P W Connelly

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint The prevalence of hyperlipidemia in women and its association with use of oral contraceptives, sex hormone replacement therapy and nonlipid coronary artery disease risk factors. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:419-27. 1999
  2. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
  3. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
  4. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
  5. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
  6. ncbi request reprint Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite
    Philip W Connelly
    J Alick Little Lipid Research Laboratory, Toronto, ON, Canada
    Free Radic Biol Med 38:164-74. 2005
  7. ncbi request reprint Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
    P W Connelly
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Int J Obes Relat Metab Disord 27:347-54. 2003
  8. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
  9. ncbi request reprint Separation and quantitative recovery of mouse serum arylesterase and carboxylesterase activity
    Philip W Connelly
    Department of Medicine, University of Toronto, and St Michael s Hospital, Toronto, Canada
    J Lipid Res 45:561-6. 2004
  10. ncbi request reprint Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma
    Philip W Connelly
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    J Lipid Res 49:245-50. 2008

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint The prevalence of hyperlipidemia in women and its association with use of oral contraceptives, sex hormone replacement therapy and nonlipid coronary artery disease risk factors. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:419-27. 1999
    ..To report the prevalence of lipid and nonlipid coronary artery disease risk factors in women classified by use of oral contraceptives or sex hormone replacement therapy...
  2. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  3. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
    ..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
  4. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
    ..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
  5. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
    ..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
  6. ncbi request reprint Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite
    Philip W Connelly
    J Alick Little Lipid Research Laboratory, Toronto, ON, Canada
    Free Radic Biol Med 38:164-74. 2005
    ..We conclude that PON1 does not affect the accumulation of phosphatidylcholine oxidation products. Further, we have no evidence that PON1 has an intrinsic phospholipase A2 activity toward oxidized phospholipids...
  7. ncbi request reprint Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
    P W Connelly
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Int J Obes Relat Metab Disord 27:347-54. 2003
    ....
  8. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
  9. ncbi request reprint Separation and quantitative recovery of mouse serum arylesterase and carboxylesterase activity
    Philip W Connelly
    Department of Medicine, University of Toronto, and St Michael s Hospital, Toronto, Canada
    J Lipid Res 45:561-6. 2004
    ..The contribution of serum carboxylesterase to the total esterase activity significantly confounds the interpretation of total arylesterase activity in mouse serum...
  10. ncbi request reprint Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma
    Philip W Connelly
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    J Lipid Res 49:245-50. 2008
    ..8%. The mass of PON1 in serum was significantly correlated with arylesterase activity (r = 0.85). Thus, we have demonstrated the feasibility of measuring PON1 mass in either serum or EDTA plasma...
  11. doi request reprint Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones
    Philip W Connelly
    Department of Medicine, University of Toronto, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Biochim Biophys Acta 1811:39-45. 2011
    ..In contrast, medium-chain length fatty acid lactones are stable in mouse serum in the absence of PON1, suggesting that PON1 plays a specific role in the metabolism of these compounds...
  12. ncbi request reprint Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins
    R A Hegele
    Department of Medicine, St Michael s Hospital, London, Canada
    Arterioscler Thromb Vasc Biol 17:2753-8. 1997
    ..However, the associations could also have resulted from linkage disequilibrium with other functional variants in APOC3 or the closely linked APOA1 and/or APOA4 genes...
  13. ncbi request reprint Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1060-6. 1997
    ..045, and P = .047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprotein phenotypes in this study sample...
  14. ncbi request reprint Are Canadian Inuit at increased genetic risk for coronary heart disease?
    R A Hegele
    Department of Medicine, University of Toronto, Ontario, Canada
    J Mol Med (Berl) 75:364-70. 1997
    ..This suggests that differences in environment, such as the type of fatty acid consumed, interacts with functional differences in gene products involved in candidate metabolic pathways to produce phenotypic differences...
