David J Lynn

Summary

Affiliation: Simon Fraser University
Country: Canada

Publications

  1. ncbi Detecting the effects of selection at the population level in six bovine immune genes
    Abigail R Freeman
    Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    BMC Genet 9:62. 2008
  2. ncbi InnateDB: facilitating systems-level analyses of the mammalian innate immune response
    David J Lynn
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Mol Syst Biol 4:218. 2008
  3. ncbi InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation
    Karin Breuer
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A1S6, Canada
    Nucleic Acids Res 41:D1228-33. 2013
  4. ncbi Bioinformatics: implications for medical research and clinical practice
    David J Lynn
    Education Research Centre, St. Vincent's University Hospital, Dublin, Ireland
    Clin Invest Med 26:70-4. 2003
  5. ncbi In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)
    David J Lynn
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Vet Immunol Immunopathol 93:177-84. 2003
  6. ncbi Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
    David J Lynn
    Education and Research Centre, St Vincent s University Hospital, 4, Dublin, Ireland
    Immunogenetics 56:170-7. 2004
  7. ncbi The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens
    Rowan Higgs
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Immunogenetics 57:90-8. 2005

Collaborators

  • Fiona S L Brinkman
  • Dan Tulpan
  • Mario A Fares
  • Karin Breuer
  • Abigail R Freeman
  • Rowan Higgs
  • Raymond Lo
  • Robert E W Hancock
  • Anastasia Sribnaia
  • Geoffrey L Winsor
  • Amir K Foroushani
  • Carol Chen
  • Matthew R Laird
  • Caitriona Murray
  • Daniel G Bradley
  • Tharappel James
  • Grace Mulcahy
  • Andrew T Lloyd
  • Joanna Tierney
  • Jessica McMahon
  • Cliona O'Farrelly
  • Susan Gaines

Detail Information

Publications7

  1. ncbi Detecting the effects of selection at the population level in six bovine immune genes
    Abigail R Freeman
    Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    BMC Genet 9:62. 2008
    ..Past adaptive change implies that more recent variation may have also been subject to selective forces...
  2. ncbi InnateDB: facilitating systems-level analyses of the mammalian innate immune response
    David J Lynn
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Mol Syst Biol 4:218. 2008
    ....
  3. ncbi InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation
    Karin Breuer
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A1S6, Canada
    Nucleic Acids Res 41:D1228-33. 2013
    ..Finally, the recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism...
  4. ncbi Bioinformatics: implications for medical research and clinical practice
    David J Lynn
    Education Research Centre, St. Vincent's University Hospital, Dublin, Ireland
    Clin Invest Med 26:70-4. 2003
  5. ncbi In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)
    David J Lynn
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Vet Immunol Immunopathol 93:177-84. 2003
    ..We have identified in silico the full-length sequence for liver-expressed antimicrobial peptide 2 (LEAP-2). This is the first time a non-mammalian LEAP-2 has been described...
  6. ncbi Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
    David J Lynn
    Education and Research Centre, St Vincent s University Hospital, 4, Dublin, Ireland
    Immunogenetics 56:170-7. 2004
    ..An evolutionary analysis of the gallinacin family has detected sites-primarily in the mature AMP-that are under positive selection in these molecules. The functional implications of these results are discussed...
  7. ncbi The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens
    Rowan Higgs
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Immunogenetics 57:90-8. 2005
    ..Antimicrobial activity of synthetic Gal-11 has been demonstrated against a range of bacteria and is predominantly active against the intestinal pathogens Salmonella typhimurium and Listeria monocytogenes...