K Kovacs

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Sheehan syndrome
    Kalman Kovacs
    Division of Pathology, Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Toronto, Canada
    Lancet 361:520-2. 2003
  2. ncbi request reprint Thrombotic thrombocytopenic purpura associated with a prolactin-producing pituitary adenoma
    Kalman Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 74:55-9. 2003
  3. ncbi request reprint Immunohistochemical localization of amylin in human pancreas, thyroid, pituitary and their tumors
    Fabio Rotondo
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Acta Histochem 105:303-7. 2003
  4. ncbi request reprint Pituitary pathology in Erdheim-Chester disease
    Kalman Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada
    Endocr Pathol 15:159-66. 2004
  5. ncbi request reprint Silent adenoma subtype 3 of the pituitary--immunohistochemical and ultrastructural classification: a review of 29 cases
    E Horvath
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ultrastruct Pathol 29:511-24. 2005
  6. ncbi request reprint Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings
    Kalman Kovacs
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8
    Hum Pathol 38:185-9. 2007
  7. ncbi request reprint Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism
    Kalman Kovacs
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B1W8
    Endocr Pathol 18:42-5. 2007
  8. ncbi request reprint Double adenomas of the pituitary: a clinicopathological study of 11 tumors
    G Kontogeorgos
    Department of Pathology, St Michael s Hospital, Toronto, Ontario, Canada
    Neurosurgery 31:840-9; discussion 849. 1992
  9. ncbi request reprint Plurihormonal gonadotroph cell pituitary adenoma: report of a unique case
    M Al-Shraim
    Department of Laboratory Medicine, St Michael s Hospital, Ontario, Canada
    Clin Neuropathol 28:182-7. 2009
  10. ncbi request reprint Reversible transdifferentiation: interconversion of somatotrophs and lactotrophs in pituitary hyperplasia
    S Vidal
    Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada
    Mod Pathol 14:20-8. 2001

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Sheehan syndrome
    Kalman Kovacs
    Division of Pathology, Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Toronto, Canada
    Lancet 361:520-2. 2003
  2. ncbi request reprint Thrombotic thrombocytopenic purpura associated with a prolactin-producing pituitary adenoma
    Kalman Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 74:55-9. 2003
    ..Further studies are required to determine whether prolactin released from the pituitary tumor in excess played a role in the formation of microthrombi causing multiple organ failure and the demise of the patient...
  3. ncbi request reprint Immunohistochemical localization of amylin in human pancreas, thyroid, pituitary and their tumors
    Fabio Rotondo
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Acta Histochem 105:303-7. 2003
    ..It can be concluded that amylin is not a satisfactory immunohistochemical marker to identify pancreatic islet tumors, medullary thyroid carcinomas and pituitary adenomas...
  4. ncbi request reprint Pituitary pathology in Erdheim-Chester disease
    Kalman Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada
    Endocr Pathol 15:159-66. 2004
    ..It appears that in our patient the clinically apparent anterior hypopituitarism was not due to the lack of storage but rather to insufficient release of adenohypophysial hormones caused by the defect in hypothalamic regulation...
  5. ncbi request reprint Silent adenoma subtype 3 of the pituitary--immunohistochemical and ultrastructural classification: a review of 29 cases
    E Horvath
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ultrastruct Pathol 29:511-24. 2005
    ..Possible derivation of SAS-3 from rostral thyrotrophs, a cell type presently known in rodents is contemplated...
  6. ncbi request reprint Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings
    Kalman Kovacs
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8
    Hum Pathol 38:185-9. 2007
    ..Based on the clinical, laboratory, and morphological findings, we recommend temozolomide therapy in patients with pituitary tumors not responding adequately to other treatment options...
  7. ncbi request reprint Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism
    Kalman Kovacs
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B1W8
    Endocr Pathol 18:42-5. 2007
    ..The question can be raised whether chemotherapeutic agents may damage parathyroid cells leading to loss of self-tolerance and autoimmune chronic parathyroiditis...
  8. ncbi request reprint Double adenomas of the pituitary: a clinicopathological study of 11 tumors
    G Kontogeorgos
    Department of Pathology, St Michael s Hospital, Toronto, Ontario, Canada
    Neurosurgery 31:840-9; discussion 849. 1992
    ..The literature regarding multiple adenomas is reviewed as are the diagnostic and therapeutic difficulties associated with these rare lesions...
