Lawrence A Leiter

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Efficacy and safety of rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolemia: results of the POLARIS study
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Canada
    Atherosclerosis 194:e154-64. 2007
  2. pmc Are post-treatment low-density lipoprotein subclass pattern analyses potentially misleading?
    Harold Bays
    Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA
    Lipids Health Dis 9:136. 2010
  3. ncbi request reprint Should you put all diabetic patients on statins?
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    J Fam Pract 56:294-300. 2007
  4. ncbi request reprint Diagnosis of coronary artery disease in the diabetic patient
    Lawrence A Leiter
    Division of Endocrinology, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Can J Cardiol 22:7A-8A. 2006
  5. ncbi request reprint Optimal care of cardiovascular disease and type 2 diabetes patients: shared responsibilities between the cardiologist and diabetologist
    Lawrence A Leiter
    Division of Endocrinology and Metabolism and Cardiology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ont, M5C 2T2, Canada
    Atheroscler Suppl 7:37-42. 2006
  6. ncbi request reprint Can thiazolidinediones delay disease progression in type 2 diabetes?
    Lawrence A Leiter
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, ON, Canada
    Curr Med Res Opin 22:1193-201. 2006
  7. ncbi request reprint How to reach LDL targets quickly in patients with diabetes or metabolic syndrome
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Fam Pract 57:661-8. 2008
  8. doi request reprint Efficacy and safety of ezetimibe added on to atorvastatin (40 mg) compared with uptitration of atorvastatin (to 80 mg) in hypercholesterolemic patients at high risk of coronary heart disease
    Lawrence A Leiter
    St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1495-501. 2008
  9. ncbi request reprint Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety
    Vladimir Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Nutr Metab Cardiovasc Dis 18:46-56. 2008
  10. ncbi request reprint Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
    Am J Clin Nutr 81:380-7. 2005

Detail Information

Publications97

  1. ncbi request reprint Efficacy and safety of rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolemia: results of the POLARIS study
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Canada
    Atherosclerosis 194:e154-64. 2007
    ..Rosuvastatin may therefore improve LDL-C goal achievement in high-risk patients with hypercholesterolemia...
  2. pmc Are post-treatment low-density lipoprotein subclass pattern analyses potentially misleading?
    Harold Bays
    Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA
    Lipids Health Dis 9:136. 2010
    ....
  3. ncbi request reprint Should you put all diabetic patients on statins?
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    J Fam Pract 56:294-300. 2007
  4. ncbi request reprint Diagnosis of coronary artery disease in the diabetic patient
    Lawrence A Leiter
    Division of Endocrinology, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Can J Cardiol 22:7A-8A. 2006
  5. ncbi request reprint Optimal care of cardiovascular disease and type 2 diabetes patients: shared responsibilities between the cardiologist and diabetologist
    Lawrence A Leiter
    Division of Endocrinology and Metabolism and Cardiology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ont, M5C 2T2, Canada
    Atheroscler Suppl 7:37-42. 2006
    ..Optimal care of diabetic and cardiac patients requires a multidisciplinary team approach, with key roles for the cardiologist and diabetologist...
  6. ncbi request reprint Can thiazolidinediones delay disease progression in type 2 diabetes?
    Lawrence A Leiter
    Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, ON, Canada
    Curr Med Res Opin 22:1193-201. 2006
    ..Further deterioration of beta-cell function is associated with progression of diabetes and the potential development of microvascular and macrovascular complications...
  7. ncbi request reprint How to reach LDL targets quickly in patients with diabetes or metabolic syndrome
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Fam Pract 57:661-8. 2008
    ..To investigate whether using an algorithm to select the starting dose of a statin according to baseline and target LDL-cholesterol (LDL-C) values would facilitate achieving lipid targets in patients with diabetes or the metabolic syndrome...
  8. doi request reprint Efficacy and safety of ezetimibe added on to atorvastatin (40 mg) compared with uptitration of atorvastatin (to 80 mg) in hypercholesterolemic patients at high risk of coronary heart disease
    Lawrence A Leiter
    St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1495-501. 2008
    ..Both treatments were generally well tolerated (clinical trial no. NCT00276484)...
