G M T Hare

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Tolerance of anemia: understanding the adaptive physiological mechanisms which promote survival
    Gregory M T Hare
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada Electronic address
    Transfus Apher Sci 50:10-2. 2014
  2. doi request reprint Anemia and cerebral outcomes: many questions, fewer answers
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Anesth Analg 107:1356-70. 2008
  3. ncbi request reprint Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    J Appl Physiol (1985) 103:1021-9. 2007
  4. ncbi request reprint Beta2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats
    G M T Hare
    Department of Anaesthesia and the Cara Phelan Centre for Trauma Research, University of Toronto, St Michael s Hospital 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Br J Anaesth 97:617-23. 2006
  5. ncbi request reprint Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:1061-8. 2003
  6. doi request reprint Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation
    A Rigamonti
    Department of Anaesthesia, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Br J Anaesth 100:357-64. 2008
  7. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
  8. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
  9. ncbi request reprint Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats
    Anya T McLaren
    Department of Anesthesia, Cara Phelan Trauma Research Centre, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R403-14. 2007
  10. ncbi request reprint Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression
    Gregory M T Hare
    Department of Anaesthesia, University of Toronto, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Appl Physiol (1985) 94:2058-67. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Tolerance of anemia: understanding the adaptive physiological mechanisms which promote survival
    Gregory M T Hare
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada Electronic address
    Transfus Apher Sci 50:10-2. 2014
    ..We continue to explore the possibility that methemoglobin, and other hypoxic signaling molecules, may be biomarkers of anemia induced tissue hypoxia which can be used to guide optimal treatment of anemic patents. ..
  2. doi request reprint Anemia and cerebral outcomes: many questions, fewer answers
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Anesth Analg 107:1356-70. 2008
    ..A clearer understanding of these mechanisms may help us target therapies that will minimize anemia-induced cerebral injury in perioperative patients...
  3. ncbi request reprint Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    J Appl Physiol (1985) 103:1021-9. 2007
    ..05 for both). Hemodilutional anemia reduced cerebral Pbr(O(2)) and oxygen extraction and increased cell death following TBI. These results support our hypothesis that acute anemia accentuated hypoxic cerebral injury after neurotrauma...
  4. ncbi request reprint Beta2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats
    G M T Hare
    Department of Anaesthesia and the Cara Phelan Centre for Trauma Research, University of Toronto, St Michael s Hospital 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Br J Anaesth 97:617-23. 2006
    ..This study tests the hypothesis that inhibition of cerebral vasodilatation by systemic beta2 adrenergic blockade would impair cerebral oxygen delivery leading to tissue hypoxia in severely haemodiluted rats...
  5. ncbi request reprint Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:1061-8. 2003
    ..To test the hypotheses that deliberate elevation of PaCO(2) increases cerebral tissue oxygen tension (PBrO(2)) by augmenting PaO(2) and regional cerebral blood flow (rCBF)...
  6. doi request reprint Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation
    A Rigamonti
    Department of Anaesthesia, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Br J Anaesth 100:357-64. 2008
    ..Some studies demonstrate reduced microvascular oxygen delivery, whereas others do not. We hypothesize that storage of rat blood will limit its ability to deliver oxygen to cerebral tissue...
  7. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
    ..These data suggest that transfusion with hemoglobin raffimer may help to maintain cerebral oxygenation during severe anemia...
  8. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
    ..To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101)...
  9. ncbi request reprint Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats
    Anya T McLaren
    Department of Anesthesia, Cara Phelan Trauma Research Centre, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R403-14. 2007
    ..nNOS and VEGF protein levels were also increased within the cerebral cortex of anemic rats at clinically relevant hemoglobin concentrations...
  10. ncbi request reprint Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression
    Gregory M T Hare
    Department of Anaesthesia, University of Toronto, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Appl Physiol (1985) 94:2058-67. 2003
    ..Hemodilutional anemia caused an acute reduction in Pbr(O(2)) and an increase in cerebral cortical nNOS mRNA, supporting a role for nNOS in the physiological response to acute anemia...
