David J Gladstone

Summary

Affiliation: Sunnybrook and Women's College Health Sciences Centre
Country: Canada

Publications

  1. doi request reprint Vascular and nonvascular mimics of the CT angiography "spot sign" in patients with secondary intracerebral hemorrhage
    Steve Gazzola
    Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 39:1177-83. 2008
  2. ncbi request reprint Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial
    David J Gladstone
    Regional Stroke Centre, Division of Neurology, Department of Medicine, and Neurosciences Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 37:179-85. 2006
  3. pmc Management and outcomes of transient ischemic attacks in Ontario
    David J Gladstone
    Division of Neurology, Department of Medicine, and the Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
    CMAJ 170:1099-104. 2004
  4. ncbi request reprint Commentary: Toward an emergency response to transient ischemic attacks
    David J Gladstone
    Division of Neurology and Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Postgrad Med 117:9-14. 2005
  5. doi request reprint Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated
    David J Gladstone
    FRCPC, Director, Regional Stroke Prevention Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada
    Stroke 40:235-40. 2009
  6. doi request reprint Spot sign number is the most important spot sign characteristic for predicting hematoma expansion using first-pass computed tomography angiography: analysis from the PREDICT study
    Thien J Huynh
    Division of Neuroradiology and Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    Stroke 44:972-7. 2013
  7. doi request reprint Crescendo transient Aura attacks: a transient ischemic attack mimic caused by focal subarachnoid hemorrhage
    Aaron Izenberg
    Dr Thomas and Harriet Black Acute TIA Unit and Regional Stroke Prevention Clinic, Division of Neurology and Brain Sciences Program, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Toronto, Toronto, Ontario Canada
    Stroke 40:3725-9. 2009
  8. doi request reprint Predictive value of the Ontario prehospital stroke screening tool for the identification of patients with acute stroke
    Jordan Chenkin
    Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
    Prehosp Emerg Care 13:153-9. 2009
  9. ncbi request reprint Effect of online medical control on prehospital Code Stroke triage
    Aikta Verma
    Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
    CJEM 12:103-10. 2010
  10. doi request reprint The spot sign is more common in the absence of multiple prior microbleeds
    Andrea Evans
    Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Stroke 41:2210-7. 2010

