Stacey L Hembruff

Summary

Affiliation: Sudbury Regional Hospital
Country: Canada

Publications

  1. ncbi Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
    Stacey L Hembruff
    Regional Cancer Program, Sudbury Regional Hospital, and Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON Canada
    BMC Cancer 8:318. 2008
  2. ncbi Hypermethylation of the ABCB1 downstream gene promoter accompanies ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast tumor cells
    Kerry Reed
    Department of Biomolecular Sciences, Laurentian University, Sudbury, Ontario, Canada
    Epigenetics 3:270-80. 2008
  3. ncbi Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance
    Zachary W Veitch
    Department of Biology, Laurentian University, Northern Ontario School of Medicine, Sudbury, Canada
    Pharmacogenet Genomics 19:477-88. 2009
  4. ncbi Gene expression profiles as biomarkers for the prediction of chemotherapy drug response in human tumour cells
    Amadeo M Parissenti
    Tumour Biology Research Program, Sudbury Regional Hospital, Department of Biology, Laurentian University, Sudbury, Ottawa, Ontario, Canada
    Anticancer Drugs 18:499-523. 2007
  5. ncbi cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance
    David J Villeneuve
    Tumor Biology Research Program, Sudbury Regional Hospital, Sudbury, Ont, Canada
    Breast Cancer Res Treat 96:17-39. 2006
  6. ncbi Changes in expression of cell wall turnover genes accompany inhibition of chromosome segregation by bovine protein kinase C alpha expression in Saccharomyces cerevisiae
    Jason A Sprowl
    Department of Biology, Laurentian University, Sudbury, Ontario, Canada
    Cell Biol Int 31:1160-72. 2007
  7. ncbi Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells
    Jason A Sprowl
    Regional Cancer Program, Sudbury Regional Hospital, 41 Ramsey Lake Road, Sudbury ON P3E 5J1, Canada
    Breast Cancer Res 14:R2. 2012

Collaborators

  • Amadeo M Parissenti
  • Jason A Sprowl
  • David J Villeneuve
  • Baoqing Guo
  • Kerry Reed
  • Zachary W Veitch
  • Irina Kalatskaya
  • Adam Tam
  • Lincoln Stein
  • Carita Lanner
  • Stephen R Armstrong
  • Adam J Bewick
  • Jamei Eng
  • Stephanie Cull
  • David A MacLean
  • Allan D Heibein
  • Monique L Laberge
  • Gilbert B Côté
  • Andrew J M Young
  • Zachary Veitch
  • William A Dew
  • Melanie Cecchetto

Detail Information

Publications7

  1. ncbi Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
    Stacey L Hembruff
    Regional Cancer Program, Sudbury Regional Hospital, and Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON Canada
    BMC Cancer 8:318. 2008
    ..During selection cells were assessed for drug sensitivity, drug uptake, and the expression of various drug transporters...
  2. ncbi Hypermethylation of the ABCB1 downstream gene promoter accompanies ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast tumor cells
    Kerry Reed
    Department of Biomolecular Sciences, Laurentian University, Sudbury, Ontario, Canada
    Epigenetics 3:270-80. 2008
    ....
  3. ncbi Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance
    Zachary W Veitch
    Department of Biology, Laurentian University, Northern Ontario School of Medicine, Sudbury, Canada
    Pharmacogenet Genomics 19:477-88. 2009
    ....
  4. ncbi Gene expression profiles as biomarkers for the prediction of chemotherapy drug response in human tumour cells
    Amadeo M Parissenti
    Tumour Biology Research Program, Sudbury Regional Hospital, Department of Biology, Laurentian University, Sudbury, Ottawa, Ontario, Canada
    Anticancer Drugs 18:499-523. 2007
    ..Genetic predictors of response to a variety of anticancer agents are discussed, including the anthracyclines, taxanes, topoisomerase I and II inhibitors, nucleoside analogs, alkylating agents, and vinca alkaloids...
  5. ncbi cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance
    David J Villeneuve
    Tumor Biology Research Program, Sudbury Regional Hospital, Sudbury, Ont, Canada
    Breast Cancer Res Treat 96:17-39. 2006
    ..Moreover, this study provides significant insight into the wide variety of mechanisms through which resistance to these agents may be acquired in breast cancer...
  6. ncbi Changes in expression of cell wall turnover genes accompany inhibition of chromosome segregation by bovine protein kinase C alpha expression in Saccharomyces cerevisiae
    Jason A Sprowl
    Department of Biology, Laurentian University, Sudbury, Ontario, Canada
    Cell Biol Int 31:1160-72. 2007
    ....
  7. ncbi Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells
    Jason A Sprowl
    Regional Cancer Program, Sudbury Regional Hospital, 41 Ramsey Lake Road, Sudbury ON P3E 5J1, Canada
    Breast Cancer Res 14:R2. 2012
    ..Our study aimed to correlate alterations in the TNF pathway with taxane cytotoxicity and the acquisition of taxane resistance...