M Steriade

Summary

Country: Canada

Publications

  1. ncbi Neocortical cell classes are flexible entities
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Nat Rev Neurosci 5:121-34. 2004
  2. ncbi Neuronal plasticity in thalamocortical networks during sleep and waking oscillations
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec, Canada G1K 7P4
    Neuron 37:563-76. 2003
  3. ncbi The corticothalamic system in sleep
    Mircea Steriade
    Laboratory of Neurophysiology, School of Medicine, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Front Biosci 8:d878-99. 2003
  4. ncbi Slow-wave sleep: serotonin, neuronal plasticity, and seizures
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Arch Ital Biol 142:359-67. 2004
  5. ncbi Sleep, epilepsy and thalamic reticular inhibitory neurons
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Trends Neurosci 28:317-24. 2005
  6. ncbi Impact of network activities on neuronal properties in corticothalamic systems
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 86:1-39. 2001
  7. ncbi Coalescence of sleep rhythms and their chronology in corticothalamic networks
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    Sleep Res Online 1:1-10. 1998
  8. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
  9. ncbi Sleep oscillations developing into seizures in corticothalamic systems
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Epilepsia 44:9-20. 2003
  10. ncbi Acetylcholine systems and rhythmic activities during the waking--sleep cycle
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, QC G1K 7P4, Canada
    Prog Brain Res 145:179-96. 2004