  9. ncbi request reprint Plurihormonal gonadotroph cell pituitary adenoma: report of a unique case
    M Al-Shraim
    Department of Laboratory Medicine, St Michael s Hospital, Ontario, Canada
    Clin Neuropathol 28:182-7. 2009
    ..Our aim was to obtain some insight into the possible cytogenesis of this unusual tumor...
  10. ncbi request reprint Reversible transdifferentiation: interconversion of somatotrophs and lactotrophs in pituitary hyperplasia
    S Vidal
    Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada
    Mod Pathol 14:20-8. 2001
    ....
  11. ncbi request reprint Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation
    L Stefaneanu
    Department of Pathology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Endocrinology 125:2710-8. 1989
    ..Focal PRL cell hyperplasia noted in three pituitaries could also be due to a GRF effect. Longer exposure to GRF is needed to clarify whether GRF can cause adenoma...
  12. ncbi request reprint Effects of growth hormone-releasing hormone (GHRH) on densely granulated somatotroph adenomas and sparsely granulated somatotroph adenomas in vitro: a morphological and functional investigation
    S Kawakita
    Department of Pathology, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Endocrinol Invest 12:443-48. 1989
    ..These results indicate that (1) both types of somatotroph adenoma cells react similarly to GHRH stimulation, despite their morphologic differences, and (2) GHRH stimulates GH synthesis as well as GH release by somatotroph adenoma cells...
  13. pmc Overexpression of the growth-hormone-releasing hormone gene in acromegaly-associated pituitary tumors. An event associated with neoplastic progression and aggressive behavior
    K Thapar
    Department of Neurosurgery, University of Toronto, Ontario, Canada
    Am J Pathol 151:769-84. 1997
    ..More generally, these data merge essential elements of the hypothalamic and pituitary hypotheses of pituitary tumorigenesis, providing for a more unified concept of neoplastic progression in the pituitary...
  14. ncbi request reprint Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line
    S L Asa
    Department of Pathology, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 75:68-75. 1992
    ..Our data strengthen the view that these three plurihormonal adenomas of the acidophil cell line are not only morphologically but also functionally different and warrant separation...
  15. ncbi request reprint Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas
    S Vidal
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Canada
    Ultrastruct Pathol 23:141-8. 1999
    ..The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from...
  16. ncbi request reprint Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study
    E Horvath
    Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada
    Acta Neuropathol 101:631-7. 2001
    ..In addition to prolactin cells and growth hormone cells, immunoelectron microscopy showed several bihormonal mammosomatotrophs, also appropriate for pregnancy...
  17. ncbi request reprint Ultrastructural features of apoptosis in human pituitary adenomas
    S Vidal
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Canada
    Ultrastruct Pathol 25:85-92. 2001
    ..Occasional examples occur in lactotroph or gonadotroph adenomas. Although electron microscopic specimens are admittedly small, the large number of investigated cases gives credence to the observations...
  18. ncbi request reprint Lactotroph hyperplasia in the pituitaries of female mice expressing high levels of bovine growth hormone
    S Vidal
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Transgenic Res 8:191-202. 1999
    ..The infertility of PEPCK/bGH transgenic females may be attributed to lactotroph hyperplasia and marked reduction in number of gonadotrophs...
  19. ncbi request reprint Estrogen receptors alpha and beta immunohistochemical expression: clinicopathological correlations in pituitary adenomas
    B Manoranjan
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Anticancer Res 30:2897-904. 2010
    ..We investigated the immunohistochemical expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in pituitary adenoma subtypes combined with clinicopathological factors...
  20. ncbi request reprint Subcellular localization of leptin in non-tumorous and adenomatous human pituitaries: an immuno-ultrastructural study
    S Vidal
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Histochem Cytochem 48:1147-52. 2000
    ....
  21. ncbi request reprint Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes
    F Rotondo
    Department of Laboratory Medicine, University of Toronto, Toronto, ON, Canada
    Neoplasma 57:590-3. 2010
    ..Keywords: immunohistochemistry, endoglin, CD34, microvascular density, angiogenesis, pituitary...
  22. ncbi request reprint The differential diagnosis of lesions involving the sella turcica
    K Kovacs
    St. Michael's Hospital, Division of Pathology, Department of Laboratory Medicine, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Endocr Pathol 12:389-95. 2001
    ....
