J W Semple

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint ITP: a new regulatory issue!
    John W Semple
    The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada
    Eur J Haematol 79:279-80. 2007
  2. doi request reprint The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Ontario, Canada
    Curr Opin Hematol 19:357-62. 2012
  3. doi request reprint Recent progress in understanding the pathogenesis of immune thrombocytopenia
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Toronto, Ontario, Canada
    Curr Opin Hematol 17:590-5. 2010
  4. ncbi request reprint Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura
    John W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, 30 Bond St, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 25:S11-3. 2003
  5. ncbi request reprint Leucodepletion and immune response mechanisms
    J W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, The University of Toronto, Toronto, Canada
    Vox Sang 87:136-8. 2004
  6. ncbi request reprint Autoimmune pathogenesis and autoimmune hemolytic anemia
    John W Semple
    Department of Laboratory Medicine, St Micheal s Hospital, University of Toronto, Ontario, Canada
    Semin Hematol 42:122-30. 2005
  7. ncbi request reprint Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets
    John W Semple
    Department of Laboratory Medicine, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
    Blood 109:4803-5. 2007
  8. doi request reprint A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Transfusion 48:1917-24. 2008
  9. doi request reprint Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Hematol Oncol Clin North Am 23:1177-92. 2009
  10. doi request reprint Platelets and innate immunity
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Cell Mol Life Sci 67:499-511. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint ITP: a new regulatory issue!
    John W Semple
    The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada
    Eur J Haematol 79:279-80. 2007
  2. doi request reprint The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Ontario, Canada
    Curr Opin Hematol 19:357-62. 2012
    ..The purpose of this review is to report on the ITP pathophysiology literature published from January 2011 to early in 2012...
  3. doi request reprint Recent progress in understanding the pathogenesis of immune thrombocytopenia
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Toronto, Ontario, Canada
    Curr Opin Hematol 17:590-5. 2010
    ..The cause of this platelet-specific autoimmunity remains unknown, but there has been a constant stream of recent publications that suggest ITP is the result of T-cell dysregulation...
  4. ncbi request reprint Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura
    John W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, 30 Bond St, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 25:S11-3. 2003
    ..It will focus on the relationship between T-cell reactivities and cytokine profiles in patients with AITP. Understanding these cellular immune aspects of AITP is vital for developing antigen-specific immunotherapies to treat the disease...
  5. ncbi request reprint Leucodepletion and immune response mechanisms
    J W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, The University of Toronto, Toronto, Canada
    Vox Sang 87:136-8. 2004
  6. ncbi request reprint Autoimmune pathogenesis and autoimmune hemolytic anemia
    John W Semple
    Department of Laboratory Medicine, St Micheal s Hospital, University of Toronto, Ontario, Canada
    Semin Hematol 42:122-30. 2005
    ..Both human and animal studies will be discussed. Understanding theses mechanism is vital for developing antigen-specific immunotherapies to treat the disease...
  7. ncbi request reprint Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets
    John W Semple
    Department of Laboratory Medicine, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
    Blood 109:4803-5. 2007
    ....
  8. doi request reprint A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Transfusion 48:1917-24. 2008
    ..To further analyze this, we focused on NO's major metabolite peroxynitrite (ONOO(-)) and its ability to affect PLT immunity...
  9. doi request reprint Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Hematol Oncol Clin North Am 23:1177-92. 2009
    ....
  10. doi request reprint Platelets and innate immunity
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Cell Mol Life Sci 67:499-511. 2010
    ....
  11. ncbi request reprint T cell and cytokine abnormalities in patients with autoimmune thrombocytopenic purpura
    John W Semple
    Canadian Blood Services and the Toronto Platelet Immunobiology Group, Ont, Toronto, Canada
    Transfus Apher Sci 28:237-42. 2003
    ..Understanding the immune mechanisms controlling cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat the disease...
  12. ncbi request reprint Leukoreduction just doesn't "take away" immunogenic leukcocytes, it creates an immunosuppressive leukocyte dose
    John W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, The University of Toronto and The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada
    Vox Sang 83:425-7. 2002
  13. doi request reprint Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study
    Elisabeth Semple
    Canadian Blood Services, Research and Development, Toronto, Ontario, Canada
    J Oral Maxillofac Surg 66:632-8. 2008
    ....
