G F Lewis

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 46:1111-9. 1997
  2. ncbi request reprint Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 48:570-6. 1999
  3. ncbi request reprint Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 84:1037-46. 1999
  4. ncbi request reprint Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men
    N Leung
    Department of Medicine, Division of Endocrinology and Metabolism and the Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 47:204-13. 2004
  5. ncbi request reprint The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism
    A Carpentier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 50:1402-13. 2001
  6. ncbi request reprint Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans
    A Carpentier
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Diabetologia 44:1989-97. 2001
  7. pmc Portal venous and enteric exocrine drainage versus systemic venous and bladder exocrine drainage of pancreas grafts: clinical outcome of 40 consecutive transplant recipients
    M S Cattral
    Multiorgan Transplantation Program, The Toronto General Hospital, University Health Network, and the Departments of Surgery and Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Surg 232:688-95. 2000
  8. ncbi request reprint Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men
    C Xiao
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 51:139-46. 2008
  9. ncbi request reprint Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans
    C Xiao
    Department of Medicine and Physiology, University of Toronto, Toronto, ON, Canada
    Diabetologia 49:1371-9. 2006
  10. ncbi request reprint Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance
    K Adeli
    Division of Clinical Biochemistry, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toeonto, Toronto, Ontario, Canada
    Trends Cardiovasc Med 11:170-6. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 46:1111-9. 1997
    ..This suggests that other mechanisms, most likely hepatic, dominate the acute insulin-induced suppression of glucose production...
  2. ncbi request reprint Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 48:570-6. 1999
    ..In conclusion, this is the first study in patients with type 2 diabetes to characterize insulin resistance to the acute direct suppressive effect of insulin on hepatic glucose production...
  3. ncbi request reprint Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans
    G F Lewis
    Department of Medicine, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 84:1037-46. 1999
    ..The clinical importance of these observations in diabetic subjects as they relate to route of insulin delivery (portal or peripheral) during insulin dissipation remains to be determined...
  4. ncbi request reprint Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men
    N Leung
    Department of Medicine, Division of Endocrinology and Metabolism and the Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 47:204-13. 2004
    ..A prolonged increase of plasma NEFA impairs acute glucose-stimulated insulin secretion (GSIS) in vitro and in vivo. Our study therefore examined the combined effect of increased plasma NEFA and glucose on GSIS in humans...
  5. ncbi request reprint The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism
    A Carpentier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 50:1402-13. 2001
    ....
  6. ncbi request reprint Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans
    A Carpentier
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Diabetologia 44:1989-97. 2001
    ..These findings suggest that the previously demonstrated NEFA-induced impairment in insulin secretory response to glucose cannot be generalized for non-glucose secretagogues...
  7. pmc Portal venous and enteric exocrine drainage versus systemic venous and bladder exocrine drainage of pancreas grafts: clinical outcome of 40 consecutive transplant recipients
    M S Cattral
    Multiorgan Transplantation Program, The Toronto General Hospital, University Health Network, and the Departments of Surgery and Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Surg 232:688-95. 2000
    ....
  8. ncbi request reprint Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men
    C Xiao
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 51:139-46. 2008
    ..The aim of the present study was to examine the effects of two orally administered antioxidants, N-acetylcysteine (NAC) and taurine (TAU), on lipotoxicity in humans...
  9. ncbi request reprint Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans
    C Xiao
    Department of Medicine and Physiology, University of Toronto, Toronto, ON, Canada
    Diabetologia 49:1371-9. 2006
    ..Prolonged elevation of plasma specific fatty acids may exert differential effects on glucose-stimulated insulin secretion (GSIS), insulin sensitivity and clearance...
  10. ncbi request reprint Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance
    K Adeli
    Division of Clinical Biochemistry, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toeonto, Toronto, Ontario, Canada
    Trends Cardiovasc Med 11:170-6. 2001
    ..g., in streptozotocin-treated animals), which appears to have a different etiology and is related to a catabolic defect rather than secretory overproduction of triglyceride-rich lipoproteins...
  11. ncbi request reprint Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits
    S Rashid
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    J Lipid Res 42:265-71. 2001
    ..Further studies are needed to determine whether, in the presence of HL, TG enrichment of HDL alters selective HDL CE clearance...
  12. doi request reprint Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice
    D Song
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 54:1181-9. 2011
    ..Here we examined the relative contributions of acute CNS and extra-CNS CB1R modulation on insulin sensitivity using pharmacological gain- and loss-of-function of CB1R in mice...