira Valiyeva
    The Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont
    CMAJ 179:438-46. 2008
    ..We assessed the impact of these warnings on prescription rates of antipsychotic drugs in this patient population...
  19. ncbi Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge
    Nathan Herrmann
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 28:296-301. 2008
    ..Psychostimulants may be effective in treating features of apathy in AD, and dopaminergic changes may predict response...
  20. ncbi Antipsychotic drug use and mortality in older adults with dementia
    Sudeep S Gill
    Queen s University, Kingston, Ontario, Canada
    Ann Intern Med 146:775-86. 2007
    ..Antipsychotic drugs are widely used to manage behavioral and psychological symptoms in dementia despite concerns about their safety...
  21. ncbi Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial
    Jennifer R Glass
    Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 28:182-8. 2008
    ..The choice of agent to use in the elderly must consider these relative benefits and risks...
  22. ncbi Are vascular risk factors associated with post-stroke depressive symptoms?
    Gayla Tennen
    Department of Clinical Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Geriatr Psychiatry Neurol 24:215-21. 2011
    ..The objective of the current study was to determine whether VRFs are associated with the risk of PSD in an acute stroke population...
  23. ncbi Verbal memory performance and completion of cardiac rehabilitation in patients with coronary artery disease
    Walter Swardfager
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Psychosom Med 73:580-7. 2011
    ..To assess cognitive performance as a predictor of noncompletion of cardiac rehabilitation (CR) using a standardized verbal memory test...
  24. ncbi Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients
    Nathan Herrmann
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 18:215-20. 2004
    ..Individual patient characteristics, including underlying neurotransmitter changes, may be useful for predicting response to therapy...
  25. ncbi Initiation of benzodiazepines in the elderly after hospitalization
    Chaim M Bell
    Department of Medicine, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    J Gen Intern Med 22:1024-9. 2007
    ..To estimate the rate of new chronic benzodiazepine use after hospitalization in older adults not previously prescribed with benzodiazepines...
  26. ncbi Changes in nursing burden following memantine for agitation and aggression in long-term care residents with moderate to severe Alzheimer's disease: an open-label pilot study
    Nathan Herrmann
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    CNS Drugs 25:425-33. 2011
    ..Agitation and aggression are common neuropsychiatric symptoms of Alzheimer's disease (AD) with a negative impact on caregivers...
  27. ncbi A functional neuroimaging study of appetite loss in Alzheimer's disease
    Zahinoor Ismail
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Neurol Sci 271:97-103. 2008
    ..Alzheimer's Disease (AD) is frequently associated with changes in appetite. This study investigated the relationship between regional cerebral perfusion and appetite loss in AD...
  28. ncbi A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease
    Nathan Herrmann
    Neuropharmacology Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Dement Geriatr Cogn Disord 23:116-9. 2007
    ..To assess the efficacy and tolerability of valproate for the treatment of agitation and aggression in moderate-to-severe Alzheimer's disease (AD)...
  29. ncbi Predictors of driving cessation in mild-to-moderate dementia
    Nathan Herrmann
    Sunnybrook Health Sciences Centre and the Department of Psychiatry, University of Toronto, Toronto, Ont
    CMAJ 175:591-5. 2006
    ..The purpose of our study was to explore factors that may affect the likelihood of driving cessation in a sample of elderly, community-dwelling patients with dementia...
  30. ncbi Atypical antipsychotics and risk of cerebrovascular accidents
    Nathan Herrmann
    Institute for Clinical and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Psychiatry 161:1113-5. 2004
    ..This study examined the association between atypical antipsychotic use and stroke in the elderly...
  31. ncbi Antidepressants, warfarin, and the risk of hemorrhage
    Paul A Kurdyak
    The Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychopharmacol 25:561-4. 2005
    ..We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an increased risk of hospitalization for upper gastrointestinal tract bleeding (UGIB)...
  32. ncbi Serotonin-1A receptors in frontotemporal dementia compared with controls
    Krista L Lanctot
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Psychiatry Res 156:247-50. 2007
    ..These pilot data suggest that profound 5-HT(1A) BP losses may be present and contribute to symptomatology and treatment response in FTLD...
