Research Topics
| T AntoniouSummaryAffiliation: St. Michael's Hospital Country: Canada Publications
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Detail Information
Publications
Severe anemia secondary to a probable drug interaction between zidovudine and valproic acidTony Antoniou
Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Clin Infect Dis 38:e38-40. 2004..The inhibition of zidovudine glucuronidation by valproic acid and the resultant zidovudine hematologic toxicity is the proposed mechanism of the interaction...
Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control studyTony Antoniou
University of Toronto, Toronto, ON, Canada
BMJ 343:d5228. 2011..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone...
Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with menT Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Int J STD AIDS 20:180-3. 2009..Cultured MRSA underwent pulsed-field gel electrophoresis and virulence testing for Panton-Valentine leukocidin gene expression. The prevalence of CA-MRSA colonization was 1.6% (95% CI: 0.5-2.6%)...- Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophyTony Antoniou
Canadian Immunodeficiency Research Collaborative, Canada
AIDS Care 21:1247-52. 2009..001) and mental health (p=0.01) were observed from baseline to week 96. In conclusion, treatment with PAIG was associated with sustained improvements in both the physical and psychological components of FLA through 96 weeks of follow-up... - Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patientsTony Antoniou
St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Ther Drug Monit 27:779-81. 2005..No patient discontinued the regimen because of indinavir-related urologic or retinoid-type adverse effects. Further study of the regimen with larger cohorts of patients is necessary... - Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort studyT Antoniou
University of Toronto, Toronto, Ontario, Canada
HIV Med 6:284-90. 2005..Despite the recent publication of case reports describing various manifestations of tenofovir-related nephrotoxicity, data regarding the incidence of and risk factors for this adverse effect are currently lacking... - Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literatureTony Antoniou
Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Pharmacotherapy 25:899-903. 2005..In addition, they should continue to reserve its use for moderate-to-severe Pneumocystis jiroveci pneumonia for which trimethoprim-sulfamethoxazole is ineffective or contraindicated... - Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based studyTony Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 170:1045-9. 2010..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB... - Interactions between antiretrovirals and antineoplastic drug therapyTony Antoniou
St Michael s Hospital, Toronto, Ontario, Canada
Clin Pharmacokinet 44:111-45. 2005..Further research delineating the combined safety and pharmacokinetics of antiretrovirals and antineoplastic therapy is necessary... - Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practiceTony Antoniou
University of Toronto, Toronto, Ontario, Canada, Maple Leaf Medical Clinical, Toronto, Ontario, Canada
J Int Assoc Physicians AIDS Care (Chic) 9:382-9. 2010..Objective: To compare the effectiveness and safety of ritonavir (TPV/r)- and darunavir/ritonavir (DRV/ r)-based therapies in treatment-experienced patients (n = 38 and 47, respectively)... - Ciprofloxacin-induced theophylline toxicity: a population-based studyTony Antoniou
University of Toronto, Toronto, ON, Canada
Eur J Clin Pharmacol 67:521-6. 2011..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline... - Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based studyTony Antoniou
University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Br J Clin Pharmacol 71:544-9. 2011..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin... - Symptomatic hyperlactatemia in an HIV-positive patient: a case report and discussionTony Antoniou
St Michael s Hospital, Toronto, ON
CMAJ 168:195-8. 2003..We also review the pathophysiology, prevalence, spectrum and management of disturbances in lactate homeostasis induced by nucleoside reverse transcriptase inhibitors... - Validation of case-finding algorithms derived from administrative data for identifying adults living with human immunodeficiency virus infectionTony Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 6:e21748. 2011..We sought to validate a case-finding algorithm for human immunodeficiency virus (HIV) infection using administrative health databases in Ontario, Canada... - A large prospective study assessing injection site reactions, quality of life and preference in patients using the Biojector vs standard needles for enfuvirtide administrationM R Loutfy
Department of Medicine, University of Toronto, Maple Leaf Medical Clinic, and Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
HIV Med 8:427-32. 2007..Tualatin, OR, USA) relative to standard needles... - Virologic and immunologic impact and durability of enfuvirtide-based antiretroviral therapy in HIV-infected treatment-experienced patients in a clinical settingM R Loutfy
