M G Fehlings

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Changes in axonal physiology and morphology after chronic compressive injury of the rat thoracic spinal cord
    R Nashmi
    Division of Neurosurgery and the University Health Network, The Toronto Western Hospital Research Institute, Institute of Medical Science, University of Toronto, M5T 2S8, Toronto, Canada
    Neuroscience 104:235-51. 2001
  2. ncbi request reprint An evidence-based review of decompressive surgery in acute spinal cord injury: rationale, indications, and timing based on experimental and clinical studies
    M G Fehlings
    Division of Neurosurgery and Spinal Program, Toronto Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 91:1-11. 1999
  3. ncbi request reprint The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part II: Results of a multicenter study
    M G Fehlings
    Division of Neurosurgery, University of Toronto, Toronto Hospital Western Division
    Spine (Phila Pa 1976) 24:605-13. 1999
  4. ncbi request reprint A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
    M G Fehlings
    Division of Neurosurgery, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 23:2730-7. 1998
  5. ncbi request reprint A new model of acute compressive spinal cord injury in vitro
    M G Fehlings
    The Toronto Hospital Research Institute, University of Toronto, Ontario, Canada
    J Neurosci Methods 71:215-24. 1997
  6. ncbi request reprint Changes in pharmacological sensitivity of the spinal cord to potassium channel blockers following acute spinal cord injury
    M G Fehlings
    Playfair Neuroscience Unit, Toronto Hospital Research Institute, University of Toronto, Ontario, Canada
    Brain Res 736:135-45. 1996
  7. ncbi request reprint Current use and timing of spinal surgery for management of acute spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study
    C H Tator
    Division of Neurosurgery and Spinal Program, Toronto Western Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 91:12-8. 1999
  8. ncbi request reprint Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat
    S Casha
    Division of Neurosurgery, Toronto Western Research, The University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neuroscience 103:203-18. 2001
  9. ncbi request reprint Somatosensory cortical atrophy after spinal cord injury: a voxel-based morphometry study
    M T Jurkiewicz
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurology 66:762-4. 2006
  10. ncbi request reprint Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole
    G Schwartz
    Division of Cell and Molecular Biology, The Toronto Western Research Institute, Ontario, Canada
    J Neurosurg 94:245-56. 2001

Detail Information

Publications26

  1. ncbi request reprint Changes in axonal physiology and morphology after chronic compressive injury of the rat thoracic spinal cord
    R Nashmi
    Division of Neurosurgery and the University Health Network, The Toronto Western Hospital Research Institute, Institute of Medical Science, University of Toronto, M5T 2S8, Toronto, Canada
    Neuroscience 104:235-51. 2001
    ..These results further clarify the mechanisms underlying neurological dysfunction after chronic neurotrauma and have significant implications regarding approaches to augment neural repair and regeneration...
  2. ncbi request reprint An evidence-based review of decompressive surgery in acute spinal cord injury: rationale, indications, and timing based on experimental and clinical studies
    M G Fehlings
    Division of Neurosurgery and Spinal Program, Toronto Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 91:1-11. 1999
    ..The authors conducted an evidence-based review of the literature to evaluate critically the rationale and indications for and the timing of decompressive surgery for the treatment of acute, nonpenetrating spinal cord injury (SCI)...
  3. ncbi request reprint The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part II: Results of a multicenter study
    M G Fehlings
    Division of Neurosurgery, University of Toronto, Toronto Hospital Western Division
    Spine (Phila Pa 1976) 24:605-13. 1999
    ..A multicenter, retrospective study using computed tomographic and magnetic resonance imaging data to establish quantitative, reliable criteria of canal compromise and cord compression in patients with cervical spinal cord injury...
  4. ncbi request reprint A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
    M G Fehlings
    Division of Neurosurgery, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 23:2730-7. 1998
    ..Fundamental research at a cellular and molecular level, particularly in the areas of glutamatergic toxicity and apoptosis may result in clinically relevant treatments for this condition...
