Research Topics
| Neill K J AdhikariSummaryAffiliation: Sunnybrook Health Sciences Centre Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort studyMarius J Terblanche
Critical Care and Anaesthesia Research Group, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
Crit Care 15:R74. 2011..We tested the hypothesis that statin therapy, administered for standard clinical indications to ventilated intensive care unit patients, prevents acute organ failure without harming the liver...- Statin research in critical illness: hampered by poor trial design?Marius Terblanche
Department of Critical Care Medicine, Guy s and St Thomas NHS Foundation Trust, London, UK
Crit Care 13:1015. 2009.... - Statins, bugs and prophylaxis: intriguing possibilitiesMarius Terblanche
Department of Critical Care Medicine, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Crit Care 10:168. 2006..Emerging data indicate a potential prophylactic role in these high-risk groups... - Drotrecogin alfa (activated): down and not out, but not really in eitherJan O Friedrich
Crit Care 10:420. 2006 - Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of deathJan O Friedrich
Crit Care 10:427. 2006 - The hemodynamic tolerability and feasibility of sustained low efficiency dialysis in the management of critically ill patients with acute kidney injuryHeather E Fieghen
Department of Medicine, University of Toronto, Toronto, ON, Canada
BMC Nephrol 11:32. 2010..We also compared the feasibility of SLED administration with that of CRRT and intermittent hemodialysis (IHD)... - Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysisNeill K J Adhikari
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
BMJ 334:779. 2007.... 
Self-reported depressive symptoms and memory complaints in survivors five years after ARDSNeill K J Adhikari
Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
Chest 140:1484-93. 2011..Survivors of ARDS report depressive symptoms and memory complaints, the prevalence of which after 5 years is unknown...- High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysisSachin Sud
Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
BMJ 340:c2327. 2010..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)... - Critical care and the global burden of critical illness in adultsNeill K J Adhikari
Interdepartmental Division of Critical Care, University of Toronto and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Lancet 376:1339-46. 2010.... - High-frequency oscillation in adults: a utilization reviewNeill K J Adhikari
Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
Crit Care Med 39:2631-44. 2011..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes... - Worldwide demand for critical careNeill K J Adhikari
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
Curr Opin Crit Care 17:620-5. 2011..Interest in the global burden of critical illness is growing, but comprehensive data to describe this burden and the resources available to provide care for critically ill patients are lacking... - Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysisSachin Sud
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
Intensive Care Med 36:585-99. 2010..Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is severe... - Electronic prescribing in an ambulatory care setting: a cluster randomized trialKatie N Dainty
St Michael s Hospital, Toronto, ON, Canada
J Eval Clin Pract 18:761-7. 2012..Medication errors resulting in preventable adverse drug events most commonly occur at the ordering stage. Electronic prescribing may prevent such errors but its impact has not been rigorously evaluated... - Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysisEwan C Goligher
Interdepartmental Division of Critical Care, Mount Sinai Hospital and the University Health Network, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Crit Care 15:R46. 2011..Pleural effusions are frequently drained in mechanically ventilated patients but the benefits and risks of this procedure are not well established... - Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort studyTushar D Mahambrey
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Can J Anaesth 56:740-50. 2009..To determine associations between red blood cell (RBC) transfusion and early and late clinical outcomes in massively transfused adult trauma patients... - Quality of professional society guidelines and consensus conference statements in critical careTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 36:1049-58. 2008..To examine the quality of professional society critical care guidelines and consensus statements... - Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysisSachin Sud
Interdepartmental Division of Critical Care, University of Toronto, Faculty of Science, Toronto, Ont
CMAJ 178:1153-61. 2008..We sought to determine the effect of mechanical ventilation in the prone position on mortality, oxygenation, duration of ventilation and adverse events in patients with acute hypoxemic respiratory failure... - A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trialDamon C Scales
Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
JAMA 305:363-72. 2011..Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement... - A guide for the design and conduct of self-administered surveys of cliniciansKaren E A Burns
Interdepartmental Division of Critical Care, University of Toronto, and Keenan Research Centre and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont
CMAJ 179:245-52. 2008 - Has mortality from acute respiratory distress syndrome decreased over time?: A systematic reviewJason Phua
F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
Am J Respir Crit Care Med 179:220-7. 2009..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing... - Sex-and age-based differences in the delivery and outcomes of critical careRobert A Fowler
Interdepartmental Division of Critical Care Medicine and Department of Medicine, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ont
CMAJ 177:1513-9. 2007..Our objective was to determine whether sex and age are associated with differences in admission practices, processes of care and clinical outcomes for critically ill patients... - Clinical review: critical care in the global context--disparities in burden of illness, access, and economicsRobert A Fowler
Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D478, Toronto, ON, Canada M4N 3M5
Crit Care 12:225. 2008.... - Implementation of a research awareness program in the critical care unit: effects on families and cliniciansCraig Dale
Trauma, Emergency and Critical Care Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Intensive Crit Care Nurs 26:69-74. 2010..Successful conduct of research studies in the critically ill requires communication with families, substitute decision-makers and clinicians... - Noninvasive ventilation for acute respiratory failure near the end of lifeTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 36:789-94. 2008.... - Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysisKaren E A Burns
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
PLoS ONE 6:e14623. 2011..We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing pressure and volume-limited (PVL) ventilation strategies with more traditional mechanical ventilation in adults with ALI and ARDS... 
Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort studyAyodele Odutayo
Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Can J Anaesth 59:934-42. 2012..We undertook this study to characterize the epidemiology of acute kidney injury (AKI) in Canadian critical care units. We aimed to identify predictors of mortality for patients diagnosed with AKI...- Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approachesJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
BMC Res Notes 2:5. 2009..The objective of this study was to assess the robustness of the rosiglitazone results by using alternative reasonable methodologic approaches and by analyzing additional related outcomes... - Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulationJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
Stat Med 31:1857-86. 2012.... - Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available dataJan O Friedrich
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
BMC Med Res Methodol 7:5. 2007..This study examined the influence of such trials on pooled treatment effects... - Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic dataJan O Friedrich
Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
Crit Care 14:324. 2010..Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients... - High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysisRyan Van Wert
Department of Medicine, University of Toronto, Toronto, Canada
Crit Care Med 38:1360-9. 2010..To determine the effect of renal replacement therapy dose on mortality and dialysis dependence in patients with acute kidney injury... - Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methodsJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Clin Epidemiol 64:556-64. 2011..Ratio of means (RoM) is an alternative effect measure that performs comparably in simulation. We compared treatment effects and heterogeneity for RoM, MD, and SMD using empiric data... - Update in critical care 2007Robert A Fowler
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Respir Crit Care Med 177:808-19. 2008 - The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation studyJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
BMC Med Res Methodol 8:32. 2008..SMD and RoM allow pooling of outcomes expressed in different units and comparisons of effect sizes across interventions, but RoM interpretation does not require knowledge of the pooled SD, a quantity generally unknown to clinicians... - Survey of information technology in Intensive Care Units in Ontario, CanadaStephen E Lapinsky
Intensive Care Unit, Mount Sinai Hospital, Toronto, Canada
BMC Med Inform Decis Mak 8:5. 2008..We surveyed ICUs in the province of Ontario, Canada, to determine the availability, implementation and variability of information systems... - Real-time automated paging and decision support for critical laboratory abnormalitiesEdward Etchells
Centre for Patient Safety, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada
BMJ Qual Saf 20:924-30. 2011..For patients with critical laboratory abnormalities, timely clinical alerts with decision support could improve management and reduce adverse events... - Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: secondary analysis from a randomized trialKevin M Sanders
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
J Crit Care 23:58-63. 2008..To examine the predictive validity of prior cultures at predicting the microorganism isolated at the time of suspicion of ventilator-associated pneumonia (VAP)... - Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?Jan O Friedrich
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
Crit Care 10:145. 2006..Consequently, further randomised trials of this agent in prospectively defined high-risk patients are required to clarify its role in the management of severe sepsis... - Pay for performance in the intensive care unit--opportunity or threat?Kristina Khanduja
Department of Anaesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Crit Care Med 37:852-8. 2009..Our objective was to describe these programs and their potential implementation in intensive care units (ICUs)... - Self-reported symptoms of depression and memory dysfunction in survivors of ARDSNeill K J Adhikari
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Chest 135:678-87. 2009..Survivors of ARDS have well documented physical limitations, but psychological effects are less clear. We determined the prevalence of self-reported depression and memory dysfunction in ARDS survivors... - Mortality predictions in the intensive care unit: comparing physicians with scoring systemsTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Crit Care Med 34:878-85. 2006..The overall accuracy of both predictions of patient mortality was moderate, implying limited usefulness of outcome prediction in the first 24 hrs for clinical decision making... - Outcomes of interfacility critical care adult patient transport: a systematic reviewEddy Fan
Interdepartmental Division of Critical Care Medicine, University of Toronto, 399 Bathurst Street, F2-150, Toronto, Ontario, M5T 2S8, Canada
Crit Care 10:R6. 2006..Further study is required to define the risks and benefits of interfacility transfer in this patient population. Such information is important for the planning and allocation of resources related to transporting critically ill adults... - Randomized trials stopped early for benefit: a systematic reviewVictor M Montori
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 294:2203-9. 2005..These findings suggest clinicians should view the results of such trials with skepticism... - Abstract reporting in randomized clinical trials of acute lung injury: an audit and assessment of a quality of reporting scoreKaren E A Burns
Graduate Program in Health Research Methodology, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 33:1937-45. 2005..Checklists may aid authors and editors in prioritizing important criteria for inclusion in RCT abstracts... - Effect of prone positioning in patients with acute respiratory distress syndrome and high Simplified Acute Physiology Score IISachin Sud
Crit Care Med 36:2711-2; author reply 2712-3. 2008 - A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilationKaren E A Burns
Division of Critical Care Medicine, London Health Sciences Centre Victoria Hospital
Can J Anaesth 53:305-15. 2006.... - The evolution of intensive care unit performance assessmentMarius Terblanche
Department of Critical Care Medicine, B 702 Sunnybrook and Women s College Health Science Centre, Toronto, Ontario, Canada M4N 3M5
J Crit Care 21:19-22. 2006..Successful performance assessment requires the quantification of relevant indexes of performance. Although these indexes are increasingly being developed, it will be some time before widely recognized, validated systems are available... - Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic reviewAmit X Garg
Division of Nephrology, University of Western Ontario, London, Canada
JAMA 293:1223-38. 2005..001). CONCLUSIONS: Many CDSSs improve practitioner performance. To date, the effects on patient outcomes remain understudied and, when studied, inconsistent... - Legislative barriers to outpatient e-prescribing in a randomized trialSherman Quan
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario
Healthc Q 10:106-10, 112. 2007.... - Corticosteroids for acute respiratory distress syndromeNeill K J Adhikari
BMJ 336:969-70. 2008 - Lost in (knowledge) translation: "All breakthrough, no follow through"?Damon C Scales
Crit Care Med 36:1654-5. 2008 - Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practiceKaren E A Burns
Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
Crit Care Med 33:1477-83. 2005..Some factors associated with variation in NIV use may be suitable targets for utilization improvement interventions...