ROBERT LOUGHLIN MACDONALD

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. pmc Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage
    Hyojin Jeon
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    BMC Neurosci 10:103. 2009
  2. ncbi request reprint Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution
    R Loch MacDonald
    Division of Neurosurgery at St Michael s Hospital, University of Toronto, Toronto, Canada
    Nat Clin Pract Neurol 3:256-63. 2007
  3. ncbi request reprint Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage
    R Loch MacDonald
    University of Toronto, St Michael Hospital, Division of Neurosurgery, Keenan Research Centre, Toronto, Ontario, Canada
    Expert Opin Investig Drugs 17:1761-7. 2008
  4. doi request reprint Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial
    R Loch MacDonald
    St Michael s Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Stroke 39:3015-21. 2008
  5. doi request reprint Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage
    Yeon Gyoe Jang
    Division of Neurosurgery, University of Toronto, Toronto, ON, Canada, M5B 1W8
    Neurocrit Care 10:141-7. 2009
  6. doi request reprint Anterior circulation mouse model of subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Brain Res 1295:179-85. 2009
  7. doi request reprint Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage?
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    World Neurosurg 73:646-53. 2010
  8. pmc Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s, Toronto, Ontario, Canada
    Brain Res 1238:163-71. 2008
  9. doi request reprint Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article
    Nir Lipsman
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg 111:67-74. 2009
  10. pmc Induction of housekeeping gene expression after subarachnoid hemorrhage in dogs
    Yasuo Aihara
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    J Neurosci Methods 172:1-7. 2008

Research Grants

  1. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
  2. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2000

Collaborators

Detail Information

Publications11

  1. pmc Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage
    Hyojin Jeon
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    BMC Neurosci 10:103. 2009
    ..Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment...
  2. ncbi request reprint Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution
    R Loch MacDonald
    Division of Neurosurgery at St Michael s Hospital, University of Toronto, Toronto, Canada
    Nat Clin Pract Neurol 3:256-63. 2007
    ....
  3. ncbi request reprint Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage
    R Loch MacDonald
    University of Toronto, St Michael Hospital, Division of Neurosurgery, Keenan Research Centre, Toronto, Ontario, Canada
    Expert Opin Investig Drugs 17:1761-7. 2008
    ..All patients will undergo neurosurgical aneurysm clipping and outcome will be assessed primarily based on mortality and vasospasm-related morbidity...
  4. doi request reprint Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial
    R Loch MacDonald
    St Michael s Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Stroke 39:3015-21. 2008
    ....
  5. doi request reprint Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage
    Yeon Gyoe Jang
    Division of Neurosurgery, University of Toronto, Toronto, ON, Canada, M5B 1W8
    Neurocrit Care 10:141-7. 2009
    ..We performed a meta-analysis of these trials to assess the effect of tirilazad on unfavorable outcome, symptomatic vasospasm, and cerebral infarction after SAH...
  6. doi request reprint Anterior circulation mouse model of subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Brain Res 1295:179-85. 2009
    ..The model is simple to perform and may be useful for investigating the pathophysiology of SAH...
  7. doi request reprint Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage?
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    World Neurosurg 73:646-53. 2010
    ..Statins have been studied in patients with aneurysmal subarachnoid hemorrhage (SAH) but the history, pharmacology, and studies have not been reviewed recently...
  8. pmc Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s, Toronto, Ontario, Canada
    Brain Res 1238:163-71. 2008
    ..These changes coupled with neurological deterioration seen in patients may present a possible reason for the poor outcome in SAH patients...
  9. doi request reprint Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article
    Nir Lipsman
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg 111:67-74. 2009
    ..Because treatment can vary between countries and continents, the authors used a large database of patients with SAH to determine the effect of the geographic location of treatment on outcome...
  10. pmc Induction of housekeeping gene expression after subarachnoid hemorrhage in dogs
    Yasuo Aihara
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    J Neurosci Methods 172:1-7. 2008
    ..Transcripts for housekeeping genes are increased after SAH, making standardization to them potentially invalid. The increase is due to proliferation of cells in the adventitia and increased total mRNA in the media and adventitia...
  11. doi request reprint Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage
    Timour Al-Khindi
    University of Toronto, Toronto, Ontario, Canada
    Stroke 41:e519-36. 2010
    ..The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning...

Research Grants5

  1. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    ..abstract_text> ..
  2. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2000
    ....