  15. ncbi request reprint Absence of association between genetic variation of the beta 3-adrenergic receptor and metabolic phenotypes in Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Diabetes Care 21:851-4. 1998
    ..To assess the association between the common missense variant, Y64R, in the gene encoding the beta 3-adrenergic receptor, ADRB3, and intermediate phenotypes related to obesity and NIDDM in Canadian Oji-Cree...
  16. ncbi request reprint Intestinal fatty acid-binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre
    R A Hegele
    Department of Medicine, Faculty of Medicine, University of Toronto, Canada
    Eur J Clin Invest 27:857-62. 1997
    ..Genetic variation in FABP2 may thus contribute to interindividual variation in the response of plasma lipoproteins to different dietary fibres, but the mechanism does not appear to be related to increases in fecal bile acid secretion...
  17. ncbi request reprint Cross-sectional and prospective associations between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition
    A J Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 24:1240-7. 2001
    ..CONCLUSIONS: These results confirm previously reported cross-sectional associations between proinsulin and lipid concentrations. In addition, an unexpected association between baseline lipids and proinsulin change was documented...
  18. ncbi request reprint Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Department of Medicine, London, Ont, Canada
    Atherosclerosis 146:153-60. 1999
    ....
  19. ncbi request reprint Genetic and biochemical factors associated with variation in blood pressure in a genetic isolate
    R A Hegele
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Hypertension 27:308-12. 1996
    ..The association between plasma apo B concentration and diastolic blood pressure suggests that these traits may share some determinants...
  20. doi request reprint Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy, irrespective of gestational glucose tolerance status
    L Maple-Brown
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 025, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 97:4148-55. 2012
    ..However, these studies have yielded markedly conflicting results, including increased, decreased, and unchanged leptin levels in women with GDM as compared with their peers...
  21. ncbi request reprint Elevated C-reactive protein in Native Canadian children: an ominous early complication of childhood obesity
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:483-91. 2006
    ..Thus, we sought to determine whether subclinical inflammation is an early complication of obesity in Native children...
  22. ncbi request reprint Prevalence of high plasma triglyceride combined with low HDL-C levels and its association with smoking, hypertension, obesity, diabetes, sedentariness and LDL-C levels in the Canadian population. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:428-33. 1999
    ..In particular, the associations for persons with high triglyceride and low HDL-C levels were examined...
  23. ncbi request reprint Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Department of Medicine, Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, 406 100 Perth Drive, Ont, N6A 5K8, London, Canada
    Atherosclerosis 154:579-87. 2001
    ..The inconsistencies could be due to differences in genetic background or to unspecified environmental or genetic factors...
  24. pmc Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada
    Diabetologia 53:268-76. 2010
    ..Thus, we sought to determine whether adiponectin, leptin and CRP levels during pregnancy relate to the postpartum metabolic defects linking GDM with type 2 diabetes...
  25. ncbi request reprint Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 48:993-1001. 2005
    ..We conducted the current investigation to determine whether adiponectin is associated with beta cell dysfunction in GDM...
  26. doi request reprint The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy
    R Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:706-12. 2011
    ....
  27. ncbi request reprint ABCC6 gene polymorphism associated with variation in plasma lipoproteins
    J Wang
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, ON, Canada
    J Hum Genet 46:699-705. 2001
    ..The results suggest that ABCC6 may be a determinant of plasma lipoproteins...
  28. ncbi request reprint Plasmodium falciparum-infected erythrocytes and oxidized low-density lipoprotein bind to separate domains of CD36
    I Crandall
    Tropical Disease Unit, The Toronto Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 180:473-9. 1999
    ..These results suggest that, although oxLDL competitively inhibits the adherence of pRBCs, these ligands interact with distinct domains on the CD36 receptor...
  29. ncbi request reprint Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, London, Ontario, Canada
    Clin Biochem 32:143-8. 1999
    ....
