John C Marshall

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Sepsis research: where have we gone wrong?
    John C Marshall
    Department of Surgery, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    Crit Care Resusc 8:241-3. 2006
  2. doi request reprint Transfusion in the intensive care unit
    John C Marshall
    St Michael s Hospital, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 6:S33-9. 2005
  3. doi request reprint Investigator-led clinical research consortia: the Canadian Critical Care Trials Group
    John C Marshall
    Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 37:S165-72. 2009
  4. ncbi request reprint Lipopolysaccharide: an endotoxin or an exogenous hormone?
    John C Marshall
    Interdepartmental Division of Critical Care Medicine, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 41:S470-80. 2005
  5. doi request reprint The immune system in critical illness
    John C Marshall
    Interdepartmental Division of Critical Care, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Clin Chest Med 29:605-16, vii. 2008
  6. pmc Iatrogenesis, inflammation and organ injury: insights from a murine model
    John C Marshall
    University of Toronto, St Michael s Hospital, 30 Bond St Rm 4 007, Bond Wing, Toronto, Ontario, Canada M5B 1W8
    Crit Care 10:173. 2006
  7. doi request reprint Biomarkers of sepsis
    John C Marshall
    Li Ka Shing Knowledge Institute, The Keenan Research Centre, Toronto, Ontario, Canada
    Crit Care Med 37:2290-8. 2009
  8. doi request reprint Principles of source control in the management of sepsis
    John C Marshall
    Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Clin 25:753-68, viii-ix. 2009
  9. doi request reprint Critical illness is an iatrogenic disorder
    John C Marshall
    Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 38:S582-9. 2010
  10. doi request reprint Principles of source control in the management of sepsis
    John C Marshall
    Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Nurs Clin North Am 23:99-114. 2011

Detail Information

Publications90

  1. ncbi request reprint Sepsis research: where have we gone wrong?
    John C Marshall
    Department of Surgery, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    Crit Care Resusc 8:241-3. 2006
  2. doi request reprint Transfusion in the intensive care unit
    John C Marshall
    St Michael s Hospital, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 6:S33-9. 2005
    ....
  3. doi request reprint Investigator-led clinical research consortia: the Canadian Critical Care Trials Group
    John C Marshall
    Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 37:S165-72. 2009
    ..This review summarizes the history, activities, approaches, and challenges of the CCCTG, in the conviction that investigator-led groups such as ours represent the future of intensive care unit-based research...
  4. ncbi request reprint Lipopolysaccharide: an endotoxin or an exogenous hormone?
    John C Marshall
    Interdepartmental Division of Critical Care Medicine, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 41:S470-80. 2005
    ..Thus, LPS is not less an endotoxin than an exohormone, and its neutralization may potentially result in either benefit or harm...
  5. doi request reprint The immune system in critical illness
    John C Marshall
    Interdepartmental Division of Critical Care, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Clin Chest Med 29:605-16, vii. 2008
    ..Critical illness results in derangements of all components of the immune response, but the very complexity of the process has frustrated attempts to correct these derangements and to affect significantly the clinical course of sepsis...
  6. pmc Iatrogenesis, inflammation and organ injury: insights from a murine model
    John C Marshall
    University of Toronto, St Michael s Hospital, 30 Bond St Rm 4 007, Bond Wing, Toronto, Ontario, Canada M5B 1W8
    Crit Care 10:173. 2006
    ....
  7. doi request reprint Biomarkers of sepsis
    John C Marshall
    Li Ka Shing Knowledge Institute, The Keenan Research Centre, Toronto, Ontario, Canada
    Crit Care Med 37:2290-8. 2009
    ..Validated biomarkers of sepsis may improve diagnosis and therapeutic decision making for these high-risk patients...
  8. doi request reprint Principles of source control in the management of sepsis
    John C Marshall
    Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Clin 25:753-68, viii-ix. 2009
    ..This article discusses specific approaches to source control in the abdomen, chest, and skin and soft tissues...
  9. doi request reprint Critical illness is an iatrogenic disorder
    John C Marshall
    Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 38:S582-9. 2010
    ....
  10. doi request reprint Principles of source control in the management of sepsis
    John C Marshall
    Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Nurs Clin North Am 23:99-114. 2011
    ..As every intensivist learns, appropriate source-control intervention can rapidly alter the course of sepsis to a more favorable direction, and suboptimal decision-making can change a difficult clinical challenge into a nightmare...
  11. ncbi request reprint The pathogenesis and molecular biology of sepsis
    John C Marshall
    Department of Surgery, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    Crit Care Resusc 8:227-9. 2006
  12. doi request reprint Sepsis: rethinking the approach to clinical research
    John C Marshall
    Department of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    J Leukoc Biol 83:471-82. 2008
    ....