Research Grants

Detail Information

Publications59

  1. ncbi Neocortical cell classes are flexible entities
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Nat Rev Neurosci 5:121-34. 2004
  2. ncbi Neuronal plasticity in thalamocortical networks during sleep and waking oscillations
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec, Canada G1K 7P4
    Neuron 37:563-76. 2003
    ..Similar phenomena occur as a consequence of fast oscillations during brain-activated states...
  3. ncbi The corticothalamic system in sleep
    Mircea Steriade
    Laboratory of Neurophysiology, School of Medicine, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Front Biosci 8:d878-99. 2003
    ..Fast (beta and gamma) oscillations are roduced by the depolarizing effects of mesopontine cholinergic neurons acting on TC neurons and nucleus basalis neurons acting on cortical neurons...
  4. ncbi Slow-wave sleep: serotonin, neuronal plasticity, and seizures
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Arch Ital Biol 142:359-67. 2004
    ....
  5. ncbi Sleep, epilepsy and thalamic reticular inhibitory neurons
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Trends Neurosci 28:317-24. 2005
    ....
  6. ncbi Impact of network activities on neuronal properties in corticothalamic systems
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 86:1-39. 2001
    ..The results indicate that intact-brain preparations are necessary to investigate global brain functions such as behavioral states of vigilance and paroxysmal activities...
  7. ncbi Coalescence of sleep rhythms and their chronology in corticothalamic networks
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    Sleep Res Online 1:1-10. 1998
    ..This unexpectedly rich activity raises the possibility that, during sleep, the brain is occupied to specify/reorganize circuits and to consolidate memory traces acquired during wakefulness...
  8. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..In view of the high firing rates in the functionally disconnected state of slow-wave sleep, we suggest that neocortical neurons are engaged in processing internally generated signals...
  9. ncbi Sleep oscillations developing into seizures in corticothalamic systems
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Epilepsia 44:9-20. 2003
    ..5-2.5 Hz, often associated with fast runs at 10-15 Hz, as in the Lennox-Gastaut syndrome...
  10. ncbi Acetylcholine systems and rhythmic activities during the waking--sleep cycle
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, QC G1K 7P4, Canada
    Prog Brain Res 145:179-96. 2004
    ....
  11. ncbi Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Cereb Cortex 7:583-604. 1997
    ..All these data congruently show the power of cortical control upon thalamic oscillators...
  12. ncbi Grouping of brain rhythms in corticothalamic systems
    M Steriade
    Laboratory of Neurophysiology, Laval University, Faculty of Medicine, Quebec, Canada G1K 7P4
    Neuroscience 137:1087-106. 2006
    ....
  13. ncbi Slow sleep oscillation, rhythmic K-complexes, and their paroxysmal developments
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Sleep Res 7:30-5. 1998
    ..We also show that the slow cortical oscillation underlies the onset of spike-wave seizures during sleep by transforming the periodic K-complexes into recurrent paroxysmal spike-wave complexes...
  14. pmc Presynaptic dendrites of thalamic local-circuit neurons and sculpting inhibition during activated states
    Mircea Steriade
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada
    J Physiol 546:1. 2003
  15. ncbi Corticothalamic resonance, states of vigilance and mentation
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, G1K 7P4, Quebec, Canada
    Neuroscience 101:243-76. 2000
    ....
  16. ncbi Callosal responses of fast-rhythmic-bursting neurons during slow oscillation in cats
    Y Cisse
    Department of Anatomy and Physiology, Laval University, Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Quebec, Canada G1J 2G3
    Neuroscience 147:272-6. 2007
    ..Our data show that callosal volleys excite and lead to spiking in fast-rhythmic-bursting neurons during prolonged hyperpolarizations, thus enabling them to transmit information within intracortical networks during slow-wave sleep...
  17. ncbi Impact of intrinsic properties and synaptic factors on the activity of neocortical networks in vivo
    I Timofeev
    Laboratory of Neurophysiology, Department of Anatomy and Physiology, School of Medicine, Laval University, PQ G1K 7P4, Quebec, Canada
    J Physiol Paris 94:343-55. 2000
    ....
  18. ncbi Spontaneous field potentials influence the activity of neocortical neurons during paroxysmal activities in vivo
    F Grenier
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, QC, Canada G1K 7P4
    Neuroscience 119:277-91. 2003
    ..We propose a mechanism for seizure initiation involving these phenomena...
  19. ncbi Focal synchronization of ripples (80-200 Hz) in neocortex and their neuronal correlates
    F Grenier
    Laboratoire de Neurophysiologie, , , Quebec G1K 7P4, Canada
    J Neurophysiol 86:1884-98. 2001
    ..The mechanisms of generation and synchronization, and the possible functions of neocortical ripples in plasticity processes are discussed...
  20. ncbi Neuronal and glial membrane potentials during sleep and paroxysmal oscillations in the neocortex
    F Amzica
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    J Neurosci 20:6648-65. 2000
    ....
  21. pmc Membrane bistability in thalamic reticular neurons during spindle oscillations
    Pablo Fuentealba
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, G1K 7P4, Canada
    J Neurophysiol 93:294-304. 2005
    ....
  22. pmc Disfacilitation and active inhibition in the neocortex during the natural sleep-wake cycle: an intracellular study
    I Timofeev
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, QC, Canada G1K 7P4
    Proc Natl Acad Sci U S A 98:1924-9. 2001
    ....
  23. ncbi The role of chloride-dependent inhibition and the activity of fast-spiking neurons during cortical spike-wave electrographic seizures
    I Timofeev
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, QC, Canada G1K 7P4
    Neuroscience 114:1115-32. 2002