  30. ncbi request reprint Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, J Alick Little Core Lipid Laboratory, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 65:1524-33. 1997
    ..We conclude that psyllium lowered LDL- and HDL-cholesterol concentrations similarly at both MUFA intakes. However, there may be some advantage in combining soluble fiber and MUFA to reduce the ratio of LDL to HDL cholesterol...
  31. ncbi request reprint Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 82:3373-7. 1997
    ....
  32. ncbi request reprint Angiotensinogen gene variation associated with variation in blood pressure in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Centre, Toronto, Ontario, Canada
    Hypertension 29:1073-7. 1997
    ..The high frequency of the angiotensinogen T235 variant suggests that subjects in this young, essentially normotensive population might be predisposed to hypertension, which may become more apparent in the presence of secondary factors...
  33. ncbi request reprint Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    Hui Song
    Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
    Am J Physiol Endocrinol Metab 290:E17-E25. 2006
    ..Some of the phenotypes are not readily explained by known mechanisms and may represent novel regulatory pathways...
  34. ncbi request reprint Identification of disulfide-linked apolipoprotein species in human lipoproteins
    P W Connelly
    Department of Biochemistry, University of Toronto, Ontario, Canada
    J Lipid Res 34:1717-27. 1993
    ..These results demonstrate that the molecular species of cysteine-containing apolipoproteins are complex and should be considered in studies of human lipoprotein composition and function...
  35. ncbi request reprint Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Center, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:4334-7. 1996
    ..These findings suggest that the T54 variant of the intestinal fatty acid-binding protein is associated with differences in fat metabolism in this aboriginal population...
  36. ncbi request reprint Apolipoprotein E R112; R251G: a carboxy-terminal variant found in patients with hyperlipidemia and coronary heart disease
    A K Kang
    Department of Medicine, University of Toronto, Canada
    Mutat Res 382:57-65. 1997
    ....
  37. ncbi request reprint -6A promoter variant of angiotensinogen and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    St Michael s Hospital, Toronto, Ontario, Canada
    J Hum Genet 43:37-41. 1998
    ..Our findings are consistent with a marginally deleterious effect of the AGT -6A allele on blood pressure, but linkage disequilibrium with another causative variant cannot be ruled out in this sample of aboriginal Canadians...
  38. ncbi request reprint Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor
    Z Ahmed
    J. Alick Little Lipid Research Laboratory, St. Michael's Hospital, University of Toronto, 38 Shuter Street, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 276:24473-81. 2001
    ..We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1...
  39. ncbi request reprint Common and rare ABCA1 variants affecting plasma HDL cholesterol
    J Wang
    John P Robarts Research Institute, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 20:1983-9. 2000
    ....
  40. ncbi request reprint Interaction between variant apolipoproteins C-II and E that affects plasma lipoprotein concentrations
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Arterioscler Thromb 11:1303-9. 1991
    ....
  41. ncbi request reprint Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Diabet Med 24:245-52. 2007
    ..e. representing an early stage in the natural history of the disease), we sought to determine if decreased HMW adiponectin is a feature of GDM...
  42. pmc Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia
    D S Ng
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Clin Invest 93:223-9. 1994
    ..This kindred, the third reported apoA-I gene mutation causing isolated complete apoA-I deficiency, appears to be at significantly increased risk for atherosclerosis...
  43. ncbi request reprint Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency
    R A Hegele
    Department of Medicine, University of Toronto, Ontario, Canada
    Biochem Biophys Res Commun 179:78-84. 1991
    ..We now report the identification of three more hepatic lipase gene mutations in this family and demonstrate that compound heterozygosity for two hepatic lipase mutations (designated S267F and T383M) underlies hepatic lipase deficiency...
  44. ncbi request reprint Genetic variation in factor VII associated with variation in plasma lipoprotein(a) concentration
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1701-6. 1997
    ..71 micrograms/mL and to increase by 0.301 microgram/mL plasma Lp(a) concentration from the sample mean. This suggests that common genomic variation in F7 is associated with variation in plasma Lp(a) concentration...