  33. ncbi Antipsychotic drugs and hyperglycemia in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Arch Intern Med 169:1282-9. 2009
    ..Evidence suggests that there is an association between antipsychotic drugs and new-onset diabetes, but little is known about the risk of hyperglycemia among persons with preexisting diabetes...
  34. ncbi Factor analysis of the Rivermead Post-Concussion Symptoms Questionnaire in mild-to-moderate traumatic brain injury patients
    Nathan Herrmann
    Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada
    J Neuropsychiatry Clin Neurosci 21:181-8. 2009
    ..These results suggest that depression post-TBI may influence patient perception of postconcussion symptoms...
  35. ncbi Validity and responsiveness to change of clinically derived MDS scales in Alzheimer disease outcomes research
    Kelly A Smart
    Neuropsychopharmacology Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Geriatr Psychiatry Neurol 24:67-72. 2011
    ..As these findings are preliminary, further research is needed to determine the utility of MDS scales in outcomes research...
  36. ncbi The relation between disease severity and cost of caring for patients with Alzheimer disease in Canada
    Nathan Herrmann
    Medical Outcomes and Research in Economics MORE Group, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Psychiatry 55:768-75. 2010
    ..to characterize the cost of caring for an outpatient in Canada with Alzheimer disease (AD) based on disease severity, and to describe how costs change with increases in disease severity...
  37. ncbi Does pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease relieve caregiver burden?
    Karen Levy
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Drugs Aging 29:167-79. 2012
    ..Given the importance of caregiver burden and its negative consequences for the caregiver and the patient, future clinical trials should pay more attention to this crucial outcome...
  38. ncbi Pharmacologic management of neuropsychiatric symptoms of Alzheimer disease
    Nathan Herrmann
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 52:630-46. 2007
    ..To systematically review published clinical trials of the pharmacotherapy of neuropsychiatric symptoms of Alzheimer disease (AD)...
  39. ncbi Outcome after traumatic brain injury sustained in older adulthood: a one-year longitudinal study
    Mark J Rapoport
    Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 14:456-65. 2006
    ..The clinical significance of this may become more evident with time in this vulnerable population...
  40. ncbi Discontinuing cholinesterase inhibitors: results of a survey of Canadian dementia experts
    Nathan Herrmann
    Department of Psychiatry and Faculty of Medicine, University of Toronto, and Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int Psychogeriatr 23:539-45. 2011
    ..Because there is little data to help clinicians to decide on when it is safe and appropriate to discontinue ChEIs after long-term use, practices may vary widely...
  41. ncbi Efficacy and tolerability of antidepressants for treatment of depression in coronary artery disease: a meta-analysis
    Yekta Dowlati
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario
    Can J Psychiatry 55:91-9. 2010
    ..Our objective was to quantitatively summarize the data on the efficacy and tolerability of antidepressant (AD) treatment for depression in CAD...
  42. ncbi The relationship between variations in antipsychotic prescribing across nursing homes and short-term mortality: quality of care implications
    Susan E Bronskill
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Med Care 47:1000-8. 2009
    ..Determining the extent to which variations in antipsychotic use are a symptom of facility-level quality problems as compared with a drug safety issue is important for selecting the correct interventions to effect change...
  43. ncbi Benzodiazepine use and driving: a meta-analysis
    Mark J Rapoport
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Psychiatry 70:663-73. 2009
    ..The purpose of the present study was to examine the experimental and epidemiologic evidence linking benzodiazepine use to driving impairment...
  44. ncbi Persistence with cholinesterase inhibitor therapy for dementia: an observational administrative health database study
    Nathan Herrmann
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Drugs Aging 26:403-7. 2009
    ..To determine if choice of drug and ease of administration affect persistence of therapy with cholinesterase inhibitors (ChEIs) for treatment of dementia...
  45. ncbi At-fault motor vehicle crash risk in elderly patients treated with antidepressants
    Mark J Rapoport
    University of Toronto, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 19:998-1006. 2011
    ..To assess whether antidepressant treatment is associated with a temporary increase in the risk of a motor vehicle crash among older adults...