  23. ncbi request reprint Dopamine D2 receptor gene expression in human adenohypophysial adenomas
    L Stefaneanu
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Endocrine 14:329-36. 2001
    ..In conclusion, D2R gene is expressed in the majority of pituitary adenomas representing all tumor types. The significance of nuclear localization of D2R protein remains to be clarified...
  24. ncbi request reprint Genetic basis of pituitary adenoma invasiveness: a review
    A Suhardja
    Division of Neurosurgery, University of Toronto, Ontario, Canada
    J Neurooncol 52:195-204. 2001
    ....
  25. ncbi request reprint Localization of insulin-like growth factor-II mRNA in human pituitary adenomas
    S Yokoyama
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Virchows Arch 432:241-6. 1998
    ..The results suggest that IGF-II, when highly expressed, may have a role in pituitary adenoma proliferation...
  26. ncbi request reprint Pituitary corticotroph hyperplasia preceding adenoma in a patient with Nelson's syndrome
    K Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Clin Neuropathol 25:74-80. 2006
    ..Our study supports the view that protracted stimulation of corticotrophs resulting from the elimination of the negative inhibitory feedback effect by corticosteroids plays a role in adenoma initiation...
  27. ncbi request reprint Pituitary adenoma with neuronal choristoma (PANCH): composite lesion or lineage infidelity?
    E Horvath
    Department of Pathology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Ultrastruct Pathol 18:565-74. 1994
    ..It appears that NCH is the result of neuronal differentiation within sparsely granulated GH cell adenomas...
  28. ncbi request reprint Hemangiopericytoma of the sella mimicking pituitary adenoma: case report and review of the literature
    J Juco
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Clin Neuropathol 26:288-93. 2007
    ..To our knowledge, only 9 cases of HPC presenting as a sellar or suprasellar mass have been reported in the literature. Often, these cases can mimic and be mistaken for a pituitary adenoma...
  29. ncbi request reprint Papillary carcinoma of thyroid metastatic to the pituitary gland
    C D Bell
    Division of Anatomical Pathology, Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arch Pathol Lab Med 125:935-8. 2001
    ..The findings confirmed the tumor to be papillary thyroid carcinoma. To our knowledge, this is the first report citing use of thyroid transcription factor-1 to establish a thyroid source of a pituitary metastasis...
  30. ncbi request reprint Classification of pituitary adenomas
    K Kovacs
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Neurooncol 54:121-7. 2001
    ..Despite several recent attempts to assess the growth rate, aggressiveness and invasiveness of pituitary tumors, more work is required to draw conclusions on their prognosis...
  31. ncbi request reprint Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly
    N H Othman
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 55:135-40. 2001
    ....
  32. pmc Invasive thymoma metastatic to the cavernous sinus
    F Nassiri
    Divisions of Pathology, St Michael s Hospital, Toronto, Ontario, Canada Department of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    Surg Neurol Int 4:74. 2013
    ..Metastases to distal sites, particularly intracranial locations, are extremely rare. Herein, we present the third case of thymoma and the second invasive thymoma to metastasize to the cavernous sinus, adjacent to the pituitary...
  33. ncbi request reprint Prognostic indicators in an aggressive pituitary Crooke's cell adenoma
    K Kovacs
    Department of Laboratory Medicine and Pathobiology, St Michaels Hospital, University of Toronto, Toronto, ON, Canada
    Can J Neurol Sci 32:540-5. 2005
    ..To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary...
  34. ncbi request reprint Granulomatous hypophysitis with psammoma bodies: a diagnostic dilemma
    R Jastania
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Canada
    Endocr Pathol 15:359-63. 2004
    ..This finding has not previously been described in the literature. The diagnostic implications of this finding are complex, and the pathogenesis of psammoma body formation in this idiopathic disorder remains unknown...
  35. ncbi request reprint Pituitary adenomas in mice transgenic for growth hormone-releasing hormone
    S L Asa
    Department of Pathology, St Michael s Hospital University of Toronto, Ontario, Canada
    Endocrinology 131:2083-9. 1992
    ..These findings provide conclusive evidence that protracted GRH stimulation of secretory activity can result in proliferation, hyperplasia, and adenoma of adenohypophysial cells...
  36. ncbi request reprint MAP-2 expression in the human adenohypophysis and in pituitary adenomas. An immunohistochemical study
    Fabio Rotondo
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, Toronto, ON, Canada
    Pituitary 8:75-9. 2005
    ..It can be concluded that the functional activity of MAP-2 is not associated with the manufacture of any specific adenohypophysial hormone(s) and is not limited to one specific cell type...
