P Dorian

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Is inappropriate implantable defibrillator shock therapy predictable?
    Kumaraswamy Nanthakumar
    Arrhythmia Service, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    J Interv Card Electrophysiol 8:215-20. 2003
  2. ncbi request reprint Rate control in atrial fibrillation: looking beyond the average heart rate
    Kamran Ahmad
    Division of Cardiology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Curr Opin Cardiol 21:88-93. 2006
  3. doi request reprint Role of antiarrhythmic drugs in patients with implantable cardioverter defibrillators
    Hugo Van Herendael
    Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, 6 050 Queen Wing, Toronto, ON, Canada
    Europace 12:618-25. 2010
  4. doi request reprint Mechanisms underlying the lack of effect of implantable cardioverter-defibrillator therapy on mortality in high-risk patients with recent myocardial infarction: insights from the Defibrillation in Acute Myocardial Infarction Trial (DINAMIT)
    Paul Dorian
    St Michael s Hospital, 30 Bond St, 6 050Q, Toronto, Ontario, M5B 1W8, Canada
    Circulation 122:2645-52. 2010
  5. pmc Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia
    Hugo Van Herendael
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Vasc Health Risk Manag 6:465-72. 2010
  6. ncbi request reprint Pharmacological and nonpharmacological methods for rate control
    Paul Dorian
    University of Toronto, Toronto, Ontario
    Can J Cardiol 21:26B-30B. 2005
  7. doi request reprint Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial
    Paul Dorian
    Division of Cardiology, St Michael s Hospital University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 52:1076-83. 2008
  8. ncbi request reprint Antiarrhythmic drug therapy of atrial fibrillation: focus on new agents
    Paul Dorian
    St Michael s Hospital, Cardiology Division, 30 Bond Street 7051 Q 7 D81 Queen Wing, Toronto, Ontario M5B 1W8, Canada
    J Cardiovasc Pharmacol Ther 8:S27-31. 2003
  9. ncbi request reprint Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation
    Paul Dorian
    Department of Medicine, University of Toronto and Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol Ther 15:15S-8S. 2010
  10. ncbi request reprint Advances in the acute pharmacologic management of cardiac arrhythmias
    Andrea Sarkozy
    Division of Cardiology, St Michael s Hospital, 30 Bond Street, 7 050Q, Toronto, Ontario M5B 1W8, Canada
    Curr Cardiol Rep 5:387-94. 2003

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Is inappropriate implantable defibrillator shock therapy predictable?
    Kumaraswamy Nanthakumar
    Arrhythmia Service, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    J Interv Card Electrophysiol 8:215-20. 2003
    ..To identify implantable cardioverter defibrillator (ICD) patients who are at risk of receiving inappropriate shock...
  2. ncbi request reprint Rate control in atrial fibrillation: looking beyond the average heart rate
    Kamran Ahmad
    Division of Cardiology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Curr Opin Cardiol 21:88-93. 2006
    ....
  3. doi request reprint Role of antiarrhythmic drugs in patients with implantable cardioverter defibrillators
    Hugo Van Herendael
    Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, 6 050 Queen Wing, Toronto, ON, Canada
    Europace 12:618-25. 2010
    ..This review provides an overview of potential reasons for AAD initiation, candidates for treatment, current medical options, and possible drug-device interactions...
  4. doi request reprint Mechanisms underlying the lack of effect of implantable cardioverter-defibrillator therapy on mortality in high-risk patients with recent myocardial infarction: insights from the Defibrillation in Acute Myocardial Infarction Trial (DINAMIT)
    Paul Dorian
    St Michael s Hospital, 30 Bond St, 6 050Q, Toronto, Ontario, M5B 1W8, Canada
    Circulation 122:2645-52. 2010
    ..Our objective was to investigate possible mechanisms underlying the lack of mortality benefit in the Defibrillation in Acute Myocardial Infarction Trial (DINAMIT)...
  5. pmc Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia
    Hugo Van Herendael
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Vasc Health Risk Manag 6:465-72. 2010
    ..Both the pharmacokinetics and the electrophysiologic profile of amiodarone are complex, and its optimal and safe use requires careful patient surveillance with respect to potential adverse effects...
  6. ncbi request reprint Pharmacological and nonpharmacological methods for rate control
    Paul Dorian
    University of Toronto, Toronto, Ontario
    Can J Cardiol 21:26B-30B. 2005
    ..Taking a patient's symptoms into account, reasonable target ventricular rates are less than 80 beats/min at rest and less than 100 beats/min, on average, over 24 h...
