Sandra Black

Summary

Affiliation: Sunnybrook Health Sciences Centre
Country: Canada

Publications

  1. pmc True functional ability of chronic stroke patients
    William J Tippett
    L C Campbell Cognitive Neurology Research Unit, Toronto, ON, Canada
    J Neuroeng Rehabil 10:20. 2013
  2. doi request reprint Long-term prediction of functional outcome after stroke using the Alberta Stroke Program Early Computed Tomography Score in the subacute stage
    Lisa D Alexander
    Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada
    J Stroke Cerebrovasc Dis 21:737-44. 2012
  3. pmc The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
    Allison B Gold
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Neuroinflammation 8:17. 2011
  4. pmc Correlating lesion size and location to deficits after ischemic stroke: the influence of accounting for altered peri-necrotic tissue and incidental silent infarcts
    Lisa D Alexander
    Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada
    Behav Brain Funct 6:6. 2010
  5. doi request reprint Canadian Alzheimer's disease caregiver survey: baby-boomer caregivers and burden of care
    Sandra E Black
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 25:807-13. 2010
  6. doi request reprint Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment
    Sandra Black
    FRCP C, Brill Professor of Neurology, Cognitive Neurology, A421, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5
    Stroke 40:S48-52. 2009
  7. ncbi request reprint Donepezil preserves cognition and global function in patients with severe Alzheimer disease
    S E Black
    Division of Neurology, Department of Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Neurology 69:459-69. 2007
  8. doi request reprint Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management
    S E Black
    Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada
    J R Coll Physicians Edinb 41:49-56. 2011
  9. ncbi request reprint Cognitive rehabilitation in the elderly: overview and future directions
    Gordon Winocur
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:166-71. 2007
  10. ncbi request reprint Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial
    Sandra Black
    University of Toronto, Department of Medicine Division of Neurology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Stroke 34:2323-30. 2003