  37. ncbi request reprint Cox-2 expression in the oxyphilic cells of the normal, hyperplastic, and adenomatous parathyroid gland
    C David Bell
    Division of Pathology, Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, Faculty of Medicine, Toronto, Ontario, Canada
    Endocr Pathol 15:29-38. 2004
    ..It is suggested that the oncocytic cells play a role in prostaglandin metabolism within the parathyroids and may have a role in the regulation of PTH secretion...
  38. ncbi request reprint Immunohistochemical expression of nestin in the non-tumorous hypophysis and in pituitary neoplasms
    Fabio Rotondo
    Department of Laboratory Medicine, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada, M5B 1W8
    Acta Neuropathol 111:272-7. 2006
    ..The patchy expression of nestin in endothelial cells remains unexplained and its significance requires further studies...
  39. doi request reprint Pituitary adenoma with peliosis: a report of two cases
    Safraz Mohammed
    Division of Neurosurgery, St Michael s Hospital, Toronto, ON, Canada M5C 3G7
    Endocr Pathol 20:41-5. 2009
    ..In the tumor, peliosis was noted. Peliosis in a pituitary adenoma is an intriguing finding. The question arises whether it represents vasculogenic mimicry...
  40. doi request reprint Immunohistochemical expression of SNAP-25 protein in adenomas of the human pituitary
    Fabio Rotondo
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Appl Immunohistochem Mol Morphol 16:477-81. 2008
    ..It is conceivable that SNAP-25 plays an important role in PRL release and is involved in the bromocriptine-induced suppression of PRL secretion from PRL-producing adenoma cells...
  41. doi request reprint Rab3B immunoexpression in human pituitary adenomas
    Fabio Rotondo
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Appl Immunohistochem Mol Morphol 17:185-8. 2009
    ..Immunopositivity was cytoplasmic and was evenly distributed. No staining was noted in normal adenohypophyses. Our results add new information to the view that Rab3B is involved in the regulation of pituitary hormone secretion...
  42. doi request reprint Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction
    Fateme Salehi
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Neurosurg 108:118-23. 2008
    ..The aim of this work was to investigate the immunohistochemical expression of nestin, a member of the intermediate filament family, in adenohypophysial vasculature during development and progression of pituitary infarction...
  43. ncbi request reprint Malignant paraganglioma of the urinary bladder: Immunohistochemical study of prognostic indicators
    Kalman Kovacs
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 16:363-9. 2005
    ..Abnormalities in vascular architecture and marked expression of VEGF in the tumor cells may be regarded as prognostic signs to predict the formation of metastases...
  44. ncbi request reprint Expression of caveolin-1 and caveolin-2 in the human pituitary: an immunohistochemical study
    Fabio Rotondo
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Endocr Pathol 15:345-50. 2004
    ..Not every endothelial cell was immunoreactive for the two caveolins, suggesting that the functional status of endothelial cells is not the same within the adenomas, not even in the same capillary...
  45. ncbi request reprint Cyclooxygenase-2 expression in human pituitary tumors
    Sergio Vidal
    Department of Laboratory Medicine and Pathobiology, St Michaels Hospital, University of Toronto, Ontario, Canada
    Cancer 97:2814-21. 2003
    ..Cyclooxygenase-2 (COX-2) plays a role in progression of colon, breast, pancreas, and lung carcinomas. The authors investigated COX-2 expression in pituitary tumors...
  46. pmc Adenohypophysitis in rat pituitary allografts
    Fabio Rotondo
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Exp Pathol 91:445-50. 2010
    ....
  47. doi request reprint Rosai-Dorfman disease involving the neurohypophysis
    Fabio Rotondo
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Pituitary 13:256-9. 2010
    ..Extranodal lesions with or without nodal involvement also occur. We report the case of a 63 year-old woman with disseminated Rosai-Dorfman disease involving the neurohypophysis and associated with adenohypophysial PRL cell hyperplasia...
  48. doi request reprint O-methylguanine-DNA methyltransferase immunoexpression in a double pituitary adenoma: case report
    Safraz Mohammed
    Division of Neurosurgery, St Michael s Hospital, and Department of Surgery, University of Toronto, Toronto, Canada
    Neurosurgery 66:E421-2; discussion E422. 2010
    ..The incidence in published surgical specimens ranges from 0.4% to 1.3%. We present a treatment dilemma of a double adenoma that had differential O-methylguanine-DNA methyltransferase (MGMT) reactivity...