  9. ncbi request reprint Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety
    Vladimir Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Nutr Metab Cardiovasc Dis 18:46-56. 2008
    ....
  10. ncbi request reprint Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
    Am J Clin Nutr 81:380-7. 2005
    ..Newer dietary approaches combining cholesterol-lowering foods may offer another option, but these approaches have not been compared directly with statins in the same persons...
  11. doi request reprint Management of risk factors among ambulatory patients at high cardiovascular risk in Canada: a follow-up study
    Esam A Elbarasi
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1586-92. 2013
    ..Limited longitudinal data are available on attainment of guideline-recommended treatment targets among ambulatory patients at high risk for cardiovascular events...
  12. ncbi request reprint Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs...
  13. ncbi request reprint Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 83:582-91. 2006
    ..Cholesterol-lowering foods may be more effective when consumed as combinations rather than as single foods...
  14. ncbi request reprint The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 87:114-25. 2008
    ..The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown...
  15. ncbi request reprint Effect of a low-glycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    JAMA 300:2742-53. 2008
    ..Low-glycemic index diets may improve both glycemic control and cardiovascular risk factors for patients with type 2 diabetes but debate over their effectiveness continues due to trial limitations...
  16. ncbi request reprint The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 52:1478-83. 2003
    ..Combining a number of foods and food components in a single dietary portfolio may lower LDL-C similarly to statins and so increase the potential effectiveness of dietary therapy...
  17. doi request reprint Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
    ..Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations...
  18. doi request reprint The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada
    Can J Cardiol 29:528-42. 2013
    ..However, both of these issues will be examined on an ongoing basis, in particular as new evidence emerges...
  19. pmc 'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials
    John L Sievenpiper
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Nutr 108:418-23. 2012
    ..There is a need for larger, longer ( ≥ 6 months) trials using 'catalytic' fructose to confirm these results...
  20. pmc Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS)
    Shaun G Goodman
    St Michael s Hospital and University of Toronto, Toronto, Ontario
    Can J Cardiol 26:e330-5. 2010
    ..Despite clear guideline recommendations, there is a growing body of evidence that there is suboptimal use of lipid-lowering treatment in Canadians...
  21. doi request reprint Applying the evidence: do patients with stroke, coronary artery disease, or both achieve similar treatment goals?
    Gustavo Saposnik
    Division of Cardiology, Canadian Heart Research Centre and Terrence Donnelly Heart Centre, University of Toronto, Canada
    Stroke 40:1417-24. 2009
    ..We sought to evaluate and compare differences in treatment patterns and the attainment of current guideline-recommended targets in unselected high-risk ambulatory patients with CAD, CVD, or both...
  22. doi request reprint Relation between obesity and the attainment of optimal blood pressure and lipid targets in high vascular risk outpatients
    Vineet Bhan
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am J Cardiol 106:1270-6. 2010
    ..Our findings underscore the opportunity to optimize the treatment of these high-risk patients...
  23. doi request reprint Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, 61 Queen St E, Toronto, ON M5C 2T2, Canada
    JAMA 306:831-9. 2011
    ..Combining foods with recognized cholesterol-lowering properties (dietary portfolio) has proven highly effective in lowering serum cholesterol under metabolically controlled conditions...
  24. pmc Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials
    Adrian I Cozma
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1611-20. 2012
    ..The effect of fructose on cardiometabolic risk in humans is controversial. We conducted a systematic review and meta-analysis of controlled feeding trials to clarify the effect of fructose on glycemic control in individuals with diabetes...
  25. pmc The effects of fructose intake on serum uric acid vary among controlled dietary trials
    D David Wang
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, ON, Canada
    J Nutr 142:916-23. 2012
    ..Hypercaloric fructose intake may, however, increase uric acid concentrations. The effect of the interaction of energy and fructose remains unclear. Larger, well-designed trials of fructose feeding at "real world" doses are needed...
  26. doi request reprint Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis
    John L Sievenpiper
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 156:291-304. 2012
    ..The contribution of fructose consumption in Western diets to overweight and obesity in populations remains uncertain...