  14. ncbi request reprint Immune pathophysiology of autoimmune thrombocytopenic purpura
    J W Semple
    St Michael s Hospital and the University of Toronto, Toronto, Ontario, Canada
    Blood Rev 16:9-12. 2002
    ..Despite this, their exact mechanisms of action remain elusive. This review focuses on cell-mediated and cytokine abnormalities within AITP, and presents data related to the mechanism of action of anti-D...
  15. ncbi request reprint Recipient antigen-processing pathways of allogeneic platelet antigens: essential mediators of immunity
    John W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronto, Ontario, Canada
    Transfusion 42:958-61. 2002
  16. ncbi request reprint Anti-D (WinRho SD) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production
    J W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronoto, Ontario, Canada
    Am J Hematol 69:225-7. 2002
    ..It is possible that the induced cytokine/chemokine storm may have an effect on several physiological processes such as those mediating either adverse effects or potentially RES phagocytic activity...
  17. ncbi request reprint The cellular immunology associated with autoimmune thrombocytopenic purpura: an update
    J W Semple
    Division of Haematology, St Michael s Hospital, Ontario, Canada
    Transfus Sci 19:245-51. 1998
    ..Understanding these cellular immune responses in AITP may lead to the development of more immune specific therapies for the management of this disease...
  18. doi request reprint A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy
    Leola Chow
    Toronto Platelet Immunobiology Group, Toronto, Canada
    Blood 115:1247-53. 2010
    ..This novel model not only shows both antibody- and cell-mediated ITP and bleeding but also suggests that these 2 effector mechanisms have a differential response to therapy...
  19. ncbi request reprint Comparison of platelet immunity in patients with SLE and with ITP
    A H Lazarus
    Division of Immunohaematology, St Michael s Hospital, Toronto, Ont, Canada
    Transfus Sci 22:19-27. 2000
    ..While the number of subjects evaluated with SLE-TP was small, these data reveal a number of differences in the immunopathogenesis between SLE-TP and ITP...
  20. ncbi request reprint Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations
    V Leytin
    Departments of Transfusion Medicine and Laboratory Medicine and Pathobiology, St Michael s Hospital and University of Toronto, Toronto, Canada
    Biochem Biophys Res Commun 269:85-90. 2000
    ..Multiparameter analysis of CD62 expression may be useful for selective diagnosis of disorders with systemic or localized platelet activation and for monitoring the clinical course of the disease and effect of therapeutic interventions...
  21. ncbi request reprint Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo
    Rukhsana Aslam
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, 30 Bond St, Toronto, ON, Canada, M5B 1W8
    Blood 107:637-41. 2006
    ..This work implicates platelets as important mediators of innate immune responses against invading microorganisms...
  22. ncbi request reprint Quantification of platelet activation status by analyzing P-selectin expression
    V Leytin
    Department of Transfusion Medicine, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 273:565-70. 2000
    ....
  23. ncbi request reprint A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
    Andrew R Crow
    Canadian Blood Services, Department of Laboratory Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8
    Blood 109:155-8. 2007
    ..This suggests that while IVIg may mediate the release of a variety of cytokines, the cytokines tested do not directly participate in the mechanism of IVIg action...
  24. ncbi request reprint Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype
    Ebrahim Sayeh
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronto, Ontario, Canada
    Transfusion 44:1572-8. 2004
    ..To understand how the recipient's MHC class II molecules may influence PLT alloimmunity, immune responsiveness against transfused PLTs was tested in different mouse strains...
  25. ncbi request reprint IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells
    Ebrahim Sayeh
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, ON, Canada
    Blood 103:2705-9. 2004
    ....
  26. ncbi request reprint IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity
    A R Crow
    Transfusion Medicine Research and the Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Canada
    Br J Haematol 115:679-86. 2001
    ..Our data suggest that IVIg exerts its rapid effect by inhibiting RES function and that anti-idiotype interactions are not required...