    ....
  24. ncbi Neocortical very fast oscillations (ripples, 80-200 Hz) during seizures: intracellular correlates
    Francois Grenier
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 89:841-52. 2003
    ....
  25. ncbi Synaptic interactions between thalamic and cortical inputs onto cortical neurons in vivo
    Pablo Fuentealba
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 91:1990-8. 2004
    ..These results suggest a short-lasting but strong shunting between thalamocortical and cortical inputs onto cortical neurons...
  26. pmc Hyperpolarisation rectification in cat lateral geniculate neurons modulated by intact corticothalamic projections
    D A Nita
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    J Physiol 552:325-32. 2003
    ....
  27. ncbi Active neocortical processes during quiescent sleep
    M Steriade
    Laboratoire de Neurophysiologie, , , , Canada G1K 7P4
    Arch Ital Biol 139:37-51. 2001
    ..This may serve to support resonant phenomena and reorganize corticothalamic circuitry...
  28. ncbi Neocortical seizures: initiation, development and cessation
    I Timofeev
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Neuroscience 123:299-336. 2004
    ....
  29. ncbi Selective amplification of neocortical neuronal output by fast prepotentials in vivo
    S Crochet
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Cereb Cortex 14:1110-21. 2004
    ..We suggest that FPPs represent attenuated spikes generated in hot spots of the dendritic arbor and constitute a powerful mechanism to reinforce the functional connections between specific elements of the cortical networks...
  30. ncbi Synaptic responsiveness of neocortical neurons to callosal volleys during paroxysmal depolarizing shifts
    Y Cisse
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Neuroscience 124:231-9. 2004
    ....
  31. ncbi Hyperexcitability of intact neurons underlies acute development of trauma-related electrographic seizures in cats in vivo
    Lisa Topolnik
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4, Canada
    Eur J Neurosci 18:486-96. 2003
    ..Our results suggest that trauma-induced electrographic seizures first arise in cortical fields that are closest to the site of injury and such seizures do not require long-term neuronal reorganization...
  32. ncbi Synaptic plasticity in local cortical network in vivo and its modulation by the level of neuronal activity
    Sylvain Crochet
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Cereb Cortex 16:618-31. 2006
    ..Our results demonstrate that high levels of neuronal activity in the cortical network promote potentiation and insure the stability of synaptic connections...
  33. ncbi The cortically evoked secondary depolarization affects the integrative properties of thalamic reticular neurons
    Pablo Fuentealba
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Eur J Neurosci 20:2691-6. 2004
    ..This late component affected the integrative properties of RE neurons, including their spiking output and temporal summation of incoming cortical inputs...
  34. pmc Prolonged hyperpolarizing potentials precede spindle oscillations in the thalamic reticular nucleus
    Pablo Fuentealba
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, QC, Canada G1K 7P4
    Proc Natl Acad Sci U S A 101:9816-21. 2004
    ..These data are further arguments for the generation of spindles within the thalamic RE nucleus...
  35. ncbi The blockage of ponto-geniculo-occipital waves in the cat lateral geniculate nucleus by nicotinic antagonists
    B Hu
    Departement de Physiologie, Faculte de Medecine, Université Laval Qué, Canada
    Brain Res 473:394-7. 1988
    ..These results suggest that the genesis of thalamic PGO waves involves a nicotinic activation of relay neurons by PB cholinergic afferents...
  36. ncbi Diffuse transmission by acetylcholine in the CNS
    L Descarries
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, QC, Canada
    Prog Neurobiol 53:603-25. 1997
    ..The notions of diffuse transmission and of an ambient level of ACh in the CNS could also be of clinical relevance, in accounting for the production and nature of certain cholinergic deficits and the efficacy of substitution therapies...
  37. ncbi Neuronal substrates of spike-wave seizures and hypsarrhythmia in corticothalamic systems
    Mircea Steriade
    Faculty of Medicine, Laval University, Quebec, Canada
    Adv Neurol 97:149-54. 2006
  38. ncbi Waking-sleep modulation of paroxysmal activities induced by partial cortical deafferentation
    Dragos A Nita
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Cereb Cortex 17:272-83. 2007
    ....
  39. ncbi Electrophysiological properties and input-output organization of callosal neurons in cat association cortex
    Youssouf Cisse
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec G1K 7P4, Canada
    J Neurophysiol 89:1402-13. 2003
    ..Data are discussed in relation to the commissural spread of fast and slow normal oscillations as well as paroxysmal activities...
  40. ncbi Increased propensity to seizures after chronic cortical deafferentation in vivo
    Dragos A Nita
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Neurophysiol 95:902-13. 2006
    ..The increased amplitudes of both slow oscillation and SW seizures, and their enhanced synchrony expressed by shorter time of propagation, are ascribed to increased neuronal and network excitability after cortical undercut...
  41. ncbi Generators of ictal and interictal electroencephalograms associated with infantile spasms: intracellular studies of cortical and thalamic neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1 K 7P4
    Int Rev Neurobiol 49:77-98. 2002
  42. pmc Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities
    Igor Timofeev
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec City, QC, Canada G1K 7P4
    Proc Natl Acad Sci U S A 99:9533-7. 2002
    ..Computational models showed how, after the increased [K(+)](o), the interplay between I(h), I(K(Ca)), and a persistent Na(+) current, I(Na(P)), could organize paroxysmal oscillations at a frequency of 2-3 Hz...
  43. ncbi [Cellular basis of transition between sleep and electrographic seizures]
    Mircea Steriade