Detail Information

Publications53

  1. pmc True functional ability of chronic stroke patients
    William J Tippett
    L C Campbell Cognitive Neurology Research Unit, Toronto, ON, Canada
    J Neuroeng Rehabil 10:20. 2013
    ..The goal of this paper is to determine how VS and VM performance in chronic stroke patients compare to the performance of healthy participants...
  2. doi request reprint Long-term prediction of functional outcome after stroke using the Alberta Stroke Program Early Computed Tomography Score in the subacute stage
    Lisa D Alexander
    Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada
    J Stroke Cerebrovasc Dis 21:737-44. 2012
    ..528; P < .001) poststroke. Our data indicate that in the subacute stage, ASPECTS is reliable and can help predict which patients may be likely to regain functional independence up to 1 year after sustaining ischemic stroke...
  3. pmc The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
    Allison B Gold
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Neuroinflammation 8:17. 2011
    ....
  4. pmc Correlating lesion size and location to deficits after ischemic stroke: the influence of accounting for altered peri-necrotic tissue and incidental silent infarcts
    Lisa D Alexander
    Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada
    Behav Brain Funct 6:6. 2010
    ....
  5. doi request reprint Canadian Alzheimer's disease caregiver survey: baby-boomer caregivers and burden of care
    Sandra E Black
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 25:807-13. 2010
    ....
  6. doi request reprint Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment
    Sandra Black
    FRCP C, Brill Professor of Neurology, Cognitive Neurology, A421, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5
    Stroke 40:S48-52. 2009
    ..Further research is needed to understand and treat this chronic subcortical vascular disease, which is epidemic in our aging population...
  7. ncbi request reprint Donepezil preserves cognition and global function in patients with severe Alzheimer disease
    S E Black
    Division of Neurology, Department of Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Neurology 69:459-69. 2007
    ..To evaluate the efficacy and safety of donepezil for severe Alzheimer disease (AD)...
  8. doi request reprint Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management
    S E Black
    Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada
    J R Coll Physicians Edinb 41:49-56. 2011
    ....
  9. ncbi request reprint Cognitive rehabilitation in the elderly: overview and future directions
    Gordon Winocur
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:166-71. 2007
    ..The benefits were attributed to several factors, including the program's emphasis on techniques that promoted efficient strategic processing. Limitations of the program and directions for future research are discussed...
  10. ncbi request reprint Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial
    Sandra Black
    University of Toronto, Department of Medicine Division of Neurology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Stroke 34:2323-30. 2003
    ..Clinical observations suggest that patients with vascular dementia (VaD) may benefit from treatment with cholinesterase inhibitors. This study evaluated the efficacy and safety of donepezil for relieving symptoms of dementia in VaD...
  11. doi request reprint Genetic testing in combination with preventive donepezil treatment for patients with amnestic mild cognitive impairment: an exploratory economic evaluation of personalized medicine
    Sandjar Djalalov
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Mol Diagn Ther 16:389-99. 2012
    ....
  12. doi request reprint Stroke in the very elderly: hospital care, case fatality and disposition
    Gustavo Saposnik
    Stroke Research Program, South East Toronto Regional Stroke Center, Division of Neurology, Department of Medicine, St Michael s Hospital, Ont, Canada
    Cerebrovasc Dis 27:537-43. 2009
    ..However, limited information is available about the burden of stroke in individuals over 90...
  13. doi request reprint Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias
    Tiffany W Chow
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
    Alzheimer Dis Assoc Disord 22:327-35. 2008
    ..While volumetry identified left-sided atrophy as useful for identifying FTD cases, future studies should determine whether clinicians could make these distinctions on viewing routine diagnostic magnetic resonance imaging scans...
  14. ncbi request reprint Cognitive rehabilitation in the elderly: a randomized trial to evaluate a new protocol
    Donald T Stuss
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:120-31. 2007
    ..The results for each functional domain are reported in separate papers in this series...
  15. doi request reprint Renal safety of CT angiography and perfusion imaging in the emergency evaluation of acute stroke
    J J Hopyan
    Division of Neurology, Department of Medicine, North and East Greater Toronto Area Ontario Regional Stroke Centre, and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 29:1826-30. 2008
    ....
  16. doi request reprint Association between weekend hospital presentation and stroke fatality
    Jiming Fang
    Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    Neurology 75:1589-96. 2010
    ..Previous studies have found higher stroke case fatality in patients admitted to the hospital on weekends compared to weekdays, but the reasons for this association are not known...
  17. doi request reprint Incidence and profile of inpatient stroke-induced aphasia in Ontario, Canada
    Laura Dickey
    Aphasia Institute incorporating the Pat Arato Aphasia Centre, Toronto, ON, Canada
    Arch Phys Med Rehabil 91:196-202. 2010
    ..To determine the incidence rate of inpatient stroke-induced aphasia in Ontario, Canada, and to examine the demographic and clinical characteristics for stroke patients with and without aphasia...
  18. ncbi request reprint Imaging biomarkers and their role in dementia clinical trials
    Howard Chertkow
    Department of Clinical Neuroscience, Sir Mortimer B Davis Jewish General Hospital, Toronto, ON, Canada
    Can J Neurol Sci 34:S77-83. 2007
    ..At the present time, however, no single measure has sufficient proven reliability, replicability, or robustness, to replace clinical primary outcome measures...
  19. doi request reprint Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients
    Andrew J Baker
    Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 26:1227-40. 2009
    ..Pre-hospital resuscitation with HSD is associated with a reduction in serum S100B, NSE, and MBP concentrations, which are correlated with better outcome after severe TBI...
  20. pmc Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
    Morris Moscovitch
    Department of Psychology, University of Toronto and Rotman Research Institute Baycrest Centre, Ontario, Canada
    J Anat 207:35-66. 2005
    ....
  21. doi request reprint A comparative case study of face recognition: the contribution of configural and part-based recognition systems, and their interaction
    Josée Rivest
    Cognitive Behavioral Health Program, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada
    Neuropsychologia 47:2798-811. 2009
    ..Our results suggest that the configural system is always necessary for face recognition, and appears to support what remains of face identification even in prosopagnosic people who have an intact part-based system...
  22. ncbi request reprint Simple linear and area MR measurements can help distinguish between Alzheimer's disease, frontotemporal dementia, and normal aging: the Sunnybrook dementia study
    N A Deshpande
    Department of Medicine Neurology, Sunnybrook and Women s College, Health Sciences Centre, University of Toronto, Ont, Canada
    Brain Cogn 54:165-6. 2004
  23. ncbi request reprint Cholinesterase inhibitors slow decline in executive functions, rather than memory, in Alzheimer's disease: a 1-year observational study in the Sunnybrook dementia cohort
    P Behl
    L C Campbell Cognitive Neurology Research Unit, University of Toronto, Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    Curr Alzheimer Res 3:147-56. 2006
    ..4-0.8). Executive, language and visuospatial functions, rather than memory, appeared to be more amenable to stabilization over one year by cholinesterase inhibitors in AD...
  24. doi request reprint Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation
    Norman A S Farb
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Cortex 49:1856-73. 2013
    ..Recent neuroimaging research also associates FTD with alterations in the brain's intrinsic connectivity networks. The present study explored the relationship between neural network connectivity and specific behavioral symptoms in FTD...
  25. doi request reprint Stroke outcome in those over 80: a multicenter cohort study across Canada
    Gustavo Saposnik
    South East Toronto Regional Stroke Center, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 39:2310-7. 2008
    ..However, limited information is available about the burden of stroke in individuals over 80. We sought to evaluate differences in clinical outcomes in Canadians over 80 years old hospitalized for an acute ischemic stroke...
  26. ncbi request reprint Analyses of deficits in gestural pantomime
    E A Roy
    Department of Kinesiology, University of Waterloo, Ontario, Canada
    J Clin Exp Neuropsychol 20:628-43. 1998
    ..Analyses of intrahemispheric lesion localization implicated damage to subcortical areas involving periventricular white matter tracts at the temporoparietal junction with apraxia...
  27. doi request reprint A SPECT study of sleep disturbance and Alzheimer's disease
    Z Ismail
    Centre for Addiction and Mental Health, Toronto, Ont, Canada
    Dement Geriatr Cogn Disord 27:254-9. 2009
    ..This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD)...
  28. ncbi request reprint Handicap in stroke survivors
    P J Clarke
    Graduate Department of Community Health, and Institute for Human Development, Life Course and Aging, University of Toronto, Ontario, Canada
    Disabil Rehabil 21:116-23. 1999
    ....
  29. doi request reprint Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
    H H Feldman
    Division of Neurology, University of British Columbia, UBCH Clinic for Alzheimer s Disease and Related Disorders, Vancouver, Canada
    Neurology 74:956-64. 2010
    ..The LEADe study is a randomized controlled trial (RCT) evaluating the efficacy and safety of atorvastatin in patients with mild to moderate AD...
  30. ncbi request reprint Task demands and limb apraxia in stroke
    E A Roy
    Department of Kinesiology, Waterloo, Ontario, Canada
    Brain Cogn 44:253-79. 2000
    ....
  31. ncbi request reprint Recognition memory and verbal fluency differentiate probable Alzheimer disease from subcortical ischemic vascular dementia
    M C Tierney
    Geriatric Research, A145, Sunnybrook and Women s Health Sciences Center, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5
    Arch Neurol 58:1654-9. 2001
    ....
  32. ncbi request reprint Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics
    K R Peters
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Neurology 66:523-8. 2006
    ..To characterize the neuropsychiatric symptoms (NPS) of subjects classified as not cognitively impaired (NCI), cognitively impaired-not demented (CIND), and dementia...
  33. pmc Anterior-medial thalamic lesions in dementia: frequent, and volume dependently associated with sudden cognitive decline
    R H Swartz
    Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Neurol Neurosurg Psychiatry 77:1307-12. 2006
    ..The anterior-medial thalamus (AMT), which is associated with memory processing, is severely affected by Alzheimer's disease pathology and, when damaged, can be the sole cause of dementia...
  34. ncbi request reprint Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia
    S J Duff Canning
    Cognitive Neurology Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Neurology 62:556-62. 2004
    ..Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency...
  35. ncbi request reprint Focal cortical atrophy syndromes
    S E Black
    Cognitive Neurology Unit, Sunnybrook Health Science Centre, North York, Ontario, Canada
    Brain Cogn 31:188-229. 1996
    ..The clinico-pathological features of each syndrome are reviewed and compared to those typical for AD, and single photon emission computerized tomography scans representative for each are illustrated...
  36. ncbi request reprint Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements
    B D Murphy
    University of Western Ontario, London, ON, Canada
    Stroke 37:1771-7. 2006
    ....
  37. ncbi request reprint Automatic activation of positive but not negative attitudes after traumatic brain injury
    N W Park
    Kunin Lunenfeld Applied Research Unit and Department of Psychology, Baycrest Centre for Geriatric Care, University of Toronto, 3560 Bathurst Street, Suite 2W 02, Ont, M6A 2E1, Toronto, Canada
