- Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium ratesYoanna Skrobik
Hopital Maisonneuve Rosemont, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
Anesth Analg 111:451-63. 2010..We hypothesized that the likely reduction in iatrogenic coma would result in less delirium, because these 2 morbid conditions seem to be linked...
- The pain, agitation, and delirium practice guidelines for adult critically ill patients: a post-publication perspectiveYoanna Skrobik
Soins Intensifs, Hopital Maisonneuve Rosemont, Montreal, QC H1T 2M4, Canada
Ann Intensive Care 3:9. 2013..The details of these recommendations, as well as more recent publications that complement the guidelines, are provided in this commentary...
- Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium: a post-hoc analysis of a double-blind, randomized, placebo-controlled studyJohn W Devlin
Northeastern University School of Pharmacy, 360 Huntington Avenue, Mugar 206, Boston, MA 02115, USA
Crit Care 15:R215. 2011....
- Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedsideJohn W Devlin
School of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02118, USA
Crit Care 12:R19. 2008..We sought to measure the impact of a simple educational intervention on the ability of intensive care unit (ICU) nurses to clinically identify delirium and to use a standardized delirium scale correctly...
- Delirium prevention and treatmentYoanna Skrobik
Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
Crit Care Clin 25:585-91, x. 2009..No nonpharmacologic approach or drug has been shown to be beneficial once delirium is established. Considering the importance and the consequences of delirium in the critical care setting, addiction studies are urgently needed...
- Pain may be inevitable; inadequate management is notYoanna Skrobik
Hopital Maisonneuve Rosemont, 5415 Boulevard de l Assomption, Montreal, Quebec, Canada
Crit Care 12:142. 2008....
- Broadening our perspectives on ICU delirium risk factorsYoanna Skrobik
Department of Medicine and Critical Care, Universite de Montreal, Hopital Maisonneuve Rosemont, Soins Intensifs 5415 boul, de l Assomption, Montreal, Quebec, Canada, H1T 2M4
Crit Care 13:160. 2009..Several potentially modifiable associations deserve prospective study: these include administration of sedatives and opiates; multiple catheters; as well as minimizing physical restraints and enabling visitors...
- Nonleg venous thrombosis in critically ill adults: a nested prospective cohort studyFrancois Lamontagne
Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
JAMA Intern Med 174:689-96. 2014..The risk of nonleg deep venous thromboses (NLDVTs), predisposing factors, and the association between NLDVTs and pulmonary embolism (PE) or death are unclear...
- Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT studyJames Douketis
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 168:1805-12. 2008..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency...
- I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluationDon Kelena Awissi
Pharmacy Department, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
Ann Pharmacother 46:21-8. 2012..Intensive care units (ICUs) account for considerable health care costs. Adequate pain and sedation management is important to clinical care...
- Evaluating pain, sedation, and delirium in the neurologically critically ill-feasibility and reliability of standardized tools: a multi-institutional studyAmy Yu
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Crit Care Med 41:2002-7. 2013....
- Alcohol, nicotine, and iatrogenic withdrawals in the ICUDon Kelena Awissi
Pharmacy Department, Hopital Maisonneuve Rosemont, Montreal, QC, Canada
Crit Care Med 41:S57-68. 2013..Description of nicotine withdrawal and related publications specific to the critically ill are also reviewed. A brief comment as to sedative and opiate withdrawal follows...
- Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxisFrancois Lauzier
Division of Critical Care, Departments of Medicine and of Anesthesiology, Centre de Recherche du CHU de Québec, Axe Santé des populations et pratiques optimales en santé, Universite Laval, 1401, 18e rue, Quebec, QC, G1J 1Z4, Canada
Intensive Care Med 39:2135-43. 2013..Our objectives are to describe the predictors of major bleeding and the association between bleeding and mortality in medical-surgical critically ill patients receiving heparin thromboprophylaxis...
- Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factorsYoanna Skrobik
Maisonneuve Rosemont Hospital and Université de Montréal, Intensive Care Unit, Montreal, Quebec, Canada
Crit Care Med 41:999-1008. 2013..Both may be associated with sedative or opiate doses and pharmacokinetic or pharmacogenetic variables, such as drug plasma levels (exposure), drug metabolism, and/or their transport across the blood-brain barrier...
- Pain, sedation, and delirium management in the neurocritically ill: lessons learned from recent researchCeline Gelinas
Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Semin Respir Crit Care Med 34:236-43. 2013..Patients with neurological injury or illness are often excluded from ICU studies addressing pain, sedation, and delirium, but this need not be the case. We review what is understood in this area based on current evidence...
- A critical appraisal of sedation, analgesia and delirium in neurocritical careJeanne S Teitelbaum
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Can J Neurol Sci 38:815-25. 2011..Clearly, little information exists on analgesia, sedation and delirium in the NICU. Systematic evaluation of pain improves outcome. No evidence-based therapeutic recommendations can be proffered...
- Subsyndromal delirium in the ICU: evidence for a disease spectrumSébastien Ouimet
Maisonneuve Rosemont Hospital and Université de Montréal, Intensive Care Unit, 5415 Boulevard del Assomption, H1T 2M4, Montreal, QC, Canada
Intensive Care Med 33:1007-13. 2007..The Intensive Care Delirium Screening Checklist (ICDSC) score ranges from 0 to 8, with a score of 4 or higher indicating clinical delirium. We investigated whether lower (subsyndromal) values affect outcome...