  45. ncbi request reprint Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, Department of Medicine, Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Quebec, Canada
    Metabolism 50:494-503. 2001
    ..We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation...
  46. ncbi request reprint Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
    R A Guy
    Department of Medicine, Institute of Medical Science, University of Toronto, Rm. 7202 Medical Sciences Building, 8 Taddle Creek Road, Ont, M5S 1A8, Toronto, Canada
    Atherosclerosis 155:19-28. 2001
    ....
  47. ncbi request reprint Reference values of plasma apolipoproteins A-I and B, and association with nonlipid risk factors in the populations of two Canadian provinces: Quebec and Saskatchewan. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:409-18. 1999
    ..To determine the population distribution of apolipoproteins A-I and B, and the relationship of apolipoprotein B to lipid risk factors for coronary artery disease...
  48. ncbi request reprint Hypoadiponectinaemia in South Asian women during pregnancy: evidence of ethnic variation in adiponectin concentration
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabet Med 21:388-92. 2004
    ..Here, we report the impact of ethnicity on plasma adiponectin concentration in that study...
  49. doi request reprint Utility of non-high-density lipoprotein cholesterol in assessing incident type 2 diabetes risk
    S H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Diabetes Obes Metab 14:821-5. 2012
    ....
  50. ncbi request reprint Paraoxonase 1 arylesterase activity and mass are reduced and inversely related to C-reactive protein in patients on either standard or home nocturnal hemodialysis
    J Kannampuzha
    Keenan Research Center, Li Ka Shing Knowledge Institute, Ontario, Canada
    Clin Nephrol 73:131-8. 2010
    ..We determined serum PON1 mass and arylesterase activities in a group of HNHD patients and compared them to SHD patients and a group of healthy controls (HC)...
  51. ncbi request reprint Direct comparison of dietary portfolio vs statin on C-reactive protein
    D J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Eur J Clin Nutr 59:851-60. 2005
    ..3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known...
  52. pmc Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease
    P W Connelly
    Lipid Research Clinic, St Michael s Hospital, Toronto, Canada
    J Clin Invest 80:1597-606. 1987
    ..Both siblings and several relatives had premature ischemic vascular disease, in contrast with its apparent absence in other apoCII-deficient families...
  53. ncbi request reprint A hepatic lipase gene mutation associated with heritable lipolytic deficiency
    R A Hegele
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 72:730-2. 1991
    ..We propose that T383M is specific to families with heritable HL deficiency. Furthermore, structural variation at the HL gene, possibly in combination with other factors, appears to be etiologic in HL deficiency...
  54. pmc A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy
    Xianghong Zhu
    Department of Medicine, St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario M5B 1A6 Canada
    Am J Pathol 165:1269-78. 2004
    ....
  55. ncbi request reprint Nontraditional cardiovascular risk factors in pediatric metabolic syndrome
    Ravi Retnakaran
    Division of Endocrinology, The Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 148:176-82. 2006
    ..To study the relationships between nontraditional cardiovascular (CV) risk factors and components of the metabolic syndrome in Native Canadian children, a population at risk of future CV disease...
  56. ncbi request reprint An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia
    R A Hegele
    Department of Medicine, University of Toronto, Canada
    Dis Markers 9:73-80. 1991
    ....
  57. ncbi request reprint Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Biol Chem 277:11715-20. 2002
    ..This modulation of oxidative stress may in part contribute to the reduced atherosclerosis seen in the apoE-/- xlcat-/- mice...
  58. ncbi request reprint Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite
    Zakaria Ahmed
    J Alick Little Lipid Research Laboratory, St Michael s Hospital, University of Toronto, 38 Shuter Street, Toronto, Ontario M5B 1A6, Canada
    Biochem Biophys Res Commun 290:391-6. 2002
    ..We conclude that PON-1 minimizes the accumulation of phosphatidylcholine oxidation products by the hydrolysis of phosphatidylcholine isoprostanes and core aldehydes to lysophosphatidylcholine with a serine esterase-independent mechanism...
