Affiliation: Sunnybrook Health Sciences Centre
- Prolonged antibiotic treatment in long-term care: role of the prescriberNick Daneman
Division of Infectious Diseases, Department of Medicine, SunnybrookHealth Sciences Centre, University of Toronto, Toronto, Canada
JAMA Intern Med 173:673-82. 2013..Given that most common bacterial infections can be treated with antibiotic courses of 7 or fewer days, reducing standard antibiotic treatment durations may be an avenue to curtailing antibiotic overuse in long-term care...
- Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysisNick Daneman
Trauma, Emergency, and Critical Care Program, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada
Lancet Infect Dis 13:328-41. 2013..We aimed to assess the effect of SDD and SOD on antimicrobial resistance rates in patients in ICUs...
- Reduction in Clostridium difficile infection rates after mandatory hospital public reporting: findings from a longitudinal cohort study in CanadaNick Daneman
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
PLoS Med 9:e1001268. 2012..Our objective was to determine whether mandatory public reporting by hospitals is associated with a reduction in hospital rates of Clostridium difficile infection...
- Validation of administrative population-based data sets for the detection of cesarean delivery surgical site infectionNick Daneman
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 32:1213-5. 2011..Although these data sets are highly specific and could be used to define research cohorts, their low sensitivity and positive predictive value make them inadequate for use as quality indicators...
- Antibiotic use in long-term care facilitiesNick Daneman
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
J Antimicrob Chemother 66:2856-63. 2011..Our goal was to examine the prevalence of antibiotic use among long-term care facility residents and the extent of variability across these institutions...
- Duration of hospital admission and the need for empirical antipseudomonal therapyN Daneman
Sunnybrook Health Sciences Centre, Department of Microbiology and Division of Infectious Diseases, Toronto, Ontario, Canada
J Clin Microbiol 50:2695-701. 2012..aeruginosa isolation. Any guidelines which distinguish early from late hospital-acquired infection must consider the implications of time point selection on the likelihood of inadequate P. aeruginosa empirical coverage...
- How long should peripherally inserted central catheterization be delayed in the context of recently documented bloodstream infection?Nick Daneman
Division of Infectious Diseases and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Vasc Interv Radiol 23:123-5. 2012..The relapse risk was higher when PICCs were inserted within 2 days (two of 31; 6.5%) versus at least 3 days (one of 317; 0.3%) after documentation of bacteremia (P = .02)...
- Statin use and the risk of surgical site infections in elderly patients undergoing elective surgeryNick Daneman
Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, G Wing Room 106, Toronto, ON M4N 3M5, Canada
Arch Surg 144:938-45. 2009..To examine whether preoperative statin use is associated with a reduced risk of surgical site infections...
- Antibiotic treatment duration for bloodstream infections in critically ill patients: a national survey of Canadian infectious diseases and critical care specialistsNick Daneman
University of Toronto, Department of Medicine, Toronto, ON, Canada
Int J Antimicrob Agents 38:480-5. 2011..There is equipoise for a randomised trial comparing shorter versus longer courses of antibiotics for most bacteraemic syndromes and pathogens...
- Validation of a modified version of the national nosocomial infections surveillance system risk index for health services researchNick Daneman
Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 30:563-9. 2009..To validate the National Nosocomial Infections Surveillance system risk index through administrative data to predict surgical site infections...
- Discharge after discharge: predicting surgical site infections after patients leave hospitalN Daneman
Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
J Hosp Infect 75:188-94. 2010..Post-discharge SSIs are frequent, severe, scattered over time and location, and hard to predict using common risk indices. They represent an important hidden burden in our healthcare system...
- The co-seasonality of pneumonia and influenza with Clostridium difficile infection in the United States, 1993-2008Kevin A Brown
Dalla Lana School of Public Health, University of Toronto, Ontario, Canada
Am J Epidemiol 178:118-25. 2013..073, 1.153). Future research could seek to understand which mediating pathways, including changes in broad-spectrum antibiotic prescribing and hospital crowding, are most responsible for the associated changes in incidence. ..
- The economic burden of patient safety targets in acute care: a systematic reviewNicole Mittmann
Health Outcomes and Pharmaco Economics HOPE Research Centre, Division of Clinical Pharmacology, Toronto, ON, Canada
Drug Healthc Patient Saf 4:141-65. 2012..Our objective was to determine the quality of literature in costing of the economic burden of patient safety...
- Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control studyJanine R Hutson
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Drugs Aging 29:205-11. 2012..Donepezil is metabolized by the cytochrome P450 isozyme 3A4 (CYP3A4). Clarithromycin is a potent inhibitor of CYP3A4, and patients taking both of these drugs may be at increased risk of cardiac adverse events...
- Identification of predictors of early infection in acute burn patientsLaura Schultz
Sunnybrook Health Sciences Centre, Department of Pharmacy, Canada
Burns 39:1355-66. 2013..05). This pilot project identified significant predictors of early infection and sepsis in acute burns and will be validated in a prospective study...
- Delirium after elective surgery among elderly patients taking statinsDonald A Redelmeier
Department of Medicine, University of Toronto, Ontario, Toronto, Canada
CMAJ 179:645-52. 2008..We sought to determine whether the use of statin medications was associated with a higher risk of postoperative delirium than other medications that do not alter microvascular autoregulation...