  27. doi request reprint Discordance between physicians' estimation of patient cardiovascular risk and use of evidence-based medical therapy
    Jennifer L Y Tsang
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1142-5. 2008
    ....
  28. ncbi request reprint Effect of plant sterols in combination with other cholesterol-lowering foods
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada M5C 2T2
    Metabolism 57:130-9. 2008
    ....
  29. doi request reprint Identification and management of patients at elevated cardiometabolic risk in canadian primary care: how well are we doing?
    Hwee Teoh
    Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 29:960-8. 2013
    ..We evaluated the risk assessment and management patterns employed by primary care physicians in patients at elevated cardiometabolic risk...
  30. doi request reprint The effect of strawberries in a cholesterol-lowering dietary portfolio
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 57:1636-44. 2008
    ..Added fruit may improve the overall utility of diets designed to lower coronary heart disease risk...
  31. ncbi request reprint Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function
    P Mark Stavro
    Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Hypertension 47:791-6. 2006
    ..Ginseng did not affect serum cystatin C level. Overall, long-term ginseng use had no effect on 24-hour BP and renal function in hypertensive individuals...
  32. ncbi request reprint Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides
    John L Sievenpiper
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, ON, Canada
    J Am Coll Nutr 23:248-58. 2004
    ..We assessed the effect of eight popular ginseng types on postprandial plasma glucose (PG) and insulin (PI) indices, linking effects to ginsenoside profiles...
  33. ncbi request reprint Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Arch Intern Med 172:1653-60. 2012
    ..Yet, to our knowledge, they have never been used specifically to lower the GI of the diet. We have therefore undertaken a study of low-GI foods in type 2 DM with a focus on legumes in the intervention...
  34. doi request reprint Low-density lipoprotein cholesterol and high-sensitivity C-reactive protein lowering with atorvastatin in patients of South Asian compared with European origin: insights from the Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (ACT
    Milan Gupta
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Clin Pharmacol 52:850-8. 2012
    ....
  35. ncbi request reprint Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    JAMA 290:502-10. 2003
    ....
  36. pmc Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ont, Canada
    CMAJ 182:1961-7. 2010
    ....
  37. doi request reprint Glucose lowering and cardiovascular disease: what do we know and what should we do?
    Alice Y Y Cheng
    Division of Endocrinology and Metabolism, University of Toronto and Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Canada
    Eur J Cardiovasc Prev Rehabil 17:S25-31. 2010
    ..For the time being, there remains good evidence for targeting A1c <7% for microvascular protection but attempts to lower A1c beyond this must be considered on an individual basis...
  38. doi request reprint Viscosity rather than quantity of dietary fibre predicts cholesterol-lowering effect in healthy individuals
    Vladimir Vuksan
    Li Ka Shing Knowledge Institute, Clinical Nutrition and Risk Factor Modification Centre, Saint Michael s, Toronto, ON, Canada
    Br J Nutr 106:1349-52. 2011
    ..These data support the inclusion of high-viscosity fibre in the diet to reduce plasma lipids among apparently healthy individuals consuming a typical NA diet...
  39. ncbi request reprint Are Canadian guidelines for cholesterol lowering in high-risk patients optimal?
    David H Fitchett
    Canadian Heart Research Centre, Toronto, Ontario
    Can J Cardiol 21:85-90. 2005
    ..However, future recommendations may suggest much lower LDL-C targets than those currently recommended...
  40. ncbi request reprint Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial
    David J A Jenkins
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaClinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, ON, CanadaDivision of Endocrinology and Metabolism, St Michael s Hospital, Toronto, ON, CanadaLi Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Diabetes Care 37:1806-14. 2014
    ..We therefore determined the combined effect of ALA, MUFA, and low GL on glycemic control and CVD risk factors in type 2 diabetes...
  41. doi request reprint Supplemental barley protein and casein similarly affect serum lipids in hypercholesterolemic women and men
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
    J Nutr 140:1633-7. 2010
    ..Nevertheless, because no adverse effects were observed on cardiovascular risk factors, barley protein remains an additional option for raising the protein content of the diet...