    Laboratoire de Neurophysiologie, Département d anatomie et physiologie, Faculte de Medecine, Universite Laval, Quebec, G1K 7P4 Canada
    Med Sci (Paris) 19:999-1002. 2003
    ..Simultaneously, thalamocortical neurons are steadily inhibited and cannot relay signals from the outside world to cortex. This may explain the unconsciousness during certain types of epilepsy...
  44. ncbi Mircea Steriade (1924-2006)
    I Timofeev
    Department of Anatomy and Physiology, Universite Laval, Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Quebec, G1J 2G3, Canada
    Neuroscience 142:917-20. 2006
    ..Dr. Mircea Steriade passed away at age 82. In this obituary I briefly describe some of the most important achievements of his remarkable life and I express deepest sympathies to his family members, collaborators and trainees...
  45. ncbi Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures
    Igor Timofeev
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec G1K 7P4, Canada
    J Neurophysiol 92:1133-43. 2004
    ..We conclude that intrinsic cellular factors have significant role in the generation of depolarizing and hyperpolarizing components of seizures...
  46. ncbi Synaptic enhancement induced through callosal pathways in cat association cortex
    Youssouf Cisse
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 92:3221-32. 2004
    ..These data suggest that callosal activities occurring within low-frequency and fast-frequency oscillations play a role in cortical synaptic plasticity...
  47. pmc Short- and medium-term plasticity associated with augmenting responses in cortical slabs and spindles in intact cortex of cats in vivo
    Igor Timofeev
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    J Physiol 542:583-98. 2002
    ..These data suggest that augmenting responses elicited by stimulation, as well as spontaneously occurring spindles, may induce short- and medium-term plasticity of neuronal responses...
  48. ncbi Local gating of information processing through the thalamus
    Mircea Steriade
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Neuron 41:493-4. 2004
    ....
  49. ncbi The functional significance of K-complexes
    Florin Amzica
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, G1K 7P4, Canada
    Sleep Med Rev 6:139-49. 2002
    ..The KC is mainly a spontaneous event generated in cortical networks. During nocturnal epileptic seizures, the KCs are precursors of paroxysmal spike-wave complexes...
  50. pmc Experimental evidence and modeling studies support a synchronizing role for electrical coupling in the cat thalamic reticular neurons in vivo
    Pablo Fuentealba
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec City, Canada G1K 7P4
    Eur J Neurosci 20:111-9. 2004
    ..These experimental and modeling data suggest that electrotonic coupling within the RE nucleus plays an important role in the generation and synchronization of low-frequency (spindling) activities in the thalamus...
  51. ncbi Partial cortical deafferentation promotes development of paroxysmal activity
    Lisa Topolnik
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec G1K 7P4, Canada
    Cereb Cortex 13:883-93. 2003
    ..These results indicate that alterations in neuronal synchrony following neuronal trauma can be a critical factor triggering electrographic seizures...
  52. ncbi The reticular nucleus revisited: intrinsic and network properties of a thalamic pacemaker
    Pablo Fuentealba
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Que, Canada G1K 7P4
    Prog Neurobiol 75:125-41. 2005
    ....
  53. ncbi Model of thalamocortical slow-wave sleep oscillations and transitions to activated States
    Maxim Bazhenov
    The Salk Institute, Howard Hughes Medical Institute, Computational Neurobiology Laboratory, La Jolla, California 92037, USA
    J Neurosci 22:8691-704. 2002
    ..The model describes many essential features of SWS and activated states in the thalamocortical system as well as the transition between them...
  54. pmc Homeostatic synaptic plasticity can explain post-traumatic epileptogenesis in chronically isolated neocortex
    Arthur R Houweling
    The Salk Institute, Computational Neurobiology Laboratory, La Jolla, CA 92037, USA
    Cereb Cortex 15:834-45. 2005
    ..Our results support a role for homeostatic synaptic plasticity as a novel mechanism of post-traumatic epileptogenesis...
  55. ncbi Bursting of thalamic neurons and states of vigilance
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York, USA
    J Neurophysiol 95:3297-308. 2006
    ..In addition, thalamocortical activity has been shown to be involved in the genesis of several neuropsychiatric conditions collectively described as thalamocortical dysrhythmia syndrome...
  56. pmc Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability
    Flavio Frohlich
    The Salk Institute for Biological Studies, Computational Neurobiology Laboratory, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    J Neurosci 26:6153-62. 2006
    ..We therefore predict that extracellular potassium dynamics can cause alternating episodes of fast and slow oscillatory states in both normal and epileptic neocortical networks...
  57. pmc Frequency-selective augmenting responses by short-term synaptic depression in cat neocortex
    Arthur R Houweling
    Computational Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    J Physiol 542:599-617. 2002
    ..These results suggest that short-term plasticity of cortical synapses could shape the dynamics of synchronized oscillations in the brain...
  58. ncbi Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease
    Claudio Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, University La Sapienza, Rome, Italy
    Clin Neurophysiol 117:1113-29. 2006
    ..Am J Neuroradiol. 2003 24(3):481-487]. In this study, we tested the hypothesis that such a relationship does exist not only in AD patients but also across the continuum of subjects with mild cognitive impairment (MCI) and AD...

Research Grants1

  1. IMPACT OF SYNAPTIC BOMBARDMENT ON NEOCORTICAL NEURONS
    Mircea Steriade; Fiscal Year: 2001
    ..The potential impact of this study for the modeling community is therefore broad, from models of information processing to the simulations of pathological states, such as epilepsy. ..