- Audit and feedback to reduce broad-spectrum antibiotic use among intensive care unit patients: a controlled interrupted time series analysisMarion Elligsen
Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 33:354-61. 2012..We aimed to rigorously evaluate the impact of prospective audit and feedback on broad-spectrum antimicrobial use among critical care patients...
- Postoperative pneumonia in elderly patients receiving acid suppressants: a retrospective cohort analysisDonald A Redelmeier
Department of Medicine, University of Toronto, Toronto, Canada
BMJ 340:c2608. 2010..To test whether gastric acid suppressants are associated with an increased risk of postoperative pneumonia in patients undergoing elective surgery...
- Introducing a methodology for estimating duration of surgery in health services researchDonald A Redelmeier
Department of Medicine, Infectious Disease, and Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
J Clin Epidemiol 61:882-9. 2008..We introduce a new methodology for assessing the duration of surgery based on anesthesiology billing records, along with reviewing its fundamental logic and limitations...
- Lessons from audit and feedback of hospitalized patients with bacteriuriaJerome A Leis
Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada Centre for Quality Improvement and Patient Safety, University of Toronto, Toronto, ON, Canada Electronic address
Am J Infect Control 42:1136-7. 2014..This study highlights the limitations of educational initiatives in overcoming engrained beliefs about bacteriuria even when advice is provided in real time...
- Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infectionKevin A Brown
Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Antimicrob Agents Chemother 57:2326-32. 2013..Avoidance of high-risk antibiotics (such as clindamycin, CMCs, and fluoroquinolones) in favor of lower-risk antibiotics (such as penicillins, macrolides, and tetracyclines) may help reduce the incidence of CDI...
- Impact of antimicrobial stewardship in critical care: a systematic reviewReham Kaki
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Antimicrob Chemother 66:1223-30. 2011..To evaluate the current state of evidence for antimicrobial stewardship interventions in the critical care unit...
- The magnitude and duration of Clostridium difficile infection risk associated with antibiotic therapy: a hospital cohort studyKevin A Brown
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 9:e105454. 2014..These findings are consistent with studies showing higher risk associated with longer antibiotic use in hospitalized patients, but suggest that the duration of increased risk is shorter than previously thought. ..
- Determination of tobramycin pharmacokinetics in burn patients to evaluate the potential utility of once-daily dosing in this populationDiane Vella
From the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Leslie L Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada Department of Microbiology and Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada and Faculty of Medicine, University of Toronto, Ontario, Canada
J Burn Care Res 35:e240-9. 2014..Variability in pharmacokinetics in this population and change in pharmacokinetics with time postburn injury necessitate monitoring of tobramycin levels to ensure targets are met and maintained. ..
- Reducing the risk of severe complications among patients with Clostridium difficile infectionKamran Manek
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Can J Gastroenterol 25:368-72. 2011..The incidence and severity of Clostridium difficile infections are increasing, and there is a need to optimize the prevention of complicated disease...
- Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000Nick Daneman
University of Toronto, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Ann Intern Med 147:234-41. 2007..Streptococcus pyogenes can cause severe disease in the individual patient and dramatic hospital outbreaks...
- The impact of infection on population health: results of the Ontario burden of infectious diseases studyJeffrey C Kwong
Institute for Clinical Evaluative Sciences, Toronto, Canada
PLoS ONE 7:e44103. 2012..We sought to quantify the contribution of a wide range of infectious diseases to the overall infectious disease burden in a high-income setting...
- Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysisThomas C Havey
Department of Medicine, University of Toronto, 1 Kings College Circle, O, M5S 1A8, Canada
Crit Care 15:R267. 2011....
- Staphylococcus aureus decolonization as a prevention strategyAndrew E Simor
Department of Medicine, University of Toronto, Toronto, ON, Canada M4N 3M5
Infect Dis Clin North Am 23:133-51. 2009..This article reviews available data regarding various proposed treatment regimens for eradicating staphylococcal carriage and the effectiveness of decolonization for infection prevention and as an infection control measure...
- At the threshold: defining clinically meaningful resistance thresholds for antibiotic choice in community-acquired pneumoniaNick Daneman
Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, USA
Clin Infect Dis 46:1131-8. 2008..Guidelines suggest a 25% rate of high-level macrolide resistance in the community as the threshold beyond which macrolides should not be used. We evaluated the implications of this threshold for clinical failure rates...
- Predictive utility of prior positive urine culturesDerek R MacFadden
Department of Medicine, University of Toronto
Clin Infect Dis 59:1265-71. 2014..We sought to evaluate how well previous urine cultures predict the identity and susceptibility of organisms in a patient's subsequent urine cultures...
- Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept studyJerome A Leis
Division of Infectious Diseases, Department of Medicine, University of Toronto
Clin Infect Dis 58:980-3. 2014..Larger studies are needed to confirm the generalizability, safety, and sustainability of this model of care. ..
- Comparative economic analyses of patient safety improvement strategies in acute care: a systematic reviewEdward Etchells
University of Toronto Centre for Patient Safety, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
BMJ Qual Saf 21:448-56. 2012..The objective was to systematically review comparative economic analyses of patient safety improvements in the acute care setting...
- Use of a structured panel process to define quality metrics for antimicrobial stewardship programsAndrew M Morris
Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
Infect Control Hosp Epidemiol 33:500-6. 2012..There is no standardized approach to evaluate the impact of these programs...