    Neuropsychologia 39:7-24. 2001
    ..In Experiment 3 AM and controls both showed normal semantic priming effects. The results are interpreted within the component process model of memory...
  38. ncbi request reprint The Sunnybrook Stroke Study: a prospective study of depressive symptoms and functional outcome
    N Herrmann
    Department of Psychiatry, Sunnybrook Health Science Centre and University of Toronto, North York, Ontario, Canada
    Stroke 29:618-24. 1998
    ....
  39. ncbi request reprint Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions
    R S Rosenbaum
    Department of Psychology, University of Toronto, 100 St George St, Toronto, Ontario M5S1A1, Canada
    Nat Neurosci 3:1044-8. 2000
    ....
  40. ncbi request reprint Bilateral movement enhances ipsilesional cortical activity in acute stroke: a pilot functional MRI study
    W R Staines
    Sunnybrook and Women s College Health Sciences Centre, Department of Medicine Neurology, and Graduate Department of Rehabilitation Science, University of Toronto, Ontario, Canada
    Neurology 56:401-4. 2001
    ..With recovery, activation of M1 in the affected hemisphere did not differ between unilateral paretic hand and bilateral movement. These preliminary data may have potential implications for acute stroke motor rehabilitation...
  41. ncbi request reprint Preventing dementia
    S E Black
    Department of Medicine, Neurology, University of Toronto, Ontario, Canada
    Can J Neurol Sci 28:S56-66. 2001
    ..Further research to develop and test preventative therapies in AD and other dementias should be strongly encouraged...
  42. ncbi request reprint Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD
    D J Callen
    Cognitive Neurology Unit and Research Program in Aging, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada
    Neurology 57:1669-74. 2001
    ..The measures require further exploration in samples more representative of those seen by primary care physicians before their utility can be accurately assessed...
  43. ncbi request reprint A robust method for extraction and automatic segmentation of brain images
    N Kovacevic
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Neuroimage 17:1087-100. 2002
    ..The algorithm was also insensitive to variation in parameter initialization values. The protocol is robust, fast, and its success in segmenting normal as well as diseased brains makes it an attractive clinical application...
  44. ncbi request reprint Linear width of the medial temporal lobe can discriminate Alzheimer's disease from normal aging: the Sunnybrook dementia study
    F Q Gao
    Cognitive Neurology Unit, Neuroscience Research Program, Sunnybrook and Women s College Health Sciences Center, University of Toronto, A421 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
    Neurobiol Aging 25:441-8. 2004
    ..This quick, reliable, and standardized measurement of tMTL can be helpful in differentiating even mild AD from controls with reasonable accuracy...
  45. ncbi request reprint Differential topography of Alzheimer's disease and frontotemporal dementia: an MRI volumetric analysis from Sunnybrook dementia study
    C Bocti
    Department of Medicine Neurology, Sunnybrook and Women s College Health Science Centre, University of Toronto, Toronto, Ont, Canada
    Brain Cogn 54:151-3. 2004
  46. doi request reprint The Toronto traumatic brain injury study: injury severity and quantified MRI
    B Levine
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada
    Neurology 70:771-8. 2008
    ..To assess the relationship between regional brain volume changes and traumatic brain injury (TBI) severity in patients with and without focal lesions...
  47. ncbi request reprint The behavioural neurology assessment
    S Darvesh
    Department Neurology and Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 32:167-77. 2005
    ..The BNA-Short Form consists of 13 subtests within the domains of Attention, Memory, Naming, Visuospatial Function and Executive Function. In addition to individual domain indices, a Grand Total score was calculated for both BNA versions...
  48. ncbi request reprint Cognitive impairment in dementia: correlations with atrophy and cerebrovascular disease quantified by magnetic resonance imaging
    R H Swartz
    Brain Cogn 49:228-32. 2002
    ..33), and white matter lesions predicted executive dysfunction (R2 = .48). Both atrophy and CVD burden correlated highly with cognitive impairment and should be simultaneously assessed in studies of brain-behaviour relations in dementia...
  49. doi request reprint The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics
    Roy W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
    Alzheimers Dement 4:145-53. 2008
    ....
  50. ncbi request reprint A Canadian cohort study of cognitive impairment and related dementias (ACCORD): study methods and baseline results
    H Feldman
    Department of Medicine Neurology, Vancouver Hospital and Health Sciences Center, University of British Columbia, S192 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada
    Neuroepidemiology 22:265-74. 2003
    ..4%, dementia with Lewy bodies 2.5%, and unclassifiable 1.8%. The ACCORD cohort will allow a detailed study of the longitudinal course of CIND, and the longer-term outcomes of both treated and untreated dementia subjects...
  51. ncbi request reprint Transitive gesture production in apraxia: visual and nonvisual sensory contributions
    D A Westwood
    Department of Psychology, Faculty of Medicine, University of Waterloo
    Brain Cogn 46:300-4. 2001
    ..Various patterns of performance were observed in the stroke groups, indicating that selective damage to the haptic/kinesthetic processing system is possible and common following unilateral stroke...
  52. ncbi request reprint Patterns of apraxia associated with the production of intransitive limb gestures following left and right hemisphere stroke
    M Heath
    Department of Kinesiology, University of Waterloo, Canada
    Brain Cogn 46:165-9. 2001
    ..The results indicated that a significant proportion of LHD and RHD patients were selectively impaired in formulating the ideational component of intransitive limb gestures...
  53. ncbi request reprint Behavioural measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study
    M Blair
    Department of Cognitive Neurology and Alzheimer s Research Centre, St Joseph s Health Care, University of Western Ontario, London, Canada
    Dement Geriatr Cogn Disord 23:406-15. 2007
    ....