  42. doi request reprint Use of a treatment optimization algorithm involving statin-ezetimibe combination aids in achievement of guideline-based low-density lipoprotein targets in patients with dyslipidemia at high vascular risk Guideline-based Undertaking to Improve Dyslipidemia
    Pamela M Katz
    Divisions of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:138-45. 2011
    ....
  43. pmc Lower is better: implications of the Treating to New Targets (TNT) study for Canadian patients
    David H Fitchett
    Division of Cardiology, St Michael s Hospital, Toronto, Ontario
    Can J Cardiol 22:835-9. 2006
    ..Furthermore, registry data show that one-half of these patients are not even achieving the current LDL-C target of 2.5 mmol/L. Causes of the care gap are discussed and possible remedies to achieve the new lower targets are suggested...
  44. pmc Hypertension in diabetes: a call to action
    Norman R C Campbell
    Department of Medicine, University of Calgary, Calgary, Canada
    Can J Cardiol 25:299-302. 2009
    ..Intensive individualized lifestyle modification is recommended to prevent and treat hypertension, dyslipidemia, dysglycemia and other vascular risks in people with diabetes...
  45. ncbi request reprint Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals
    Anamaria Dascalu
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S3E2, Canada
    Can J Physiol Pharmacol 85:856-64. 2007
    ..05.) American ginseng decreased postprandial glycemia and insulinemia; however, 40% of the batches did not reduce glycemia with the anticipated magnitude, irrespective of their saponin composition...
  46. ncbi request reprint From hyperglycemia to the risk of cardiovascular disease
    Lawrence A Leiter
    Division of Endocrinology and Metabolism, St Michael s Hospital and Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Rev Cardiovasc Med 7:S3-9. 2006
    ..Finally, there are multiple mechanisms by which hyperglycemia can increase the risk for CVD...
  47. doi request reprint Effect of fructose on postprandial triglycerides: a systematic review and meta-analysis of controlled feeding trials
    D David Wang
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, Toronto, ON, Canada
    Atherosclerosis 232:125-33. 2014
    ..In the absence of consistent clinical evidence, concerns have been raised that fructose raises postprandial triglycerides...
  48. pmc Missed opportunities for the secondary prevention of cardiovascular disease in Canada
    Daniel G Hackam
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Cardiol 23:1124-30. 2007
    ....
  49. pmc Patient age, ethnicity, medical history, and risk factor profile, but not drug insurance coverage, predict successful attainment of glycemic targets: Time 2 Do More Quality Enhancement Research Initiative (T2DM QUERI)
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 33:2558-60. 2010
    ..To identify factors in patients with type 2 diabetes and A1C >7.0% associated with attainment of A1C ≤ 7.0%...
  50. pmc Treatment gaps in the management of cardiovascular risk factors in patients with type 2 diabetes in Canada
    Manoela Braga
    Keenan Research Center, Li Ka Shing Knowledge Institute at St Michael s Hospital, University of Toronto, ON, Canada
    Can J Cardiol 26:297-302. 2010
    ..To evaluate vascular protection treatment patterns and attainment of the 2003 Canadian Diabetes Association's recommended targets in ambulatory patients with type 2 diabetes...
  51. ncbi request reprint Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies
    John L Sievenpiper
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    J Am Coll Nutr 25:100-7. 2006
    ....
  52. doi request reprint Usefulness of statin-ezetimibe combination to reduce the care gap in dyslipidemia management in patients with a high risk of atherosclerotic disease
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 104:798-804. 2009
    ..In conclusion, an algorithm-based statin uptitration/ezetimibe combination regimen is useful to increase LDL cholesterol lowering where statin monotherapy has not achieved target lipid values...
  53. ncbi request reprint Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Metabolism 56:649-55. 2007
    ..19 +/- 1.24 vs 1.97 +/- 0.90, P = .6). Our findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus...
  54. doi request reprint Role of renin-angiotensin system blockade in patients with diabetes mellitus
    Manoela F B Braga
    Cardiometabolic Risk Initiative, St Michael s Hospital, University of Toronto, Toronto, Ontario Canada
    Am J Cardiol 104:835-9. 2009
    ..In conclusion, overwhelming evidence suggests that the RAS plays an important role in the pathogenesis of DM and its associated cardiovascular risks...
