Andrew T Yan

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. doi request reprint Recurrent ischemia across the spectrum of acute coronary syndromes: prevalence and prognostic significance of (re-)infarction and ST-segment changes in a large contemporary registry
    Andrew T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Cardiol 145:15-20. 2010
  2. doi request reprint Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:769-75. 2008
  3. ncbi request reprint Understanding physicians' risk stratification of acute coronary syndromes: insights from the Canadian ACS 2 Registry
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, Queen 6 030, 30 Bond Street, Toronto, Ontario, Canada
    Arch Intern Med 169:372-8. 2009
  4. ncbi request reprint Optimal medical therapy at discharge in patients with acute coronary syndromes: temporal changes, characteristics, and 1-year outcome
    Andrew T Yan
    Division of Cardiology, Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 154:1108-15. 2007
  5. doi request reprint Management patterns of non-ST segment elevation acute coronary syndromes in relation to prior coronary revascularization
    Esam Elbarasi
    Terrence Donnelly Heart Center, Division of Cardiology, St Michael s Hospital, University of Toronto, and Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am Heart J 159:40-6. 2010
  6. doi request reprint Temporal patterns of lipid testing and statin therapy in acute coronary syndrome patients (from the Canadian GRACE Experience)
    Basem Elbarouni
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Cardiol 109:1418-24. 2012
  7. doi request reprint Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the Global Registry of Acute Coronary Events
    Matthew Sibbald
    Division of Cardiology, Canadian Heart Research Center and Terrence Donnelly Heart Center, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Am Heart J 160:855-61. 2010
  8. ncbi request reprint ST-segment depression in non-ST elevation acute coronary syndromes: quantitative analysis may not provide incremental prognostic value beyond comprehensive risk stratification
    Andrew T Yan
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:270-6. 2006
  9. doi request reprint Management of risk factors among ambulatory patients at high cardiovascular risk in Canada: a follow-up study
    Esam A Elbarasi
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1586-92. 2013
  10. doi request reprint Relation between previous angiotensin-converting enzyme inhibitor use and in-hospital outcomes in acute coronary syndromes
    Sheldon M Singh
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am J Cardiol 109:332-6. 2012

Detail Information

Publications78

  1. doi request reprint Recurrent ischemia across the spectrum of acute coronary syndromes: prevalence and prognostic significance of (re-)infarction and ST-segment changes in a large contemporary registry
    Andrew T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Cardiol 145:15-20. 2010
    ..We examined the clinical features and treatment associated with, and the differential prognostic impact of, the various types of RI in unselected patients across the broad spectrum of ACS in the contemporary era...
  2. doi request reprint Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:769-75. 2008
    ..We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their independent long-term prognostic significance...
  3. ncbi request reprint Understanding physicians' risk stratification of acute coronary syndromes: insights from the Canadian ACS 2 Registry
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, Queen 6 030, 30 Bond Street, Toronto, Ontario, Canada
    Arch Intern Med 169:372-8. 2009
    ..Our objective was to examine patient risk assessment by physicians in relation to treatment and objective risk score evaluation and the underlying patient characteristics that physicians consider to indicate high risk...
  4. ncbi request reprint Optimal medical therapy at discharge in patients with acute coronary syndromes: temporal changes, characteristics, and 1-year outcome
    Andrew T Yan
    Division of Cardiology, Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 154:1108-15. 2007
    ....
  5. doi request reprint Management patterns of non-ST segment elevation acute coronary syndromes in relation to prior coronary revascularization
    Esam Elbarasi
    Terrence Donnelly Heart Center, Division of Cardiology, St Michael s Hospital, University of Toronto, and Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am Heart J 159:40-6. 2010
    ..However, little is known about the management pattern of these patients in "real world."..
  6. doi request reprint Temporal patterns of lipid testing and statin therapy in acute coronary syndrome patients (from the Canadian GRACE Experience)
    Basem Elbarouni
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Cardiol 109:1418-24. 2012
    ..Lipid testing was strongly associated with in-hospital statin use. A substantial proportion of patients with ACS, especially those at higher risk, still do not receive these guideline-recommended interventions in contemporary practice...