  7. doi request reprint Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial
    Paul Dorian
    Division of Cardiology, St Michael s Hospital University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 52:1076-83. 2008
    ....
  8. ncbi request reprint Antiarrhythmic drug therapy of atrial fibrillation: focus on new agents
    Paul Dorian
    St Michael s Hospital, Cardiology Division, 30 Bond Street 7051 Q 7 D81 Queen Wing, Toronto, Ontario M5B 1W8, Canada
    J Cardiovasc Pharmacol Ther 8:S27-31. 2003
    ....
  9. ncbi request reprint Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation
    Paul Dorian
    Department of Medicine, University of Toronto and Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol Ther 15:15S-8S. 2010
    ..Gender, renal dysfunction, weight, and age have little effect on the pharmacokinetics of dronedarone, and dose adjustment for these variables is not required...
  10. ncbi request reprint Advances in the acute pharmacologic management of cardiac arrhythmias
    Andrea Sarkozy
    Division of Cardiology, St Michael s Hospital, 30 Bond Street, 7 050Q, Toronto, Ontario M5B 1W8, Canada
    Curr Cardiol Rep 5:387-94. 2003
    ..In shock-refractory ventricular fibrillation, lidocaine, and magnesium are ineffective; intravenous amiodarone should be the treatment of choice...
  11. ncbi request reprint Role of amiodarone in the era of the implantable cardioverter defibrillator
    Paul Dorian
    Cardiology Division, St Michael s Hospital, Toronto, Ontario, Canada
    J Cardiovasc Electrophysiol 14:S78-81. 2003
    ..Amiodarone is a complicated drug, and its optimal use requires careful patient surveillance with respect to potential adverse effects...
  12. ncbi request reprint Quality of life variables in the selection of rate versus rhythm control in patients with atrial fibrillation: observations from the Canadian Trial of Atrial Fibrillation
    Paul Dorian
    St Michael s Hospital, Toronto, ON, Canada
    Card Electrophysiol Rev 7:276-9. 2003
    ..Quality of life improves with treatment atrial fibrillation and at least some of these improvements are related to the restoration and maintenance of sinus rhythm...
  13. pmc A novel, simple scale for assessing the symptom severity of atrial fibrillation at the bedside: the CCS-SAF scale
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Can J Cardiol 22:383-6. 2006
    ..Quantifying the effect of AF on patient well-being is important but there is no simple, commonly accepted measure of the effect of AF on quality of life (QoL). Current QoL measures are cumbersome and impractical for clinical use...
  14. ncbi request reprint Validation of a new simple scale to measure symptoms in atrial fibrillation: the Canadian Cardiovascular Society Severity in Atrial Fibrillation scale
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Circ Arrhythm Electrophysiol 2:218-24. 2009
    ..This study was performed to validate the scale...
  15. ncbi request reprint The effect of vernakalant (RSD1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humans
    Paul Dorian
    St Michael s Hospital, and University of Toronto, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol 50:35-40. 2007
    ..To determine the acute effects of vernakalant (RSD1235) on electrophysiologic (EP) properties in humans...
  16. ncbi request reprint Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    Circulation 110:3646-54. 2004
    ....
  17. ncbi request reprint The burden of atrial fibrillation: should we abandon antiarrhythmic drug therapy?
    Paul Dorian
    Division of Cardiology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol Ther 9:257-62. 2004
    ....
  18. ncbi request reprint Randomized controlled study of detection enhancements versus rate-only detection to prevent inappropriate therapy in a dual-chamber implantable cardioverter-defibrillator
    Paul Dorian
    St Michael s Hospital, Toronto, Ontario, Canada
    Heart Rhythm 1:540-7. 2004
    ..The purpose of this study was to compare rate-only detection to enhanced detection in a dual-chamber implantable cardioverter-defibrillator (ICD), to discriminate ventricular tachycardia from supraventricular tachycardia...
  19. ncbi request reprint Implanted cardioverter defibrillators for the prevention of sudden death
    Paul Dorian
    St Michael s Hospital, Toronto, Ontario
    Can J Cardiol 21:31A-36A. 2005
    ..5% to 3.0%, but the risk of death in an individual patient is hard to quantify. Poor left ventricular function is the best predictor of both mortality risk and ICD benefit. Other risk predictors need to be identified...
  20. ncbi request reprint Antiarrhythmic action of beta-blockers: potential mechanisms
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Cardiovasc Pharmacol Ther 10:S15-22. 2005
    ..Antagonism of cardiac adrenergic activity by beta-blockade in particular is the best-established drug therapy to prevent ventricular arrhythmias...