  13. ncbi request reprint The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivo
    Rachel G Khadaroo
    Department of Surgery, University Health Network, and University of Toronto, Ontario, Canada
    Surgery 136:483-8. 2004
    ..In the present studies, we hypothesize that oxidant priming by S/R in vivo involves Src family kinases...
  14. ncbi request reprint Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway
    Rachel G Khadaroo
    Department of Surgery, University Health Network, and University of Toronto, Ontario, Canada
    Surgery 134:242-6. 2003
    ..Because the Src family has been shown to activate the p38 mitogen-activated protein kinase (MAPK) pathway, we hypothesize that LPS signaling after oxidant stress involves the p38 pathway and is activated by Src kinases...
  15. ncbi request reprint Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  16. ncbi request reprint Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
    Song Hui Jia
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Biol Chem 283:5402-13. 2008
    ....
  17. ncbi request reprint Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity
    Ravi Taneja
    Department of Surgery, The Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Crit Care Med 32:1460-9. 2004
    ....
  18. doi request reprint Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase
    Zeenat Malam
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada
    J Immunol 186:6474-84. 2011
    ..Taken together, these results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane, and this occurs in a MAPK-dependent fashion...
  19. doi request reprint Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study)
    Karen E A Burns
    Division of Critical Care Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:1212-8. 2013
    ..Limited cross-sectional data exist to characterize the challenges of enrolling critically ill patients into research studies...
  20. doi request reprint Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto and Pharmacy Department, St Michael s Hospital, Toronto, Canada
    Crit Care Med 39:1167-73. 2011
    ..To determine whether catheter-associated urinary tract infections are associated with increased morbidity and mortality in critically ill patients...
  21. ncbi request reprint Twenty-five percent albumin prevents lung injury following shock/resuscitation
    Kinga A Powers
    Department of Surgery, University Health Network, Toronto, Canada
    Crit Care Med 31:2355-63. 2003
    ....
  22. pmc Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages
    Kinga A Powers
    Department of Surgery, St Michael s Hospital and University Health Network, Toronto, Ontario, Canada
    J Exp Med 203:1951-61. 2006
    ..Collectively, these studies suggest a novel mechanism whereby oxidative stress might prime the responsiveness of cells of the innate immune system...
  23. doi request reprint Altered inhibitory κBα expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shock
    Guiseppe Papia
    Li Ka Shing Knowledge Institute and the Keenan Research Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Shock 35:171-7. 2011
    ..Together, these effects on the important regulatory molecule IκB in the macrophage may contribute to the heightened inflammatory response observed after S/R...
  24. doi request reprint Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection
    Giuseppe Papia
    Department of Surgery, St Michael s Hospital and University of Toronto, and the Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Surgery 144:814-21. 2008
    ....
  25. ncbi request reprint Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome?
    Mary Anne W Aarts
    University of Toronto, Interdepartmental Division of Critical Care Medicine and the Department of Surgery, Toronto, Canada
    Intensive Care Med 33:1369-78. 2007
    ..To characterize empiric antibiotic use in patients with suspected nosocomial ICU-acquired infections (NI), and determine the impact of prolonged therapy in the absence of infection...
  26. ncbi request reprint Empiric antimicrobial therapy in critical illness: results of a surgical infection society survey
    Mary Anne W Aarts
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 8:329-36. 2007
    ..Often, therapy is initiated empirically; practice patterns are not well characterized. We documented approaches to empiric antibiotic therapy among members of the Surgical Infection Society (SIS)...
  27. pmc Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
    Song Hui Jia
    Department of Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    J Clin Invest 113:1318-27. 2004
    ..These data identify PBEF as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis...
  28. ncbi request reprint Daily variation in endotoxin levels is associated with increased organ failure in critically ill patients
    David J Klein
    St Michael s Hospital, University of Toronto, Ontario, Canada
    Shock 28:524-9. 2007
    ..Further studies are warranted to assess the role of daily variation in endotoxin levels in the pathogenesis and potential therapy of organ failure in the critically ill...
  29. doi request reprint Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity
    Tracy Luk
    Department of Surgery and the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Leukoc Biol 83:804-16. 2008
    ..This review summarizes the admittedly incomplete body of emerging knowledge about a remarkable new mediator of innate immunity...
  30. doi request reprint Endotoxin in the pathogenesis of sepsis
    John C Marshall
    Department of Surgery, University of Toronto, and the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
    Contrib Nephrol 167:1-13. 2010
    ..Future studies of antiendotoxin strategies in acute illness are more likely to succeed if they recruit patients with endotoxemia, and titrate therapy to an optimal level...
