S G Goodman

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint PROTECT (Prospective Reinfarction Outcomes in the Thrombolytic Era Cardizem CD Trial): a randomized, double-blind clinical trial of diltiazem versus atenolol in secondary prophylaxis post non-Q wave myocardial infarction
    S Goodman
    St Michael s Hospital Clinical Trials Unit, University of Toronto, Ontario
    Can J Cardiol 12:1183-90. 1996
  2. ncbi request reprint The greatest benefit of enoxaparin over unfractionated heparin in acute coronary syndromes is achieved in patients presenting with ST-segment changes: the Enoxaparin in Non-Q-Wave Coronary Events (ESSENCE) Electrocardiogram Core Laboratory Substudy
    Shaun G Goodman
    Division of Cardiology, Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:791-7. 2006
  3. ncbi request reprint The diagnostic and prognostic impact of the redefinition of acute myocardial infarction: lessons from the Global Registry of Acute Coronary Events (GRACE)
    Shaun G Goodman
    Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:654-60. 2006
  4. ncbi request reprint Enoxaparin and glycoprotein IIb/IIIa inhibition in non-ST-elevation acute coronary syndrome: insights from the INTERACT trial
    Shaun Goodman
    St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 149:S73-80. 2005
  5. ncbi request reprint The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: the GUSTO-IIb ECG Core Laboratory experience
    Shaun G Goodman
    The Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Am Heart J 152:277-84. 2006
  6. ncbi request reprint Acute ST-segment elevation myocardial infarction: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Shaun G Goodman
    St Michael s Hospital, Division of Cardiology, 30 Bond Street, Queen, Toronto, Ontario, Canada
    Chest 133:708S-775S. 2008
  7. doi request reprint The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, Room 6 034 Queen, Toronto, Ontario M5B 1W8, Canada
    Am Heart J 158:193-201.e1-5. 2009
  8. ncbi request reprint Drip-and-ship for acute ST-segment myocardial infarction: the pharmacoinvasive strategy for patients treated with fibrinolytic therapy
    Shaun G Goodman
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    Pol Arch Med Wewn 119:726-30. 2009
  9. pmc Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS)
    Shaun G Goodman
    St Michael s Hospital and University of Toronto, Toronto, Ontario
    Can J Cardiol 26:e330-5. 2010
  10. ncbi request reprint Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Circulation 107:238-44. 2003

Detail Information

Publications72

  1. ncbi request reprint PROTECT (Prospective Reinfarction Outcomes in the Thrombolytic Era Cardizem CD Trial): a randomized, double-blind clinical trial of diltiazem versus atenolol in secondary prophylaxis post non-Q wave myocardial infarction
    S Goodman
    St Michael s Hospital Clinical Trials Unit, University of Toronto, Ontario
    Can J Cardiol 12:1183-90. 1996
    ..To describe the rationale and design of the Prospective Reinfarction Outcomes in the Thrombolytic Era Cardizem CD Trial (PROTECT)...
  2. ncbi request reprint The greatest benefit of enoxaparin over unfractionated heparin in acute coronary syndromes is achieved in patients presenting with ST-segment changes: the Enoxaparin in Non-Q-Wave Coronary Events (ESSENCE) Electrocardiogram Core Laboratory Substudy
    Shaun G Goodman
    Division of Cardiology, Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:791-7. 2006
    ....
  3. ncbi request reprint The diagnostic and prognostic impact of the redefinition of acute myocardial infarction: lessons from the Global Registry of Acute Coronary Events (GRACE)
    Shaun G Goodman
    Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:654-60. 2006
    ..The impact and prognostic value of the redefinition of myocardial infarction (MI) with more sensitive markers have not been evaluated prospectively in a large, less selected population with acute coronary syndrome (ACS)...
  4. ncbi request reprint Enoxaparin and glycoprotein IIb/IIIa inhibition in non-ST-elevation acute coronary syndrome: insights from the INTERACT trial
    Shaun Goodman
    St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 149:S73-80. 2005
    ....
  5. ncbi request reprint The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: the GUSTO-IIb ECG Core Laboratory experience
    Shaun G Goodman
    The Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Am Heart J 152:277-84. 2006
    ....
  6. ncbi request reprint Acute ST-segment elevation myocardial infarction: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Shaun G Goodman
    St Michael s Hospital, Division of Cardiology, 30 Bond Street, Queen, Toronto, Ontario, Canada
    Chest 133:708S-775S. 2008
    ....
