Research Topics
| David J GladstoneSummaryAffiliation: Sunnybrook and Women's College Health Sciences Centre Country: Canada Publications
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Detail Information
Publications
Vascular and nonvascular mimics of the CT angiography "spot sign" in patients with secondary intracerebral hemorrhageSteve Gazzola
Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
Stroke 39:1177-83. 2008..The purpose of this study was to assess for the presence of the Spot Sign in secondary ICH and to document potential mimics of the Spot Sign and their distinguishing features...
Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trialDavid J Gladstone
Regional Stroke Centre, Division of Neurology, Department of Medicine, and Neurosciences Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
Stroke 37:179-85. 2006..Hemiparesis is the commonest disabling deficit caused by stroke. In animals, dextroamphetamine (AMPH) paired with training enhances motor recovery, but its clinical efficacy is uncertain...
Management and outcomes of transient ischemic attacks in OntarioDavid J Gladstone
Division of Neurology, Department of Medicine, and the Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
CMAJ 170:1099-104. 2004..We studied prospectively a cohort of consecutive patients presenting with TIA to the emergency department of 4 regional stroke centres in Ontario...- Commentary: Toward an emergency response to transient ischemic attacksDavid J Gladstone
Division of Neurology and Regional Stroke Centre, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Postgrad Med 117:9-14. 2005 - Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulatedDavid J Gladstone
FRCPC, Director, Regional Stroke Prevention Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada
Stroke 40:235-40. 2009..This study examined the magnitude of this problem in a large contemporary, prospective stroke registry... - Crescendo transient Aura attacks: a transient ischemic attack mimic caused by focal subarachnoid hemorrhageAaron Izenberg
Dr Thomas and Harriet Black Acute TIA Unit and Regional Stroke Prevention Clinic, Division of Neurology and Brain Sciences Program, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Toronto, Toronto, Ontario Canada
Stroke 40:3725-9. 2009..Diagnosis of transient ischemic attack can be difficult because many mimics exist. We report the clinical and neuroimaging features of a distinct hemorrhagic transient ischemic attack mimic... - The spot sign is more common in the absence of multiple prior microbleedsAndrea Evans
Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Stroke 41:2210-7. 2010..We hypothesize that the Spot sign is more common in patients without multiple prior chronic microbleeds... - Effect of online medical control on prehospital Code Stroke triageAikta Verma
Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
CJEM 12:103-10. 2010..We sought to determine whether online medical control (whereby paramedics contact the medical control physician before a Code Stroke triage is assigned) reduced the proportion of false-positive Code Stroke patients... - Predictive value of the Ontario prehospital stroke screening tool for the identification of patients with acute strokeJordan Chenkin
Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
Prehosp Emerg Care 13:153-9. 2009..Patients identified by paramedics through the use of this tool in the field were transported to a regional stroke center under an acute stroke protocol... - Urgency of carotid endarterectomy for secondary stroke prevention: results from the Registry of the Canadian Stroke NetworkDavid J Gladstone
Stroke Prevention Clinic, Division of Neurology and Regional Stroke Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada M4N 3M5
Stroke 40:2776-82. 2009..This study examined time to endarterectomy at designated stroke centers as a measure of evidence-based best practices for stroke prevention... - A citywide prehospital protocol increases access to stroke thrombolysis in TorontoDavid J Gladstone
North and East GTA Ontario Regional Stroke Centre and Division of Neurology, Department of Medicine, and Brain Sciences Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Stroke 40:3841-4. 2009..This report describes the initial impact of the activation protocol at our regional stroke center... - Poststroke "pushing": natural history and relationship to motor and functional recoveryCynthia J Danells
Heart and Stroke Foundation of Ontario Centre for Stroke Recovery, Sunnybrook and Women's College Health Science Centre, Toronto, Canada
Stroke 35:2873-8. 2004..In light of this potential recovery, rehabilitation specialists need to refine treatment approaches for the pushers to further improve functional outcome... - CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhageRyan Wada
Division of Neuroradiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Stroke 38:1257-62. 2007..We hypothesized that the presence of tiny, enhancing foci ("spot sign") within acute hematomas is associated with hematoma expansion... - Defining the CT angiography 'spot sign' in primary intracerebral hemorrhageAndrew L Thompson
Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Can J Neurol Sci 36:456-61. 2009..We propose radiological criteria for diagnosis of the CTA 'spot sign' and describe different morphological patterns... - Postcontrast CT extravasation is associated with hematoma expansion in CTA spot negative patientsAshraf Ederies
Department of Medical Imaging, Division of Neuroradiology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
Stroke 40:1672-6. 2009..The purpose of this study was to assess the effect of postcontrast CT (PCCT) leakage (PCL) on hematoma growth in CTA spot negative patients... - The relationship between inflammatory markers and post stroke cognitive impairmentLana S Rothenburg
Neuropsychopharmacology Research Group, Toronto, Ontario, Canada
J Geriatr Psychiatry Neurol 23:199-205. 2010..Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of CRP, interleukin 6 (IL-6), and interferon gamma (IFN-gamma)... - Anticoagulation after anterior myocardial infarction and the risk of strokeJacob A Udell
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
PLoS ONE 5:e12150. 2010..We examined the effectiveness of anticoagulation therapy for the prevention of stroke after anterior MI... - The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement propertiesDavid J Gladstone
Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Neurorehabil Neural Repair 16:232-40. 2002..Based on the available evidence, the Fugl-Meyer motor scale is recommended highly as a clinical and research tool for evaluating changes in motor impairment following stroke... - Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic menNavneet Singh
Department of Diagnostic Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview St, Toronto, ON, Canada M4N 3M5
Radiology 252:502-8. 2009.... - Turning a stroke into a TIA: curative thrombolysis with combined intravenous and intra-arterial tPADavid J Gladstone
North and East GTA Regional Stroke Centre and Division of Neurology, Department of Medicine and Neuroscience Program, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, ON
CJEM 8:54-7. 2006..v.) and intra-arterial (IA) tPA. This case illustrates the potential value of the combined i.v.-IA thrombolytic approach, which is an emerging investigational treatment strategy for selected patients with severe acute ischemic stroke... - Severe hypomagnesemia associated with reversible subacute ataxia and cerebellar hyperintensities on MRIMark I Boulos
Department of Medicine Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Neurologist 18:223-5. 2012..In this report we document isolated, reversible cerebellar findings with the corresponding neuroimaging correlates associated with critically low magnesium levels... - The safety of proton pump inhibitors and clopidogrel in patients after strokeDavid N Juurlink
Sunnybrook Research Institute, Toronto, Ontario, Canada
Stroke 42:128-32. 2011..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown... - Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directionsDavid J Gladstone
Division of Neurology and Regional Stroke Program, Sunnybrook and Women s College Health Sciences Centre, and Institute of Medical Sciences, Toronto, Ontario, Canada
Stroke 33:2123-36. 2002.... - Should people with asymptomatic carotid artery stenosis undergo endarterectomy for primary stroke prevention?David J Gladstone
Division of Neurology, Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ont
CMAJ 171:726-7. 2004 - Intracerebral hemorrhage: outcomes and eligibility for factor VIIa treatment in a National Stroke RegistryJanel O Nadeau
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Cerebrovasc Dis 22:271-5. 2006..In Canada, about one fifth of ICH patients might potentially benefit from rFVIIa if it is approved, with the major exclusion factor being time... - Patients with transient ischemic attack or minor stroke should be admitted to hospital: forGeoffrey A Donnan
Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
Stroke 37:1137-8. 2006 - Importance of protocol target definition on the ability to spare normal tissue: an IMRT and 3D-CRT planning comparison for intraorbital tumorsPatrick A Hein
Section of Radiation Oncology, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
Int J Radiat Oncol Biol Phys 62:1540-8. 2005..Our results can add to the ongoing discussion in the design of future 3D-CRT/IMRT protocols... - Radiation-induced cardiomyopathy as a function of radiation beam gating to the cardiac cycleDavid J Gladstone
Division of Radiation Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Phys Med Biol 49:1475-84. 2004..This technique may be useful in reducing radiation damage to the heart secondary to treatment for diseases such as Hodgkin's disease and breast cancer... - Detecting paroxysmal atrial fibrillation after ischemic stroke and transient ischemic attack: if you don't look, you won't findDavid J Gladstone
Stroke 39:e78-9; discussion e80. 2008