  46. ncbi Antipsychotic use in the elderly: shifting trends and increasing costs
    Mark Rapoport
    Sunnybrook and Women s College Health Sciences Centre Departments of Psychiatry, Toronto, Canada
    Int J Geriatr Psychiatry 20:749-53. 2005
    ....
  47. ncbi A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease
    Krista L Lanctot
    Neuropharmacology Research Program and Geriatric Psychiatry, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:888-98. 2007
    ..Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD...
  48. ncbi The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease
    Sarah Thompson
    Sunnybrook and Women's College Health Sciences Centre, Department of Psychiatry, Rm FG-05, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada
    Expert Opin Drug Saf 3:425-40. 2004
    ..Further study is needed to examine other indications for ChEIs, as well as their combination with newer treatments, such as memantine...
  49. ncbi Epidemiology of social phobia in later life
    John Cairney
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:224-33. 2007
    ..Although anxiety disorders, including social phobia (SP), are common among older adults, very little is known about the epidemiology of SP in later life...
  50. ncbi Growth hormone response to clonidine predicts aggression in Alzheimer's disease
    Nathan Herrmann
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, Room FG05, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Psychoneuroendocrinology 29:1192-7. 2004
    ..The neurobiology of aggression in Alzheimer's Disease (AD) remains unknown. The objective of this study was to determine if altered central noradrenergic (NE) responsiveness is related to aggression in AD...
  51. ncbi The serotonin transporter polymorphisms and major depression following traumatic brain injury
    Florance Chan
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Brain Inj 22:471-9. 2008
    ..The purpose of this study was to examine the role of the serotonin transporter gene polymorphisms on the risk of major depression following traumatic brain injury (TBI)...
  52. ncbi Comorbidity in bipolar disorder among the elderly: results from an epidemiological community sample
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook and Women s Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Am J Psychiatry 163:319-21. 2006
    ..This study sought to determine psychiatric comorbidity among elderly individuals with bipolar disorder...
  53. ncbi Mild cognitive impairment: an operational definition and its conversion rate to Alzheimer's disease
    Daphne M Geslani
    Geriatric Research, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Dement Geriatr Cogn Disord 19:383-9. 2005
    ..We aimed to develop an operational definition of MCI consistent with criteria proposed by the Mayo Alzheimer's Disease Center, and to examine its conversion rate to AD...
  54. ncbi Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial
    David J Gladstone
    Regional Stroke Centre, Division of Neurology, Department of Medicine, and Neurosciences Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 37:179-85. 2006
    ..Hemiparesis is the commonest disabling deficit caused by stroke. In animals, dextroamphetamine (AMPH) paired with training enhances motor recovery, but its clinical efficacy is uncertain...
  55. ncbi The role of dopamine in symptoms and treatment of apathy in Alzheimer's disease
    Robert A Mitchell
    Neuropsychopharmacology, Sunnybrook Health Sciences Centre, Toronto, Canada
    CNS Neurosci Ther 17:411-27. 2011
    ..The DAergic system is closely related to the brain reward system (BRS) and some studies have suggested that dysfunction in the DAergic system may account for symptoms of apathy in the AD population...
  56. ncbi Exercise intervention and inflammatory markers in coronary artery disease: a meta-analysis
    Walter Swardfager
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Am Heart J 163:666-76.e1-3. 2012
    ..We performed a meta-analysis of changes in inflammatory biomarkers over the course of exercise interventions in patients with CAD...
  57. ncbi Determining the impact of dementia on antidepressant treatment response in older adults
    Corinne E Fischer
    Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Neuropsychiatry Clin Neurosci 23:358-61. 2011
    ..Depressed elderly patients with dementia may improve on antidepressant treatment, although treatment response may be less robust than in depressed patients without dementia...
  58. ncbi Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease
    Walter Swardfager
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Psychoneuroendocrinology 34:1560-6. 2009
    ..non-depressed patients (45.6+/-20.0 micromol/mmol vs. 38.5+/-15.7 micromol/mmol, F=3.778, p=.055) when controlling for age, sex and tACS. Activation of IDO is associated with the severity of depressive symptoms among patients with CAD...
