Laura Y Park-Wyllie

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. pmc Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study
    Laura Y Park-Wyllie
    Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
    PLoS Med 6:e1000157. 2009
  2. doi The adherence support gap: the 'ideal' versus 'reality' of antiretroviral adherence support provided by HIV health providers in clinical practice
    Laura Y Park-Wyllie
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Ann Pharmacother 43:1036-44. 2009
  3. ncbi Adverse quality of life consequences of antiretroviral medications
    L Y Park-Wyllie
    St Michael s Hospital, Toronto, Ontario
    AIDS Care 19:252-7. 2007
  4. ncbi Outcomes of dosage adjustments used to manage antiretroviral drug interactions
    Laura Y Park-Wyllie
    Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 45:933-6. 2007
  5. doi Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study
    Sudeep S Gill
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Arch Intern Med 169:867-73. 2009
  6. doi Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
    JAMA 305:783-9. 2011
  7. ncbi Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
  8. ncbi Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphoma
    Matthew C Cheung
    Department of Medicine, Division of Hematology Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Ann Hematol 86:631-8. 2007
  9. ncbi Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection
    Tony Antoniou
    Inner City Health HIV Program, Toronto, Ontario, Canada
    Pharmacotherapy 23:29-43. 2003
  10. ncbi Potentially unintended discontinuation of long-term medication use after elective surgical procedures
    Chaim M Bell
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 166:2525-31. 2006

Detail Information

Publications18

  1. pmc Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study
    Laura Y Park-Wyllie
    Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
    PLoS Med 6:e1000157. 2009
    ..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia...
  2. doi The adherence support gap: the 'ideal' versus 'reality' of antiretroviral adherence support provided by HIV health providers in clinical practice
    Laura Y Park-Wyllie
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Ann Pharmacother 43:1036-44. 2009
    ....
  3. ncbi Adverse quality of life consequences of antiretroviral medications
    L Y Park-Wyllie
    St Michael s Hospital, Toronto, Ontario
    AIDS Care 19:252-7. 2007
    ..A broad concept of quality of life is needed to encompass all dimensions important to people living with HIV...
  4. ncbi Outcomes of dosage adjustments used to manage antiretroviral drug interactions
    Laura Y Park-Wyllie
    Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 45:933-6. 2007
    ..03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01)...
  5. doi Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study
    Sudeep S Gill
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Arch Intern Med 169:867-73. 2009
    ..These drugs can provoke symptomatic bradycardia and syncope, which may lead to permanent pacemaker insertion. Drug-induced syncope may also precipitate fall-related injuries, including hip fracture...
  6. doi Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
    JAMA 305:783-9. 2011
    ..Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures...
  7. ncbi Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
    ..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
  8. ncbi Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphoma
    Matthew C Cheung
    Department of Medicine, Division of Hematology Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Ann Hematol 86:631-8. 2007
    ..The majority prefer to use cART in combination with CHOP for ARL. The use and perceived benefit of rituximab may be influenced by interprovincial formulary differences and regional variation in guideline recommendations...
  9. ncbi Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection
    Tony Antoniou
    Inner City Health HIV Program, Toronto, Ontario, Canada
    Pharmacotherapy 23:29-43. 2003
    ..Given the ease of administration and relative safety from the perspectives of adverse effects and drug interactions, tenofovir has the potential to assume a large role in the treatment of patients with HIV infection...
  10. ncbi Potentially unintended discontinuation of long-term medication use after elective surgical procedures
    Chaim M Bell
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 166:2525-31. 2006
    ..Transitions between health care settings represent vulnerable periods for medical error. Discontinuation of long-term medication use may occur during discharge from the hospital to the community...
  11. doi Chronic dialysis and death among survivors of acute kidney injury requiring dialysis
    Ron Wald
    Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
    JAMA 302:1179-85. 2009
    ..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge...
  12. ncbi Representation of patients with dementia in clinical trials of donepezil
    Sudeep S Gill
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario
    Can J Clin Pharmacol 11:e274-85. 2004
    ..To evaluate the representation of frail older adults in randomized controlled trials (RCTs), and to assess consequences of under representation by analyzing drug discontinuation rates...
  13. doi Angiotensin inhibition in renovascular disease: a population-based cohort study
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 156:549-55. 2008
    ....
  14. ncbi Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Lancet 367:413-8. 2006
    ..The relation between statins and risk of sepsis in patients with atherosclerosis is unknown...
  15. pmc Influenza morbidity and mortality in elderly patients receiving statins: a cohort study
    Jeffrey C Kwong
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 4:e8087. 2009
    ..Statins possess immunomodulatory properties and have been proposed for reducing morbidity during an influenza pandemic. We sought to evaluate the effect of statins on hospitalizations and deaths related to seasonal influenza outbreaks...
  16. doi Health impact of hospital restrictions on seriously ill hospitalized patients: lessons from the Toronto SARS outbreak
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Care 46:991-7. 2008
    ..Restrictions on non-urgent hospital care imposed to control the 2003 Toronto severe acute respiratory syndrome outbreak led to substantial disruptions in hospital clinical practice, admission, and transfer patterns...
  17. doi When laboratories report estimated glomerular filtration rates in addition to serum creatinines, nephrology consults increase
    Arsh K Jain
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 76:318-23. 2009
    ..However, it remains to be seen whether the routine reporting of eGFR results in improved treatment and outcomes for those with chronic kidney disease...
  18. doi Association between hospital cardiac management and outcomes for acute myocardial infarction patients
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 48:157-65. 2010
    ..Randomized trials have shown that medical and interventional therapies improve outcomes for acute myocardial infarction (AMI) patients. The extent to which hospital quality improvement translates into better patient outcomes is unclear...