  55. doi request reprint Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group
    Lawrence A Leiter
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:e1-e33. 2011
    ..Health care professionals must also consider risk factors related to ethnicity in order to appropriately evaluate everyone in their diverse patient populations...
  56. ncbi request reprint Postprandial glucose regulation: new data and new implications
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, Toronto, Canada
    Clin Ther 27:S42-56. 2005
    ..However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) to guide management...
  57. doi request reprint Effect of dietary pulses on blood pressure: a systematic review and meta-analysis of controlled feeding trials
    Viranda H Jayalath
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Hypertens 27:56-64. 2014
    ..To quantify the effect of dietary pulse interventions on BP and provide evidence for their inclusion in dietary guidelines, a systematic review and meta-analysis of controlled feeding trials was conducted...
  58. ncbi request reprint Diabetes and cardiovascular disease: the role of glycemic control
    Alice Y Y Cheng
    St Michael s Hospital, 6121 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
    Curr Diab Rep 9:65-72. 2009
    ....
  59. pmc Metabolic syndrome under fire: weighing in on the truth
    A Y Cheng
    Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Canada
    Can J Cardiol 22:379-82. 2006
    ..Therefore, the 'metabolic syndrome' continues to serve a useful clinical purpose to raise awareness among health care professionals and aid in identifying high-risk individuals...
  60. doi request reprint Nutritional considerations for older adults with type 2 diabetes
    Andrea R Josse
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital and Department of Nutritional Sciences, Faculty of Medicine, University of Tornoto, 150 College Street, Toronto, Ontario, Canada
    J Nutr Elder 27:363-80. 2008
    ....
  61. ncbi request reprint Contemporary management of dyslipidemia in high-risk patients: targets still not met
    Andrew T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, Toronto, Ontario, Canada
    Am J Med 119:676-83. 2006
    ..Our objective was to evaluate treatment patterns and the attainment of current National Cholesterol Education Program (NCEP)-recommended lipid targets in unselected high-risk ambulatory patients...
  62. ncbi request reprint How does the prognosis of diabetes compare with that of established vascular disease? Insights from the Canadian Vascular Protection (VP) Registry
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:1028-33. 2004
    ....
  63. ncbi request reprint Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Alice Yy Cheng
    Division of Endocrinology and Metabolism, St Michael s Hospital, Canada
    Curr Opin Cardiol 21:400-4. 2006
    ..This review discusses the results of key clinical trials released in 2005 and their potential impact on the guidelines...
  64. pmc The incretin system and cardiometabolic disease
    Paul E Szmitko
    Division of General Internal Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Can J Cardiol 26:87-95. 2010
    ..The influence of incretins on the cardiovascular system beyond the proatherogenic effect of type 2 diabetes will also be discussed...
  65. ncbi request reprint Clinical use of ezetimibe
    Alice Y Y Cheng
    St Michael s Hospital, Toronto, Ontario
    Can J Clin Pharmacol 10:21A-5A. 2003
    ....
  66. doi request reprint Efficacy and safety of ursodeoxycholic acid in primary, type IIa or IIb hypercholesterolemia: a multicenter, randomized, double-blind clinical trial
    Manoela F B Braga
    St Michael s Hospital, University of Toronto, ON, Canada
    Atherosclerosis 203:479-82. 2009
    ..Purpose of this study was to determine whether UDCA had potential to be an effective, safe cholesterol-lowering agent in primary type IIa or IIb hypercholesterolemia...
  67. ncbi request reprint Willingness to pay for inhaled insulin: a contingent valuation approach
    Hamid Sadri
    Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Pharmacoeconomics 23:1215-27. 2005
    ..To determine the willingness to pay (WTP) of patients with diabetes mellitus for inhaled insulin...
  68. ncbi request reprint North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension
    P Mark Stavro
    Risk Factor Modification Centre, St Michael s Hospital, 61 Queen St E, 6th Floor, Suite 138, Toronto, Ontario, M5C 2T2, Canada
    Hypertension 46:406-11. 2005
    ..The findings together suggested that North American ginseng exerts a neutral acute effect on blood pressure in hypertensive individuals...