  21. ncbi request reprint Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation
    Paul Dorian
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 143:984-90. 2002
    ..The impact of atrial fibrillation (AF) and its treatment on health-related quality of life (QOL) is not well understood. We assessed QOL in patients with symptomatic AF participating in the Canadian Trial of Atrial Fibrillation...
  22. ncbi request reprint Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation
    Paul Dorian
    Departments of Medicine and Emergency Medicine, St Michael s Hospital, Toronto
    N Engl J Med 346:884-90. 2002
    ..We performed a randomized trial comparing intravenous lidocaine with intravenous amiodarone as an adjunct to defibrillation in victims of out-of-hospital cardiac arrest...
  23. ncbi request reprint An overview of the management of electrical storm
    P Dorian
    Department of Medicine, University of Toronto, Ontario
    Can J Cardiol 13:13A-17A. 1997
    ..In this article, several different clinical syndromes of electrical storm and the management of each are examined...
  24. ncbi request reprint Intravenous antiarrhythmic agents
    A Pinter
    St Michael s Hospital, Toronto, Ontario, Canada
    Curr Opin Cardiol 16:17-22. 2001
    ..Adrenergic blockade is likely important in the management of tachyarrhythmias, particularly in electrical storm, but more data will be necessary to establish its role...
  25. ncbi request reprint The future of atrial fibrillation therapy
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    J Cardiovasc Electrophysiol 17:S11-6. 2006
    ..In the future, treatment of AF will progress beyond today's focus on AF as a purely electrocardiographic disease toward a patient and context-specific management strategy involving multiple treatment modalities...
  26. ncbi request reprint Order in disorder: effect of barium on ventricular fibrillation
    P Dorian
    Department of Medicine, University of Toronto, Ontario
    Can J Cardiol 12:399-406. 1996
    ..The mechanism of this effect is unknown, and may relate to modulation of the effect of defibrillatory shocks, or an alteration of the pattern of ventricular fibrillation (VF) by the drug...
  27. ncbi request reprint Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue
    J Irvine
    Toronto General Hospital, University Health Network, Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychosom Med 61:729-37. 1999
    ..This study examined the impact of depressive symptoms and social support on 2-year sudden cardiac death (SCD) risk, controlling for fatigue symptoms...
  28. ncbi request reprint Wavelet-based markers of ventricular fibrillation in optimizing human cardiac resuscitation
    F H Foomany
    Ryerson University, Toronto, Canada
    Conf Proc IEEE Eng Med Biol Soc 2010:2001-4. 2010
    ..3% in predicting the shock outcomes and hence demonstrate potential to provide near real-time feedback to EMS personnel in optimizing resuscitation outcomes...
  29. ncbi request reprint Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone
    S J Connolly
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 101:1297-302. 2000
    ..The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with medical therapy with amiodarone...
  30. ncbi request reprint [Etiologies of electric storm]
    P Dorian
    Hôpital St Michael s, Toronto, Canada
    Arch Mal Coeur Vaiss 90:27-31. 1997
    ..The authors review several clinical syndromes of the electrical storm and the treatment of each...
  31. ncbi request reprint Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 114:104-9. 2006
    ..The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial...
  32. ncbi request reprint Poor adherence to placebo or amiodarone therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial
    J Irvine
    The Toronto Hospital, Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychosom Med 61:566-75. 1999
    ..This study examined the relationship between adherence, mortality, and psychosocial factors...
  33. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  34. ncbi request reprint Antiarrhythmic drugs and ventricular defibrillation energy requirements
    X Qi
    Division of Cardiology, Department of Medicine, St Michael s Hospital, University of Toronto, Canada
    Chin Med J (Engl) 112:1147-52. 1999
    ..To understand the potential interaction between antiarrhythmic therapy and the implantable cardioverter-defibrillator (ICD) in patients who receive pharmacologic therapy as an adjunct to ICD therapy...
  35. ncbi request reprint Update on advanced life support and resuscitation techniques
    Mauricio F Hong
    Department of Medicine, Division of Cardiology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Cardiol 20:1-6. 2005
    ..The article focuses particularly on the period after July 1, 2003, but relevant new findings before this period are also included...
  36. ncbi request reprint Long-term amiodarone therapy and the risk of complications after cardiac surgery: results from the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT)
    Eugene Crystal
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 125:633-7. 2003
    ....