Collaborators

Detail Information

Publications32

  1. doi request reprint Vascular and nonvascular mimics of the CT angiography "spot sign" in patients with secondary intracerebral hemorrhage
    Steve Gazzola
    Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 39:1177-83. 2008
    ..The purpose of this study was to assess for the presence of the Spot Sign in secondary ICH and to document potential mimics of the Spot Sign and their distinguishing features...
  2. ncbi request reprint Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial
    David J Gladstone
    Regional Stroke Centre, Division of Neurology, Department of Medicine, and Neurosciences Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 37:179-85. 2006
    ..Hemiparesis is the commonest disabling deficit caused by stroke. In animals, dextroamphetamine (AMPH) paired with training enhances motor recovery, but its clinical efficacy is uncertain...
  3. pmc Management and outcomes of transient ischemic attacks in Ontario
    David J Gladstone
    Division of Neurology, Department of Medicine, and the Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
    CMAJ 170:1099-104. 2004
    ..We studied prospectively a cohort of consecutive patients presenting with TIA to the emergency department of 4 regional stroke centres in Ontario...
  4. ncbi request reprint Commentary: Toward an emergency response to transient ischemic attacks
    David J Gladstone
    Division of Neurology and Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Postgrad Med 117:9-14. 2005
  5. doi request reprint Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated
    David J Gladstone
    FRCPC, Director, Regional Stroke Prevention Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada
    Stroke 40:235-40. 2009
    ..This study examined the magnitude of this problem in a large contemporary, prospective stroke registry...
  6. doi request reprint Spot sign number is the most important spot sign characteristic for predicting hematoma expansion using first-pass computed tomography angiography: analysis from the PREDICT study
    Thien J Huynh
    Division of Neuroradiology and Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    Stroke 44:972-7. 2013
    ..We sought to validate the SSS and assess prognostic performance of individual spot characteristics associated with hematoma expansion from a prospective multicenter intracerebral hemorrhage study...
  7. doi request reprint Crescendo transient Aura attacks: a transient ischemic attack mimic caused by focal subarachnoid hemorrhage
    Aaron Izenberg
    Dr Thomas and Harriet Black Acute TIA Unit and Regional Stroke Prevention Clinic, Division of Neurology and Brain Sciences Program, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Toronto, Toronto, Ontario Canada
    Stroke 40:3725-9. 2009
    ..Diagnosis of transient ischemic attack can be difficult because many mimics exist. We report the clinical and neuroimaging features of a distinct hemorrhagic transient ischemic attack mimic...
  8. doi request reprint Predictive value of the Ontario prehospital stroke screening tool for the identification of patients with acute stroke
    Jordan Chenkin
    Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
    Prehosp Emerg Care 13:153-9. 2009
    ..Patients identified by paramedics through the use of this tool in the field were transported to a regional stroke center under an acute stroke protocol...
  9. ncbi request reprint Effect of online medical control on prehospital Code Stroke triage
    Aikta Verma
    Division of Emergency Medicine, University of Toronto, Toronto, Ontario, Canada
    CJEM 12:103-10. 2010
    ..We sought to determine whether online medical control (whereby paramedics contact the medical control physician before a Code Stroke triage is assigned) reduced the proportion of false-positive Code Stroke patients...
  10. doi request reprint The spot sign is more common in the absence of multiple prior microbleeds
    Andrea Evans
    Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Stroke 41:2210-7. 2010
    ..We hypothesize that the Spot sign is more common in patients without multiple prior chronic microbleeds...
  11. doi request reprint A citywide prehospital protocol increases access to stroke thrombolysis in Toronto
    David J Gladstone
    North and East GTA Ontario Regional Stroke Centre and Division of Neurology, Department of Medicine, and Brain Sciences Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Stroke 40:3841-4. 2009
    ..This report describes the initial impact of the activation protocol at our regional stroke center...
  12. doi request reprint Urgency of carotid endarterectomy for secondary stroke prevention: results from the Registry of the Canadian Stroke Network
    David J Gladstone
    Stroke Prevention Clinic, Division of Neurology and Regional Stroke Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A442, Toronto, Ontario, Canada M4N 3M5
    Stroke 40:2776-82. 2009
    ..This study examined time to endarterectomy at designated stroke centers as a measure of evidence-based best practices for stroke prevention...
  13. ncbi request reprint Poststroke "pushing": natural history and relationship to motor and functional recovery
    Cynthia J Danells
    Heart and Stroke Foundation of Ontario Centre for Stroke Recovery, Sunnybrook and Women s College Health Science Centre, Toronto, Canada
    Stroke 35:2873-8. 2004
    ..This research identified pushers from stroke patients with moderate to severe hemiparesis and examined longitudinal changes in symptoms, level of impairment, and functional independence...
  14. ncbi request reprint Defining the CT angiography 'spot sign' in primary intracerebral hemorrhage
    Andrew L Thompson
    Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Can J Neurol Sci 36:456-61. 2009
    ..We propose radiological criteria for diagnosis of the CTA 'spot sign' and describe different morphological patterns...
  15. ncbi request reprint CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhage
    Ryan Wada
    Division of Neuroradiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Stroke 38:1257-62. 2007
    ..We hypothesized that the presence of tiny, enhancing foci ("spot sign") within acute hematomas is associated with hematoma expansion...
  16. doi request reprint Postcontrast CT extravasation is associated with hematoma expansion in CTA spot negative patients