Department of Medicine, University of Toronto, Toronto, Ontario Maple Leaf Medical Clinical, Toronto, Ontario, Canada
HIV Clin Trials 8:36-44. 2007..To evaluate the effectiveness and safety of enfuvirtide-based therapy in treatment-experienced patients in a clinical setting... - Risk factors for grade 3-4 liver enzyme elevation in HIV and hepatitis C coinfected patients on combination antiretroviral therapyS Chihrin
Maple Leaf Medical Clinic, Toronto, Ontario, Canada
AIDS Patient Care STDS 21:469-78. 2007..0001), and nucleoside analogues (p = 0.0009) compared to the rest of the cohort. Further research to better clarify risk factors for hepatotoxicity in coinfected patients is warranted given the challenges in treating this population... - Prospective cohort study of HIV post-exposure prophylaxis for sexual assault survivorsMona Rafik Loutfy
Department of Medicine, University of Toronto, Ontario, Canada
Antivir Ther 13:87-95. 2008..There is a lack of standardized programs for HIV counselling and post-exposure prophylaxis (PEP) in the setting of sexual assault... - Randomized controlled trial of once-daily tenofovir, lamivudine, and lopinavir/ritonavir versus remaining on the same regimen in virologically suppressed HIV-infected patients on their first PI-containing HAART regimenMona R Loutfy
Department of Medicine, University of Toronto, Toronto, Canada
HIV Clin Trials 8:259-68. 2007.... - Interactions between recreational drugs and antiretroviral agentsTony Antoniou
HIV Program/Inner City Health, St. Michael's Hospital, Toronto, Ontario, Canada
Ann Pharmacother 36:1598-613. 2002..Clinicians should encourage open dialog with their patients on this topic, to avoid compromising antiretroviral efficacy and increasing the risk of drug toxicity... - Outcomes of dosage adjustments used to manage antiretroviral drug interactionsLaura Y Park-Wyllie
Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada
Clin Infect Dis 45:933-6. 2007..03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01)... - Immediate versus delayed polyalkylimide gel injections to correct facial lipoatrophy in HIV-positive patientsMona R Loutfy
Maple Leaf Medical Clinic, 70 Carlton Street, Toronto, Ontario, Canada
AIDS 21:1147-55. 2007..To evaluate the safety and efficacy of polyalkylimide gel (PAIG) in the treatment of HIV-associated facial lipoatrophy... - Adverse quality of life consequences of antiretroviral medicationsL Y Park-Wyllie
St Michael s Hospital, Toronto, Ontario
AIDS Care 19:252-7. 2007..A broad concept of quality of life is needed to encompass all dimensions important to people living with HIV... - Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two casesDenise Jaworsky
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Antivir Ther 15:677-80. 2010..However, data on their safety and efficacy in preventing vertical transmission are limited... - Assay of HIV gp41 amino acid sequence to identify baseline variation and mutation development in patients with virologic failure on enfuvirtideM R Loutfy
University of Toronto, Toronto, Ont, Canada
Antiviral Res 75:58-63. 2007..Further study is required to determine the clinical relevance of the clade related polymorphisms and the new mutations identified in the patients with virologic failure... - Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infectionTony Antoniou
Inner City Health HIV Program, Toronto, Ontario, Canada
Pharmacotherapy 23:29-43. 2003..Given the ease of administration and relative safety from the perspectives of adverse effects and drug interactions, tenofovir has the potential to assume a large role in the treatment of patients with HIV infection... - Tenofovir disoproxil fumarateTony Antoniou
Inner City Health/HIV Program, St Michael's Hospital, Toronto, Ontario, Canada
Drugs 63:1609-10. 2003 - Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphomaMatthew C Cheung
Department of Medicine, Division of Hematology Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Ann Hematol 86:631-8. 2007..The majority prefer to use cART in combination with CHOP for ARL. The use and perceived benefit of rituximab may be influenced by interprovincial formulary differences and regional variation in guideline recommendations... - A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapyTony Antoniou
J Acquir Immune Defic Syndr 37:1666-7. 2004 - Concurrent use of bupropion with CYP2B6 inhibitors, nelfinavir, ritonavir and efavirenz: a case seriesLaura Y Park-Wyllie
AIDS 17:638-40. 2003 - Impact of acid-suppressive therapy on virologic response to atazanavir-based regimens in antiretroviral-experienced patients: a case seriesTony Antoniou
J Acquir Immune Defic Syndr 39:126-8. 2005 - Advances in human immunodeficiency virus therapeuticsPatrick G Clay
Kansas City University of Medicine and Biosciences, Kansas City, MO 64106, USA
Ann Pharmacother 40:704-9. 2006..To review recent advances in the management of persons infected with HIV...