Benjamin I Goldstein

Summary

Affiliation: Sunnybrook Health Sciences Centre
Country: Canada

Publications

  1. pmc Obesity and the three-year longitudinal course of bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Bipolar Disord 15:284-93. 2013
  2. pmc Toward clinically applicable biomarkers in bipolar disorder: focus on BDNF, inflammatory markers, and endothelial function
    Benjamin I Goldstein
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Curr Psychiatry Rep 15:425. 2013
  3. pmc Predictors of first-onset substance use disorders during the prospective course of bipolar spectrum disorders in adolescents
    Benjamin I Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, University of Toronto Electronic address
    J Am Acad Child Adolesc Psychiatry 52:1026-37. 2013
  4. doi request reprint Pharmacologic treatment of bipolar disorder in children and adolescents
    Benjamin I Goldstein
    Departments of Psychiatry and Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Child Adolesc Psychiatr Clin N Am 21:911-39. 2012
  5. doi request reprint Recent progress in understanding pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, FG53, Toronto, ON M4N 3M5, Canada
    Arch Pediatr Adolesc Med 166:362-71. 2012
  6. pmc Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States
    Benjamin I Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Bipolar Disord 11:657-62. 2009
  7. pmc The burden of obesity among adults with bipolar disorder in the United States
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Bipolar Disord 13:387-95. 2011
  8. pmc Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Child Adolesc Psychopharmacol 21:479-84. 2011
  9. doi request reprint Comorbid substance use disorders among youth with bipolar disorder: opportunities for early identification and prevention
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, FG53, Toronto, Ontario, Canada
    J Clin Psychiatry 71:348-58. 2010
  10. pmc Preliminary findings regarding overweight and obesity in pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 69:1953-9. 2008