  5. ncbi request reprint A new model of acute compressive spinal cord injury in vitro
    M G Fehlings
    The Toronto Hospital Research Institute, University of Toronto, Ontario, Canada
    J Neurosci Methods 71:215-24. 1997
    ..Ultrastructurally, injured dorsal column segments showed considerable axonal and myelin pathology including splaying of the myelin sheath and vesicular degeneration...
  6. ncbi request reprint Changes in pharmacological sensitivity of the spinal cord to potassium channel blockers following acute spinal cord injury
    M G Fehlings
    Playfair Neuroscience Unit, Toronto Hospital Research Institute, University of Toronto, Ontario, Canada
    Brain Res 736:135-45. 1996
    ..The data suggest that acute traumatic myelin disruption following SCI causes axonal dysfunction partly due to abnormal activation of 4-AP-sensitive 'fast' K+ channels...
  7. ncbi request reprint Current use and timing of spinal surgery for management of acute spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study
    C H Tator
    Division of Neurosurgery and Spinal Program, Toronto Western Hospital and University of Toronto, Ontario, Canada
    J Neurosurg 91:12-8. 1999
    ..The study was performed to obtain information required for the planning of a randomized controlled trial in which early and late decompressive surgery are compared...
  8. ncbi request reprint Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat
    S Casha
    Division of Neurosurgery, Toronto Western Research, The University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neuroscience 103:203-18. 2001
    ..Activation of the FAS and p75 death receptor pathways may be involved in initiating this process...
  9. ncbi request reprint Somatosensory cortical atrophy after spinal cord injury: a voxel-based morphometry study
    M T Jurkiewicz
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurology 66:762-4. 2006
    ..SCI subjects had reduced gray matter volume bilaterally in primary somatosensory cortex (p < 0.001). These findings suggest that the somatosensory cortex of the human brain atrophies after SCI...
  10. ncbi request reprint Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole
    G Schwartz
    Division of Cell and Molecular Biology, The Toronto Western Research Institute, Ontario, Canada
    J Neurosurg 94:245-56. 2001
    ..CONCLUSIONS: Systemic Na+ channel blockers, in particular riluzole, can confer significant neuroprotection after in vivo SCI and result in behavioral recovery and sparing of both gray and white matter...
  11. ncbi request reprint Changes in glial cell white matter AMPA receptor expression after spinal cord injury and relationship to apoptotic cell death
    E Park
    Division of Neurosurgery, University of Toronto, Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Centre, Toronto, Ontario, M5T 2S8, Canada
    Exp Neurol 182:35-48. 2003
    ..A large decline in GluR3-expressing oligodendrocytes suggests that this subunit may be associated with the induction of apoptosis in white matter glia, thus contributing to secondary injury mechanisms...
  12. ncbi request reprint The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part I: An evidence-based analysis of the published literature
    S C Rao
    Division of Neurosurgery and Spinal Program, University of Toronto, Toronto Hospital Western Division, Ontario, Canada
    Spine (Phila Pa 1976) 24:598-604. 1999
    ..CONCLUSIONS: To date, there are few quantitative, reliable radiologic outcome measures for assessing spinal canal compromise or cord compression in patients with acute cervical spinal cord injury...
  13. doi request reprint Blood alcohol concentration as a determinant of outcomes after traumatic spinal cord injury
    J C Furlan
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Eur J Neurol 20:1101-6. 2013
    ..Given this, an examination of whether blood alcohol concentration (BAC) is a potential determinant of survival and neurological and functional recovery after acute traumatic SCI was carried out...
  14. doi request reprint Early versus late surgery for traumatic spinal cord injury: the results of a prospective Canadian cohort study
    J R Wilson
    Department of Surgery, Division of Neurosurgery and Spinal Program, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Spinal Cord 50:840-3. 2012
    ..A multicenter Canadian cohort study...
  15. doi request reprint Advanced MR imaging techniques and characterization of residual anatomy
    P W Stroman
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Clin Neurol Neurosurg 114:460-70. 2012
    ..Applications for specific purposes of assessing traumatic injury in the brain or spinal cord, and for multiple-sclerosis are also presented, and are used as examples of how the advanced techniques are being used in practice...