  37. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  38. ncbi request reprint Terikalant and barium decrease the area of vulnerability to ventricular fibrillation induction by T-wave shocks
    Xiangqian Qi
    Division of Cardiology, Department of Medicine, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol 39:242-50. 2002
    ..83, p < 0.01). Potassium channel blockers of the current reduce the ability to induce VF; this effect may be related to the anti-fibrillatory action of class III anti-arrhythmic drugs and their ability to decrease DFT...
  39. ncbi request reprint Strategies for reversing shock-resistant ventricular fibrillation
    Andrea Sarkozy
    Division of Cardiology, St Michaels s Hospital, Ontario, Canada
    Curr Opin Crit Care 9:189-93. 2003
    ..In approximately 10 to 25% of all cardiac arrests, shock-resistant ventricular fibrillation develops, and 87 to 98% of these patients die...
  40. ncbi request reprint The effect of sinus node depression on heart rate variability in humans using zatebradine, a selective bradycardic agent
    Y Khaykin
    Department of Medicine, University of Toronto, St Michael s Hospital, ON, Canada
    Can J Physiol Pharmacol 76:806-10. 1998
    ..001), and HF (-26+/-5%, p<0.001). The reduction in HRV following zatebradine is due to depression of sinus node response to all external stimuli and underscores the need for documentation of normal sinus node function in HRV research...
  41. ncbi request reprint A population-based method for the estimation of defibrillation energy requirements in humans. Assessment of time-dependent effects with a transvenous defibrillation system
    D Newman
    Division of Cardiology, St Michael s Hospital, University of Toronto, ON, Canada
    Circulation 96:267-73. 1997
    ..A weighted logistic regression analysis was developed to allow pooling of patient data for the study of the stability of defibrillation energy requirements with a new nonthoracotomy lead defibrillation system...
  42. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  43. ncbi request reprint Effect of physiological mechanical perturbations on intact human myocardial repolarization
    K Nanthakumar
    Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Cardiovasc Res 45:303-9. 2000
    ....
  44. doi request reprint Simultaneous right atrioventricular pacing: a novel model to study atrial remodeling and fibrillation in the setting of heart failure
    Gabriel Laurent
    Division of Cardiology, University of Toronto and Terrence Donnelly Cardiovascular Laboratories, St Michael s Hospital, Ontario, Canada
    J Card Fail 14:254-62. 2008
    ..Atrial remodeling is a key substrate for the development of AF in HF. However, experimental models that study AF in the setting of HF have important limitations. We evaluated a new dog model of atrial remodeling and AF...
  45. ncbi request reprint Quality of life in the Canadian Implantable Defibrillator Study (CIDS)
    Jane Irvine
    Department of Psychology, York University, University of Toronto, Ontario, Canada
    Am Heart J 144:282-9. 2002
    ..A secondary aim was to evaluate the effects on quality-of-life outcomes of receiving shocks from the device...
  46. ncbi request reprint Long-term comparison of the implantable cardioverter defibrillator versus amiodarone: eleven-year follow-up of a subset of patients in the Canadian Implantable Defibrillator Study (CIDS)
    Fayez Bokhari
    Terrence Donnelly Heart Center, Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 110:112-6. 2004
    ..Thus, our objective was to evaluate the long-term consequences of using amiodarone versus an ICD as first-line monotherapy in patients with a prior history of sustained ventricular tachycardia/ventricular fibrillation or cardiac arrest...
  47. ncbi request reprint Downward delegation of implantable cardioverter defibrillator decision-making in a restricted-resource environment: the pitfalls of bedside rationing
    Christopher S Simpson
    Arrhythmia Service Cardiology, Department of Medicine, Queen s University, Kingston, Canada
    Can J Cardiol 21:595-9. 2005
    ..Macro- and meso-level stakeholders must also recognize and take responsibility for their part in restricting resources in a broadly inclusive and transparent process...
  48. ncbi request reprint Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation
    Charles R Kerr
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Am Heart J 149:489-96. 2005
    ..After its initial diagnosis, atrial fibrillation (AF) may progress from paroxysmal to chronic AF (CAF). The rate of progression and risk factors for progression are not clearly defined...
  49. ncbi request reprint Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 295:165-71. 2006
    ..Implantable cardioverter defibrillator (ICD) therapy is effective but is associated with high-voltage shocks that are painful...
  50. ncbi request reprint Improving SVT discrimination in single-chamber ICDs: a new electrogram morphology-based algorithm
    George J Klein
    University of Western Ontario, London, Ontario, Canada
    J Cardiovasc Electrophysiol 17:1310-9. 2006
    ..More sophisticated discrimination algorithms based on ventricular electrogram morphology have been made practicable by the increased computational ability of modern ICDs...