  31. ncbi request reprint Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line
    Rachel G Khadaroo
    Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 278:47834-41. 2003
    ....
  32. ncbi request reprint Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum
    John C Marshall
    Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Canada
    Crit Care Med 33:1708-16. 2005
    ..We sought to evaluate existing approaches and to draw on insights from other disciplines to propose a comprehensive approach to outcome evaluation in sepsis clinical trials...
  33. ncbi request reprint Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10
    George D Oreopoulos
    Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Hepatology 40:211-20. 2004
    ....
  34. doi request reprint Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, The University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:256-61. 2013
    ..Outcome measures that integrate mortality and morbidity, like quality-adjusted life years (QALYs), have been proposed for critical care clinical trials...
  35. ncbi request reprint Intensive care unit management of intra-abdominal infection
    John C Marshall
    Department of Surgery, University of Toronto and Toronto General Hospital, University Health Network, Ontario, Canada
    Crit Care Med 31:2228-37. 2003
    ..To review the biologic characteristics of, and management approaches to, intra-abdominal infection in the critically ill patient...
  36. pmc A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine and Departments of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Trials 12:70. 2011
    ....
  37. doi request reprint Interleukin-1beta mediates LPS-induced inhibition of apoptosis in retinoic acid-differentiated HL-60 cells
    John C Marshall
    Department of Surgery, St Michael s Hospital, University of Toronto, 4th Floor Bond Wing, Room 4 007, 30 Bond Street, Toronto, Ont, Canada
    Biochem Biophys Res Commun 369:532-8. 2008
    ..These studies provide further evidence of a complex regulatory pathway that modulates the expression of granulocyte apoptosis during inflammation, and point to a specific role for IL-1beta as an autocrine survival factor...
  38. ncbi request reprint Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000
    John C Marshall
    Department of Surgery and Interdepartmental, Division of Critical Care, University of Toronto, Canada
    Crit Care Med 31:1560-7. 2003
    ..The evaluation of effective therapies has been hampered by limitations in our ability to characterize the process and to stratify patients into more homogeneous groups with respect to pathogenesis...
  39. ncbi request reprint Source control in the management of severe sepsis and septic shock: an evidence-based review
    John C Marshall
    From the Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Crit Care Med 32:S513-26. 2004
    ....
  40. ncbi request reprint Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials
    Mary Anne W Aarts
    Department of Surgery, University of Toronto, Toronto, Ontario
    Crit Care Med 36:108-17. 2008
    ..To compare specific antibiotic regimens, and monotherapy vs. combination therapy, for the empirical treatment of ventilator-associated pneumonia (VAP)...
  41. ncbi request reprint Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
    Yumiko Imai
    Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario
    JAMA 289:2104-12. 2003
    ..Recent clinical trials have demonstrated a decrease in multiple organ dysfunction syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS) treated with a protective ventilatory strategy...
  42. doi request reprint Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey
    Clarence Chant
    Pharmacy Department, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 36:1158-67. 2008
    ..To determine physician practice and perception about the management of intensive care unit (ICU)-acquired bacteriuria and funguria...
  43. ncbi request reprint Such stuff as dreams are made on: mediator-directed therapy in sepsis
    John C Marshall
    Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Eaton North 9 234, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada
    Nat Rev Drug Discov 2:391-405. 2003
    ....
  44. ncbi request reprint Preclinical models of shock and sepsis: what can they tell us?
    John C Marshall
    St Michael s Hospital, Toronto, Ontario, Canada
    Shock 24:1-6. 2005
    ..Hence, greater model standardization would aid in interpreting data and in pooling results into systematic data syntheses: such efforts should be promoted and undertaken...
  45. pmc The staging of sepsis: understanding heterogeneity in treatment efficacy
    John C Marshall
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:626-8. 2005
    ..They will be no less important in the optimal management of sepsis...
  46. doi request reprint Participation of ICUs in critical care pandemic research: a province wide, cross-sectional survey
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Centre and the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 41:1009-16. 2013
    ..We sought to characterize clinical research activity during the recent influenza A pandemic and to understand the experiences, beliefs, and practices of key stakeholders involved in pandemic research implementation...
  47. pmc Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence
    John C Marshall
    Medical Surgical Intensive Care Unit, University Health Network, Toronto, Ontario, Canada
    Crit Care 6:342-8. 2002
    ..The relationship between endotoxaemia, Gram-negative infection and the clinical syndrome of sepsis has been difficult to establish, in part because of the limitations of available endotoxin assays...