  49. doi request reprint Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes
    Fateme Salehi
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Surg Pathol 18:5-13. 2010
    ..We investigated the correlation between immunohistochemical expression of the pituitary tumor transforming gene (PTTG) and pituitary adenoma subtype...
  50. ncbi request reprint Role of transcription factors in the pathogenesis of pituitary adenomas: a review
    A Suhardja
    Division of Neurosurgery, St. Michael's Hospital, Toronto, Ontario, Canada
    J Neurooncol 55:185-93. 2001
    ....
  51. ncbi request reprint Histologic, immunohistochemical, and ultrastructural findings in a case of minocycline-associated "black thyroid"
    C D Bell
    Division of Anatomical Pathology, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Endocr Pathol 12:443-51. 2001
    ..This appears to be the only case of minocyclin-associated "black thyroid" in which extensive immunohistochemical investigations have been performed...
  52. ncbi request reprint An immunohistochemical survey of nine cases of medullary carcinoma of thyroid including reactivity for Cox-1 and Cox-2 enzymes
    C David Bell
    Division of Pathology, Department of Laboratory Medicine and Pathobiology St Michael s Hospital, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 13:331-40. 2002
    ..A practical application of the preceding finding might involve the use of Cox staining to distinguish invasive medullary carcinoma cells from hyperplastic C-cells...
  53. ncbi request reprint Folliculo-stellate cells of the human pituitary: a type of adult stem cell?
    Eva Horvath
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Ultrastruct Pathol 26:219-28. 2002
    ..5) Considering the multifaceted nature of FSC, it is suggested that they represent a type of pluripotent adult stem cell...
  54. ncbi request reprint Effects of medical therapy on pituitary tumors
    Kalman Kovacs
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ultrastruct Pathol 29:163-7. 2005
    ..Recently GH receptor blockers (pegvisomant) were introduced in the treatment of GH-producing pituitary adenomas. To the authors' knowledge the effect of these drugs on the morphology of pituitary tumors has not been revealed so far...
  55. doi request reprint Folliculo-stellate cells of the human pituitary as adult stem cells: examples of their neoplastic potential
    Eva Horvath
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ultrastruct Pathol 34:133-9. 2010
    ..The latter showed appreciable endocrine differentiation. The assumed parent cell is the folliculo-stellate cell as pluripotent adult stem cell...
  56. ncbi request reprint Angiogenesis and the growth potential of craniopharyngiomas
    Sergio Vidal
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 16:219-28. 2005
    ..More studies are needed to assess whether integrin alphavbeta3 antagonists or drugs that arrest the cell cycle of endothelial cells can inhibit angiogenesis in craniopharyngiomas...
  57. doi request reprint Use of temozolomide in aggressive pituitary tumors: case report
    Safraz Mohammed
    Division of Neurosurgery, St Michael s Hospital, Toronto, Canada
    Neurosurgery 64:E773-4; discussion E774. 2009
    ..Multiple surgical procedures (transsphenoidal, transcranial, or a combination of both) are the first line management, followed by radiotherapy and chemotherapy...
  58. ncbi request reprint Immunocytochemical localization of mast cells in lymphocytic hypophysitis
    Sergio Vidal
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Pathol 117:478-83. 2002
    ....
  59. ncbi request reprint Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia
    Sergio Vidal
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Endocr Pathol 13:157-65. 2002
    ..The fact that these two lesions were contiguous in the surgically removed material raises the possibility that hyperplasia can precede and transform into adenoma...
  60. ncbi request reprint Pathology of acromegaly
    Eva Horvath
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neuroendocrinology 83:161-5. 2006
    ..The medical therapy of acromegaly is reviewed briefly, including long-acting somatostatin analogs and pegvisomant, a GH receptor blocker...
  61. ncbi request reprint The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    Shelly Bhayana
    Department of Medicine, Mount Sinai Hospital, 600 University Avenue, Room 437, Toronto, Ontario, Canada M5G 1X5
    J Clin Endocrinol Metab 90:6290-5. 2005
    ..Persistently elevated GH and IGF-I levels are associated with increased mortality. Their response to somatostatin analogs (SSA) is variable...
