Genomes and Genes
Anna Marie Mulligan
Affiliation: St. Michael's Hospital
- Encapsulated Papillary Carcinoma of the BreastAnna Marie Mulligan
Department of Laboratory Medicine, St Michael s Hospital and University of Toronto, 30 Bond Street, Room 2 089 CCW, Toronto, Ontario M5B 1W8, Canada Electronic address
Surg Pathol Clin 2:319-50. 2009..This article presents a practical approach to the diagnosis of encapsulated papillary carcinoma with a review of its histologic mimics and clinical significance. ..
- Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriersAntonis C Antoniou
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
Breast Cancer Res 14:R33. 2012..2)...
- CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the breast cancer family registryAnna Marie Mulligan
Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital and the Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Cancer 117:1350-9. 2011....
- JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancerMichael Reedijk
Department of Surgical Oncology, University of Toronto, Toronto, ON, Canada, M5G 2M9
Breast Cancer Res Treat 111:439-48. 2008..As JAG1 is a target of several oncogenic signaling pathways, and is a ligand for Notch, these data provide novel insights into signaling that may contribute to progression of early stage breast cancer...
- Prognostic effect of basal-like breast cancers is time dependent: evidence from tissue microarray studies on a lymph node-negative cohortAnna Marie Mulligan
Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Clin Cancer Res 14:4168-74. 2008..Subsequent to this validation, we examined outcome in specific subgroups defined using TMA data...
- Elevated expression of podocalyxin is associated with lymphatic invasion, basal-like phenotype, and clinical outcome in axillary lymph node-negative breast cancerCatherine L Forse
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada
Breast Cancer Res Treat 137:709-19. 2013..001). PODXL has the potential to be a useful biomarker for identifying good prognosis patients in characteristically poor prognosis breast cancer groups and may impact treatment of women with this disease...
- Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer RegistryAnna Marie Mulligan
Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Ontario, Canada
Clin Cancer Res 19:336-46. 2013..Chemokines could play a role in attracting these cells and contribute to tumor progression. We explored tumoral expression of CXCL10 and determined the relationship between CXCL10 and lymphocytic infiltrate in a cohort of breast cancers...
- Changes in estrogen receptor, progesterone receptor and Her-2/neu status with time: discordance rates between primary and metastatic breast cancerReuben J Broom
Princess Margaret Hospital, Toronto, Canada
Anticancer Res 29:1557-62. 2009..Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree of hormone receptor discordance in archival paired pathological samples was evaluated...
- Cytokeratin 5 and estrogen receptor immunohistochemistry as a useful adjunct in identifying atypical papillary lesions on breast needle core biopsyAndrea Grin
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
Am J Surg Pathol 33:1615-23. 2009..Patterns and extent of ER and CK5 staining, when used together, are valuable adjunct stains to differentiate usual duct hyperplasia from atypical proliferations within papillary lesions on core biopsy...
- Müllerian adenosarcomas with unusual growth patterns: staging issuesBlaise Alexander Clarke
Department of Pathology, University Health Network, Toronto, Ontario, Canada
Int J Gynecol Pathol 30:340-7. 2011..This will facilitate reliable data collection such that an evidence-based staging system for these scenarios may be derived...
- Validation of Intratumoral T-bet+ Lymphoid Cells as Predictors of Disease-Free Survival in Breast CancerAnna Marie Mulligan
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Cancer Immunol Res 4:41-8. 2016..This supports their role in Th1-mediated antitumor activity and may provide insight for the development of new therapeutic strategies. Cancer Immunol Res; 4(1); 41-48. ©2015 AACR. ..
- Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registriesPaul Ryan
Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
Cancer 118:681-8. 2012..In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting LS in a cohort of patients with EC who had mutation-proven LS...
- Use of mismatch repair immunohistochemistry and microsatellite instability testing: exploring Canadian practicesSteve E Kalloger
Department of Pathology, University of British Columbia, Vancouver, BC, Canada
Am J Surg Pathol 36:560-9. 2012....
- The effect of prolonged fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast cancer: a prospective studyLeung Chu Tong
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Am J Surg Pathol 35:545-52. 2011..In 6 of these, a higher score was seen in the PF group. In conclusion, fixation for limited periods beyond 72 hours does not result in a reduction in assay sensitivity in the determination of ER, PR, or HER2 immunohistochemical status...
- High-level JAG1 mRNA and protein predict poor outcome in breast cancerBrendan C Dickson
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Mod Pathol 20:685-93. 2007....
- Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cellsAnna Marie Mulligan
Department of Laboratory Medicine, St Michaels Hospital, Toronto, ON, Canada
Am J Surg Pathol 34:1132-8. 2010..At this time, however, the cumulative data on endometrial GCC are limited and the prognostic significance of the presence and the extent of a giant cell component in endometrial carcinoma remains uncertain...
- Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancerCatherine L Forse
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
BMC Cancer 15:483. 2015..Our goal was to determine if Menacalc could be used as an independent prognostic marker for axillary node-negative (ANN) breast cancer...
- Papillary lesions of the breast: impact of breast pathology subspecialization on core biopsy and excision diagnosesKiran Jakate
Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
Am J Surg Pathol 36:544-51. 2012....
- PGDS, a novel technique combining chromogenic in situ hybridization and immunohistochemistry for the assessment of ErbB2 (HER2/neu) status in breast cancerRuoyu Ni
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Appl Immunohistochem Mol Morphol 15:316-24. 2007..It is likely that this assay will aid in immunohistochemical calibration and will also increase the sensitivity and specificity of ErbB2 testing...
- Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastasesAnna Marie Mulligan
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Ontario, Canada
Int J Surg Pathol 15:143-7. 2007..The current 2 cases offer evidence to support the use of this term for particularly large encysted lesions. Sentinel lymph node biopsy may be prudent in such cases...
- Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomasSana Alsolami
Department of Laboratory Medicine and Pathobiology S A, Sunnybrook Health Sciences Centre Department of Pediatric Laboratory Medicine C C, The Hospital For Sick Children Department of Laboratory Medicine and Pathobiology A M M, B A C, University Health Network, University of Toronto, Toronto, ON Department of Pathology S K, C B G, University of British Columbia, Vancouver, BC, Canada Dammam Regional Laboratory S A, Ministry of Health, Dammam, Saudi Arabia Department of Histopathology M E B, Imperial College, Hammersmith Hospital, London Molecular and Population Genetics Laboratory I P T, Wellcome Trust Centre for Human Genetics Oxford Biomedical Research Centre I P T, Wellcome Trust Centre for Human Genetics Henry Wellcome Building for Molecular Physiology P J P, University of Oxford, Oxford Department of Pathology W G M, Royal Group of Hospitals Trust, Northern Ireland, UK Department of Pathology and Microbiology N A, Jordan University of Science and Technology, Ar Ramtha, Jordan Department of Pathology T B P, B P Koirala Memorial Cancer Hospital, Chitwan, Nepal
Int J Gynecol Pathol 33:560-7. 2014....
- Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancerAnna Marie Mulligan
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Breast Cancer Res Treat 106:39-47. 2007..Furthermore, high expression of IR is independently and significantly associated with more favorable clinical outcomes. Follow-up intervention research is recommended...