  7. doi request reprint Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the Global Registry of Acute Coronary Events
    Matthew Sibbald
    Division of Cardiology, Canadian Heart Research Center and Terrence Donnelly Heart Center, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Am Heart J 160:855-61. 2010
    ..We sought to determine the association between clopidogrel use and clinical outcomes in smokers versus nonsmokers with a broad spectrum of acute coronary syndrome (ACS)...
  8. ncbi request reprint ST-segment depression in non-ST elevation acute coronary syndromes: quantitative analysis may not provide incremental prognostic value beyond comprehensive risk stratification
    Andrew T Yan
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:270-6. 2006
    ..It is unclear whether quantitative ST-segment assessment can improve risk stratification of unselected acute coronary syndrome (ACS) patients using the validated Global Registry of Acute Cardiac Events (GRACE) risk model...
  9. doi request reprint Management of risk factors among ambulatory patients at high cardiovascular risk in Canada: a follow-up study
    Esam A Elbarasi
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1586-92. 2013
    ..Limited longitudinal data are available on attainment of guideline-recommended treatment targets among ambulatory patients at high risk for cardiovascular events...
  10. doi request reprint Relation between previous angiotensin-converting enzyme inhibitor use and in-hospital outcomes in acute coronary syndromes
    Sheldon M Singh
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am J Cardiol 109:332-6. 2012
    ..25, p = 0.91), or the composite end point of death/re-MI (adjusted OR 1.01, CI 0.84 to 1.20, p = 0.94). In conclusion, previous use of an ACE inhibitor is not independently associated with improved in-hospital outcomes after an ACS...
  11. doi request reprint Reperfusion strategies and outcomes of ST-segment elevation myocardial infarction patients in Canada: observations from the Global Registry of Acute Coronary Events (GRACE) and the Canadian Registry of Acute Coronary Events (CANRACE)
    Andrew Czarnecki
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 28:40-7. 2012
    ..We examine the clinical characteristics and outcomes of ST-elevation myocardial infarction (STEMI) patients receiving various reperfusion therapies in 2 contemporary Canadian registries...
  12. doi request reprint The association between prior use of aspirin and/or warfarin and the in-hospital management and outcomes in patients presenting with acute coronary syndromes: insights from the Global Registry of Acute Coronary Events (GRACE)
    Hani Amad
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 28:48-53. 2012
    ..However, there are sparse data comparing the presentation and outcomes of patients who present with ACS while on ASA and/or warfarin therapy and those on neither...
  13. ncbi request reprint Efficacy and safety of a routine early invasive strategy after fibrinolysis stratified by glycoprotein IIb/IIIa inhibitor use during percutaneous coronary intervention: a pre-specified subgroup analysis of the TRANSFER-AMI randomised controlled trial
    Juan J Russo
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Heart 100:873-80. 2014
    ..We evaluated the efficacy and safety of an early invasive strategy post-fibrinolysis in relation to glycoprotein (GP) IIb/IIIa inhibitor use...
  14. doi request reprint Management and outcomes of non-ST elevation acute coronary syndromes in relation to previous use of antianginal therapies (from the Canadian Global Registry of Acute Coronary Events [GRACE] and Canadian Registry of Acute Coronary Events [CANRACE])
    Jaskaran S Kang
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 112:51-6. 2013
    ..Previous antianginal use was independently associated with a lower use of coronary angiography in hospital...
  15. doi request reprint Treatment and outcomes of patients with suspected acute coronary syndromes in relation to initial diagnostic impressions (insights from the Canadian Global Registry of Acute Coronary Events [GRACE] and Canadian Registry of Acute Coronary Events [CANRACE])
    Ravi R Bajaj
    Department of Medicine, Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Cardiol 111:202-7. 2013
    ..The GRACE risk score provided accurate risk assessment, regardless of the initial diagnostic impression...
  16. ncbi request reprint Age-related differences in the management and outcome of patients with acute coronary syndromes
    Raymond T Yan
    Division of Cardiology, Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:352-9. 2006
    ..Age-related differences in patients with an acute coronary syndrome (ACS) have not been well characterized in prior observational studies that often included only certain age groups or subjects with myocardial infarction (MI)...
  17. doi request reprint Temporal trend of in-hospital major bleeding among patients with non ST-elevation acute coronary syndromes
    Basem Elbarouni
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am Heart J 160:420-7. 2010
    ..We sought to determine the temporal trend of in-hospital major bleeding among patients with NSTE-ACS, in relation to the evolving management pattern...