  59. ncbi Galantamine treatment of problematic behavior in Alzheimer disease: post-hoc analysis of pooled data from three large trials
    Nathan Herrmann
    Dept of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada, M4N 3M5
    Am J Geriatr Psychiatry 13:527-34. 2005
    ..The authors explored the effect of galantamine on behavioral symptoms in Alzheimer disease (AD)...
  60. ncbi The role of norepinephrine in the behavioral and psychological symptoms of dementia
    Nathan Herrmann
    Division of Geriatric Psychiatry, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON M4N 3M5, Canada
    J Neuropsychiatry Clin Neurosci 16:261-76. 2004
    ..With greater appreciation of the underlying neurobiology of behavioral and psychological symptoms of dementia (BPSD) more effective, rational, targeted pharmacotherapy will hopefully emerge...
  61. ncbi Effect of antidepressant use on admissions to hospital among elderly bipolar patients
    Ayal Schaffer
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 21:275-80. 2006
    ..The goal of this study was to examine the association between antidepressant use and hospitalization rate for mania or bipolar depression in a large, community-based sample of elderly bipolar patients...
  62. ncbi Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study
    Sudeep S Gill
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMJ 330:445. 2005
    ..To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics...
  63. ncbi Neurocognitive profiles in older adults with and without major depression
    Corinne Fischer
    St Michael s Hospital, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 23:851-6. 2008
    ..To delineate the differences between older persons with and without a diagnosis of major depression...
  64. ncbi A SPECT study of apathy in Alzheimer's disease
    Krista L Lanctot
    Department of Psychiatry, University of Toronto, Toronto, Ont, Canada
    Dement Geriatr Cogn Disord 24:65-72. 2007
    ..To assess the association between regional cerebral blood flow (rCBF) and apathy in Alzheimer's Disease (AD)...
  65. ncbi Memantine in dementia: a review of the current evidence
    Nathan Herrmann
    Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Canada
    Expert Opin Pharmacother 12:787-800. 2011
    ..EXPERT OPINION: For the treatment of moderate to severe AD, memantine should be offered as a therapeutic option, either on its own, or in combination with a cholinesterase inhibitor...
  66. ncbi Electroconvulsive therapy in older adults: 13-year trends
    Mark Jeffrey Rapoport
    Sunnybrook Health Sciences Centre, Toronto, Ontario
    Can J Psychiatry 51:616-9. 2006
    ..To examine temporal trends in electroconvulsive therapy (ECT) use among all 12 million Ontario residents between January 1992 and December 2004 and to examine the differential trends in older adults, compared with younger ones...
  67. ncbi The pharmacoeconomics of cognitive enhancers in moderate to severe Alzheimer's disease
    Jaclyn Cappell
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    CNS Drugs 24:909-27. 2010
    ....
  68. ncbi Current and emerging drug treatment options for Alzheimer's disease: a systematic review
    Nathan Herrmann
    Neuropsychopharmacology Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Drugs 71:2031-65. 2011
    ..This systematic review critically examines the efficacy and safety data for currently approved drugs and emerging treatments in AD, as well as discussing the present and future directions of innovation in this field...
  69. ncbi Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis
    Krista L Lanctot
    Neuropharmacology Research Program, Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON
    CMAJ 169:557-64. 2003
    ..Our objective was to quantitatively summarize data on the efficacy and safety of ChEIs in Alzheimer's disease in a format useful to clinicians...
  70. ncbi GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia
    Krista L Lanctot
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario
    Can J Psychiatry 49:439-53. 2004
    ..We review the clinical use of GABAergic agents in treating persons with AD symptoms. While newer generation GABAergic medications are now available, they have yet to be evaluated among patients with AD...
  71. ncbi Medial temporal hypoperfusion and aggression in Alzheimer disease
    Krista L Lanctot
    Neuropharmacology Research, Department of Psychiatry, Cognitive Neurology Unit, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Arch Neurol 61:1731-7. 2004
    ..It is not understood why some patients with Alzheimer disease (AD) display aggression and others do not...