- Delirium in critically ill patientsNicolas Bergeron
Critical Care Division, University of Montreal Hospital, Montreal, Quebec, Canada
Crit Care 6:181-2. 2002..e. acute or fluctuating onset, inattention, disorganized thinking and altered level of consciousness). Its development for use in the critical care setting represents a significant advance that could lead to better care for such patients...
- Individual delirium symptoms: do they matter?Francois Marquis
Intensive Care Unit, Maisonneuve Rosemont Hospital, Universite de Montreal, Montreal, Quebec, Canada
Crit Care Med 35:2533-7. 2007..To evaluate the impact of individual manifestations of delirium on outcome, describe them in critically ill adults, and validate nurses' bedside item assessments from the Intensive Care Delirium Screening Checklist (ICDSC)...
- Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adultsSangeeta Mehta
1Department of Medicine and Interdepartmental Division of Critical Care, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada 2Departments of Medicine, Clinical Epidemiology, and Biostatistics, McMaster University, St Joseph s Healthcare, Hamilton, ON, Canada 3School of Pharmacy, Northeastern University, Boston, MA 4Département de Médecine, Soins Intensifs, Hopital Maisonneuve Rosemont, Universite de Montreal, Montreal, QC, Canada 5Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 6Department of Critical Care, Hamilton Health Sciences, Hamilton, ON, Canada 7Clinical Epidemiology Program, Ottawa Hospital Research Institute and Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada 8Department of Medicine and Interdepartmental Division of Critical Care, University Health Network and University of Toronto, Toronto, ON, Canada 9Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada 10Division of Respirology, Interdepartmental Division of Critical Care, Faculty of Medicine, School of Medicine
Crit Care Med 43:557-66. 2015..We compared characteristics and outcomes of delirious and nondelirious patients enrolled in a multicenter trial comparing protocolized sedation with protocolized sedation plus daily sedation interruption...
- Why Candida sepsis should matter to ICU physiciansYoanna Skrobik
Department of Medicine, Universite de Montreal, 5415 Boulevard de l Assomption, Montreal, Quebec H1T 2M4, Canada Respiratory Critical Care Group, Respiratory Health Network of the FRQS, Montreal, Quebec, Canada Electronic address
Crit Care Clin 29:853-64. 2013..The epidemiology of the disease, its diagnostic challenges, and management strategies, including prophylactic, preemptive, and definitive therapeutic approaches, are presented herein. ..
- Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentaryDon Kelena Awissi
Pharmacy Department, Hopital Maisonneuve Rosemont, 5415 Boulevard de l Assomption, Montreal, PQ, H1T 2M4, Canada
Intensive Care Med 39:16-30. 2013..We reviewed published manuscripts for prevalence, risk factors, screening tools, prophylactic and treatment strategies, and outcomes for alcohol withdrawal syndrome (AWS) and delirium tremens (DT) in the critically ill...
- Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factorsDeborah Cook
Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
Crit Care 12:R32. 2008..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
- Critically ill patients and end-of-life decision-making: the senior medical resident experienceStephane P Ahern
Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Adv Health Sci Educ Theory Pract 17:121-36. 2012..Educational approaches that incorporate the telling of stories would allow students to express their feelings, doubts, and opinions about their work experiences and could thus foster personal and emotional learning in critical care...
- Incidence, risk factors and consequences of ICU deliriumSébastien Ouimet
Department of Medicine, University of Montreal, Montreal, Canada
Intensive Care Med 33:66-73. 2007..Delirium in the critically ill is reported in 11-80% of patients. We estimated the incidence of delirium using a validated scale in a large cohort of ICU patients and determined the associated risk factors and outcomes...
- Toronto Critical Care Medicine Symposium reportYoanna Skrobik
Critical Care Division, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
Can J Anaesth 49:513-6. 2002
- Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trialMaureen O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
JAMA 299:637-45. 2008..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
- Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxisD Cook
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Crit Care 24:168-75. 2009....
- The development and validation of a novel questionnaire to measure patient and family satisfaction with end-of-life care: the Canadian Health Care Evaluation Project (CANHELP) QuestionnaireDaren K Heyland
Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
Palliat Med 24:682-95. 2010..We conclude that the CANHELP Questionnaire is a valid and internally consistent instrument to measure satisfaction with end-of-life care...
- Recognition and labeling of delirium symptoms by intensivists: does it matter?Catherine Z Cheung
Department of Medicine, University of Toronto, M5G 2C4, Toronto, Ontario, Canada
Intensive Care Med 34:437-46. 2008....
- Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemiaThierry Charron
Medical and Surgical Intensive Care Units, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, H1T 2M4, Montreal, PQ, Canada
Intensive Care Med 29:1273-8. 2003..To evaluate efficacy and safety of aggressive correction of hypophosphatemia with intravenous potassium phosphate in the ICU...
- Delirium as destiny: clinical precision and genetic riskYoanna Skrobik
Crit Care Med 35:304-5. 2007
- Scoring systems for the critically ill: use, misuse and abuseYoanna Skrobik
Can J Anaesth 53:432-6. 2006
- Is disturbance of consciousness an important feature of ICU delirium?Nicolas Bergeron
Intensive Care Med 31:887. 2005
- Protocols, practice, and patients--the case of alcohol withdrawalYoanna Skrobik
Crit Care Med 35:955. 2007