  51. ncbi request reprint Effects of rotigaptide, a gap junction modifier, on defibrillation energy and resuscitation from cardiac arrest in rabbits
    Jing Quan Zhong
    Department of Medicine, University of Toronto and Division of Cardiology, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada
    J Cardiovasc Pharmacol Ther 12:69-77. 2007
    ..Rotigaptide improves the ability to defibrillate after untreated VF...
  52. doi request reprint Experimental studies of atrial fibrillation: a comparison of two pacing models
    Gabriel Laurent
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 294:H1206-15. 2008
    ..7 in unpaced control dogs). In conclusion, the SAVP model induced profound mechanical and substrate atrial remodeling and reproducible sustained AF. This new model is clinically relevant and may be useful for testing AF interventions...
  53. ncbi request reprint Effect of cardiac and noncardiac conditions on survival after defibrillator implantation
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:2408-15. 2007
    ..We sought to examine outcomes in recipients of implantable cardioverter-defibrillators (ICDs) and the effect of age, gender, and comorbidities on survival...
  54. ncbi request reprint Permanent explantation of implantable cardioverter defibrillators
    M Geist
    Division of Cardiology, St Michael s Hospital and University of Toronto, Canada
    Pacing Clin Electrophysiol 23:2024-9. 2000
    ..6% survived without reimplantation. In selected patients, after not using an ICD for a long period and when clinical circumstances justify, device therapy may be discontinued with some degree of safety...
  55. ncbi request reprint The 2002/3 Canadian Cardiovascular Society consensus guideline update for the diagnosis and management of heart failure
    P Liu
    Heart and Stroke RL Centre of Excellence, Toronto General Hospital, Ontario, Canada
    Can J Cardiol 19:347-56. 2003
  56. ncbi request reprint The defibrillator in acute myocardial infarction trial (DINAMIT): study protocol
    S H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 140:735-9. 2000
    ..Patients will be followed for approximately 3 years on average with subsequent data analysis based on the intent-to-treat principle. Primary outcome is all-cause death. The trial is expected to be completed in 2003...
  57. ncbi request reprint The effect of isoproterenol on the class III effect of azimilide in humans
    Paul Dorian
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    J Cardiovasc Pharmacol Ther 7:211-7. 2002
    ..Azimilide is an investigational class III antiarrhythmic agent that blocks both IKr and IKs...
  58. ncbi request reprint Out-of-hospital cardiac arrest rectilinear biphasic to monophasic damped sine defibrillation waveforms with advanced life support intervention trial (ORBIT)
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, Institute for Clinical and Evaluative Sciences, Department of Medicine, University of Toronto, Toronto, Ont, Canada
    Resuscitation 66:149-57. 2005
    ..This effectiveness study compared monophasic and biphasic defibrillation waveform for conversion of ventricular arrhythmias in all OHCA treated with advance life support (ALS)...
  59. ncbi request reprint Effect of pacing mode on health-related quality of life in the Canadian Trial of Physiologic Pacing
    David Newman
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 145:430-7. 2003
    ..The QOL studies within the Canadian Trial of Physiologic Pacing were performed to assess whether QOL differences exist in patients randomized to these 2 pacing modes...
  60. ncbi request reprint Effect of an implantable cardioverter defibrillator with atrial detection and shock therapies on patient-perceived, health-related quality of life
    David M Newman
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 145:841-6. 2003
    ..The purpose of this study was to assess the effect of the device on patient-perceived, health-related quality of life (QOL)...
  61. pmc Out-of-hospital cardiac arrest frequency and survival: evidence for temporal variability
    Steven C Brooks
    Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Resuscitation 81:175-81. 2010
    ..Some cardiac phenomena demonstrate temporal variability. We evaluated temporal variability in out-of-hospital cardiac arrest (OHCA) frequency and outcome...
  62. ncbi request reprint Combination IK1 and IKr channel blockade: no additive lowering of the defibrillation threshold
    Pryamvada Varma
    Department of Pharmacology, University of Toronto, ON, Canada
    Can J Physiol Pharmacol 80:22-30. 2002
    ..6 and 3.1 microM) (p < 0.05), there was no significant additive interaction between barium and D,L-sotalol on VERP or VFCL. Combination I(K1) and I(Kr) channel block by barium and D,L-sotalol does not produce additive reduction of DFT...
  63. doi request reprint Quantitative assessment of brain microvascular and tissue oxygenation during cardiac arrest and resuscitation in pigs
    J Yu
    Departments of Anaesthesia and Physiology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Anaesthesia 68:723-35. 2013
    ....