  7. doi request reprint The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, Room 6 034 Queen, Toronto, Ontario M5B 1W8, Canada
    Am Heart J 158:193-201.e1-5. 2009
    ..Expanded GRACE aims to test the feasibility of a simplified data collection tool and provision of quarterly feedback to index individual hospital management practices to an international reference cohort...
  8. ncbi request reprint Drip-and-ship for acute ST-segment myocardial infarction: the pharmacoinvasive strategy for patients treated with fibrinolytic therapy
    Shaun G Goodman
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    Pol Arch Med Wewn 119:726-30. 2009
    ....
  9. pmc Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS)
    Shaun G Goodman
    St Michael s Hospital and University of Toronto, Toronto, Ontario
    Can J Cardiol 26:e330-5. 2010
    ..Despite clear guideline recommendations, there is a growing body of evidence that there is suboptimal use of lipid-lowering treatment in Canadians...
  10. ncbi request reprint Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Circulation 107:238-44. 2003
    ..A key issue of uncertainty is the safety and efficacy of combination glycoprotein IIb/IIIa inhibitor and low-molecular-weight heparin therapy...
  11. ncbi request reprint Non-Q-wave versus Q-wave myocardial infarction after thrombolytic therapy: angiographic and prognostic insights from the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries-I angiographic substudy. GUSTO-I A
    S G Goodman
    The Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Circulation 97:444-50. 1998
    ....
  12. ncbi request reprint Development and prognosis of non-Q-wave myocardial infarction in the thrombolytic era
    Shaun G Goodman
    Division of Cardiology, Canadian Heart Research Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 144:243-50. 2002
    ..Data on non-Q myocardial infarctions (MI) are derived primarily from prethrombolytic era studies. Previous trials demonstrated different development rates and none reported on clinical outcomes...
  13. ncbi request reprint Randomized trial of low molecular weight heparin (enoxaparin) versus unfractionated heparin for unstable coronary artery disease: one-year results of the ESSENCE Study. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events
    S G Goodman
    Canadian Heart Research Center, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Am Coll Cardiol 36:693-8. 2000
    ....
  14. ncbi request reprint Low molecular weight heparin decreases rebound ischemia in unstable angina or non-Q-wave myocardial infarction: the Canadian ESSENCE ST segment monitoring substudy
    S G Goodman
    Canadian Heart Research Center, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario
    J Am Coll Cardiol 36:1507-13. 2000
    ..The goal of this study was to determine whether enoxaparin was more effective than heparin in reducing recurrent ischemic episodes...
  15. pmc Temporal trends in the use of invasive cardiac procedures for non-ST segment elevation acute coronary syndromes according to initial risk stratification
    S Jedrzkiewicz
    Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, USA
    Can J Cardiol 25:e370-6. 2009
    ..Although studies in the 1990s suggested that highrisk patients received less aggressive treatment, there are limited data on the contemporary management patterns of NSTE-ACS in Canada...
  16. ncbi request reprint Prognostic value of dipyridamole SPECT imaging in low-risk patients after myocardial infarction
    V Chiamvimonvat
    Division of Cardiology, Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
    J Nucl Cardiol 8:136-43. 2001
    ..The extent of scintigraphic reversibility was directly correlated with clinical events. Therefore scintigraphic imaging remains clinically relevant for risk stratification in the current low-risk population after MI...
  17. ncbi request reprint A comparison of the assessment and management of cardiometabolic risk in patients with and without type 2 diabetes mellitus in Canadian primary care
    H Teoh
    Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 15:1093-100. 2013
    ..To investigate the cardiometabolic risk (CMR) assessment and management patterns for individuals with and without type 2 diabetes mellitus (T2DM) in Canadian primary care practices...
  18. ncbi request reprint Rationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Ontario, Canada
    Am Heart J 155:19-25. 2008
    ..The role of routine early PCI after fibrinolysis, using stents and contemporary pharmacotherapy, has not been studied in a large adequately powered randomized trial...
  19. ncbi request reprint Efficacy and safety of the low-molecular weight heparin enoxaparin compared with unfractionated heparin across the acute coronary syndrome spectrum: a meta-analysis
    Sabina A Murphy
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 350 Longwood Avenue, First Floor, Boston, MA 02115, USA
    Eur Heart J 28:2077-86. 2007
    ....