  48. pmc Challenges in evaluating surgical innovation
    Patrick L Ergina
    Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
    Lancet 374:1097-104. 2009
    ..Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential...
  49. doi request reprint The Surviving Sepsis Campaign: a history and a perspective
    John C Marshall
    Department of Surgery and Critical Care Medicine and Keenan Research Centre of Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 11:275-81. 2010
    ....
  50. ncbi request reprint Sepsis: current status, future prospects
    John C Marshall
    Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Curr Opin Crit Care 10:250-64. 2004
  51. pmc Transfusion trigger: when to transfuse?
    John C Marshall
    University of Toronto, Toronto, Ontario, Canada
    Crit Care 8:S31-3. 2004
    ..Arbitrary numeric hemoglobin triggers, however, cannot supercede intervention based on individual physiologic need and clinical circumstances...
  52. pmc Measurements in the intensive care unit: what do they mean?
    John C Marshall
    Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Toronto General Hospital, University Health Network, Toronto, Canada
    Crit Care 7:415-6. 2003
  53. ncbi request reprint Neutrophils in the pathogenesis of sepsis
    John C Marshall
    St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 33:S502-5. 2005
  54. ncbi request reprint Saturday night fever: finding and controlling the source of sepsis in critical illness
    Sandro B Rizoli
    Department of Surgery, Interdepartmental Division of Critical Care, Sepsis Research Laboratories, Toronto General Hospital, University of Toronto, Ontario, Canada
    Lancet Infect Dis 2:137-44. 2002
    ....
  55. pmc New translational research provides insights into liver dysfunction in sepsis
    John C Marshall
    Departments of Surgery and Critical Care Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 9:e1001341. 2012
    ..John Marshall discusses new research detailing the early onset in liver dysfunction in a rodent sepsis model, which he says can fundamentally change our understanding of this common clinical problem...
  56. pmc Gastrointestinal dysfunction in the critically ill: can we measure it?
    Rachel G Khadaroo
    Department of Surgery, and Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada, M5B 1W8
    Crit Care 12:180. 2008
    ..Nonetheless, and even with its shortcomings, their effort is a welcome contribution to the surprisingly complex process of describing the morbidity of critical illness...
  57. pmc The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
    John C Marshall
    University of Toronto, General and Critical Care Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Crit Care 6:465-7. 2002
  58. ncbi request reprint Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide
    Jie Fan
    Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:5252-9. 2002
    ....
  59. ncbi request reprint Surgical decision-making: integrating evidence, inference, and experience
    John C Marshall
    Departments of Surgery and Critical Care Medicine, University of Toronto, St Michael s Hospital, 4th Floor Bond Wing, Room 4 007, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Surg Clin North Am 86:201-15, xii. 2006
    ....
  60. ncbi request reprint Modulating neutrophil apoptosis
    John C Marshall
    Department of Surgery, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Novartis Found Symp 280:53-66; discussion 67-72, 160-4. 2007
    ..A complex series of interactions between the neutrophil and microorganisms or their products regulates the duration and intensity of an inflammatory response, and so provides an attractive target for therapeutic manipulation...
  61. ncbi request reprint The effects of granulocyte colony-stimulating factor in preclinical models of infection and acute inflammation
    John C Marshall
    Department of Surgery and the Interdepartmental Division of Critical Care, Toronto General Hospital, University of Toronto, Ontario, Canada
    Shock 24:120-9. 2005
    ..Significant variability in the design and reporting of studies of preclinical models of acute illness precludes more sophisticated data synthesis...
  62. ncbi request reprint Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases
    Ian D McGilvray
    Department of Surgery, University of Toronto and University Health Network, Ontario, Canada
    Shock 18:51-7. 2002
    ..The selective inhibition of the mitogen-activated protein kinases may offer a novel therapeutic means of modulating this inflammatory sequence...
  63. doi request reprint Coming of age
    John C Marshall
    Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Sepsis Research Laboratory, Li Ka Shing Knowledge Institute, St Michaels Hospital, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 9:111-20. 2008
  64. ncbi request reprint Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis
    Ziqiang Ding
    Division of Thoracic Surgery, Department of Surgery, Toronto General Research Institute of the University Health Network, University of Toronto, Toronto, ON, Canada
    Crit Care Med 34:3011-7. 2006
    ..The purpose of this study was to examine chemokine receptor expression and function in lymphocytes from septic patients and healthy donors...
  65. pmc Early observational research and registries during the 2009-2010 influenza A pandemic
    Robert A Fowler
    Canadian Critical Care Trials Group, Toronto, Ontario, Canada
    Crit Care Med 38:e120-32. 2010
    ....