  64. ncbi request reprint Optimizing cardiac resuscitation outcomes using wavelet analysis
    K Umapathy
    THFCFM Laboratory, Toronto, Canada
    Conf Proc IEEE Eng Med Biol Soc 2009:6761-4. 2009
    ..Using data collected from 16 pigs during VF, the proposed wavelet methodology achieved an overall accuracy of 94% in successfully predicting the shock outcomes...
  65. ncbi request reprint Emergency arrhythmia management: an assessment of learning needs
    B A Morris
    Department of Family and Community Medicine, University of Toronto, Ontario
    Can J Cardiol 13:7A-11A. 1997
    ..These results will be used to guide an ongoing program of continuing medical education...
  66. ncbi request reprint Effects of rhythm regularization and rate control in improving left ventricular function in atrial fibrillation patients undergoing atrioventricular nodal ablation
    A Verma
    St Michael's Hospital, University of Toronto, Toronto, Canada
    Can J Cardiol 17:437-45. 2001
    ..However, more marked improvements in left ventricular function seen after ablation are primarily due to rate reduction alone...
  67. ncbi request reprint Thrombogenicity of radiofrequency ablation procedures: what factors influence thrombin generation?
    D S Lee
    St Michael s Hospital, Division of Cardiology, Toronto, Canada
    Europace 3:195-200. 2001
    ..The aim of this study was to determine whether radiofrequency ablation has a procoagulant effect and to examine variables that affect thrombio generation...
  68. doi request reprint Assessment of resynchronization therapy on functional status and quality of life in patients requiring an implantable defibrillator
    Arnold Pinter
    Department of Medicine, Division of Cardiology, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Pacing Clin Electrophysiol 32:1509-19. 2009
    ..The effect of cardiac resynchronization therapy (CRT) on physical function and Quality of Life (QoL) in patients who require an implantable defibrillator but do not meet guideline criteria for CRT has not been studied in detail...
  69. pmc Applying the new STEMI guidelines: 2. Disturbances of cardiac rhythm after ST-segment elevation myocardial infarction
    Paul Dorian
    Department of Medicine, St Michael s Hospital, University of Toronto, Ont
    CMAJ 171:1042-4. 2004
  70. ncbi request reprint Correlates of therapeutic response in panic disorder presenting with palpitations: heart rate variability, sleep, and placebo effect
    Brian Baker
    Department of Psychiatry, University of Toronto, Toronto, Ontario
    Can J Psychiatry 48:381-7. 2003
    ..To examine the correlates of therapeutic response of patients with panic disorder presenting with palpitations, we hypothesized that therapeutic response would correlate with heart rate variability (HRV) and sleep measures...
  71. ncbi request reprint Feasibility of implantable cardioverter defibrillator use in elderly patients: a case series of octogenarians
    Peter A Noseworthy
    Arrhythmia Service, Saint Michael s Hospital, University of Toronto, Toronto, Canada
    Pacing Clin Electrophysiol 27:373-8. 2004
    ..1%, respectively, P = 0.16). Age alone may not be sufficient criteria to exclude ICD implantation. The current consensus guidelines for ICD implantation appear to be generalizable to treating octogenarians who are otherwise medically fit...
  72. ncbi request reprint Approach to antiarrhythmic therapy in patients with ICDs and frequent activations
    Arnold Pinter
    Division of Cardiology, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Curr Cardiol Rep 7:376-81. 2005
    ..Electrical storm is a serious condition that occurs in 20% of patients living with a defibrillator, and its management requires a complex approach to the patient...
  73. ncbi request reprint A randomized controlled feasibility trial comparing safety and effectiveness of prehospital pacing versus conventional treatment: 'PrePACE'
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook Health Sciences Centre, Toronto, Ont, Canada
    Resuscitation 76:341-9. 2008
    ..To evaluate the feasibility of a prehospital randomized controlled trial comparing transcutaneous pacing (TCP) with dopamine for unstable bradycardia...
  74. pmc Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles
    P P S So
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Br J Pharmacol 155:1185-94. 2008
    ..I(Ks) block during drug-induced AP prolongation may promote Torsades de Pointes (TdP), but whether this is due to additional AP prolongation is uncertain...
  75. ncbi request reprint The impact of implantable cardiac defibrillators for primary prophylaxis in the community: baseline risk and clinically meaningful benefits
    S Jolly
    St Michael s Hospital, University of Toronto, Ontario, Canada
    J Eval Clin Pract 12:190-5. 2006
    ..To estimate the baseline risk of arrhythmic death required for prophylactic implantable cardiac defibrillators (ICDs) to result in clinically meaningful survival benefits in the population...