  20. ncbi request reprint Comparison of effectiveness of enoxaparin versus unfractionated heparin to reduce silent and clinically apparent acute myocardial infarction in patients presenting with non-ST-segment elevation acute coronary syndrome
    Sanjit Jolly
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 99:186-8. 2007
    ..7% vs 35.9%, p = 0.03). In conclusion, enoxaparin significantly decreased the composite of silent AMI or clinical AMI and death at 1 year (9.3% vs 21%, p = 0.0001)...
  21. ncbi request reprint Use of proven therapies in non-ST-elevation acute coronary syndromes according to evidence-based risk stratification
    Gustavo B F Oliveira
    Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil
    Am Heart J 153:493-9. 2007
    ..Our objective was to evaluate the relationship between risk stratification and therapeutic decision making in patients with non-ST-segment elevation acute coronary syndromes...
  22. ncbi request reprint Long-term prognostic value and therapeutic implications of continuous ST-segment monitoring in acute coronary syndrome
    Andrew T Yan
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 153:500-6. 2007
    ....
  23. ncbi request reprint Relationship of ST elevation in lead aVR with angiographic findings and outcome in non-ST elevation acute coronary syndromes
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, and Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am Heart J 154:71-8. 2007
    ..Limited data suggest that ST elevation (ST elevation) in aVR is associated with higher mortality and more extensive coronary artery disease in the setting of non-ST elevation acute coronary syndromes (ACS)...
  24. ncbi request reprint Treatment and outcomes of patients with evolving myocardial infarction: experiences from the SYNERGY trial
    Chadwick D Miller
    Department of Emergency Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Eur Heart J 28:1079-84. 2007
    ..We compared the initial treatment and clinical outcomes of patients presenting with evolving MI (EMI) with those presenting with MI...
  25. ncbi request reprint Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent?
    Michael C Nguyen
    Centre for Cardiovascular Therapeutics, Western Hospital, Melbourne, Australia
    Eur Heart J 28:1717-22. 2007
    ..dual antiplatelet therapy plus warfarin leads to an excess of adverse outcomes...
  26. ncbi request reprint Interactions between heparins, glycoprotein IIb/IIIa antagonists, and coronary intervention. The Global Registry of Acute Coronary Events (GRACE)
    David Brieger
    Concord Hospital, Sydney, Australia
    Am Heart J 153:960-9. 2007
    ....
  27. ncbi request reprint Management patterns in relation to risk stratification among patients with non-ST elevation acute coronary syndromes
    Andrew T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8
    Arch Intern Med 167:1009-16. 2007
    ..We examined the use of in-hospital cardiac catheterization and medications in relation to risk across the broad spectrum of non-ST elevation ACSs...
  28. ncbi request reprint Comparison of utilization of statin therapy at hospital discharge and six-month outcomes in patients with an acute coronary syndrome and serum low-density lipoprotein>or=100 mg/dl versus<100 mg/dl
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada, and Coronary Care Unit, Concord Hospital, Sydney, Australia
    Am J Cardiol 100:913-8. 2007
    ....
  29. pmc Paradoxical use of invasive cardiac procedures for patients with non-ST segment elevation myocardial infarction: an international perspective from the CRUSADE Initiative and the Canadian ACS Registries I and II
    Mohammad I Zia
    Canadian Heart Research Centre, Toronto, Canada
    Can J Cardiol 23:1073-9. 2007
    ..Practice guidelines support an early invasive strategy in patients with non-ST segment elevation acute coronary syndromes, particularly in those at higher risk...
  30. ncbi request reprint Increasing use of single and combination medical therapy in patients hospitalized for acute myocardial infarction in the 21st century: a multinational perspective
    Robert J Goldberg
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, USA
    Arch Intern Med 167:1766-73. 2007
    ..Current practice guidelines recommend the routine use of several effective cardiac medications in hospital survivors of acute myocardial infarction (AMI)...
  31. doi request reprint Bleeding and outcome in acute coronary syndrome: insights from continuous electrocardiogram monitoring in the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:769-75. 2008
    ..We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their independent long-term prognostic significance...
  32. doi request reprint Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial I
    Stephen D Wiviott
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 118:1626-36. 2008
    ..We compared prasugrel with clopidogrel among subjects with DM in TRITON-TIMI 38...
  33. doi request reprint Smoking status and antithrombin therapy in patients with non-ST-segment elevation acute coronary syndrome
    Steve Leung
    University of Kentucky, Lexington, KY, USA
    Am Heart J 156:177-84. 2008
    ..Smoking remains a major public health issue. We investigated the incidence of smoking and outcomes in high-risk patients with acute coronary syndromes. Differences in treatment effect of antithrombin therapies were also investigated...
