Esther M Verheyen

Summary

Affiliation: Simon Fraser University
Country: Canada

Publications

  1. Verheyen E, Mirkovic I, MacLean S, Langmann C, Andrews B, MacKinnon C. The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development. Mech Dev. 2001;101:119-32 pubmed
    ..The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis. ..
  2. Swarup S, Pradhan Sundd T, Verheyen E. Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila. Development. 2015;142:1502-15 pubmed publisher
    ..The Wnt and Hedgehog pathways function in tandem in multiple developmental contexts, and the identification of several shared phospho-regulators serve as potential nodes of control under conditions of aberrant signaling and disease. ..
  3. Yu Q, Verheyen E, Zeng Y. Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel). 2016;8: pubmed publisher
    ..In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology. ..
  4. Blaquiere J, Verheyen E. Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease. Curr Top Dev Biol. 2017;123:73-103 pubmed publisher
    ..Given the diverse signaling pathways regulated by Hipk proteins, it is likely that Hipks act to fine-tune signaling and may mediate cross talk in certain contexts. Such regulation is emerging as vital for development and in disease. ..
  5. Hall E, Pradhan Sundd T, Samnani F, Verheyen E. The protein phosphatase 4 complex promotes the Notch pathway and wingless transcription. Biol Open. 2017;6:1165-1173 pubmed publisher
    ..Furthermore, we show that PP4 regulates proliferation independent of its interaction with Notch. ..
  6. Pradhan Sundd T, Verheyen E. The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless. Dev Biol. 2014;392:93-107 pubmed publisher
    ..Our study highlights the importance of early endosomal trafficking for Wg secretion, and identifies a novel role for Mop in Wg signaling. ..
  7. Fernandes V, Panchapakesan S, Braid L, Verheyen E. Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors. Dev Biol. 2014;392:334-43 pubmed publisher
    ..Furthermore, Notch hyperactivity can compensate for nmo loss in the Drosophila eye. Thus nmo promotes Notch-mediated lateral inhibition downstream of proneural factors during neurogenesis. ..
  8. Fernandes V, Pradhan Sundd T, Blaquiere J, Verheyen E. Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc. Dev Biol. 2015;402:109-18 pubmed publisher
    ..This study identifies a novel mode by which the Ras/MEK/MAPK pathway regulates regional-fate specification via HSPGs during development. ..
  9. Blaquiere J, Wong K, Kinsey S, Wu J, Verheyen E. Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior. Dis Model Mech. 2018;11: pubmed publisher
    ..i> Our study reveals that elevated levels of Hipk on their own can promote both hyperproliferation and invasive cell behavior, suggesting that Hipk family members could be potent oncogenes and drivers of EMT. ..

More Information

Publications13

  1. Blaquiere J, Lee W, Verheyen E. Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression. Dev Biol. 2014;390:14-25 pubmed publisher
    ..Because Ey repression within the retinal field is a critical step in eye development, we propose that Hipk is a key link between eye specification and patterning. ..
  2. Fernandes V, McCormack K, Lewellyn L, Verheyen E. Integrins regulate apical constriction via microtubule stabilization in the Drosophila eye disc epithelium. Cell Rep. 2014;9:2043-55 pubmed publisher
    ..Thus, integrins act as a genetic link between tissue-level signaling events and morphological change at the cellular level, leading to morphogenesis and neurogenesis in the eye. ..
  3. Pradhan Sundd T, Verheyen E. The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled. Mol Biol Cell. 2015;26:3329-42 pubmed publisher
    ..In the absence of the ubiquitin ligase Cbl, Mop is dispensable. These findings support a previously unknown role for Mop in endosomal trafficking of Fz in Wnt-receiving cells. ..
  4. Hall E, Verheyen E. Ras-activated Dsor1 promotes Wnt signaling in Drosophila development. J Cell Sci. 2015;128:4499-511 pubmed publisher
    ..Taken together, our results suggest that there is a new crosstalk pathway between insulin and Wg signaling that is mediated by Dsor1. ..