Detail Information

Publications46

  1. pmc Obesity and the three-year longitudinal course of bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Bipolar Disord 15:284-93. 2013
    ..Despite substantial cross-sectional evidence that obesity is associated with an increased medical and psychiatric burden in bipolar disorder (BD), few longitudinal studies have examined this topic...
  2. pmc Toward clinically applicable biomarkers in bipolar disorder: focus on BDNF, inflammatory markers, and endothelial function
    Benjamin I Goldstein
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Curr Psychiatry Rep 15:425. 2013
    ..A systematic approach to biomarker development in mood disorders is clearly warranted. ..
  3. pmc Predictors of first-onset substance use disorders during the prospective course of bipolar spectrum disorders in adolescents
    Benjamin I Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, University of Toronto Electronic address
    J Am Acad Child Adolesc Psychiatry 52:1026-37. 2013
    ..Substance use disorders (SUD) are common and problematic in bipolar disorder (BP). We prospectively examined predictors of first-onset SUD among adolescents with BP...
  4. doi request reprint Pharmacologic treatment of bipolar disorder in children and adolescents
    Benjamin I Goldstein
    Departments of Psychiatry and Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Child Adolesc Psychiatr Clin N Am 21:911-39. 2012
    ..A clinical vignette describing a teen with bipolar disorder is presented and bipolar medications, dosing, efficacy, side effects, contraindications, and succinct comments on each medication are summarized...
  5. doi request reprint Recent progress in understanding pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, FG53, Toronto, ON M4N 3M5, Canada
    Arch Pediatr Adolesc Med 166:362-71. 2012
    ..Preliminary findings regarding biomarkers offer hope that, in the future, these biomarkers may inform diagnostic and treatment decisions...
  6. pmc Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States
    Benjamin I Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Bipolar Disord 11:657-62. 2009
    ..We therefore examined this topic in a representative epidemiologic sample...
  7. pmc The burden of obesity among adults with bipolar disorder in the United States
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Bipolar Disord 13:387-95. 2011
    ..We therefore examined this topic in a representative epidemiologic sample...
  8. pmc Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Child Adolesc Psychopharmacol 21:479-84. 2011
    ..Hypomanic/manic symptoms were positively associated with hsCRP. BDNF levels were negatively associated with interleukin-6. Forty percent had cardiovascular high-risk hsCRP levels. Larger longitudinal studies are warranted...
  9. doi request reprint Comorbid substance use disorders among youth with bipolar disorder: opportunities for early identification and prevention
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, FG53, Toronto, Ontario, Canada
    J Clin Psychiatry 71:348-58. 2010
    ..This article aims to integrate the extant literature on this topic and to suggest strategies for delaying or preventing SUD among youth with bipolar disorder...
  10. pmc Preliminary findings regarding overweight and obesity in pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 69:1953-9. 2008
    ..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder...
  11. pmc Clinical, demographic, and familial correlates of bipolar spectrum disorders among offspring of parents with bipolar disorder
    Benjamin I Goldstein
    Faculty of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
    J Am Acad Child Adolesc Psychiatry 49:388-96. 2010
    ..The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS)...
  12. pmc Negative life events in children and adolescents with bipolar disorder
    Soledad Romero
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Clin Psychiatry 70:1452-60. 2009
    ....
  13. pmc Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlates
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 71:1344-50. 2010
    ..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder. We aimed to examine the prevalence and correlates of comorbid anxiety disorders among youth with bipolar disorder...
  14. pmc Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disorders
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 73:87-94. 2012
    ..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder...
  15. pmc Significance of cigarette smoking among youths with bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Addict 17:364-71. 2008
    ..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD...
  16. pmc Psychosocial functioning among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    J Affect Disord 114:174-83. 2009
    ..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population...
  17. ncbi request reprint The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid metabolic disorders
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, Departments of Psychiatry and Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Ann Clin Psychiatry 24:69-81. 2012
    ..Our group conducted a comprehensive literature review to provide evidence-based recommendations for treating metabolic comorbidity in individuals with major depressive disorder (MDD) and bipolar disorder (BD)...
  18. pmc Family environment and suicidal ideation among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Suicide Res 13:378-88. 2009
    ..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss...
  19. pmc Predictors of prospectively examined suicide attempts among youth with bipolar disorder
    Tina R Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Arch Gen Psychiatry 69:1113-22. 2012
    ..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder...
  20. pmc Course of subthreshold bipolar disorder in youth: diagnostic progression from bipolar disorder not otherwise specified
    David A Axelson
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 50:1001-16.e3. 2011
    ....
  21. pmc Mood lability among offspring of parents with bipolar disorder and community controls
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 15:253-63. 2013
    ..To clarify this issue, this study examined the prevalence of mood lability and its components in offspring of BP parents and offspring of community control parents recruited through the Pittsburgh Bipolar Offspring Study...
  22. pmc Substance use disorders among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:469-78. 2008
    ..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)...
  23. ncbi request reprint The CANMAT task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders
    Ayal Schaffer
    Mood and Anxiety Disorders Program, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Ann Clin Psychiatry 24:6-22. 2012
    ..This article is part of a set of Canadian Network for Mood and Anxiety Treatments (CANMAT) Comorbidity Task Force papers...
  24. doi request reprint Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature
    Benjamin I Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 16213, USA
    J Clin Psychiatry 70:1078-90. 2009
    ....
  25. pmc Prevalence and correlates of bipolar I disorder among adults with primary youth-onset anxiety disorders
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:187-95. 2007
    ....
  26. ncbi request reprint Factors associated with temporal priority in comorbid bipolar I disorder and alcohol use disorders: Results from the national epidemiologic survey on alcohol and related conditions
    Benjamin I Goldstein
    Mood Disorders Program, Department of Psychiatry, Sunnybrook and Women s Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychiatry 67:643-9. 2006
