Irfan A Dhalla
Affiliation: St. Michael's Hospital
- Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodoneIrfan A Dhalla
Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
CMAJ 181:891-6. 2009..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone...
- Perspectives on the National Institute for Health and Clinical Excellence's recommendations to use health technologies only in researchIrfan A Dhalla
Medicine and Health Policy, Management and Evaluation, University of Toronto, Keenan Research Centre of Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
Int J Technol Assess Health Care 25:272-80. 2009..Nevertheless, these decisions are often controversial and implementation can be problematic...
- Potentially inappropriate prescribing in Canada relative to the USPaula A Rochon
Kunin Lunenfeld Applied Research Unit, Department of Medicine, University of Toronto, Baycrest Centre for Geriatric Care, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Drugs Aging 21:939-47. 2004..To explore the prescribing of potentially inappropriate drug therapy in Ontario, Canada where there is a restrictive drug formulary relative to the US where there is no single drug formulary...
- Potentially inappropriate prescribing in Ontario community-dwelling older adults and nursing home residentsChristopher J Lane
Department of Medicine, University of Toronto, Toronto, Canada
J Am Geriatr Soc 52:861-6. 2004..To compare patterns of potentially inappropriate drug therapy prescribing in community-dwelling older adults and nursing home residents in Ontario, Canada...
- Effect of a course-based intervention and effect of medical regulation on physicians' opioid prescribingMeldon Kahan
Department of Family and Community Medicine, University of Toronto U of T, Ontario, Canada
Can Fam Physician 59:e231-9. 2013..To examine the effects of an intensive 2-day course on physicians' prescribing of opioids...
- The burden of premature opioid-related mortalityTara Gomes
Institute for Clinical and Evaluative Sciences, Toronto, ON, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada Leslie Dan Faculty of Pharmacy, Toronto, ON, Canada Sunnybrook Research Institute, Toronto, ON, Canada
Addiction 109:1482-8. 2014..We calculated temporal trends in the proportion of deaths attributable to opioids and estimated years of potential life lost (YLL) due to opioid-related mortality in Ontario, Canada...
- Opioid dose and risk of road trauma in Canada: a population-based studyTara Gomes
Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
JAMA Intern Med 173:196-201. 2013..Use of opioids may predispose drivers to road trauma, yet the effect of opioid dose on this association is unknown...
- Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?Irfan A Dhalla
Department of Medicine, Unversity of Toronto, Ontario M4E 3E9, Canada
Antimicrob Agents Chemother 50:3216-9. 2006..difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin or moxifloxacin compared to levofloxacin...
- Clustering of opioid prescribing and opioid-related mortality among family physicians in OntarioIrfan A Dhalla
Department of Medicine, University of Toronto, Toronto, Ont
Can Fam Physician 57:e92-6. 2011..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality...
- Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort studyIrfan A Dhalla
St Michael s Hospital and Institute for Clinical Evaluative Sciences, Toronto, Ontario M5B 1W8, Canada
Ann Intern Med 158:447-55. 2013..Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension...
- Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control studyIrfan A Dhalla
Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
Chest 141:348-53. 2012..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension...
- Opioid dose and drug-related mortality in patients with nonmalignant painTara Gomes
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Arch Intern Med 171:686-91. 2011..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality...
- Creating the right evidence for system changeKenneth Lam
Kenneth Lam, Bsc, is a Keenan research summer student at the Li Ka Shing Knowledge Institute, St Michael s Hospital, in Toronto, Ontario and a medical student at Western University, in London, Ontario
Healthc Q 16:22-6. 2013..They then describe what must be done to make similar trials a regular tool of healthcare policy. ..
- Private expenditures on brand name prescription drugs after generic entryDahlia Y Balaban
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Appl Health Econ Health Policy 11:523-9. 2013..Generic drugs offer a less expensive and therapeutically equivalent alternative to brand name drugs. Nevertheless, many Canadian private drug plans continue to pay for brand name drugs even after generics become available...
- Comparative effectiveness research in Ontario, Canada: producing relevant and timely information for health care decision makersDanielle M Whicher
Center for Medical Technology Policy, University of Toronto, Canada
Milbank Q 87:585-606. 2009..As the United States begins to invest in comparative effectiveness, it would be wise to look at other functioning research networks to understand the infrastructure and funding required to support them...
- Unplanned readmissions after hospital discharge among patients identified as being at high risk for readmission using a validated predictive algorithmAndrea Gruneir
Women s College Research Institute, University of Toronto, Canada
Open Med 5:e104-11. 2011..The purpose of this study was to describe medical patients identified using a recently published and validated algorithm (the LACE index) as being at high risk for readmission and to examine their actual hospital readmission rates...
- Oral vitamin B12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectivesJeff C Kwong
Department of Family and Community Medicine, University of Toronto, 263 McCaul Street, Toronto, Ontario, M5T 1W7, Canada
BMC Fam Pract 6:8. 2005..We investigated patient perspectives on switching from injection to oral B12 therapy...
- Primary medication non-adherence after discharge from a general internal medicine serviceBrooks A Fallis
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 8:e61735. 2013....
- Dependence and addiction during chronic opioid therapyDavid N Juurlink
Sunnybrook Research Institute, Toronto, Canada
J Med Toxicol 8:393-9. 2012....
- A comparison of Canadian medical students from rural and non-rural backgroundsJeff C Kwong
Community Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Can J Rural Med 10:36-42. 2005..Very little is known about medical students from rural areas currently enrolled in Canadian medical schools...
- Risks and benefits of importing prescription medications from lower-income countriesIrfan A Dhalla
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
JAMA 300:1453-5. 2008
- Inappropriate prescribing before and after nursing home admissionIrfan A Dhalla
Faculty of Medicine, University of Toronto, 2113 40 Gerrard Street East, Toronto, Ontario M5B 2E8, Canada
J Am Geriatr Soc 50:995-1000. 2002..To compare the prevalence of inappropriate prescribing before and after nursing home admission and to determine which patient and physician characteristics are associated with inappropriate prescribing in the nursing home setting...