  18. doi request reprint Efficacy of early invasive management post-fibrinolysis in men versus women with ST-elevation myocardial infarction: a subgroup analysis from Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarctio
    Vineet Bhan
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 164:343-50. 2012
    ..However, it is not clear whether treatment efficacy differs between men and women...
  19. doi request reprint Efficacy and safety of enoxaparin compared with unfractionated heparin in the pharmacoinvasive management of acute ST-segment elevation myocardial infarction: Insights from the TRANSFER-AMI trial
    Shahar Lavi
    London Health Sciences Centre, Ontario, Canada
    Am Heart J 163:176-81.e2. 2012
    ....
  20. doi request reprint Use of clopidogrel post-coronary artery bypass surgery in canadian patients with acute coronary syndromes
    Ahmed Krimly
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:711-5. 2011
    ....
  21. doi request reprint Applying the evidence: do patients with stroke, coronary artery disease, or both achieve similar treatment goals?
    Gustavo Saposnik
    Division of Cardiology, Canadian Heart Research Centre and Terrence Donnelly Heart Centre, University of Toronto, Canada
    Stroke 40:1417-24. 2009
    ..We sought to evaluate and compare differences in treatment patterns and the attainment of current guideline-recommended targets in unselected high-risk ambulatory patients with CAD, CVD, or both...
  22. ncbi request reprint Clinical trial--derived risk model may not generalize to real-world patients with acute coronary syndrome
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:1020-7. 2004
    ..The purpose of this study was to validate and compare a modified international clinical trial and a registry-based risk model in a contemporary, less selected ACS population...
  23. doi request reprint Prognostic significance of electrocardiographic-determined left ventricular hypertrophy and associated ST-segment depression in patients with non-ST-elevation acute coronary syndromes
    Sammy Ali
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am Heart J 161:878-85. 2011
    ..Although STD is a well-established adverse prognosticator in non-ST-elevation acute coronary syndrome (NSTE-ACS), the relative prognostic importance of LVH and associated STD has not been elucidated...
  24. doi request reprint Influence of age on use of cardiac catheterization and associated outcomes in patients with non-ST-elevation acute coronary syndromes
    Alan J Bagnall
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 103:1530-6. 2009
    ..Future studies should determine whether more aggressive treatment of these high-risk elderly patients improves outcomes...
  25. ncbi request reprint Underuse of evidence-based treatment partly explains the worse clinical outcome in diabetic patients with acute coronary syndromes
    Raymond T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:676-83. 2006
    ..Diabetes-related differences in treatment and clinical outcome of patients across the entire spectrum of acute coronary syndromes (ACSs) have potential clinical implications but have not been well studied...
  26. doi request reprint Prognostic significance of presenting blood pressure in non-ST-segment elevation acute coronary syndrome in relation to prior history of hypertension
    Dana Lee
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:716-22. 2013
    ..We sought to investigate the relationships between presenting SBP, prior hypertension, antihypertensive medication use, and outcomes in non-ST-segment elevation acute coronary syndrome (NSTEACS)...
  27. doi request reprint Underutilization of clopidogrel and glycoprotein IIb/IIIa inhibitors in non-ST-elevation acute coronary syndrome patients: the Canadian global registry of acute coronary events (GRACE) experience
    Behnam Banihashemi
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, and The Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am Heart J 158:917-24. 2009
    ..There are limited contemporary data on the early use of clopidogrel or glycoprotein (Gp) IIb/IIIa inhibitors, alone versus combination therapies, in non-ST-elevation acute coronary syndrome (NSTE-ACS)...
  28. ncbi request reprint Relationship of ST elevation in lead aVR with angiographic findings and outcome in non-ST elevation acute coronary syndromes
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, and Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am Heart J 154:71-8. 2007
    ..Limited data suggest that ST elevation (ST elevation) in aVR is associated with higher mortality and more extensive coronary artery disease in the setting of non-ST elevation acute coronary syndromes (ACS)...