  69. doi request reprint The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy
    Doreen M Rabi
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 27:415-433.e1-2. 2011
    ..We also discussed the recent analyses that examined the association between angiotensin II receptor blockers (ARBs) and cancer...
  70. pmc PROVE-IT proved it: lower is better--pro
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, Ontario
    Can J Cardiol 22:91B-94B. 2006
    ..An aggressive approach to LDL-C lowering, especially in the high-risk patient, seems warranted...
  71. ncbi request reprint The prevention of diabetic microvascular complications of diabetes: is there a role for lipid lowering?
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, 61 Queen St East 6121, Toronto, Ont, Canada M5C 2T2
    Diabetes Res Clin Pract 68:S3-14. 2005
    ..These findings would provide further support for the use of lipid-lowering agents in patients with diabetes...
  72. doi request reprint Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials
    Vanessa Ha
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Hypertension 59:787-95. 2012
    ..To confirm these results, longer and larger trials are needed. Contrary to previous concerns, we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans...
  73. ncbi request reprint Temporal changes in the management and outcome of Canadian diabetic patients hospitalized for non-ST-elevation acute coronary syndromes
    Basem Elbarouni
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, ON, Canada
    Am Heart J 162:347-355.e1. 2011
    ..We sought to evaluate (1) the temporal changes in the medical and invasive management and (2) in-hospital outcome of NSTE-ACS patients with and without diabetes...
  74. ncbi request reprint PPAR-alpha: therapeutic role in diabetes-related cardiovascular disease
    Alice Y Y Cheng
    Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 10:691-8. 2008
    ..However, their potential role in combination with statin therapy remains to be further elucidated with ongoing studies...
  75. ncbi request reprint Of the renin-angiotensin system and reactive oxygen species Type 2 diabetes and angiotensin II inhibition
    Lawrence A Leiter
    University of Toronto, Ontario, Canada
    Am J Hypertens 18:121-8. 2005
    ....
  76. ncbi request reprint Lipids and diabetes mellitus: a review of therapeutic options
    Jeannette M Goguen
    St Michael s Hospital and Department of Medicine, University of Toronto, Ontario, Canada
    Curr Med Res Opin 18:s58-74. 2002
    ..An approach to the patient with diabetes mellitus and dyslipidaemia is provided...
  77. ncbi request reprint Statin therapy and the management of acute coronary syndromes
    Anatoly Langer
    Canadian Heart Research Centre and St Michael s Hospital, University of Toronto, Toronto, Canada
    Can J Cardiol 19:921-7. 2003
    ....
  78. ncbi request reprint Diabetic dyslipidaemia: effective management reduces cardiovascular risk
    Lawrence A Leiter
    Departments of Medicine and Nutritional Sciences, University of Toronto, St Michael s Hospital, 61 Queen Street East 6121Q, Toronto, Ontario, Canada M5C 2T2
    Atheroscler Suppl 6:37-43. 2005
    ..The availability of more effective statins should help to close this "action gap", in concert with other measures such as initiatives to improve patient compliance...
  79. ncbi request reprint Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 25:1522-8. 2002
    ..Cohort studies indicate that cereal fiber reduces the risk of diabetes and coronary heart disease (CHD). Therefore, we assessed the effect of wheat bran on glycemic control and CHD risk factors in type 2 diabetes...
  80. ncbi request reprint Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 76:365-72. 2002
    ..Many of the benefits of soy have been attributed to soy isoflavones...
  81. ncbi request reprint A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 51:1596-604. 2002
    ....
  82. ncbi request reprint Null and opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on acute glycemia: results of two acute dose escalation studies
    John L Sievenpiper
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, 6 138 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
    J Am Coll Nutr 22:524-32. 2003
    ..We investigated whether Asian ginseng is able to replicate this glycemia-lowering efficacy in two separate acute dose escalation studies...
  83. ncbi request reprint Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
    Roger S McIntyre
    University of Toronto, Department of Psychiatry, Toronto, ON, Canada
    Expert Opin Pharmacother 8:1615-28. 2007
    ..Extant data provide the basis for formulating a hypothesis that TZDs may be salutary for cognitive deficits and several aspects of somatic health (e.g., cardiovascular disease) associated with mood disorders...