  76. ncbi request reprint Canadian Cardiovascular Society commentary on implantable cardioverter defibrillators in Canada: waiting times and access to care issues
    C S Simpson
    Department of Medicine, Division of Cardiology, Queen s University, Kingston, Ontario
    Can J Cardiol 21:19A-24A. 2005
    ..A maximum recommended waiting time is proposed and the framework for a solution-oriented approach is presented...
  77. doi request reprint Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts
    Stephane Masse
    Division of Cardiology, Toronto General Hospital, GW 3 522, 150 Gerrard St West, Toronto, ON, Canada M5G 2C4
    Am J Physiol Heart Circ Physiol 297:H1984-91. 2009
    ..Global myocardial ischemia of 3 min leads to complex spatiotemporal changes during VF in myopathic human hearts; these changes can be reversed by a short duration of reperfusion...
  78. ncbi request reprint Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs
    Gabriel Laurent
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
    Circ Arrhythm Electrophysiol 2:171-8. 2009
    ..The present study assessed the effect of the gap junction conduction-enhancing antiarrhythmic peptide GAP-134 on AF inducibility and maintenance in a dog model of atrial cardiomyopathy...
  79. pmc Outcomes in heart failure patients referred for consideration of implantable cardioverter defibrillator for primary prophylaxis of sudden cardiac death: what are the risks of waiting?
    Nina Ghosh
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Can J Cardiol 25:e342-346. 2009
    ..The 'real-world' prognosis before ICD implantation in such patients is not known. The estimated risk of death is 0.8% per month, and this forms the basis for wait-time recommendations...
  80. ncbi request reprint Prognostic differences between atrial fibrillation and atrial flutter
    Paul Lelorier
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 93:647-9. 2004
    ..We also evaluated warfarin use over time and compared left atrial dimensions in patients with atrial flutter with those with atrial fibrillation...
  81. pmc Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis
    David J A Jenkins
    Department of Medicine, Division of Endocrinology, St Michael s Hospital, Toronto, Ont
    CMAJ 178:157-64. 2008
    ....
  82. ncbi request reprint The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation
    Ratika Parkash
    University of Ottawa, Ottawa, Ontario, Canada
    Am Heart J 148:649-54. 2004
    ..We evaluated the effect of LA dimension on the occurrence of AF using 2- and 4-year echocardiographic data in a large cohort of patients with new onset AF...
  83. ncbi request reprint I(Ks) block by HMR 1556 lowers ventricular defibrillation threshold and reverses the repolarization shortening by isoproterenol without rate-dependence in rabbits
    Petsy Pui Sze So
    Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    J Cardiovasc Electrophysiol 18:750-6. 2007
    ..It is unclear whether I(Ks) plays a role during ventricular fibrillation (VF) or ventricular repolarization at rapid rates during beta-adrenergic stimulation...
  84. ncbi request reprint Psychological correlates of quality of life in atrial fibrillation
    Lephuong Ong
    Department of Psychology, York University, Toronto, Ontario, M3J 1P3, Canada
    Qual Life Res 15:1323-33. 2006
    ..We examined whether specific personality traits and illness management styles would help explain the severity of QoL impairments reported in this population...
  85. ncbi request reprint Left ventricular performance during acute rate control in atrial fibrillation: the importance of heart rate and agent used
    Arnold Pinter
    Division of Cardiology, St Michael s Hospital, University of Toronto, Canada
    J Cardiovasc Pharmacol Ther 8:17-24. 2003
    ..The relation between heart rate and left ventricular function during rate control in atrial fibrillation is incompletely understood...
  86. ncbi request reprint Gender differences and quality of life in atrial fibrillation: the mediating role of depression
    Lephuong Ong
    Department of Psychology, York University, Toronto, Canada
    J Psychosom Res 61:769-74. 2006
    ..This study investigated gender differences, depression, and health-related quality of life (QoL) in a cross-sectional sample of patients with atrial fibrillation (AF)...
  87. ncbi request reprint Cardiac electrophysiological consequences of neuromuscular incapacitating device discharges
    Kumaraswamy Nanthakumar
    University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 48:798-804. 2006
    ..The purpose of this study was to evaluate the cardiac consequences of neuromuscular incapacitating device (NID)/stun gun discharge in an experimental model...