  29. doi request reprint Management and outcome of acute coronary syndrome patients in relation to prior history of atrial fibrillation
    Darar Al Khdair
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 28:443-9. 2012
    ..The prognostic impact of atrial fibrillation (AF) in the setting of acute coronary syndrome (ACS) is controversial. Furthermore, there are limited real-world data on the management of ACS patients with history of AF...
  30. doi request reprint Disparities in management patterns and outcomes of patients with non-ST-elevation acute coronary syndrome with and without a history of cerebrovascular disease
    Tony C Lee
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 105:1083-9. 2010
    ....
  31. ncbi request reprint Differences between local hospital and core laboratory interpretation of the admission electrocardiogram in patients with acute coronary syndromes and their relation to outcome
    Raymond T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 100:169-74. 2007
    ..01 to 1.96, p = 0.043). In conclusion, these findings underscore an urgent need to promote more accurate interpretation of electrocardiograms in contemporary clinical practice to bridge treatment gaps and improve patient outcome...
  32. doi request reprint Relation between obesity and the attainment of optimal blood pressure and lipid targets in high vascular risk outpatients
    Vineet Bhan
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am J Cardiol 106:1270-6. 2010
    ..Our findings underscore the opportunity to optimize the treatment of these high-risk patients...
  33. ncbi request reprint Temporal changes in the management and outcome of Canadian diabetic patients hospitalized for non-ST-elevation acute coronary syndromes
    Basem Elbarouni
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, ON, Canada
    Am Heart J 162:347-355.e1. 2011
    ..We sought to evaluate (1) the temporal changes in the medical and invasive management and (2) in-hospital outcome of NSTE-ACS patients with and without diabetes...
  34. doi request reprint Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events
    Sanjit S Jolly
    Population Health Research Institute, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Heart 97:197-202. 2011
    ..The objective of this study was to determine if the extent of quantitative troponin elevation predicted mortality as well as in-hospital complications of cardiac arrest, new heart failure and cardiogenic shock...
  35. doi request reprint Usefulness of quantitative versus qualitative ST-segment depression for risk stratification of non-ST elevation acute coronary syndromes in contemporary clinical practice
    Raymond T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 101:919-24. 2008
    ..In conclusion, the findings do not support the quantification of STD in routine clinical practice beyond simple evaluation for the presence of STD as an integral part of comprehensive risk stratification using the GRACE risk score...
  36. doi request reprint Has the ClOpidogrel and Metoprolol in Myocardial Infarction Trial (COMMIT) of early β-blocker use in acute coronary syndromes impacted on clinical practice in Canada? Insights from the Global Registry of Acute Coronary Events (GRACE)
    Jeremy Edwards
    Division of Cardiology, Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 161:291-7. 2011
    ..We sought to assess the short-term impact of this landmark trial by comparing the use of early BB therapy in patients with a broad spectrum of ACS before and after 2005...
  37. doi request reprint Quantitative troponin elevation does not provide incremental prognostic value beyond comprehensive risk stratification in patients with non-ST-segment elevation acute coronary syndromes
    Ki Dong Lim
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 155:718-24. 2008
    ....
  38. doi request reprint Clinical implications of a next-day follow-up electrocardiogram in patients with non-ST elevation acute coronary syndromes
    Salem Alkaabi
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:797-803. 2008
    ..The prognostic value of admission ST-segment changes in patients with non-ST elevation acute coronary syndromes (NSTE ACS) is well established; however, the value of a next-day follow-up electrocardiogram (ECG) is unclear...
  39. ncbi request reprint Temporal management patterns and outcomes of non-ST elevation acute coronary syndromes in patients with kidney dysfunction
    Jorge A Wong
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur Heart J 30:549-57. 2009
    ..without kidney dysfunction...
  40. doi request reprint Comparative prognostic value of T-wave inversion and ST-segment depression on the admission electrocardiogram in non-ST-segment elevation acute coronary syndromes
    Nigel S Tan
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:290-7. 2013
    ....
  41. ncbi request reprint Local hospital vs. core-laboratory interpretation of the admission electrocardiogram in acute coronary syndromes: increased mortality in patients with unrecognized ST-elevation myocardial infarction
    Ram Vijayaraghavan
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Eur Heart J 29:31-7. 2008
    ....
  42. ncbi request reprint Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better
    Andrew T Yan
    Canadian Heart Research Centre, Toronto, Ontario, Canada
    Eur Heart J 28:1072-8. 2007
    ....
