T Antoniou

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Clin Infect Dis 38:e38-40. 2004
  2. pmc Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ont
    CMAJ 185:1035-41. 2013
  3. doi request reprint Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men
    T Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Int J STD AIDS 20:180-3. 2009
  4. doi request reprint Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy
    Tony Antoniou
    Canadian Immunodeficiency Research Collaborative, Canada
    AIDS Care 21:1247-52. 2009
  5. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
  6. doi request reprint Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice
    Tony Antoniou
    University of Toronto, Toronto, Ontario, Canada, Maple Leaf Medical Clinical, Toronto, Ontario, Canada
    J Int Assoc Physicians AIDS Care (Chic) 9:382-9. 2010
  7. ncbi request reprint Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients
    Tony Antoniou
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 27:779-81. 2005
  8. ncbi request reprint Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study
    T Antoniou
    University of Toronto, Toronto, Ontario, Canada
    HIV Med 6:284-90. 2005
  9. ncbi request reprint Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Pharmacotherapy 25:899-903. 2005
  10. doi request reprint Ciprofloxacin-induced theophylline toxicity: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 67:521-6. 2011

Detail Information

Publications34

  1. ncbi request reprint Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Clin Infect Dis 38:e38-40. 2004
    ..The inhibition of zidovudine glucuronidation by valproic acid and the resultant zidovudine hematologic toxicity is the proposed mechanism of the interaction...
  2. pmc Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ont
    CMAJ 185:1035-41. 2013
    ..We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers...
  3. doi request reprint Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men
    T Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Int J STD AIDS 20:180-3. 2009
    ..Cultured MRSA underwent pulsed-field gel electrophoresis and virulence testing for Panton-Valentine leukocidin gene expression. The prevalence of CA-MRSA colonization was 1.6% (95% CI: 0.5-2.6%)...
  4. doi request reprint Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy
    Tony Antoniou
    Canadian Immunodeficiency Research Collaborative, Canada
    AIDS Care 21:1247-52. 2009
    ..001) and mental health (p=0.01) were observed from baseline to week 96. In conclusion, treatment with PAIG was associated with sustained improvements in both the physical and psychological components of FLA through 96 weeks of follow-up...
  5. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
    ..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB...
  6. doi request reprint Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice
    Tony Antoniou
    University of Toronto, Toronto, Ontario, Canada, Maple Leaf Medical Clinical, Toronto, Ontario, Canada
    J Int Assoc Physicians AIDS Care (Chic) 9:382-9. 2010
    ..Objective: To compare the effectiveness and safety of ritonavir (TPV/r)- and darunavir/ritonavir (DRV/ r)-based therapies in treatment-experienced patients (n = 38 and 47, respectively)...
  7. ncbi request reprint Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients
    Tony Antoniou
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 27:779-81. 2005
    ..No patient discontinued the regimen because of indinavir-related urologic or retinoid-type adverse effects. Further study of the regimen with larger cohorts of patients is necessary...
  8. ncbi request reprint Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study
    T Antoniou
    University of Toronto, Toronto, Ontario, Canada
    HIV Med 6:284-90. 2005
    ..Despite the recent publication of case reports describing various manifestations of tenofovir-related nephrotoxicity, data regarding the incidence of and risk factors for this adverse effect are currently lacking...
  9. ncbi request reprint Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Pharmacotherapy 25:899-903. 2005
    ..In addition, they should continue to reserve its use for moderate-to-severe Pneumocystis jiroveci pneumonia for which trimethoprim-sulfamethoxazole is ineffective or contraindicated...
  10. doi request reprint Ciprofloxacin-induced theophylline toxicity: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 67:521-6. 2011
    ..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline...
  11. pmc Symptomatic hyperlactatemia in an HIV-positive patient: a case report and discussion
    Tony Antoniou
    St Michael s Hospital, Toronto, ON
    CMAJ 168:195-8. 2003
    ..We also review the pathophysiology, prevalence, spectrum and management of disturbances in lactate homeostasis induced by nucleoside reverse transcriptase inhibitors...
  12. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011
    ..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone...
  13. pmc Validation of case-finding algorithms derived from administrative data for identifying adults living with human immunodeficiency virus infection
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e21748. 2011
    ..We sought to validate a case-finding algorithm for human immunodeficiency virus (HIV) infection using administrative health databases in Ontario, Canada...
  14. pmc Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Br J Clin Pharmacol 71:544-9. 2011
    ..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin...
  15. ncbi request reprint Interactions between antiretrovirals and antineoplastic drug therapy
    Tony Antoniou
    St Michael s Hospital, Toronto, Ontario, Canada
    Clin Pharmacokinet 44:111-45. 2005
    ..Further research delineating the combined safety and pharmacokinetics of antiretrovirals and antineoplastic therapy is necessary...
  16. ncbi request reprint A large prospective study assessing injection site reactions, quality of life and preference in patients using the Biojector vs standard needles for enfuvirtide administration
