R M Henkelman

Summary

Affiliation: Sunnybrook and Women's College Health Sciences Centre
Country: Canada

Publications

  1. ncbi Can MTR be used to assess cartilage in the presence of Gd-DTPA2-?
    R M Henkelman
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Magn Reson Med 48:1081-4. 2002
  2. ncbi Magnetization transfer in MRI: a review
    R M Henkelman
    Department of Medical Biophysics University of Toronto, Toronto, Canada
    NMR Biomed 14:57-64. 2001
  3. ncbi Diffusional anisotropy of T2 components in bovine optic nerve
    G J Stanisz
    Imaging Research, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada
    Magn Reson Med 40:405-10. 1998
  4. ncbi Heat-source orientation and geometry dependence in proton-resonance frequency shift magnetic resonance thermometry
    R D Peters
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Centre, Canada
    Magn Reson Med 41:909-18. 1999
  5. ncbi Analysis of changes in MR properties of tissues after heat treatment
    S J Graham
    Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 42:1061-71. 1999
  6. ncbi Characterizing white matter with magnetization transfer and T(2)
    G J Stanisz
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 42:1128-36. 1999
  7. ncbi Quantifying tissue damage due to focused ultrasound heating observed by MRI
    S J Graham
    Sunnybrook and Women s College Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Magn Reson Med 41:321-8. 1999
  8. ncbi Understanding pulsed magnetization transfer
    S J Graham
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Centre, Ontario, Canada
    J Magn Reson Imaging 7:903-12. 1997
  9. ncbi Gd-DTPA relaxivity depends on macromolecular content
    G J Stanisz
    Departments of Medical Biophysics and Imaging Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 44:665-7. 2000
  10. doi Comparative structural and hemodynamic analysis of vascular trees
    J Yang
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 298:H1249-59. 2010

Collaborators

Detail Information

Publications20

  1. ncbi Can MTR be used to assess cartilage in the presence of Gd-DTPA2-?
    R M Henkelman
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Magn Reson Med 48:1081-4. 2002
    ....
  2. ncbi Magnetization transfer in MRI: a review
    R M Henkelman
    Department of Medical Biophysics University of Toronto, Toronto, Canada
    NMR Biomed 14:57-64. 2001
    ..Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed...
  3. ncbi Diffusional anisotropy of T2 components in bovine optic nerve
    G J Stanisz
    Imaging Research, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada
    Magn Reson Med 40:405-10. 1998
    ..This is consistent with the hypothesis that the short T2 component is associated with water within the myelin sheath, which is less restricted than axonal water that is limited by cell membrane permeability...
  4. ncbi Heat-source orientation and geometry dependence in proton-resonance frequency shift magnetic resonance thermometry
    R D Peters
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Centre, Canada
    Magn Reson Med 41:909-18. 1999
    ..This study demonstrates that spatial variations in the apparent PRF thermal coefficient could lead to errors of up to +/-30% in the magnetic resonance estimated temperature change if this effect is ignored...
  5. ncbi Analysis of changes in MR properties of tissues after heat treatment
    S J Graham
    Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 42:1061-71. 1999
    ..Magn Reson Med 42:1061-1071, 1999...
  6. ncbi Characterizing white matter with magnetization transfer and T(2)
    G J Stanisz
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 42:1128-36. 1999
    ..Magn Reson Med 42:1128-1136, 1999...
  7. ncbi Quantifying tissue damage due to focused ultrasound heating observed by MRI
    S J Graham
    Sunnybrook and Women s College Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Magn Reson Med 41:321-8. 1999
    ..These results suggest that quantitative MR guidance of thermal coagulation therapy is feasible, and they provide information useful for designing future investigations in vivo...
  8. ncbi Understanding pulsed magnetization transfer
    S J Graham
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Centre, Ontario, Canada
    J Magn Reson Imaging 7:903-12. 1997
    ..These simulations provide a method for interpreting pulsed MT effects, are easily extended to biologic tissues, and provide a basis for optimizing clinical imaging applications that exploit MT contrast...
  9. ncbi Gd-DTPA relaxivity depends on macromolecular content
    G J Stanisz
    Departments of Medical Biophysics and Imaging Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 44:665-7. 2000
    ..Quantitative MR analyses that use T(1) as an estimation of local Gd-DTPA concentration require a priori determination of the Gd relaxivity in tissue...
  10. doi Comparative structural and hemodynamic analysis of vascular trees
    J Yang
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 298:H1249-59. 2010
    ..Similar comparisons made with a series of models (starting with the simplest and increasing in complexity) enable the identification of essential features that are needed to account for the patterns and function of vascular arborization...
  11. doi Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice
    J Belik
    The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 297:L1170-8. 2009
    ..To the extent that these mice mimic human HHT1, age-associated pulmonary vascular eNOS uncoupling may explain the late childhood and adult onset of clinical lung manifestations...
  12. pmc Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion
    J Ellegood
    Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada
    Mol Psychiatry 19:99-107. 2014
    ..2 deletion-associated psychiatric and cognitive symptoms. ..
  13. pmc Mouse embryonic phenotyping by morphometric analysis of MR images
    M Zamyadi
    Department of Medical Biophysics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Physiol Genomics 42:89-95. 2010
    ..Together these findings suggest the power of this technique for detecting subtle phenotypic differences arising from mutated genes...
  14. ncbi Information content of SNR/resolution trade-offs in three-dimensional magnetic resonance imaging
    S Portnoy
    Mouse Imaging Centre, Toronto Centre for Phenogenomics, Toronto, Ontario M5T 3H7, Canada
    Med Phys 36:1442-51. 2009
    ..Using these relationships to maximize the image information content is an excellent technique for guiding the initial selection of imaging parameters...
  15. doi Volume ordering for analysis and modeling of vascular systems
    M Marxen
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada
    Ann Biomed Eng 37:542-51. 2009
    ....
  16. ncbi Proton-resonance frequency shift MR thermometry is affected by changes in the electrical conductivity of tissue
    R D Peters
    Department of Medical Biophysics, University of Toronto, Sunnybrook and Women s College Health Science Center, Ontario, Canada
    Magn Reson Med 43:62-71. 2000
    ..A simple method of overcoming this phase-shift offset is described...
  17. ncbi MR properties of rat sciatic nerve following trauma
    G J Stanisz
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Magn Reson Med 45:415-20. 2001
    ..MR parameters, therefore, are very good indicators of nerve damage and may be useful in monitoring therapies that assist nerve regeneration. Magn Reson Med 45:415-420, 2001...
  18. ncbi Development of a high resolution three-dimensional surgical atlas of the murine head for strains 129S1/SvImJ and C57Bl/6J using magnetic resonance imaging and micro-computed tomography
    E Chan
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Neuroscience 144:604-15. 2007
    ..The aim of these studies is to enhance comparative morphometric analyses and stereotactic surgical procedures in mice...
  19. ncbi Comparing microsphere deposition and flow modeling in 3D vascular trees
    M Marxen
    Hospital for Sick Children Mouse Imaging Centre, 555 Univ Ave, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 291:H2136-41. 2006
    ..This study illustrates the importance of comparing models of local perfusion with in vivo measurements of perfusion in the same biologically realistic vascular tree...
  20. ncbi Branching tree model with fractal vascular resistance explains fractal perfusion heterogeneity
    M Marxen
    Department of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, S605 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5
    Am J Physiol Heart Circ Physiol 284:H1848-57. 2003
    ..The model allows a physiological interpretation of the measured fractal parameters, which could in turn be used to characterize vascular morphology and function...