  43. ncbi request reprint Management patterns in relation to risk stratification among patients with non-ST elevation acute coronary syndromes
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8
    Arch Intern Med 167:1009-16. 2007
    ..We examined the use of in-hospital cardiac catheterization and medications in relation to risk across the broad spectrum of non-ST elevation ACSs...
  44. ncbi request reprint The management of left ventricular systolic dysfunction in patients with advanced chronic kidney disease
    Vera Dounaevskaia
    Division of Nephrology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Nephrol 24:41-9. 2011
    ..The goal of this study was to evaluate practice patterns for LVSD management across the spectrum of patients with advanced CKD, and to determine the rate of utilization of recommended therapies for LVSD...
  45. doi request reprint Temporal trends and patterns of early clopidogrel use across the spectrum of acute coronary syndromes
    Rajeev V Rao
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, and The Canadian Heart Research Centre, Ontario, Canada
    Am Heart J 157:642-50.e1. 2009
    ..The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada...
  46. doi request reprint Pre-hospital cardiac arrest in acute coronary syndromes: insights from the global registry of acute coronary events and the canadian registry of acute coronary events
    Qin Li
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ont, Canada
    Cardiology 126:27-34. 2013
    ..Cardiac arrest in acute coronary syndromes (ACS) is associated with high morbidity and mortality. We examined the clinical characteristics, contemporary management patterns and outcomes of ACS patients with pre-hospital cardiac arrest...
  47. doi request reprint The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, Room 6 034 Queen, Toronto, Ontario M5B 1W8, Canada
    Am Heart J 158:193-201.e1-5. 2009
    ..Expanded GRACE aims to test the feasibility of a simplified data collection tool and provision of quarterly feedback to index individual hospital management practices to an international reference cohort...
  48. doi request reprint Impact of delayed presentation on management and outcome of non-ST-elevation acute coronary syndromes
    Basem Elbarouni
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:262-8. 2008
    ..Furthermore, the prognostic value of initial biomarker level in relation to the time of presentation has not been determined...
  49. doi request reprint Use of cardiac catheterization for non-ST-segment elevation acute coronary syndromes according to initial risk: reasons why physicians choose not to refer their patients
    Cindy H Lee
    The Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Arch Intern Med 168:291-6. 2008
    ....
  50. pmc Treatment and one-year outcome of patients with renal dysfunction across the broad spectrum of acute coronary syndromes
    Andrew T Yan
    Canadian Heart Research Centre, and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 22:115-20. 2006
    ..There are limited data on the treatment and long-term outcome of patients with renal dysfunction across the broad spectrum of acute coronary syndromes (ACS) in Canada...
  51. ncbi request reprint Relationship between risk stratification at admission and treatment effects of early invasive management following fibrinolysis: insights from the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infa
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, and University of Toronto, Toronto, Ontario, Canada, M5B 1W8
    Eur Heart J 32:1994-2002. 2011
    ..We sought to determine the effectiveness of early routine percutaneous coronary intervention (PCI) post-fibrinolysis for ST-elevation myocardial infarction (STEMI) in relation to baseline risk status...
  52. ncbi request reprint Long-term prognostic value and therapeutic implications of continuous ST-segment monitoring in acute coronary syndrome
    Andrew T Yan
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 153:500-6. 2007
    ....
  53. ncbi request reprint In-hospital revascularization and one-year outcome of acute coronary syndrome patients stratified by the GRACE risk score
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:913-6. 2005
    ..The Global Registry of Acute Coronary Events risk score appears to be a useful risk stratification tool that identifies high-risk patients for whom more aggressive treatment is warranted...
  54. doi request reprint Relation between hemoglobin level and recurrent myocardial ischemia in acute coronary syndromes detected by continuous electrocardiographic monitoring
    Melissa Rousseau
    Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 106:1417-22. 2010
    ..This suggests that anemia might predispose patients to recurrent ischemia, which could be an important underlying mediator of worse outcomes in patients with lower hemoglobin levels...
  55. doi request reprint Evaluation of left ventricular ejection fraction in non-ST-segment elevation acute coronary syndromes and its relationship to treatment
    Sean Jedrzkiewicz
    Terrence Donnelly Heart Center, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 159:605-11. 2010
    ..There are limited data regarding the evaluation of LVEF and clinical characteristics and in-hospital management in the "real world."..