  66. ncbi request reprint ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process
    Rachel G Khadaroo
    Department of Surgery, Interdepartmental Division of Critical Care, Sepsis Research Laboratories, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Clin 18:127-41. 2002
    ..The growing recognition that iatrogenic factors contribute to the expression of MODS has highlighted the need for the clinician to be aware of the potential for harm inherent with every intervention...
  67. ncbi request reprint In defense of evidence: the continuing saga of selective decontamination of the digestive tract
    Mary Anne Aarts
    Am J Respir Crit Care Med 166:1014-5. 2002
  68. ncbi request reprint Intra-abdominal infections
    John C Marshall
    Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto and the Toronto General Hospital, University Health Network, Toronto, Ont, Canada M5G 2C4
    Microbes Infect 6:1015-25. 2004
    ..Successful management depends on aggressive resuscitation and hemodynamic support, administration of adequate antimicrobial therapy, and the timely use of source control measures appropriate to the clinical situation...
  69. ncbi request reprint Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    Edward A Panacek
    Department of Medicine, University of California Davis Medical Center, Sacramento, CA, USA
    Crit Care Med 32:2173-82. 2004
    ..To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F(ab')2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients with severe sepsis and elevated serum levels of IL-6...
  70. ncbi request reprint DNR directives are established early in mechanically ventilated intensive care unit patients
    Tasnim Sinuff
    Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 51:1034-41. 2004
    ..Our objective was to study the rate of establishing do-not-resuscitate (DNR) directives, determinants, and outcomes of those directives for mechanically ventilated patients...
  71. doi request reprint The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    J Crit Care 23:82-90. 2008
    ..The aim of this study was to determine the safety of targeted antibiotic therapy (TT) in ventilator-associated pneumonia (VAP)...
  72. ncbi request reprint Burden of illness in venous thromboembolism in critical care: a multicenter observational study
    Rakesh Patel
    Department of Medicine, University of Ottawa, Canada K1Y 4E9
    J Crit Care 20:341-7. 2005
    ....
  73. ncbi request reprint Progesterone acutely increases LH pulse amplitude but does not acutely influence nocturnal LH pulse frequency slowing during the late follicular phase in women
    Christopher R McCartney
    Center for Research in Reproduction, Box 800391, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 292:E900-6. 2007
    ....
  74. ncbi request reprint The surviving sepsis campaign
    John C Marshall
    Crit Care Resusc 8:181-2. 2006
  75. pmc Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls
    Christopher R McCartney
    Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 92:430-6. 2007
    ..Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear...
  76. ncbi request reprint Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury
    Lauralyn A McIntyre
    Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
    Neurocrit Care 5:4-9. 2006
    ..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)...
  77. ncbi request reprint Category-specificity: what is the question?
    John C Marshall
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cortex 41:861-2; discussion 869-72. 2005
  78. ncbi request reprint Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08854, USA
    J Crit Care 21:38-47. 2006
    ..Once a therapy is approved, adopting less stringent but still appropriate criteria for the use of that therapy in clinical practice may be appropriate...
  79. ncbi request reprint Dissociations: double or quits?
    Jennifer M Gurd
    Neuropsychology Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cortex 39:192-5. 2003
  80. ncbi request reprint Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome?
    John C Marshall
    Intensive Care Med 31:605-8. 2005
  81. ncbi request reprint Intraabdominal infections in infants and children: descriptions and definitions
    Ann E Thompson
    Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, PA, USA
    Pediatr Crit Care Med 6:S30-5. 2005
    ..To define intraabdominal infections in infants and children...
  82. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Crit Care Med 32:858-73. 2004
    ....
  83. pmc Surviving sepsis: a guide to the guidelines
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 12:162. 2008
    ..The revised guidelines are far from perfect, but they represent the best available synthesis of contemporary knowledge in this area and as such should be promoted...
  84. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden, NJ 08103, USA
    Intensive Care Med 30:536-55. 2004
    ....
  85. pmc The PIRO concept: O is for organ dysfunction
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 7:260-4. 2003
  86. pmc The PIRO concept: R is for response
    Herwig Gerlach
    Department of Anaesthesiology and Intensive Care Medicine, Vivantes Klinikum Neukoelln, Germany
    Crit Care 7:256-9. 2003
  87. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  88. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  89. ncbi request reprint Measuring organ dysfunction in the intensive care unit: why and how?
    John C Marshall
    Can J Anaesth 52:224-30. 2005
  90. ncbi request reprint Neutralization of tumor necrosis factor in preclinical models of sepsis
    Jose A Lorente
    Department of Critical Care Medicine, Hospital Universitario de Getafe, Madrid, Spain
    Shock 24:107-19. 2005
    ....