  16. ncbi request reprint The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury
    G K T Chu
    Division of Neurosurgery, Toronto Western Research Institute, The Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, University of Toronto, McLaughlin Pavilion, McL 12 407, Toronto, Ontario, Canada M5T 2S8
    Neuroscience 148:668-82. 2007
    ..We conclude that the p75(NTR) receptor is integral to neuronal cell survival and endogenous reparative mechanisms after compressive/contusive SCI...
  17. ncbi request reprint Role of sodium in the pathophysiology of secondary spinal cord injury
    M G Fehlings
    Spinal Cord Injury Neurophysiology Laboratory, Playfair Neuroscience Unit, Toronto Hospital Research Institute, Canada
    Spine (Phila Pa 1976) 20:2187-91. 1995
    ..The mechanism of Na(+)-associated cytotocity does not involve reverse gating of the Na(+)-Ca++ exchanger...
  18. ncbi request reprint Use of sensory-evoked potentials recorded from the human occiput for intraoperative physiologic monitoring of the spinal cord
    R J Hurlbert
    Division of Neurosurgery and Spinal Programme, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 20:2318-27. 1995
    ..These responses are very similar to the cerebellar-evoked potential recently characterized in animals and may provide a method for assessing the physiologic integrity of the ventral tracts of the spinal cord in humans...
  19. ncbi request reprint Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels
    R Nashmi
    Playfair Neuroscience Unit, Division of Neurosurgery, The Toronto Western Hospital Research Institute, University Health Network, Institute of Medical Science, University of Toronto, 399 Bathurst St, Toronto M5T 2S8, Canada
    Brain Res Brain Res Rev 38:165-91. 2001
    ..The pathology of spinal cord injury is very complex and many different mechanisms may contribute to axonal conduction deficits and the associated sensory and motor loss...
  20. ncbi request reprint Management strategies to optimize clinical outcomes after acute traumatic spinal cord injury: integration of medical and surgical approaches
    J R Wilson
    Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
    J Neurosurg Sci 56:1-11. 2012
    ..In this article we review the current evidence surrounding the medical and surgical management of SCI, as well as identify areas where future research is needed...
  21. ncbi request reprint Intradural metastasis mimicking nerve sheath tumor
    W P Ng
    Division of Neurosurgery, Toronto Western Division, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 20:2580-3. 1995
    ..CONCLUSION. Metastasis to spinal nerve roots can clinically mimic other diseases. As in this case, the proper diagnosis may be possible only at surgery...
  22. doi request reprint Attitudes towards the older patients with spinal cord injury among registered nurses: a cross-sectional observational study
    J C Furlan
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Spinal Cord 47:674-80. 2009
    ..Cross-sectional observational study...
  23. ncbi request reprint Attenuation of the electrophysiological function of the corpus callosum after fluid percussion injury in the rat
    A J Baker
    Department of Anaesthesia, University of Toronto, Toronto, Canada
    J Neurotrauma 19:587-99. 2002
    ..They also indicated a greater degree of attenuation than predicted by APP expression changes alone...
  24. ncbi request reprint Optimal treatment for severe neurogenic bowel dysfunction after chronic spinal cord injury: a decision analysis
    J C Furlan
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
    Br J Surg 94:1139-50. 2007
    ..This study employed a decision analysis to examine the optimal treatment for bowel management of young individuals with chronic refractory constipation in the setting of chronic SCI...
  25. ncbi request reprint Adaptation in the motor cortex following cervical spinal cord injury
    D J Mikulis
    Department of Medical Imaging, Toronto Western Hospital of The University Health Network, Ontario, Canada
    Neurology 58:794-801. 2002
    ..The nature of the adaptive changes that occur in the cerebral cortex following injury to the cervical spinal cord are largely unknown...
  26. ncbi request reprint FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury
    S Casha
    Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8
    Exp Neurol 196:390-400. 2005
    ..We conclude that inhibition of the FAS pathway may be a clinically attractive neuroprotective strategy directed towards oligodendroglial and axonal preservation in the treatment of SCI and neurotrauma...