  84. ncbi request reprint Lipid management in cardiovascular disease prevention guidelines: strategies and tactics for implementation
    Leif R Erhardt
    Department of Cardiology, Malmo University Hospital, Malmo, Sweden
    Atherosclerosis 196:532-41. 2008
    ..Include professional societies from different specialties in guideline development and implementation, to increase ownership and decrease fragmentation of guideline committees...
  85. ncbi request reprint Elevated ICAM-1 and MCP-1 plasma levels in subjects at high cardiovascular risk are diminished by atorvastatin treatment. Atorvastatin on Inflammatory Markers study: a substudy of Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration
    Luis Miguel Blanco-Colio
    Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
    Am Heart J 153:881-8. 2007
    ..We analyzed whether treatment with the different doses of atorvastatin affects sICAM-1 and sMCP-1 plasma levels in subjects at high cardiovascular risk...
  86. ncbi request reprint Increased soluble Fas plasma levels in subjects at high cardiovascular risk: Atorvastatin on Inflammatory Markers (AIM) study, a substudy of ACTFAST
    Luis M Blanco-Colio
    Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Avenida Reyes Catolicos 2, 28040, Madrid, Spain
    Arterioscler Thromb Vasc Biol 27:168-74. 2007
    ..We sought to analyze soluble Fas (sFas) and soluble Fas ligand (sFasL) concentrations in subjects at high cardiovascular risk and their modulation by atorvastatin treatment...
  87. doi request reprint Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk
    Luis M Blanco-Colio
    Vascular Research Lab Fundación Jimenéz Díaz Autonoma University, Madrid, Spain
    Eur J Pharmacol 586:259-65. 2008
    ..In conclusion, atorvastatin increased adiponectin plasma levels in subjects at high cardiovascular risk, revealing a novel anti-inflammatory effect of this drug...
  88. pmc Ongoing clinical trials of the pleiotropic effects of statins
    Jean Davignon
    Clinical Research Institute of Montreal, Montreal, QC, Canada
    Vasc Health Risk Manag 1:29-40. 2005
    ..The multiple effects (ie, pleiotropic effects of statins) have received increasing recognition and may have clinical applicability across a broad range of cardiovascular and noncardiovascular conditions...
  89. ncbi request reprint Prandial glucose regulation in the glucose triad: emerging evidence and insights
    Paul Beisswenger
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Endocrine 25:195-202. 2004
    ..While more interventional studies clearly are needed, the growing weight of evidence supports a therapeutic approach more directed at excessive prandial glycemic excursions that are characteristic of both type 1 and type 2 diabetes...
  90. ncbi request reprint Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Cardiol 99:56i-67i. 2007
    ..The current protocol is designed to provide an ethically justifiable test of combined statin plus fibrate treatment consistent with the highest level of safety and lipid treatment standards of care...
  91. pmc How many cardiovascular events can be prevented with optimal management of high-risk Canadians?
    Daniel T Grima
    Cornerstone Research Group Inc, Burlington
    Can J Cardiol 24:363-8. 2008
    ....
  92. pmc The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy
    N A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, BC, Canada
    Can J Cardiol 22:583-93. 2006
    ..To provide updated, evidence-based recommendations for the management of hypertension in adults...
  93. pmc The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 24:465-75. 2008
    ..To update the evidence-based recommendations for the prevention and management of hypertension in adults...
  94. ncbi request reprint The Editor's roundtable: diabetes mellitus and coronary heart disease
    Vincent E Friedewald
    Internal Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Am J Cardiol 98:842-56. 2006
  95. pmc The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Cardiol 23:539-50. 2007
    ..To provide updated, evidence-based recommendations for the prevention and management of hypertension in adults...
  96. ncbi request reprint The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 21:657-72. 2005
    ..To provide updated, evidence-based recommendations for the management of hypertension in adults...
  97. ncbi request reprint Perindopril in diabetes: perspective from the EUROPA substudy, PERSUADE
    Subodh Verma
    Eur Heart J 26:1347-9. 2005