  88. ncbi request reprint Gap junction blockers decrease defibrillation thresholds without changes in ventricular refractoriness in isolated rabbit hearts
    X Qi
    Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ont, Canada
    Circulation 104:1544-9. 2001
    ..CONCLUSIONS: Electrical uncoupling by 16-DSA and 1-heptanol significantly lowers DFT and dispersion of VFCL without altering refractoriness; lidocaine, at doses resulting in similar slowing of conduction, increases DFT...
  89. ncbi request reprint Improvement in Cheyne-Stokes respiration following cardiac resynchronisation therapy
    J Y Gabor
    Dept of Medicine, St Michael s Hospital, University of Toronto, Canada
    Eur Respir J 26:95-100. 2005
    ..In conclusion, cardiac resynchronisation therapy is associated with a reduction in Cheyne-Stokes respiration, which may contribute to improved clinical outcome in patients treated with cardiac resynchronisation therapy...
  90. pmc Limitations in the current screening practice of assessing left ventricular ejection fraction for a primary prophylactic implantable defibrillator in southern Ontario
    Christopher Lane
    Division of Cardiology, Department of Medicine, St Michael s Hospital, University of Toronto, Ontario
    Can J Cardiol 26:e118-24. 2010
    ..However, radionuclide ventriculography (RNA) is used by many implantation centres for decision making...
  91. ncbi request reprint Restoring sinus rhythm in atrial fibrillation: a Pyrrhic victory?
    Paul Dorian
    J Am Coll Cardiol 42:30-2. 2003
  92. pmc Limitations to antiarrhythmic drug use in patients with atrial fibrillation
    Karin H Humphries
    Department of Medicine, University of British Columbia and Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC
    CMAJ 171:741-5. 2004
    ....
  93. ncbi request reprint A view from the bridge: agreement between the SF-6D utility algorithm and the Health Utilities Index
    Bernie J O'Brien
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Canada
    Health Econ 12:975-81. 2003
    ..The Health Utilities Index, mark 3 (HUI3) is a valid and reliable multi-attribute health utility scale that is widely used. We assessed within-subject agreement between SF-6D utilities and those from HUI3...
  94. pmc Applying the new STEMI guidelines: 1. Reperfusion in acute ST-segment elevation myocardial infarction
    Peter Bogaty
    Quebec Heart Institute, Laval Hospital, Sainte Foy
    CMAJ 171:1039-41. 2004
  95. ncbi request reprint Continuous template collection and updating for electrogram morphology discrimination in implantable cardioverter defibrillators
    Steven J Compton
    Alaska Heart Institute, Anchorage, Alaska 99508 4615, USA
    Pacing Clin Electrophysiol 29:244-54. 2006
    ..We report the clinical performance of an automatic algorithm that creates and updates templates from non-paced, slow rhythm and continuously checks the quality of the template used for arrhythmia discrimination...
  96. ncbi request reprint Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database
    Craig M Pratt
    Department of Cardiology, Methodist DeBakey Heart Center, Houston, Texas 77030, USA
    J Am Coll Cardiol 48:471-7. 2006
    ..The purpose of this study was to assess the incidence, temporal characteristics, and risk factors associated with azimilide-associated torsades de pointes (TdP) ventricular tachycardia...
  97. ncbi request reprint Quality of life and exercise performance in patients in sinus rhythm versus persistent atrial fibrillation: a Veterans Affairs Cooperative Studies Program Substudy
    Steven N Singh
    Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    J Am Coll Cardiol 48:721-30. 2006
    ..The purpose of this study was to determine quality of life (QOL) and exercise performance (EP) in patients with persistent atrial fibrillation (AF) converted to sinus rhythm (SR) compared with those remaining in or reverting to AF...
  98. ncbi request reprint Fish oil supplementation and arrhythmias
    Martin H Strauss
    JAMA 294:2165; author reply 2165-6. 2005
  99. ncbi request reprint Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Heart J 27:3027-32. 2006
    ..The purpose of this study was to assess the incidence, features, and clinical sequelae of 'electrical storm' (ES)...
  100. ncbi request reprint Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator
    Craig M Pratt
    The Methodist DeBakey Heart Center and the Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Am J Cardiol 95:274-6. 2005
    ..The primary efficacy end points are time to all-cause shocks and time to all-cause shocks plus symptomatic ventricular arrhythmic events triggering antitachycardia pacing measured from randomization...
  101. pmc Use of implantable cardioverter defibrillators after out-of-hospital cardiac arrest: a prospective follow-up study
    Ratika Parkash
    Ottawa Health Research Institute
    CMAJ 171:1053-6. 2004
    ..We sought to determine the ICD insertion rate among survivors of out-of-hospital cardiac arrest and to determine factors associated with ICD implantation...