  72. ncbi Contribution of informant and patient ratings to the accuracy of the mini-mental state examination in predicting probable Alzheimer's disease
    Mary C Tierney
    Geriatric Research Unit, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    J Am Geriatr Soc 51:813-8. 2003
    ..To determine whether the accuracy of the Mini-Mental State Examination (MMSE) in predicting future Alzheimer's disease (AD) could be improved by the addition of patient and informant ratings of cognitive difficulties...
  73. ncbi The cost-benefit of cholinesterase inhibitors in mild to moderate dementia: a willingness-to-pay approach
    Grace Wu
    Department of Psychiatry, HOPE Research Centre and Division of Clinical Pharmacology, Room FG 05, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    CNS Drugs 17:1045-57. 2003
    ..This study aimed to measure the economic value of cholinesterase inhibitors when used to treat Alzheimer's disease using the willingness-to-pay (WTP) approach and the framework of cost-benefit analysis...
  74. ncbi IPA survey of brief cognitive screening instruments
    Kenneth I Shulman
    Department of Psychiatry, Sunnybrook and Women s, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Int Psychogeriatr 18:281-94. 2006
    ....
  75. ncbi Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine
    Lescia K Tremblay
    Psychopharmacology Research Program, Sunnybrook and Women's College Health Sciences Centre-Sunnybook Campus, University of Toronto, 2075 Bayview Ave, Room F-327, Toronto, Ontario, Canada M4N 3M5
    Arch Gen Psychiatry 59:409-16. 2002
    ....
  76. ncbi Cognitive pharmacotherapy of Alzheimer's disease and other dementias
    Nathan Herrmann
    Department of Psychiatry, Division of Geriatric Psychiatry, Faculty of Medicine, University of Toronto Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5
    Can J Psychiatry 47:715-22. 2002
    ....
  77. ncbi Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease
    Krista L Lanctot
    Psychopharmacology Research Program and Geriatric Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 207s Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Int J Geriatr Psychiatry 17:531-41. 2002
    ..Indications for serotonergic medications in the treatment of behavioral disorders associated with Alzheimer's disease (AD) remain to be established...
  78. ncbi Brain reward system activity in major depression and comorbid nicotine dependence
    Laura Cardenas
    Centre for Addiction and Mental Health, Sunnybrook and Women's College Health Sciences Centre-Sunnybrook Campus, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    J Pharmacol Exp Ther 302:1265-71. 2002
    ..Severity of depression was significantly correlated with increased rewarding effects of d-amph. Thus, although the BRS may be dysfunctional in MDD subjects, chronic nicotine use does not modify response to d-amph...
  79. ncbi A randomized, placebo-controlled trial of the discontinuation of long-term antipsychotics in dementia
    Robert van Reekum
    Baycrest Centre for Geriatric Care, Toronto, Canada
    Int Psychogeriatr 14:197-210. 2002
    ..The primary limitation of the study was the small sample size. In conclusion, a trial of discontinuation of antipsychotics should be considered in this population...
  80. ncbi Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease
    Krista L Lanctot
    Psychopharmacology Research Program and Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Neuropsychopharmacology 27:646-54. 2002
    ..These results suggest a complex link between aggression in AD and central serotonergic dysfunction having interactions with gender and cognitive impairment...
  81. ncbi The contribution of neuropsychiatric symptoms to the cost of dementia care
    Nathan Herrmann
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 21:972-6. 2006
    ..CONCLUSION: BPSD contribute significantly to the overall costs of dementia care. Interventions targeted at BPSD may help to reduce the staggering societal costs of this illness...
  82. ncbi Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects
    Jennifer R Glass
    Division of Clinical Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    J Clin Psychopharmacol 23:260-8. 2003
    ..001) but similar to that with 15 mg temazepam (NS). No psychomotor impairment was detected with 50 mg diphenhydramine. Valerian was not different from placebo on any measure of psychomotor performance or sedation...