  56. doi request reprint Treatment and outcomes of non-ST elevation acute coronary syndromes in relation to burden of pre-existing vascular disease
    Michael Mohareb
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, ON, Canada University of Toronto, Toronto, ON, Canada
    Int J Cardiol 168:2720-5. 2013
    ..However, the relationships between pre-existing vascular disease and the treatment and outcome of acute coronary syndrome (ACS), have not been well characterized...
  57. ncbi request reprint Comparative assessment of 2-dimensional echocardiography vs cardiac magnetic resonance imaging in measuring left ventricular mass in patients with and without end-stage renal disease
    Baruch D Jakubovic
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:384-90. 2013
    ..This study aimed to evaluate concordance between LVM measurements across ECHO and CMR among chronic HD recipients and matched controls...
  58. pmc Relationships between plasma levels of matrix metalloproteinases and neurohormonal profile in patients with heart failure
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur J Heart Fail 10:125-8. 2008
    ..There is also emerging preclinical information to suggest that these signalling pathways mutually regulate in HF...
  59. doi request reprint Validation of the Global Registry of Acute Coronary Event (GRACE) risk score for in-hospital mortality in patients with acute coronary syndrome in Canada
    Basem Elbarouni
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 158:392-9. 2009
    ..Because of the substantial regional variation and temporal changes in patient characteristics and management patterns, we sought to validate this risk score in a contemporary Canadian population with ACS...
  60. doi request reprint Canada Acute Coronary Syndrome Risk Score: a new risk score for early prognostication in acute coronary syndromes
    Thao Huynh
    Division of Cardiology, McGill Health University Center, Quebec, Canada
    Am Heart J 166:58-63. 2013
    ..The primary objective of this study is to develop a simple risk score that can be used for early-risk stratification of patients with ACS...
  61. doi request reprint Bridging the gender gap: Insights from a contemporary analysis of sex-related differences in the treatment and outcomes of patients with acute coronary syndromes
    Stephanie Poon
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am Heart J 163:66-73. 2012
    ....
  62. doi request reprint QRS prolongation in patients with acute coronary syndromes
    Fahad Baslaib
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Am Heart J 159:593-8. 2010
    ....
  63. ncbi request reprint Contemporary management of dyslipidemia in high-risk patients: targets still not met
    Andrew T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, Toronto, Ontario, Canada
    Am J Med 119:676-83. 2006
    ..Our objective was to evaluate treatment patterns and the attainment of current National Cholesterol Education Program (NCEP)-recommended lipid targets in unselected high-risk ambulatory patients...
  64. doi request reprint Comparison of baseline characteristics, management and outcome of patients with non-ST-segment elevation acute coronary syndrome in versus not in clinical trials
    Adam B Hutchinson-Jaffe
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 106:1389-96. 2010
    ..Consequently, generalization of ACS clinical trials over the previous decade to the "real-world" patient may remain in question...
  65. doi request reprint Correlates of left ventricular mass in chronic hemodialysis recipients
    Ron Wald
    Division of Nephrology, St Michael s Hospital, University of Toronto, 61 Queen Street East, Room 9 140, Toronto, ON, M5C 2T2, Canada
    Int J Cardiovasc Imaging 30:349-56. 2014
    ..Blood pressure and left ventricular dilatation are independent determinants of elevated left ventricular mass. Aggressive blood pressure reduction and avoidance of volume overload may confer LVM regression and improve clinical outcomes...
  66. doi request reprint Assessment of right ventricular volumes and function using cardiovascular magnetic resonance cine imaging after atrial redirection surgery for complete transposition of the great arteries
    Laura Jiménez-Juan
    Department of Medical Imaging, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada
    Int J Cardiovasc Imaging 29:335-42. 2013
    ..Axially derived measurements of RV volumes and function have better agreement and reproducibility as compared with short axis values; whereas axial volumes tend to be larger, RVEF is not significantly different between the two methods...