  34. ncbi request reprint Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Robert A Harrington
    Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Chest 133:670S-707S. 2008
    ..In low- to moderate-risk patients with NSTE ACS undergoing PCI, we recommend either bivalirudin with provisional ("bail-out") GP IIb/IIIa inhibitors or UFH plus a GP IIb/IIIa inhibitor over alternative antithrombotic regimens (Grade 1B)...
  35. doi request reprint Quantitative troponin elevation does not provide incremental prognostic value beyond comprehensive risk stratification in patients with non-ST-segment elevation acute coronary syndromes
    Ki Dong Lim
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 155:718-24. 2008
    ....
  36. doi request reprint Adverse outcomes in fibrinolytic-based facilitated percutaneous coronary intervention: insights from the ASSENT-4 PCI electrocardiographic substudy
    Michael A McDonald
    Division of Cardiology, University of Alberta, 251 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Eur Heart J 29:871-9. 2008
    ..Patients in ASSENT-4 PCI undergoing tenecteplase-facilitated percutaneous coronary intervention (PCI) had more adverse events than those undergoing primary PCI. We analysed this to gain further insights...
  37. pmc Prediction of one-year survival in high-risk patients with acute coronary syndromes: results from the SYNERGY trial
    Kenneth W Mahaffey
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Gen Intern Med 23:310-6. 2008
    ..Despite advances in pharmacologic therapy and invasive management strategies for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), these patients still suffer substantial morbidity and mortality...
  38. ncbi request reprint Optimal medical therapy at discharge in patients with acute coronary syndromes: temporal changes, characteristics, and 1-year outcome
    Andrew T Yan
    Division of Cardiology, Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 154:1108-15. 2007
    ....
  39. ncbi request reprint Time to coronary angiography and outcomes among patients with high-risk non ST-segment elevation acute coronary syndromes: results from the SYNERGY trial
    Pierluigi Tricoci
    Duke Clinical Research Institute, 2400 Pratt St, Room 0311 Terrace Level, Durham, NC 27705, USA
    Circulation 116:2669-77. 2007
    ..We evaluated the relationship between time from hospital admission to coronary angiography and outcomes in high-risk patients with non-ST-segment-elevation acute coronary syndrome who underwent angiography within 48 hours of admission...
  40. ncbi request reprint Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction?
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences, 1200 Main St W, Hamilton, Canada, L8N 3Z5
    Circulation 116:2793-801. 2007
    ..Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world" setting...
  41. ncbi request reprint Bedtime administration of graded-release diltiazem in patients with inadequate BP control: a tolerability and efficacy study
    David H Fitchett
    Canadian Heart Research Centre, Toronto, Ontario, Canada
    Am J Cardiovasc Drugs 6:393-400. 2006
    ..The long duration between administration of the last bedtime dose of antihypertensive medication and the physiologic early morning surge in BP makes it difficult to achieve satisfactory BP control...
  42. ncbi request reprint Bleeding complications in patients with acute coronary syndrome undergoing early invasive management can be reduced with radial access, smaller sheath sizes, and timely sheath removal
    Warren J Cantor
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 69:73-83. 2007
    ..Our objective was to analyze the impact of arterial access site, sheath size, timing of sheath removal, and use of access site closure devices on high-risk patients with acute coronary syndromes (ACS)...
  43. pmc Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility study
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Canada
    Can J Cardiol 22:1121-6. 2006
    ..Urgent PCI after thrombolysis may optimize reperfusion and prevent reinfarction and recurrent ischemia...
  44. ncbi request reprint Coordinated series of studies to evaluate characteristics and mechanisms of acute coronary syndromes in high-risk patients randomly assigned to enoxaparin or unfractionated heparin: design and rationale of the SYNERGY Library
    John L Petersen
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 148:269-76. 2004
    ..It is hoped that the SYNERGY Library will serve as a model for future substudy design to maximize academic insight within the framework of a large-scale, multicenter trial...
  45. ncbi request reprint Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview
    John L Petersen
    Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 292:89-96. 2004
    ....
  46. ncbi request reprint Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study
    Kim A Eagle
    University of Michigan Cardiovascular Center, Ann Arbor, Michigan, USA
    Am J Med 117:73-81. 2004
    ..To determine the rates of patient adherence to key evidence-based therapies at 6 months after hospital discharge for an acute coronary syndrome...
  47. ncbi request reprint Aborted myocardial infarction in patients with ST-segment elevation: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen-3 Trial Electrocardiographic Substudy
    Taha Taher
    University of Alberta, Edmonton, Alberta, Canada
    J Am Coll Cardiol 44:38-43. 2004
    ....