  59. ncbi request reprint Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 279:7636-42. 2004
    ..014). Both the HTG and the improved fasting glucose phenotype seen in the dko mice are at least in part attributable to an up-regulation of the hepatic srebp-1c gene...
  60. ncbi request reprint The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 87:114-25. 2008
    ..The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown...
  61. doi request reprint Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Cardiovasc Pathol 17:226-32. 2008
    ..As paraoxonase-1 has been recently shown to be a lactonase, its functional role remains to be fully elucidated. We explored additional vascular changes in Pon1 knockout mice in the absence of atherogenic diet challenge...
  62. ncbi request reprint Adiponectin in a native Canadian population experiencing rapid epidemiological transition
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Mt Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 26:3219-25. 2003
    ....
  63. doi request reprint NF-kappaB -94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Atherosclerosis 204:465-70. 2009
    ..05). These findings show that this functional polymorphism in the NF-kB gene modifies the association between PUFA intake and plasma HDL-cholesterol in two distinct populations...
  64. ncbi request reprint Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population
    Juan Liu
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Obesity (Silver Spring) 14:500-8. 2006
    ....
  65. ncbi request reprint Unmasking of type III hyperlipoproteinemia by hypothyroidism: a dramatic illustration of altered lipoprotein metabolism in a postpartum woman
    Ravi Retnakaran
    Department of Medicine, Division of Endocrinology, St Michael s Hospital and Health Centre, 61 Queen Street East, Toronto, Ontario, Canada
    Endocr Pract 11:394-8. 2005
    ..To illustrate the potential abnormalities in lipoprotein metabolism associated with type III hyper-lipoproteinemia and the modulation of their clinical expression by thyroid hormone and estrogenic status...
  66. pmc Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
  67. doi request reprint Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD)
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:227-34. 2013
    ..We aimed to explore whether long-term changes in postprandial responses on low-glycemic-index (GI) or low-CHO diets were due to acute or chronic effects in T2DM...
  68. ncbi request reprint High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center and the Department of Medicine, The Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Canada
    Am J Clin Nutr 74:57-63. 2001
    ..Further studies are required to assess the longer-term effects on renal function...
  69. ncbi request reprint Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs...
  70. ncbi request reprint Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Pediatr Nephrol 22:1007-13. 2007
    ..0072). In summary, increased cystatin C is associated with an enhanced CV risk factor profile in Aboriginal youth and may be an early event in the natural history of vascular disease...
  71. ncbi request reprint A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 51:1596-604. 2002
    ....
  72. doi request reprint Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Res Clin Pract 85:40-6. 2009
    ....
  73. pmc APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
    Piya Lahiry
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    J Lipid Res 51:843-8. 2010
    ..0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels...
  74. doi request reprint Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 56:666-70. 2010
    ..We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians...
  75. doi request reprint The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  76. ncbi request reprint Human hepatic lipase mutations and polymorphisms
    R A Hegele
    DNA and Lipid Research Laboratories, St Michael s Hospital, Toronto, Ontario, Canada
    Hum Mutat 1:320-4. 1992
    ..Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia...
  77. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis...
  78. ncbi request reprint Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 91:93-7. 2006
    ..Nevertheless, there has been limited study of insulin action during pregnancy in these ethnic groups...
  79. ncbi request reprint Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
    Am J Clin Nutr 81:380-7. 2005
    ..Newer dietary approaches combining cholesterol-lowering foods may offer another option, but these approaches have not been compared directly with statins in the same persons...
  80. pmc Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:1410-5. 2008
    ....
  81. ncbi request reprint Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 106:1327-32. 2002
    ..Furthermore, the effective dose is still unknown...