    M R Loutfy
    Department of Medicine, University of Toronto, Maple Leaf Medical Clinic, and Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    HIV Med 8:427-32. 2007
    ..Tualatin, OR, USA) relative to standard needles...
  17. ncbi request reprint Virologic and immunologic impact and durability of enfuvirtide-based antiretroviral therapy in HIV-infected treatment-experienced patients in a clinical setting
    M R Loutfy
    Department of Medicine, University of Toronto, Toronto, Ontario Maple Leaf Medical Clinical, Toronto, Ontario, Canada
    HIV Clin Trials 8:36-44. 2007
    ..To evaluate the effectiveness and safety of enfuvirtide-based therapy in treatment-experienced patients in a clinical setting...
  18. ncbi request reprint Risk factors for grade 3-4 liver enzyme elevation in HIV and hepatitis C coinfected patients on combination antiretroviral therapy
    S Chihrin
    Maple Leaf Medical Clinic, Toronto, Ontario, Canada
    AIDS Patient Care STDS 21:469-78. 2007
    ..0001), and nucleoside analogues (p = 0.0009) compared to the rest of the cohort. Further research to better clarify risk factors for hepatotoxicity in coinfected patients is warranted given the challenges in treating this population...
  19. ncbi request reprint Prospective cohort study of HIV post-exposure prophylaxis for sexual assault survivors
    Mona Rafik Loutfy
    Department of Medicine, University of Toronto, Ontario, Canada
    Antivir Ther 13:87-95. 2008
    ..There is a lack of standardized programs for HIV counselling and post-exposure prophylaxis (PEP) in the setting of sexual assault...
  20. ncbi request reprint Randomized controlled trial of once-daily tenofovir, lamivudine, and lopinavir/ritonavir versus remaining on the same regimen in virologically suppressed HIV-infected patients on their first PI-containing HAART regimen
    Mona R Loutfy
    Department of Medicine, University of Toronto, Toronto, Canada
    HIV Clin Trials 8:259-68. 2007
    ....
  21. ncbi request reprint Outcomes of dosage adjustments used to manage antiretroviral drug interactions
    Laura Y Park-Wyllie
    Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 45:933-6. 2007
    ..03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01)...
  22. ncbi request reprint Interactions between recreational drugs and antiretroviral agents
    Tony Antoniou
    HIV Program Inner City Health, St Michael s Hospital, Toronto, Ontario, Canada
    Ann Pharmacother 36:1598-613. 2002
    ..To summarize existing data regarding potential interactions between recreational drugs and drugs commonly used in the management of HIV-positive patients...
  23. ncbi request reprint Immediate versus delayed polyalkylimide gel injections to correct facial lipoatrophy in HIV-positive patients
    Mona R Loutfy
    Maple Leaf Medical Clinic, 70 Carlton Street, Toronto, Ontario, Canada
    AIDS 21:1147-55. 2007
    ..To evaluate the safety and efficacy of polyalkylimide gel (PAIG) in the treatment of HIV-associated facial lipoatrophy...
  24. ncbi request reprint Adverse quality of life consequences of antiretroviral medications
    L Y Park-Wyllie
    St Michael s Hospital, Toronto, Ontario
    AIDS Care 19:252-7. 2007
    ..A broad concept of quality of life is needed to encompass all dimensions important to people living with HIV...
  25. doi request reprint Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two cases
    Denise Jaworsky
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Antivir Ther 15:677-80. 2010
    ..However, data on their safety and efficacy in preventing vertical transmission are limited...
  26. ncbi request reprint Assay of HIV gp41 amino acid sequence to identify baseline variation and mutation development in patients with virologic failure on enfuvirtide
    M R Loutfy
    University of Toronto, Toronto, Ont, Canada
    Antiviral Res 75:58-63. 2007
    ..Further study is required to determine the clinical relevance of the clade related polymorphisms and the new mutations identified in the patients with virologic failure...
  27. ncbi request reprint Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection
    Tony Antoniou
    Inner City Health HIV Program, Toronto, Ontario, Canada
    Pharmacotherapy 23:29-43. 2003
    ..Given the ease of administration and relative safety from the perspectives of adverse effects and drug interactions, tenofovir has the potential to assume a large role in the treatment of patients with HIV infection...
  28. ncbi request reprint Tenofovir disoproxil fumarate
    Tony Antoniou
    Inner City Health HIV Program, St Michael s Hospital, Toronto, Ontario, Canada
    Drugs 63:1609-10. 2003
  29. ncbi request reprint Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphoma
    Matthew C Cheung
    Department of Medicine, Division of Hematology Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Ann Hematol 86:631-8. 2007
    ..The majority prefer to use cART in combination with CHOP for ARL. The use and perceived benefit of rituximab may be influenced by interprovincial formulary differences and regional variation in guideline recommendations...
  30. ncbi request reprint A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapy
    Tony Antoniou
    J Acquir Immune Defic Syndr 37:1666-7. 2004
  31. ncbi request reprint Concurrent use of bupropion with CYP2B6 inhibitors, nelfinavir, ritonavir and efavirenz: a case series
    Laura Y Park-Wyllie
    AIDS 17:638-40. 2003
  32. ncbi request reprint Impact of acid-suppressive therapy on virologic response to atazanavir-based regimens in antiretroviral-experienced patients: a case series
    Tony Antoniou
    J Acquir Immune Defic Syndr 39:126-8. 2005
  33. ncbi request reprint Advances in human immunodeficiency virus therapeutics
    Patrick G Clay
    Kansas City University of Medicine and Biosciences, Kansas City, MO 64106, USA
    Ann Pharmacother 40:704-9. 2006
    ..To review recent advances in the management of persons infected with HIV...