  62. ncbi request reprint November 2001: 67-year-old man in coma requiring prolonged mechanical ventilation
    Mubarak Al-Gahtany
    University of Toronto Neuropathology, St Michael s Hospital, Ontario, Canada
    Brain Pathol 12:265-6, 269. 2002
    ..The lesions represent coagulative infarctions due to ischemia. The role of the respirator is believed to be buying time to allow the changes to develop...
  63. ncbi request reprint Humoral hypercalcemia of malignancy due to bipartite squamous cell/small cell carcinoma of the esophagus immunoreactive for parathyroid hormone related protein
    F Fereidooni
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Dis Esophagus 16:335-8. 2003
    ..The finding that in our case, the pleomorphic small cell component was PHRP immunopositive and the squamous cell component showed no immunoreactivity, is intriguing and remains unexplained...
  64. ncbi request reprint Johanson-Blizzard syndrome: autopsy findings with special emphasis on hypopituitarism and review of the literature
    William H Hoffman
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA, and Department of Pathology, St Michael s Hospital, Toronto, ON, Canada
    Pediatr Dev Pathol 10:55-60. 2007
    ..The microlobules were separated by loose fibrous tissue, and there was extensive periductal fibrosis. The spectrum of the pathognomic feature of congenital pancreatic exocrine insufficiency in JBS is discussed...
  65. ncbi request reprint Juxtaposition of an ectopic corticotroph adenoma of the sphenoid sinus with orthotopic intrasellar corticotroph hyperplasia in a patient with Cushing disease. Case report
    Mubarak Al-Gahtany
    Department of Neurosurgery, St Michael s Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 98:891-6. 2003
    ..A review of the literature and a discussion of possible causes of this unique association between the ectopic corticotroph adenoma and the pituitary hyperplasia are provided...
  66. doi request reprint Ki-67 in pituitary neoplasms: a review--part I
    Fateme Salehi
    Department of Neurosurgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neurosurgery 65:429-37; discussion 437. 2009
    ..Herein, we review the literature relating Ki-67 expression and various other clinicopathological parameters and conclude that uniform definitions and methods, as well as new markers, are key to improved treatment of pituitary tumors...
  67. ncbi request reprint Histologic study of the human pituitary gland in acute traumatic brain injury
    Fateme Salehi
    Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Brain Inj 21:651-6. 2007
    ..The causative mechanisms involved in its development are not clear. To the authors' knowledge, there have been no recent morphologic studies of the pituitary following TBI...
  68. ncbi request reprint Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: report of a case and review of the literature
    Luciana Parlea
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Hormones (Athens) 5:295-302. 2006
    ..the role of pregnancy in the aggressive behavior of this tumor is discussed along with a literature review...
  69. ncbi request reprint Plurihormonality in pituitary adenomas associated with acromegaly
    Fateme Salehi
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Canada
    Endocr Pathol 17:291-6. 2006
    ..The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated...
  70. doi request reprint A double pituitary adenoma presenting as a prolactin-secreting tumor with partial response to medical therapy. Case report
    Claire I Coire
    Department of Laboratory Medicine, Trillium Health Centre, Mississauga, ON, Canada
    Endocr Pathol 21:135-8. 2010
    ..The failure of tumor shrinkage can be attributed to the presence of a double adenoma, a previously unreported cause of failure of medical therapy in prolactinoma...
  71. doi request reprint Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report
    Olga Moshkin
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, ON, Canada M5B 1W
    Endocr Pathol 20:50-5. 2009
    ..Endocrine and neuroimaging as well as detailed immunohistochemical and ultrastructural studies were undertaken. The literature is also reviewed...
  72. ncbi request reprint Angiogenesis in patients with craniopharyngiomas: correlation with treatment and outcome
    Sergio Vidal
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 94:738-45. 2002
    ..To the authors' knowledge, angiogenesis for patients with craniopharyngiomas has not been examined to date...
  73. doi request reprint A short illustrated review of sellar region schwannomas
    Safraz Mohammed
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
    Acta Neurochir (Wien) 152:885-91. 2010
    ..ANALYSIS: The absence of Schwann cells in the central nervous system and the absence of neighboring cranial nerves in these two cases raise issues of the pathogenesis of these rare but curious lesions...