  27. ncbi request reprint Quality of thrombin produced from the patient's own plasma using the TPD, a new Thrombin-processing Device
    Elisabeth Semple
    Thermogenesis Corp, Rancho Cordova, California, USA
    J Extra Corpor Technol 37:196-200. 2005
    ..TPD-produced thrombin from human plasma has consistent activity and significantly activates platelets and, thus, may have attractive applications such as the production of autologous thrombin for surgical patients...
  28. pmc A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy
    Heyu Ni
    Canadian Blood Services and Dept of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, 30 Bond St Rm 2 006, Bond Wing, Toronto, ON, Canada M5B 1W8
    Blood 107:2976-83. 2006
    ..Furthermore, maternal administration of intravenous immunoglobulin G (IgG) ameliorated FNAITP and down-regulated pathogenic antibodies in both the maternal and fetal circulations...
  29. ncbi request reprint Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia
    Valery Leytin
    Division of Transfusion Medicine, Department of Laboratory Medicine, St Michael s Hospital, Toronto, ON, Canada
    Br J Haematol 133:78-82. 2006
    ....
  30. doi request reprint HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management
    Katerina Pavenski
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Tissue Antigens 79:237-45. 2012
    ....
  31. doi request reprint Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells
    Rukhsana Aslam
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital Toronto, Canada
    Transfusion 48:1778-86. 2008
    ..We designed a murine PLT transfusion model to study whether leukoreduced PLTs mediate TRIM effects...
  32. ncbi request reprint Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist
    Malini D Coopamah
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, 30 Bond St, Toronto, M5B 1W8 ON, Canada
    Blood 102:2862-7. 2003
    ..Taken together, these results suggest that at least one mechanism of action of anti-D is via the production of the anti-inflammatory cytokine IL1ra which can negatively regulate the ability of leukocytes to phagocytose opsonized cells...
  33. ncbi request reprint Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update
    Malini D Coopamah
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronto, Ontario Canada
    Transfus Med Rev 17:69-80. 2003
    ..Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease...
  34. doi request reprint Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model
    Davor Brinc
    Canadian Blood Services, Canada
    Transfusion 50:2016-25. 2010
    ..Although this AMIS effect has been well described with many different types of cells as well as vaccines and insoluble antigens, the mechanisms behind this effect remain unresolved...
  35. ncbi request reprint Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells
    Rukhsana Aslam
    Department of Laboratory Medicine, St Michael s Hospital, The Department of Pharmacology, and the Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 47:2161-8. 2007
    ..g., reactive oxygen species) that alter signaling pathways within the phagocyte. To address this, a flow cytometric assay was used to compare the kinetics and signaling pathways responsible for opsonized PLT and RBC phagocytosis...
  36. ncbi request reprint Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response
    John W Semple
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Toronto, Ontario, Canada
    Blood 100:1055-9. 2002
    ....
  37. doi request reprint Platelets play a direct role in sepsis-associated endothelial cell death
    John W Semple
    Thromb Haemost 99:249. 2008
  38. ncbi request reprint Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets
    Mimi Kjaersgaard
    Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark
    Blood 110:1359-61. 2007
    ..001) inhibit platelet phagocytosis. The results suggest that MoAnti-D epitope specificity and isotypes are critical requirements for optimal inhibition of opsonized platelet phagocytosis...
  39. doi request reprint Plasma-derived biological medicines used to promote haemostasis
    Frederick A Ofosu
    Canadian Blood Services, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, HSC 3N26, Hamilton, ON, Canada L8N 3Z5
    Thromb Haemost 99:851-62. 2008
    ..It also considers approaches employed to minimize infectivity of biological medicines derived from human and animal plasmas and to manage patients who develop antibodies (inhibitors) to clotting factor concentrate infusions...
  40. ncbi request reprint About the mechanism of action of WinRho SDF
    John W Semple
    Transfusion 47:351; author reply 351-2. 2007
  41. ncbi request reprint Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence 02903, USA
    Transfusion 44:282-5. 2004
    ..The limitation of these assays is that the in vivo GVHD response of treated human WBCs has not been tested directly...
  42. ncbi request reprint Platelets give us many messages
    John W Semple
    Thromb Haemost 90:562-3. 2003
  43. ncbi request reprint IVIG induces dose-dependent amelioration of ITP in rodent models
    Andrew R Crow
    Blood 101:1658-9; author reply 1659. 2003