Laura Y Park-Wyllie
Affiliation: St. Michael's Hospital
- Cholinesterase inhibitors and hospitalization for bradycardia: a population-based studyLaura Y Park-Wyllie
Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
PLoS Med 6:e1000157. 2009..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia...
- The adherence support gap: the 'ideal' versus 'reality' of antiretroviral adherence support provided by HIV health providers in clinical practiceLaura Y Park-Wyllie
Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
Ann Pharmacother 43:1036-44. 2009....
- Adverse quality of life consequences of antiretroviral medicationsL Y Park-Wyllie
St Michael s Hospital, Toronto, Ontario
AIDS Care 19:252-7. 2007..A broad concept of quality of life is needed to encompass all dimensions important to people living with HIV...
- Outcomes of dosage adjustments used to manage antiretroviral drug interactionsLaura Y Park-Wyllie
Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada
Clin Infect Dis 45:933-6. 2007..03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01)...
- Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort studySudeep S Gill
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Arch Intern Med 169:867-73. 2009..These drugs can provoke symptomatic bradycardia and syncope, which may lead to permanent pacemaker insertion. Drug-induced syncope may also precipitate fall-related injuries, including hip fracture...
- Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older womenLaura Y Park-Wyllie
Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
JAMA 305:783-9. 2011..Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures...
- Outpatient gatifloxacin therapy and dysglycemia in older adultsLaura Y Park-Wyllie
Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
N Engl J Med 354:1352-61. 2006..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
- Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphomaMatthew C Cheung
Department of Medicine, Division of Hematology Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Ann Hematol 86:631-8. 2007..The majority prefer to use cART in combination with CHOP for ARL. The use and perceived benefit of rituximab may be influenced by interprovincial formulary differences and regional variation in guideline recommendations...
- Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infectionTony Antoniou
Inner City Health HIV Program, Toronto, Ontario, Canada
Pharmacotherapy 23:29-43. 2003..Given the ease of administration and relative safety from the perspectives of adverse effects and drug interactions, tenofovir has the potential to assume a large role in the treatment of patients with HIV infection...
- Potentially unintended discontinuation of long-term medication use after elective surgical proceduresChaim M Bell
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 166:2525-31. 2006..Transitions between health care settings represent vulnerable periods for medical error. Discontinuation of long-term medication use may occur during discharge from the hospital to the community...
- Chronic dialysis and death among survivors of acute kidney injury requiring dialysisRon Wald
Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
JAMA 302:1179-85. 2009..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge...
- Representation of patients with dementia in clinical trials of donepezilSudeep S Gill
Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario
Can J Clin Pharmacol 11:e274-85. 2004..To evaluate the representation of frail older adults in randomized controlled trials (RCTs), and to assess consequences of under representation by analyzing drug discontinuation rates...
- Angiotensin inhibition in renovascular disease: a population-based cohort studyDaniel G Hackam
Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
Am Heart J 156:549-55. 2008....
- Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysisDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
Lancet 367:413-8. 2006..The relation between statins and risk of sepsis in patients with atherosclerosis is unknown...
- Influenza morbidity and mortality in elderly patients receiving statins: a cohort studyJeffrey C Kwong
The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
PLoS ONE 4:e8087. 2009..Statins possess immunomodulatory properties and have been proposed for reducing morbidity during an influenza pandemic. We sought to evaluate the effect of statins on hospitalizations and deaths related to seasonal influenza outbreaks...
- Health impact of hospital restrictions on seriously ill hospitalized patients: lessons from the Toronto SARS outbreakTherese A Stukel
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Med Care 46:991-7. 2008..Restrictions on non-urgent hospital care imposed to control the 2003 Toronto severe acute respiratory syndrome outbreak led to substantial disruptions in hospital clinical practice, admission, and transfer patterns...
- When laboratories report estimated glomerular filtration rates in addition to serum creatinines, nephrology consults increaseArsh K Jain
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Kidney Int 76:318-23. 2009..However, it remains to be seen whether the routine reporting of eGFR results in improved treatment and outcomes for those with chronic kidney disease...
- Association between hospital cardiac management and outcomes for acute myocardial infarction patientsTherese A Stukel
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Med Care 48:157-65. 2010..Randomized trials have shown that medical and interventional therapies improve outcomes for acute myocardial infarction (AMI) patients. The extent to which hospital quality improvement translates into better patient outcomes is unclear...