  11. ncbi request reprint Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat
    C David Mazer
    Department of Anesthesia, University of Toronto, St Michael s Hospital, Seneca College, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:13-20. 2007
    ..This study tested the hypothesis that cardiopulmonary bypass and anemia stimulate an increase in cerebral and renal endothelial nitric oxide synthase gene expression in an experimental model of cardiopulmonary bypass...
  12. ncbi request reprint Successful treatment using recombinant factor VIIa for severe bleeding post cardiopulmonary bypass
    Viren N Naik
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:599-602. 2003
    ..To describe a case of persistent and excessive bleeding following an aortic valve and ascending aorta replacement that was successfully managed with recombinant factor VIIa (rFVIIa). The postulated mechanisms for rFVIIa are discussed...
  13. pmc Open tracheostomy in a suspect severe acute respiratory syndrome (SARS) patient: brief technical communication
    Najma Ahmed
    Critical Care Department, St Michael s Hospital, University of Toronto, Toronto, Ont
    Can J Surg 48:68-71. 2005
  14. ncbi request reprint Body mass index as a risk factor for increased serum lactate during craniotomy
    M Garavaglia
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Minerva Anestesiol 79:1132-9. 2013
    ..010). Serum CK was increased at 12 hours (P<0.05) and reached a peak level greater than 1000 U/L in 8 of 18 patients. Six of these patients experienced myoglobinuria. No other parameters correlated with increased lactate...
  15. doi request reprint Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle
    Albert K Y Tsui
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, ON, Canada
    Can J Anaesth 57:779-91. 2010
    ....
  16. ncbi request reprint A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution
    Anya T McLaren
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 56:502-9. 2009
    ..This study assessed the effects of acute hemodilution on inducible NOS (iNOS) and systemic inflammatory cytokines...
  17. ncbi request reprint Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats
    Gregory M T Hare
    Department of Anesthesia, St Michael s Hospital, Canada
    Can J Anaesth 53:1030-8. 2006
    ....
  18. doi request reprint Cerebral cortical gene expression in acutely anemic rats: a microarray analysis
    Francoise Briet
    Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:921-34. 2009
    ..This study assesses whether hemodilutional anemia up-regulated inflammatory cerebral gene expression (microarray) to help define the mechanism...
  19. doi request reprint Anemia increases the risk of renal cortical and medullary hypoxia during cardiopulmonary bypass
    P J Darby
    1Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Perfusion 28:504-11. 2013
    ..The objective of this study was to investigate the effects of CPB and anemia on tissue oxygen tension (pO2) and blood flow in the renal cortex and medulla...
  20. doi request reprint Quantitative assessment of brain microvascular and tissue oxygenation during cardiac arrest and resuscitation in pigs
    J Yu
    Departments of Anaesthesia and Physiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Anaesthesia 68:723-35. 2013
    ....
  21. doi request reprint Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats
    Tenille E Ragoonanan
    Department of Anesthesia, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 111:988-1000. 2009
    ..This study investigated the effect of beta-blockade on cerebral tissue oxygen delivery in an experimental model of blood loss and fluid resuscitation (hemodilution)...
  22. doi request reprint Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study
    W Scott Beattie
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:25-33. 2010
    ....
  23. ncbi request reprint Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury
    A Singhal
    Department of Anaesthesia, University of Toronto, Toronto, Canada
    J Neurotrauma 19:929-37. 2002
    ..This finding helps to characterize the inflammatory reaction associated with TBI and may help to develop improved treatment strategies for patients with TBI...
  24. ncbi request reprint Nitroglycerin and cerebral oxygen saturation
    Gregory M T Hare
    Can J Anaesth 55:52-3; author reply 53. 2008
  25. ncbi request reprint Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury
    Lauralyn A McIntyre
    Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
    Neurocrit Care 5:4-9. 2006
    ..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)...