    Ashraf Ederies
    Department of Medical Imaging, Division of Neuroradiology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Stroke 40:1672-6. 2009
    ..The purpose of this study was to assess the effect of postcontrast CT (PCCT) leakage (PCL) on hematoma growth in CTA spot negative patients...
  17. doi request reprint The relationship between inflammatory markers and post stroke cognitive impairment
    Lana S Rothenburg
    Neuropsychopharmacology Research Group, Toronto, Ontario, Canada
    J Geriatr Psychiatry Neurol 23:199-205. 2010
    ..Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of CRP, interleukin 6 (IL-6), and interferon gamma (IFN-gamma)...
  18. doi request reprint Multicenter accuracy and interobserver agreement of spot sign identification in acute intracerebral hemorrhage
    Thien J Huynh
    From the Divisions of Neuroradiology T J H, T L C, S P S, R I A and Division of Neurology, Department of Medicine, and Brain Sciences Program D J G, and Department of Emergency Medicine J C, Sunnybrook Health Sciences and University of Toronto, Toronto, Canada Department of Neurology, University of Cincinnati, OH M L F, J P B Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calagary, Canada A M D Department of Neurology, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Canada D D Departments of Medicine and Neurology A M, S M D and Neurointerventional Radiology P J M, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia and Department of Public Health Sciences, University of Toronto, Toronto, Canada G A T
    Stroke 45:107-12. 2014
    ..We sought to assess the accuracy and interobserver agreement for spot sign identification...
  19. ncbi request reprint Impact of disability status on ischemic stroke costs in Canada in the first year
    Nicole Mittmann
    Research Centre, Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre, 2075 Bayview Aveune, E240, Toronto, Ontario, M4N 3M5, Canada
    Can J Neurol Sci 39:793-800. 2012
    ..The objectives of this analysis were to calculate costs for the first year post-stroke and determine the impact of disability on costs...
  20. doi request reprint Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men
    Navneet Singh
    Department of Diagnostic Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview St, Toronto, ON, Canada M4N 3M5
    Radiology 252:502-8. 2009
    ....
  21. ncbi request reprint The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties
    David J Gladstone
    Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Neurorehabil Neural Repair 16:232-40. 2002
    ..Based on the available evidence, the Fugl-Meyer motor scale is recommended highly as a clinical and research tool for evaluating changes in motor impairment following stroke...
  22. pmc Anticoagulation after anterior myocardial infarction and the risk of stroke
    Jacob A Udell
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 5:e12150. 2010
    ..We examined the effectiveness of anticoagulation therapy for the prevention of stroke after anterior MI...
  23. ncbi request reprint Turning a stroke into a TIA: curative thrombolysis with combined intravenous and intra-arterial tPA
    David J Gladstone
    North and East GTA Regional Stroke Centre and Division of Neurology, Department of Medicine and Neuroscience Program, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON
    CJEM 8:54-7. 2006
    ..v.) and intra-arterial (IA) tPA. This case illustrates the potential value of the combined i.v.-IA thrombolytic approach, which is an emerging investigational treatment strategy for selected patients with severe acute ischemic stroke...
  24. doi request reprint Severe hypomagnesemia associated with reversible subacute ataxia and cerebellar hyperintensities on MRI
    Mark I Boulos
    Department of Medicine Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Neurologist 18:223-5. 2012
    ..In this report we document isolated, reversible cerebellar findings with the corresponding neuroimaging correlates associated with critically low magnesium levels...
  25. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
    ..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown...
  26. pmc Should people with asymptomatic carotid artery stenosis undergo endarterectomy for primary stroke prevention?
    David J Gladstone
    Division of Neurology, Regional Stroke Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ont
    CMAJ 171:726-7. 2004
  27. ncbi request reprint Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions
    David J Gladstone
    Division of Neurology and Regional Stroke Program, Sunnybrook and Women s College Health Sciences Centre, and Institute of Medical Sciences, Toronto, Ontario, Canada
    Stroke 33:2123-36. 2002
    ....
  28. ncbi request reprint Radiation-induced cardiomyopathy as a function of radiation beam gating to the cardiac cycle
    David J Gladstone
    Division of Radiation Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Phys Med Biol 49:1475-84. 2004
    ..This technique may be useful in reducing radiation damage to the heart secondary to treatment for diseases such as Hodgkin's disease and breast cancer...
  29. ncbi request reprint Importance of protocol target definition on the ability to spare normal tissue: an IMRT and 3D-CRT planning comparison for intraorbital tumors
    Patrick A Hein
    Section of Radiation Oncology, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Int J Radiat Oncol Biol Phys 62:1540-8. 2005
    ....
  30. ncbi request reprint Patients with transient ischemic attack or minor stroke should be admitted to hospital: for
    Geoffrey A Donnan
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:1137-8. 2006
  31. ncbi request reprint Intracerebral hemorrhage: outcomes and eligibility for factor VIIa treatment in a National Stroke Registry
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 22:271-5. 2006
    ..Intracerebral hemorrhage (ICH) is a devastating form of stroke for which the lack of treatment options, high mortality rate, and the tendency to severely disable result in high social and economic burden...
  32. doi request reprint Detecting paroxysmal atrial fibrillation after ischemic stroke and transient ischemic attack: if you don't look, you won't find
    David J Gladstone
    Stroke 39:e78-9; discussion e80. 2008