  67. pmc Regression of left ventricular mass following conversion from conventional hemodialysis to thrice weekly in-centre nocturnal hemodialysis
    Ron Wald
    Division of Nephrology, St Michael s Hospital and Univerity of Toronto, Toronto, Ontario, Canada
    BMC Nephrol 13:3. 2012
    ....
  68. doi request reprint The differential association between various anthropometric indices of obesity and subclinical atherosclerosis
    Raymond T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Atherosclerosis 207:232-8. 2009
    ..However, it remains undetermined whether indices of abdominal obesity are also more strongly associated with early subclinical atherosclerosis in asymptomatic individuals...
  69. doi request reprint Prognostic utility of quantifying evolutionary ST-segment depression on early follow-up electrocardiogram in patients with non-ST-segment elevation acute coronary syndromes
    Raymond T Yan
    Canadian Heart Research Centre and Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond Street, Room 6 034 Queen, Toronto, ON, Canada M5B 1W8
    Eur Heart J 31:958-66. 2010
    ..We determined the prognostic significance of STD on follow-up ECG performed within 12-24 h of admission and whether its quantitative evaluation can further refine risk stratification...
  70. ncbi request reprint One-year outcome of patients after acute coronary syndromes (from the Canadian Acute Coronary Syndromes Registry)
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am J Cardiol 94:25-9. 2004
    ..Moreover, there was a significant opportunity to enhance the discharge and long-term use of evidence-based secondary prevention therapies...
  71. ncbi request reprint Troponin is more useful than creatine kinase in predicting one-year mortality among acute coronary syndrome patients
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond Street, Room 4 072 Queen, Toronto, Ont, Canada M5B 1W8
    Eur Heart J 25:2006-12. 2004
    ..To compare the long-term prognostic value of troponins (Tn) vs. conventional cardiac biomarker creatine kinase (CK) and CK-MB across the spectrum of acute coronary syndromes (ACS)...
  72. pmc Potential clinical impact of cardiovascular magnetic resonance assessment of ejection fraction on eligibility for cardioverter defibrillator implantation
    Subodh B Joshi
    Keenan Research Centre at the Li Ka Shing Knowledge Institute, Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, Toronto, ON, M5B 1W8, Canada
    J Cardiovasc Magn Reson 14:69. 2012
    ..We sought to investigate the potential impact of performing cardiovascular magnetic resonance (CMR) for EF on ICD eligibility...
  73. ncbi request reprint Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure
    Andrew T Yan
    Heart and Stroke Richard Lewar Centre of Excellence, Toronto, Ontario, Canada
    J Card Fail 12:514-9. 2006
    ..We hypothesized that increased plasma MMP levels correlate with increased left ventricular (LV) volumes and reduced LV ejection fraction (LVEF) in patients with HF...
  74. ncbi request reprint Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both
    Raymond T Yan
    The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 96:698-704. 2005
    ..Serial measurements of these neurohormones may serve as useful surrogate markers of ventricular remodeling and prognosticators for clinical risk stratification...
  75. pmc Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of Atherosclerosis
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Eur Heart J 31:875-82. 2010
    ..We sought to examine the relationship between circulating interleukin-6 (IL-6) level and regional left-ventricular (LV) function among apparently healthy individuals free of cardiovascular disease...
  76. ncbi request reprint Low-molecular-weight heparins in ischemic heart disease
    Andrew T Yan
    Canadian Heart Research Centre, Toronto, Ontario, Canada
    Curr Opin Cardiol 19:309-16. 2004
    ..The objective of this review was to summarize the recent developments regarding the use of low-molecular-weight heparins in the management of acute coronary syndromes...
  77. pmc Patient age, ethnicity, medical history, and risk factor profile, but not drug insurance coverage, predict successful attainment of glycemic targets: Time 2 Do More Quality Enhancement Research Initiative (T2DM QUERI)
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 33:2558-60. 2010
    ..To identify factors in patients with type 2 diabetes and A1C >7.0% associated with attainment of A1C ≤ 7.0%...
  78. ncbi request reprint Narrative review: pharmacotherapy for chronic heart failure: evidence from recent clinical trials
    Andrew T Yan
    St Michael s Hospital, The Heart and Stroke Richard Lewar Centre of Excellence, and Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Intern Med 142:132-45. 2005
    ..This article reviews the evidence on the pharmacologic treatment of heart failure, with a focus on recent clinical trials...