  82. pmc Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 31:1275-81. 2008
    ..Thus, we hypothesized that 1-h GIGT would be associated with the same adverse outcomes as GDM, i.e., increased infant birth weight and postpartum metabolic dysfunction...
  83. pmc Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR
    Matthew B Lanktree
    Robarts Research Institute, Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:768-72. 2009
    ....
  84. ncbi request reprint Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 25:1522-8. 2002
    ..Cohort studies indicate that cereal fiber reduces the risk of diabetes and coronary heart disease (CHD). Therefore, we assessed the effect of wheat bran on glycemic control and CHD risk factors in type 2 diabetes...
  85. ncbi request reprint The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 52:1478-83. 2003
    ..Combining a number of foods and food components in a single dietary portfolio may lower LDL-C similarly to statins and so increase the potential effectiveness of dietary therapy...
  86. ncbi request reprint Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans
    Xiao Yan Wen
    Department of Experimental Therapeutics, Toronto General Research Institute, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Hum Mol Genet 12:1131-43. 2003
    ..Study of this lipase subfamily may identify novel molecular mechanisms for plasma and/or tissue TG metabolism...
  87. ncbi request reprint Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    JAMA 290:502-10. 2003
    ....
  88. ncbi request reprint C-reactive protein and gestational diabetes: the central role of maternal obesity
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
    J Clin Endocrinol Metab 88:3507-12. 2003
    ..These data suggest a model in which obesity mediates a systemic inflammatory response, with possible downstream metabolic sequelae, including insulin resistance and glucose dysregulation...
  89. ncbi request reprint Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 76:365-72. 2002
    ..Many of the benefits of soy have been attributed to soy isoflavones...
  90. ncbi request reprint Risk factors for cardiovascular disease in homeless adults
    Tony C Lee
    Centre for Research on Inner City Health, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 111:2629-35. 2005
    ..The objective of this study was to examine cardiovascular risk factors in a representative sample of homeless adults and identify opportunities for improved risk factor modification...
  91. ncbi request reprint Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, and the Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Metabolism 51:919-24. 2002
    ....
  92. pmc Cigarette smoking and cardiovascular risk factors among Aboriginal Canadian youths
    Ravi Retnakaran
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 173:885-9. 2005
    ....
  93. ncbi request reprint The impact of family history of diabetes on risk factors for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 67:754-60. 2007
    ..We thus hypothesized that the risk factors for gestational hyperglycaemia in women with FHD may differ from those in women without FHD...
  94. doi request reprint Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
    Phillip Segal
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Matern Fetal Neonatal Med 21:73-9. 2008
    ..We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population...
  95. ncbi request reprint Low serum levels of high-molecular weight adiponectin in Indo-Asian women during pregnancy: evidence of ethnic variation in adiponectin isoform distribution
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5
    Diabetes Care 29:1377-9. 2006
  96. pmc Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:1323-9. 2010
    ..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis...
  97. ncbi request reprint Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 83:582-91. 2006
    ..Cholesterol-lowering foods may be more effective when consumed as combinations rather than as single foods...
  98. ncbi request reprint Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Ontario, Canada
    Diabetes Care 29:57-62. 2006
    ..e., a single abnormal value on an OGTT), however, are not well established. We sought to evaluate the metabolic phenotype of pregnant women with IGT in relation to the timing of their isolated hyperglycemia...
  99. ncbi request reprint The Garden of Eden--plant based diets, the genetic drive to conserve cholesterol and its implications for heart disease in the 21st century
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, 61 Queen Street East, Ont, M5C 2T2, Toronto, Canada
    Comp Biochem Physiol A Mol Integr Physiol 136:141-51. 2003
    ....
  100. ncbi request reprint Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution
    Gabie K B Ong
    Faculty of Arts and Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 67:108-14. 2007
    ....
  101. ncbi request reprint Effect of plant sterols in combination with other cholesterol-lowering foods
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada M5C 2T2
    Metabolism 57:130-9. 2008
    ....