  83. ncbi How much are atypical antipsychotic agents being used, and do they reach the populations who need them? A Canadian experience
    Carolyn S Dewa
    Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Clin Ther 24:1466-76. 2002
    ..The introduction of new antipsychotic agents in the past decade has helped alter the treatments available to 2 vulnerable populations-those with schizophrenia and related psychotic conditions and elderly individuals with dementia...
  84. ncbi Pharmacokinetic and pharmacodynamic evaluation of the inhibition of alprazolam by citalopram and fluoxetine
    Judith Hall
    Psychopharmacology Research Program, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Clin Psychopharmacol 23:349-57. 2003
    ..Neither selective serotonin reuptake inhibitor significantly affected the pharmacodynamic profile of alprazolam. This experiment suggests differential effects by citalopram and fluoxetine on alprazolam kinetics...
  85. ncbi Treatment of moderate to severe Alzheimer's disease: rationale and trial design
    Nathan Herrmann
    Department of Psychiatry, Division of Geriatric Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    Can J Neurol Sci 34:S103-8. 2007
    ..While there are no published guidelines for the treatment of moderate to severe AD, these studies do provide guidance for recommendations for study design and outcome measures. Such studies are urgently needed...
  86. ncbi Relationship between cardiopulmonary fitness and depressive symptoms in cardiac rehabilitation patients with coronary artery disease
    Walter Swardfager
    Department of Pharmacology, University of Toronto, Toronto, Canada
    J Rehabil Med 40:213-8. 2008
    ..To identify independent predictors of depressive symptoms in a cohort of patients with coronary artery disease entering cardiac rehabilitation...
  87. ncbi A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxin
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Br J Clin Pharmacol 59:102-7. 2005
    ..We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting...
  88. ncbi Atypical antipsychotics for neuropsychiatric symptoms of dementia: malignant or maligned?
    Nathan Herrmann
    Department of Psychiatry, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Drug Saf 29:833-43. 2006
    ....
  89. ncbi Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
    Jennifer Glass
    University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Canada M5S 2S2
    BMJ 331:1169. 2005
    ..In people over 60, the benefits of these drugs may not justify the increased risk, particularly if the patient has additional risk factors for cognitive or psychomotor adverse events...
  90. ncbi Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study
    Howard H Feldman
    Division of Neurology, University of British Columbia Hospital, Vancouver, Canada
    Lancet Neurol 6:501-12. 2007
    ..To assess the effect of rivastigmine in patients with mild cognitive impairment (MCI) on the time to clinical diagnosis of Alzheimer's disease (AD) and the rate of cognitive decline...
  91. ncbi Efficacy and safety of antidepressants for treatment of depression in Alzheimer's disease: a metaanalysis
    Sarah Thompson
    Department of Psychiatry, Atlantic Health Sciences Corporation, Saint John, New Brunswick
    Can J Psychiatry 52:248-55. 2007
    ..Our objective was to quantitatively summarize the data on the efficacy and safety of antidepressant treatment for depression complicating AD...
  92. ncbi Is late-life depression a predictor of Alzheimer's disease? Results from a historical cohort study
    Robert van Reekum
    Int J Geriatr Psychiatry 20:80-2. 2005
  93. ncbi Correlates of response to acetylcholinesterase inhibitor therapy in Alzheimer's disease
    Krista L Lanctot
    Neuropsychopharmacology Research Program and HOPE Research Centre, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ont
    J Psychiatry Neurosci 28:13-26. 2003
    ..Studying correlates of response may help to elucidate the mechanism of action of acetylcholinesterase inhibitors...
  94. ncbi Geriatric psychiatry: a subspecialty whose time has come
    Nathan Herrmann
    Can J Psychiatry 49:415-6. 2004
  95. ncbi Donepezil therapy for neuropsychiatric symptoms in AD: methods make the message
    Nathan Herrmann
    Neurology 63:200-1. 2004
  96. ncbi Canadian Outcomes Study in Dementia: study methods and patient characteristics
    Robert Sambrook
    Syreon Corporation, Vancouver, British Columbia
    Can J Psychiatry 49:417-27. 2004
    ..To describe the methods and patient characteristics of the Canadian Outcomes Study in Dementia (COSID)...