Esther M Verheyen

Summary

Affiliation: Simon Fraser University
Country: Canada

Publications

  1. ncbi The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
    E M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, B C, V5A 1S6, Burnaby, Canada
    Mech Dev 101:119-32. 2001
  2. ncbi Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Development 134:2061-71. 2007
  3. pmc Regulation of Wnt/beta-catenin signaling by protein kinases
    Esther M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Dev Dyn 239:34-44. 2010
  4. ncbi Opposing effects of Wnt and MAPK on BMP/Smad signal duration
    Esther M Verheyen
    Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    Dev Cell 13:755-6. 2007
  5. pmc Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    PLoS ONE 3:e3893. 2008
  6. doi Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Dev Biol 325:263-72. 2009
  7. doi Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6 Canada
    Development 136:241-51. 2009
  8. ncbi Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis
    Lorena R Braid
    Dept of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Dev Biol 343:178-89. 2010
  9. pmc Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling
    Sharan Swarup
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Proc Natl Acad Sci U S A 108:9887-92. 2011
  10. pmc Drosophila nemo promotes eye specification directed by the retinal determination gene network
    Lorena R Braid
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Genetics 180:283-99. 2008

Collaborators

  • Sharon M Gorski
  • Cara J Gottardi
  • Tohru Ishitani
  • Wendy Lee
  • Sharan Swarup
  • Lorena R Braid
  • Yi Arial Zeng
  • Joanna Chen
  • Jessica A Blaquiere
  • Simon Wang
  • Maryam Rahnama
  • Bryan C Andrews
  • Yi A Zeng
  • Sheila J MacLean
  • Ivana Mirkovic
  • Amanda Heiler
  • Andrea C Uetrecht
  • Gina Papaianni
  • Uwe Walldorf
  • Michael Faust
  • Worlanyo Sosu-Sedzorme
  • Kristi Charish
  • Kristen McKnight

Detail Information

Publications16

  1. ncbi The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
    E M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, B C, V5A 1S6, Burnaby, Canada
    Mech Dev 101:119-32. 2001
    ..The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis...
  2. ncbi Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Development 134:2061-71. 2007
    ..This is the first example of the inhibition of Drosophila BMP signaling by a MAPK and represents a novel mechanism of Smad inhibition through the phosphorylation of a conserved serine residue within the MH1 domain of Mad...
  3. pmc Regulation of Wnt/beta-catenin signaling by protein kinases
    Esther M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Dev Dyn 239:34-44. 2010
    ..Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases...
  4. ncbi Opposing effects of Wnt and MAPK on BMP/Smad signal duration
    Esther M Verheyen
    Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    Dev Cell 13:755-6. 2007
    ....
  5. pmc Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    PLoS ONE 3:e3893. 2008
    ....
  6. doi Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Dev Biol 325:263-72. 2009
    ....
  7. doi Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6 Canada
    Development 136:241-51. 2009
    ..We observe similar molecular interactions between Lef1/beta-catenin and vertebrate Hipk2, suggesting a direct and conserved role for Hipk proteins in promoting Wnt signaling...
  8. ncbi Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis
    Lorena R Braid
    Dept of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Dev Biol 343:178-89. 2010
    ..These studies reveal a novel role for the Nmo kinase in embryonic pattern formation through its regulation of the homeodomain-containing transcription factor Eve...
  9. pmc Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling
    Sharan Swarup
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Proc Natl Acad Sci U S A 108:9887-92. 2011
    ....
  10. pmc Drosophila nemo promotes eye specification directed by the retinal determination gene network
    Lorena R Braid
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Genetics 180:283-99. 2008
    ..Together, our genetic analyses reveal that nmo promotes normal and ectopic eye development directed by the RDGN...
  11. ncbi Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
    Yi A Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Development 131:2911-20. 2004
    ..These observations suggest that the patterning mechanism governed by Wg involves a negative feedback circuit in which Wg induces expression of its own antagonist Nemo...
  12. doi Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth
    Joanna Chen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Curr Biol 22:1582-6. 2012
    ..Hipk phosphorylates Yki and in vivo analyses show that Hipk's regulation of Yki is kinase-dependent. To our knowledge, this is the first kinase identified to positively regulate Yki...
  13. doi Hipk proteins dually regulate Wnt/Wingless signal transduction
    Esther M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Fly (Austin) 6:126-31. 2012
    ..Moreover, we describe here that Hipk proteins have a role independent of their effect on β-catenin/Armadillo stability to enhance Wnt/Wingless signaling...
  14. ncbi Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression
    Jessica A Blaquiere
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A1S6
    Dev Biol 390:14-25. 2014
    ..Because Ey repression within the retinal field is a critical step in eye development, we propose that Hipk is a key link between eye specification and patterning. ..
  15. ncbi Drosophila nemo is an essential gene involved in the regulation of programmed cell death
    Ivana Mirkovic
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    Mech Dev 119:9-20. 2002
    ..Such an observation supports the model that there is cross-talk between Wnt, TGFbeta and JNK signaling at multiple stages of development...
  16. ncbi Characterization of Dir: a putative potassium inward rectifying channel in Drosophila
    Sheila J MacLean
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia Canada V5A 1S6
    Mech Dev 116:193-7. 2002
    ..Though there are other known potassium channels in Drosophila such as ether-a-go-go and shaker, most are voltage-gated channels. As an important first step in characterizing Kir channels in Drosophila, we initiated studies on Dir...