  74. doi request reprint Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update
    Fateme Salehi
    Department of Laboratory Medicine Neurosurgery, St Michael s Hospital, Toronto, Canada M5B 1W8
    Endocr Relat Cancer 15:721-43. 2008
    ..In addition, we discuss in vitro and in vivo therapeutic models targeting PTTG overexpression...
  75. doi request reprint Primary pituitary lymphoma: a histological, immunohistochemical, and ultrastructural study with literature review
    Olga Moshkin
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, M5B 1W8, Canada
    Endocr Pathol 20:46-9. 2009
    ..No systemic disease was found upon staging. Primary pituitary lymphoma is extremely rare. An accurate histologic diagnosis is key to successful treatment and a favorable prognosis. The literature is reviewed...
  76. ncbi request reprint Modulation of VEGF/Flk-1 receptor expression in the rat pituitary GH3 cell line by growth factors
    Matilde Lombardero
    Division of Pathology, Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Pituitary 9:137-43. 2006
    ..In summary, our findings show that VEGF/Flk-1 expression in pituitary cells may be altered by different growth factors. This may affect angiogenesis and the progression of pituitary tumors...
  77. ncbi request reprint Inflammatory pseudotumor of the pituitary: case report
    Mubarak Al-Shraim
    Division of Pathology, St Michael s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Surg Neurol 62:264-7; discussion 267. 2004
    ..Inflammatory pseudotumor of the pituitary is a very rare nonneoplastic lesion. We describe a case of a patient with past history of lymphocytic meningitis...
  78. ncbi request reprint Growth factors and cytokines in paragangliomas and pheochromocytomas, with special reference to sustentacular cells
    George Kontogeorgos
    Department of Laboratory Medicine and Pathology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 13:197-206. 2002
    ..The significance of these observations regarding paracrine activities of chief and sustentacular cells remains to be determined...
  79. ncbi request reprint Brown tumors of the skull base. Case report and review of the literature
    Mubarak Al-Gahtany
    Department of Neurosurgery, St Michael s Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 98:417-20. 2003
    ..The authors report a case of brown tumor of the ethmoidal sinus, documenting its clinical, neuroimaging, and pathological features with long-term follow-up results, and review previous reports on this disorder...
  80. ncbi request reprint Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis
    Soniya Sharma
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Anticancer Res 29:3759-68. 2009
    ....
  81. ncbi request reprint Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor
    Eleni Thodou
    Departments of Pathology, 1G Gennimatas General Hospital of Athens, KOFKA Building, 1st Floor, 154 Messogion Ave, 115 27, Athens, Greece
    Acta Neuropathol 108:115-20. 2004
    ..Our case is the first PRL-producing pituitary adenoma showing incomplete neuronal differentiation lacking mature ganglion cells...
  82. ncbi request reprint Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: report of a case unassociated with radiotherapy
    Mario Moro
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 15:149-58. 2004
    ..Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies...
  83. ncbi request reprint Pituitary adenoma with "honeycomb Golgi" appearance showing a phenotypic change at recurrence from clinically nonfunctioning to typical Cushing disease
    Toshiaki Sano
    Department of Pathology, University of Tokushima School of Medicine, Kuramoto Cho, Tokushima, Japan
    Endocr Pathol 13:125-30. 2002
    ..Study of transcription factors will be helpful to clarify whether adenomas with honeycomb Golgi represent exclusively gonadotroph adenomas...
  84. ncbi request reprint Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression
    Katharina H Ruebel
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Endocrine 29:435-44. 2006
    ..These results indicate that the LGALS3, hASH1, ID2, and TLE-4 genes may have important roles in the development of pituitary carcinomas...
  85. ncbi request reprint Pituitary corticotroph adenoma containing many apoptotic cells: a histologic, immunohistochemical, ultrastructural and molecular study
    Irene Messini
    Department of Pathology, G Gennimatas, Athens General Hospital, Greece
    Ultrastruct Pathol 26:27-32. 2002
    ....
  86. ncbi request reprint Analysis of epidermal growth factor receptor and activated epidermal growth factor receptor expression in pituitary adenomas and carcinomas
    Onder Onguru
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Mod Pathol 17:772-80. 2004
    ..These results indicate that activated epidermal growth factor receptor is expressed in pituitary adenomas and carcinomas. Higher levels in pituitary carcinomas suggest a role in pituitary tumor progression...