    ..To compare illness characteristics, comorbidities, treatment utilization, and family history among individuals with comorbid bipolar I disorder and alcohol use disorders (AUD) based on temporal priority of onset...
  27. pmc Risk for suicidal ideation among the offspring of bipolar parents: results from the Bipolar Offspring Study (BIOS)
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Suicide Res 15:207-22. 2011
    ..Offspring of parents with bipolar disorder are at elevated risk for suicidal ideation as compared with offspring of controls. Suicide risk assessment in this population should attend to specific risk factors identified...
  28. ncbi request reprint Further evidence for a developmental subtype of bipolar disorder defined by age at onset: results from the national epidemiologic survey on alcohol and related conditions
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook and Women s Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5
    Am J Psychiatry 163:1633-6. 2006
    ..This study examines the relationship between age at onset of bipolar I disorder and illness characteristics among adults in a community sample...
  29. ncbi request reprint Comorbidity in bipolar disorder among the elderly: results from an epidemiological community sample
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook and Women s Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Am J Psychiatry 163:319-21. 2006
    ..This study sought to determine psychiatric comorbidity among elderly individuals with bipolar disorder...
  30. pmc Course of comorbid anxiety disorders among adults with bipolar disorder in the U.S. population
    Regina Sala
    Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA
    J Psychiatr Res 46:865-72. 2012
    ..To examine the prevalence and correlates of comorbid anxiety disorders among individuals with bipolar disorders (BP) and their association with prospectively ascertained comorbidities, treatment, and psychosocial functioning...
  31. ncbi request reprint The specific burden of comorbid anxiety disorders and of substance use disorders in bipolar I disorder
    Benjamin I Goldstein
    Mood Disorders Program, Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Bipolar Disord 10:67-78. 2008
    ..Moreover, the independent contribution of these comorbidities to the burden of bipolar disorder (BD) is unclear...
  32. ncbi request reprint Childhood onset major depressive disorder: course of illness and psychiatric comorbidity in a community sample
    Daphne J Korczak
    Department of Psychiatry, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    J Pediatr 155:118-23. 2009
    ..To examine the effect of childhood-onset major depressive disorder (MDD) on course of illness and psychiatric comorbidity, as compared with adolescent- and adult-onset MDD, in a large nonclinical sample...
  33. pmc Factors associated with pain interference in an epidemiologic sample of adults with bipolar I disorder
    Benjamin I Goldstein
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    J Affect Disord 117:151-6. 2009
    ..Epidemiologic studies have found that major depressive disorder (MDD) and anxiety disorders are associated with pain. However, little is known regarding the prevalence and correlates of pain in bipolar I disorder (BD)...
  34. pmc Dimensional psychopathology in preschool offspring of parents with bipolar disorder
    Hagai Maoz
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Child Psychol Psychiatry 55:144-53. 2014
    ..The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (BP) and offspring of community control parents...
  35. pmc Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    José M Martínez-Ortega
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    J Psychiatr Res 47:858-64. 2013
    ..In conclusion, ND and BD predict the development of each other. The phenomenology and course of ND and BD varied significantly depending on which disorder had earlier onset...
  36. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 15:1-44. 2013
    ..Asenapine alone or as adjunctive therapy have been added as third-line options...
  37. pmc Schedule for affective disorders and schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children--a preliminary psychometric study
    Boris Birmaher
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 43:680-6. 2009
    ....
  38. ncbi request reprint Is current alcohol consumption associated with increased lifetime prevalence of major depression and suicidality? Results from a pilot community survey
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook and Women s Health Sciences Centre, University of Toronto, Toronto, ON, Canada M4N 3M5
    Compr Psychiatry 47:330-3. 2006
    ..Alcohol use disorders are associated with increased illness severity and suicidality in major depressive disorder (MDD). However, little is known about how alcohol use across the continuum relates to MDD...
  39. ncbi request reprint A gender-focused perspective on health service utilization in comorbid bipolar I disorder and alcohol use disorders: results from the national epidemiologic survey on alcohol and related conditions
    Benjamin I Goldstein
    Mood Disorders Program, Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychiatry 67:925-32. 2006
    ..This study compares health service utilization by individuals with comorbid lifetime bipolar I disorder and lifetime alcohol use disorders (AUD) to that of individuals with either diagnosis alone, using nationally representative data...
  40. ncbi request reprint Metabolic syndrome and major depressive disorder: co-occurrence and pathophysiologic overlap
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Curr Diab Rep 9:51-9. 2009
    ..This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder...
  41. ncbi request reprint The association between moderate alcohol use and illness severity in bipolar disorder: a preliminary report
    Benjamin I Goldstein
    Department of Psychiatry, University of Toronto, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Clin Psychiatry 67:102-6. 2006
    ..To examine the association of alcohol consumption with symptoms, illness course, and health care utilization among non-alcoholic patients with bipolar disorder...
  42. pmc A brief motivational intervention for preventing medication-associated weight gain among youth with bipolar disorder: treatment development and case report
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 21:275-80. 2011
    ....
  43. ncbi request reprint Panic disorder, cardiac diagnosis and emergency department utilization in an epidemiologic community sample
    Daphne J Korczak
    Department of Psychiatry, The University of Toronto, Toronto, Ontario, Canada M5S 1A1
    Gen Hosp Psychiatry 29:335-9. 2007
    ....
  44. ncbi request reprint Pharmacotherapy of alcoholism in patients with co-morbid psychiatric disorders
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Drugs 66:1229-37. 2006
    ..Effectiveness, safety and tolerability are considered, and directions for future study are discussed...
  45. ncbi request reprint The effect of tumor necrosis factor antagonists on mood and mental health-associated quality of life: novel hypothesis-driven treatments for bipolar depression?
    Joanna K Soczynska
    Institute of Medical Sciences, University of Toronto, Canada
    Neurotoxicology 30:497-521. 2009
    ..e. adalimumab, etanercept, and infliximab) on depressive symptoms and mental health-associated quality of life measures...
  46. ncbi request reprint Prevalence, clinical presentation and differential diagnosis of pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, Toronto, Canada Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania, U S A
    Isr J Psychiatry Relat Sci 49:3-14. 2012
    ..Over the past 20 years, the evidence regarding pediatric bipolar disorder (BP) has increased substantially. As a result, recent concerns have focused primarily on prevalence and differential diagnosis...