  48. ncbi request reprint One-year outcome of patients after acute coronary syndromes (from the Canadian Acute Coronary Syndromes Registry)
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am J Cardiol 94:25-9. 2004
    ..Moreover, there was a significant opportunity to enhance the discharge and long-term use of evidence-based secondary prevention therapies...
  49. ncbi request reprint Low-molecular-weight heparins in ischemic heart disease
    Andrew T Yan
    Canadian Heart Research Centre, Toronto, Ontario, Canada
    Curr Opin Cardiol 19:309-16. 2004
    ..The objective of this review was to summarize the recent developments regarding the use of low-molecular-weight heparins in the management of acute coronary syndromes...
  50. ncbi request reprint A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry
    Kim A Eagle
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA
    JAMA 291:2727-33. 2004
    ..Accurate estimation of risk for untoward outcomes after patients have been hospitalized for an acute coronary syndrome (ACS) may help clinicians guide the type and intensity of therapy...
  51. ncbi request reprint Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE)
    Mark I Furman
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 147:42-8. 2004
    ..To examine the association between elevated leukocyte count and hospital mortality and heart failure in patients enrolled in the multinational, observational Global Registry of Acute Coronary Events (GRACE)...
  52. ncbi request reprint Global patterns of use of antithrombotic and antiplatelet therapies in patients with acute coronary syndromes: insights from the Global Registry of Acute Coronary Events (GRACE)
    Andrzej Budaj
    Postgraduate Medical School, Grochowski Hospital Warsaw, Poland
    Am Heart J 146:999-1006. 2003
    ..The objective of this report was to describe patterns of use of antithrombotic and antiplatelet therapies in patients with the spectrum of ACS through the use of data from the Global Registry of Acute Coronary Events (GRACE)...
  53. ncbi request reprint ST segment resolution in ASSENT 3: insights into the role of three different treatment strategies for acute myocardial infarction
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    Eur Heart J 24:1515-22. 2003
    ..We compared ST resolution in each of the three treatment regimens in order to evaluate the speed, extent and stability of ST segment resolution and its relationship to the primary composite endpoint(s) of the trial...
  54. ncbi request reprint From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE)
    Keith A A Fox
    Department of Cardiology, The Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh EH3 9YW, Scotland, UK
    Eur Heart J 24:1414-24. 2003
    ..The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are modifiable, remain uncertain...
  55. ncbi request reprint Safety and efficacy of unfractionated heparin versus enoxaparin in patients who are obese and patients with severe renal impairment: analysis from the ESSENCE and TIMI 11B studies
    Sarah A Spinler
    Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
    Am Heart J 146:33-41. 2003
    ..However, no data are available about the safety and efficacy in patients who are obese and patients with severe renal impairment...
  56. ncbi request reprint The impact of gender on the treatment and outcomes of patients with early reinfarction after fibrinolysis: insights from ASSENT-2
    Michael C Tjandrawidjaja
    Department of Medicine, Division of Cardiology, 2 51 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada
    Eur Heart J 24:1024-34. 2003
    ..To assess gender differences in patients with early reinfarction after fibrinolysis for acute myocardial infarction (AMI) and the impact of these differences on treatment and outcomes...
  57. ncbi request reprint Clinical trial--derived risk model may not generalize to real-world patients with acute coronary syndrome
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:1020-7. 2004
    ..The purpose of this study was to validate and compare a modified international clinical trial and a registry-based risk model in a contemporary, less selected ACS population...
  58. ncbi request reprint Early cardiac catheterization is associated with lower mortality only among high-risk patients with ST- and non-ST-elevation acute coronary syndromes: observations from the OPUS-TIMI 16 trial
    Warren J Cantor
    Department of Medicine, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 149:275-83. 2005
    ..The benefit of catheterization in both syndromes may depend on patient risk for adverse clinical outcomes...
  59. ncbi request reprint Underuse of evidence-based treatment partly explains the worse clinical outcome in diabetic patients with acute coronary syndromes
    Raymond T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:676-83. 2006
    ..Diabetes-related differences in treatment and clinical outcome of patients across the entire spectrum of acute coronary syndromes (ACSs) have potential clinical implications but have not been well studied...
  60. pmc Lower is better: implications of the Treating to New Targets (TNT) study for Canadian patients
    David H Fitchett
    Division of Cardiology, St Michael s Hospital, Toronto, Ontario
    Can J Cardiol 22:835-9. 2006
    ..Furthermore, registry data show that one-half of these patients are not even achieving the current LDL-C target of 2.5 mmol/L. Causes of the care gap are discussed and possible remedies to achieve the new lower targets are suggested...
  61. ncbi request reprint Supporting a call to action for peripheral artery disease: insights from two prospective clinical registries
    Daniel G Hackam
    Canadian Heart Research Center, Toronto, Canada
    J Vasc Surg 44:776-81. 2006
    ....
  62. ncbi request reprint Prognostic significance of admission heart failure in patients with non-ST-elevation acute coronary syndromes (from the Canadian Acute Coronary Syndrome Registries)
    Amit Segev
    The Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 98:470-3. 2006
    ..In conclusion, in patients with NSTE-ACS, heart failure on admission is associated with increased short- and long-term rates of death and MI...
  63. ncbi request reprint ST-segment depression in non-ST elevation acute coronary syndromes: quantitative analysis may not provide incremental prognostic value beyond comprehensive risk stratification
    Andrew T Yan
    Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:270-6. 2006
    ..It is unclear whether quantitative ST-segment assessment can improve risk stratification of unselected acute coronary syndrome (ACS) patients using the validated Global Registry of Acute Cardiac Events (GRACE) risk model...
  64. ncbi request reprint The 12-lead electrocardiogram as a predictive tool of mortality after acute myocardial infarction: current status in an era of revascularization and reperfusion
    Mircea Petrina
    University of Michigan Medical Center, Ann Arbor, MI, USA
    Am Heart J 152:11-8. 2006
    ..8-4.3). In addition, our review discusses electrocardiographic markers of poor outcome that were not independent risk factors on multivariate analysis, conflicting findings, and knowledge gaps that can help plan future research efforts...
  65. ncbi request reprint Low-molecular-weight heparin compared with unfractionated heparin for patients with non-ST-segment elevation acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE initiative
    Kanwar P Singh
    Division of Cardiology and Duke Clinical Research Institute, Durham, NC 27705, USA
    J Thromb Thrombolysis 21:211-20. 2006
    ..We sought to compare the efficacy and safety of these treatment strategies in a large contemporary population of patients with NSTE ACS...
  66. ncbi request reprint Excess dosing of antithrombotic therapy in non-ST-segment elevation acute coronary syndromes
    Andrew T Yan
    JAMA 295:1896; author reply 1897. 2006
  67. ncbi request reprint Randomized evaluation of the efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Long-term results of the Integrilin
    David H Fitchett
    Canadian Heart Research Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:373-9. 2006
    ....
  68. ncbi request reprint Age-related differences in the management and outcome of patients with acute coronary syndromes
    Raymond T Yan
    Division of Cardiology, Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 151:352-9. 2006
    ..Age-related differences in patients with an acute coronary syndrome (ACS) have not been well characterized in prior observational studies that often included only certain age groups or subjects with myocardial infarction (MI)...
  69. ncbi request reprint High-risk patients with acute coronary syndromes treated with low-molecular-weight or unfractionated heparin: outcomes at 6 months and 1 year in the SYNERGY trial
    Kenneth W Mahaffey
    Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 294:2594-600. 2005
    ....
  70. ncbi request reprint Predictors and 1-year outcome of major bleeding in patients with non-ST-elevation acute coronary syndromes: insights from the Canadian Acute Coronary Syndrome Registries
    Amit Segev
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 150:690-4. 2005
    ..The aims were to identify predictors of major bleeding in patients with NSTE ACS and to evaluate in-hospital and 1-year outcomes...
  71. ncbi request reprint Utilization of catheterization and revascularization procedures in patients with non-ST segment elevation acute coronary syndrome over the last decade
    Glenn N Levine
    Baylor College of Medicine and the Houston VA Medical Center, Houston, Texas 77030, USA
    Catheter Cardiovasc Interv 66:149-57. 2005
    ..The percentages of patients undergoing invasive and revascularization procedures were consistently higher in the U.S. cohorts of study subjects when compared to non-U.S. cohorts of study subjects...
  72. ncbi request reprint Preventing thrombosis: update of first-line therapy in the management of non-ST segment elevation acute coronary syndromes
    David Fitchett
    St Michael s Hospital, Toronto, Canada
    Can J Cardiol 18:1179-90. 2002
    ..A risk-determined algorithm is presented, which applies observations made at the time of presentation to decide the optimal management for the individual patient...