  87. ncbi request reprint Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas
    Onder Onguru
    Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey
    Endocr Pathol 15:17-27. 2004
    ..In summary, TBXAS appears to be one of the up-regulated downstream enzymes of Cox metabolism in pituitary tumors. Both Cox-2 and TBXAS may play an important role in pituitary tumor development and progression...
  88. ncbi request reprint Effect of gamma knife radiosurgery on a pituitary gonadotroph adenoma: a histologic, immunohistochemical and electron microscopic study
    Shozo Yamada
    Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan
    Pituitary 6:53-8. 2003
    ..It can be concluded that gamma knife surgery caused severe alterations in pituitary adenoma microcirculation indicating that vascular injury plays a crucial role in tumor shrinkage...
  89. ncbi request reprint Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior
    Sergio Vidal
    Department of Anatomy, Laboratory of Histology, University of Santiago de Compostela Lugo, Spain
    Mod Pathol 15:1205-12. 2002
    ....
  90. ncbi request reprint 'Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells?
    Federico Roncaroli
    Department of Oncology, Bellaria Hospital, University of Bologna, Italy
    Am J Surg Pathol 26:1048-55. 2002
    ..The histologic, immunohistochemical, and fine structural features of these tumors were unlike those of pituitary adenoma or any other primary sellar tumor. A derivation from adenohypophyseal folliculostellate cells is suggested...
  91. ncbi request reprint Pathology of pituitary tumors
    Naoko Sanno
    Department of Neurosurgery, Nippon Medical School, 1 7 1 Nagayama, Tama, Tokyo 206 8512, Japan
    Neurosurg Clin N Am 14:25-39, vi. 2003
    ..In the second part, the classification of pituitary tumors is discussed, followed by the immunohistochemical and electron microscopic findings of pituitary adenomas and pituitary carcinomas...
  92. ncbi request reprint Effects of DNA methylation on galectin-3 expression in pituitary tumors
    Katharina H Ruebel
    Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Cancer Res 65:1136-40. 2005
    ..Because it is functionally involved in cancer progression and metastasis, Gal-3 may serve as a possible therapeutic target in the treatment of pituitary tumors...
  93. ncbi request reprint Prognostic indicators in pituitary tumors
    Agustinus Suhardja
    Department of Radiology, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Endocr Pathol 16:1-9. 2005
    ..We predict that the immunohistochemical methods now in use for assessment of tumor behavior will be complemented and partly replaced by molecular genetic procedures in the future...
  94. ncbi request reprint Salivary gland-like tumor of the sella
    Wouter van Furth
    Can J Neurol Sci 34:478-82. 2007
  95. ncbi request reprint Antitumour effects of temozolomide in a man with a large, invasive prolactin-producing pituitary neoplasm
    Luis V Syro
    Clin Endocrinol (Oxf) 65:552-3. 2006
  96. ncbi request reprint Pituitary tumor transforming gene overexpression facilitates pituitary tumor development
    Ines Donangelo
    Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    Endocrinology 147:4781-91. 2006
    ....
  97. ncbi request reprint Morphologic changes of prolactin-producing pituitary adenomas after short treatment with dopamine agonists
    George Kontogeorgos
    Department of Pathology, G Gennimatas Athens General Hospital, KOFKA Bldg, 1st Floor, 154 Messogion Avenue, 115 27, Athens, Greece
    Acta Neuropathol 111:46-52. 2006
    ..These novel findings represent characteristic features of short-term dopamine agonist treatment, which are not seen in long-term treatment...
  98. doi request reprint Effects of TGFbeta1 on gene expression in the HP75 human pituitary tumor cell line identified by gene expression profiling
    Katharina H Ruebel
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA
    Endocrine 33:62-76. 2008
    ..These findings highlight the diverse gene networks and pathways through which TGFbeta operates in its effects on pituitary tumor cells...
  99. ncbi request reprint The spectrum of malignancy in craniopharyngioma
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 31:1020-8. 2007
    ..De novo malignancy in odontogenic tumors of the sella is even more unusual, but also has an ominous prognosis...
  100. ncbi request reprint Galectin-3 Expression in Functioning and Silent ACTH-Producing Adenomas
    Long Jin
    Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Endocr Pathol 16:107-14. 2005
    ..The use of ACTH and Gal-3 immunostaining should help in the diagnosis of silent ACTH adenomas...
  101. ncbi request reprint Pituitary adenoma with tumoral granulomatous reaction
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocr Pathol 18:86-90. 2007
    ..Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction...